LOCUS       NM_001135600            3216 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 4, subfamily v,
            polypeptide 3 (Cyp4v3), mRNA.
ACCESSION   NM_001135600 XM_001061575 XM_001064152
VERSION     NM_001135600.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3216)
  AUTHORS   Nakano,M., Kelly,E.J., Wiek,C., Hanenberg,H. and Rettie,A.E.
  TITLE     CYP4V2 in Bietti's crystalline dystrophy: ocular localization,
            metabolism of omega-3-polyunsaturated fatty acids, and functional
            deficit of the p.H331P variant
  JOURNAL   Mol Pharmacol 82 (4), 679-686 (2012)
   PUBMED   22772592
REFERENCE   2  (bases 1 to 3216)
  AUTHORS   Nakano,M., Kelly,E.J. and Rettie,A.E.
  TITLE     Expression and characterization of CYP4V2 as a fatty acid
            omega-hydroxylase
  JOURNAL   Drug Metab Dispos 37 (11), 2119-2122 (2009)
   PUBMED   19661213
REFERENCE   3  (bases 1 to 3216)
  AUTHORS   Iwadate,H., Kudo,M. and Kizuki,K.
  TITLE     Expression of tissue kallikrein mRNA in developing rat brains
  JOURNAL   Can J Physiol Pharmacol 80 (4), 245-248 (2002)
   PUBMED   12025956
  REMARK    GeneRIF: Tissue kallikrein mRNA expression is increased during
            prenatal and early postnatal development stages in rat brain.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC131846.1.
            
            On or before Oct 3, 2008 this sequence version replaced
            XM_001064152.1, XM_001061575.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC131846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3216
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..3216
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /note="cytochrome P450, family 4, subfamily v, polypeptide
                     3"
                     /db_xref="GeneID:266761"
                     /db_xref="RGD:708530"
     exon            1..455
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1819
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /EC_number="1.14.14.79"
                     /EC_number="1.14.14.80"
                     /note="cytochrome P450 4V3; cytochrome P450-like protein;
                     docosahexaenoic acid omega-hydroxylase CYP4V2; long-chain
                     fatty acid omega-monooxygenase"
                     /codon_start=1
                     /product="cytochrome P450 4V2"
                     /protein_id="NP_001129072.1"
                     /db_xref="GeneID:266761"
                     /db_xref="RGD:708530"
                     /translation="MLWLWLGLSGQKLLLWGAASAVSVAGATVLLNILQMLVSYARKW
                     QQMRPIPSVARAYPLVGHALFMKPNNTEFFQQIIQYTEEFRHLPIIKLWIGPVPLVAL
                     YKAENVEVILTSSKQIDKSFMYKFLQPWLGLGLLTSTGSKWRARRKMLTPSFHFTILE
                     DFLDVMNEQANILVNKLEKHVNQEAFNCFFPITLCALDIICETAMGKNIGAQSNGDSE
                     YVRTVYRMSDMIYRRMKMPWFWFDLWYLMFKEGRDHKKGLKSLHTFTNNVIAERVNAR
                     KAEQDCIGAGRGPLPSKTKRKAFLDLLLSVTDEEGNKLSHEDIREEVDTFMFEGHDTT
                     AAAINWSLYLLGSNPEVQRKVDKELDDVFGRSHRPVTLEDLKKLKYLDCVIKETLRVF
                     PSVPLFARSLSEDCEVAGYKISKGTEAVIIPYALHRDPRYFPDPEEFQPERFFPENSQ
                     GRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILREFWIESNQKREELGLAGDLILR
                     PNNGIWIKLKRRHEDDP"
     exon            456..568
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..654
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..845
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            846..915
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1042
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1228
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1331
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1466
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1646
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..3192
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctcgggaa attgtctcca gggcctggcg ctgcggtaaa gattttcccg gcttcaaagc
       61 aggaagaccc gaaaggatct ggtgtgcctc ggggggtcct ctcactgagc ccgaagctcc
      121 tacctcccgg agttccgaac ttgtcccctg aatttagaga aagacctccc tccactacac
      181 cctgcagcga ctgcttgcca ccttctcact ggcagcccca gagaagaggg gagtaagaga
      241 gatgttgtgg ctgtggttag ggctcagcgg gcagaagcta ttgctttggg gcgcagcgag
      301 cgcggtctcc gtggccggcg ccactgtctt gctcaacatc ctgcagatgt tggtaagcta
      361 tgcacgaaag tggcagcaga tgcggccaat cccgtcggtg gctcgcgctt accccttggt
      421 gggacatgcg ctgtttatga agcccaacaa cacagaattt tttcagcaga taattcagta
      481 cacagaagaa ttccgacacc tgcccatcat taaactctgg attggaccag tgcccctggt
      541 ggcactttat aaggcagaga atgtggaggt gattttgacc agttcgaagc aaattgataa
      601 atcctttatg tacaagttcc tacagccatg gctgggacta ggacttctta caagtactgg
      661 gagcaaatgg cgtgccagga ggaagatgtt aacacccagt ttccatttta caattctgga
      721 ggatttctta gatgtcatga atgagcaagc aaatatattg gttaacaagc ttgaaaaaca
      781 tgtcaatcaa gaggccttta actgcttttt ccccatcact ctttgtgctc tggatataat
      841 ctgtgaaacg gctatgggga agaacattgg agctcaaagt aatggtgatt ctgagtatgt
      901 ccgtacagtg tataggatga gcgatatgat atacagaaga atgaagatgc cctggttttg
      961 gtttgacctt tggtacctta tgtttaaaga aggaagggac cacaaaaagg gactaaagag
     1021 tctacatact tttaccaaca atgtcattgc tgaacgggtt aatgcaagga aggcagagca
     1081 agactgcata ggtgctggga ggggtcctct cccctcgaaa actaagcgca aggcctttct
     1141 tgacttgctt ttgagtgtga ctgatgagga aggaaacaaa ttaagccatg aagacatccg
     1201 agaggaagtt gacaccttca tgtttgaggg tcacgataca actgctgctg ccataaactg
     1261 gtccttatac ctcctgggct ctaatccaga agtccagagg aaagtggaca aggagctgga
     1321 tgatgtgttt ggaagatccc atcgccctgt caccttggaa gacctgaaga aacttaaata
     1381 tctggattgt gtcattaagg agaccctccg tgttttccca tctgtccctt tatttgcccg
     1441 gagtcttagc gaagactgtg aagtggcggg ttacaaaatc tcaaaaggaa cggaagcagt
     1501 catcattccc tatgcactac atcgagaccc tagatacttc ccagaccctg aggaattcca
     1561 gccagagcgg ttctttcctg aaaactccca aggacgccac ccctatgcct atgtgccatt
     1621 ctctgctgga cctagaaact gcattggtca aaagtttgcg gtcatggagg aaaagaccat
     1681 tcttgcctgt atcctgaggg agttttggat agaatccaac cagaagagag aagaactcgg
     1741 cctggctgga gatttgattc ttaggccaaa taatggcatc tggatcaagc tgaagaggag
     1801 gcatgaagat gacccctaac gccgtcctca agctgagacc ctgtcatgac gaaggtcatt
     1861 ccataagaaa gatggcatct gcaaatttta gtttatgagc tgaaaactcg gaatcctcag
     1921 acccagtgtt tcttctttct tgtccccacc gatcttgaga cccagtctat cactgagagt
     1981 ttttgtatgt ttgttagcag cacagatgac aatgtcacac ctgttctctg tctcgagggc
     2041 actgttagca agctgaagta gcactgacat aaacgtgcag gaaaaatgat aacagagcgg
     2101 tcaccagcct gtttaatccc attggttaga cgcaaaggtc atcattttaa tgaaatctca
     2161 gaattaagaa aatagccttg ttgacttgga aatccatgta gcatttgaaa atgttggata
     2221 attaagccct tcaggatacc aggcttaagt ttttataatg tcatcagtgt atcagtcgta
     2281 acgtaattgc cagagccctt ccagctctta taatgaaaag caagtccctt gcatgcctgc
     2341 gtcaagttcc agtcaccttg ttgactgtga actagaatct tctttctgtt cttggtggac
     2401 acaaacactt tatacatctt attatttaga agagattcct ctccacaatg tcctacctct
     2461 cacagaagct taattagtgg ctttttttaa atcaataaac attaggcaga tccatttatt
     2521 ttgggtgtat tttacaagta taagtttgga tgagctattt gacaaacttc agcattaact
     2581 ctcaactcta cagacatctt taacaaggaa aggcatttat ggtggccctc tgcatacagg
     2641 cagtgtccta ttgcatatca aatggcggag atgcattgac agatttgagg acataattag
     2701 tggcttttga agttcaagtg acaacagaaa ctttctgctt atgtgccatt taattaagag
     2761 taggggtgtg gaataaaggg gacagcaaat ttctgcccac gttctgtcat ggctagaagt
     2821 agttaaaatg tctacaccaa ggcctctcca cttcctttct gaaatactct ctcctactac
     2881 acactttggc gttatggaac tcagaactgt gattggatga atcaggactc aggatttctg
     2941 ccctcgatgt gggcatgtgt ttcttgtaat tcctctactt ttagaagaaa gaatcttttc
     3001 ttctatattt agttacactg tactatcaca cttggttcag cagaagacat ttaattaact
     3061 cagtcccgtg gaacatcccc atcaagctgg caattgaatt ccactccttg cttttatttg
     3121 gtgatataat gctactattc ttcatgcaat gacttttaga aacttccttt taataaataa
     3181 tttttaacag gaaaaaaaaa aaaaaaaaaa aaaaaa
//
