LOCUS       NM_153318               1782 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 4, subfamily f,
            polypeptide 6 (Cyp4f6), mRNA.
ACCESSION   NM_153318
VERSION     NM_153318.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1782)
  AUTHORS   Wang,Y., Zhao,J., Kalsotra,A., Turman,C.M., Grill,R.J., Dash,P.K.
            and Strobel,H.W.
  TITLE     CYP4Fs expression in rat brain correlates with changes in LTB4
            levels after traumatic brain injury
  JOURNAL   J Neurotrauma 25 (10), 1187-1194 (2008)
   PUBMED   18847377
  REMARK    GeneRIF: The present study shows that traumatic brain injury (TBI)
            triggers inflammation and elicits changes in mRNA expression of
            CYP4Fs in the frontal and occipital lobes and the hippocampus.
REFERENCE   2  (bases 1 to 1782)
  AUTHORS   Kalsotra,A., Cui,X., Anakk,S., Hinojos,C.A., Doris,P.A. and
            Strobel,H.W.
  TITLE     Renal localization, expression, and developmental regulation of
            P450 4F cytochromes in three substrains of spontaneously
            hypertensive rats
  JOURNAL   Biochem Biophys Res Commun 338 (1), 423-431 (2005)
   PUBMED   16182239
  REMARK    GeneRIF: CYP4Fs are regionally distributed in the spontaneously
            hypertensive rat (SHR) kidney with CYP4F1, 4F4, and 4F5 being more
            highly expressed in the renal cortex than medulla while CYP4F6
            shows higher medullary expression.
REFERENCE   3  (bases 1 to 1782)
  AUTHORS   Bylund,J., Harder,A.G., Maier,K.G., Roman,R.J. and Harder,D.R.
  TITLE     Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6
  JOURNAL   Arch Biochem Biophys 412 (1), 34-41 (2003)
   PUBMED   12646265
  REMARK    GeneRIF: CYP4F5 and CYP4F6, due to their capacities to metabolize
            LTB(4), may play important roles in modulating inflammatory
            response in the lung and to some extent in the brain, kidney, and
            testis
REFERENCE   4  (bases 1 to 1782)
  AUTHORS   Kawashima,H. and Strobel,H.W.
  TITLE     cDNA cloning of three new forms of rat brain cytochrome P450
            belonging to the CYP4F subfamily
  JOURNAL   Biochem Biophys Res Commun 217 (3), 1137-1144 (1995)
   PUBMED   8554568
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U39208.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U39208.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1782
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1782
                     /gene="Cyp4f6"
                     /note="cytochrome P450, family 4, subfamily f, polypeptide
                     6"
                     /db_xref="GeneID:266689"
                     /db_xref="RGD:708365"
     exon            1..121
                     /gene="Cyp4f6"
                     /inference="alignment:Splign:2.1.0"
     exon            122..320
                     /gene="Cyp4f6"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1736
                     /gene="Cyp4f6"
                     /EC_number="1.14.14.1"
                     /note="CYPIVF6"
                     /codon_start=1
                     /product="cytochrome P450 4F6"
                     /protein_id="NP_695230.1"
                     /db_xref="GeneID:266689"
                     /db_xref="RGD:708365"
                     /translation="MLQLSLSRLGMGSLTASPWHLLLLGGASWILARILAWIYTFYDN
                     CCRLRCFPQPPKPSWFWGHLTLMKNNEEGMQFIAHLGRNFRDIHLSWVGPVYPILRLV
                     HPNVIAPLLQASAAVAPKEMTLYGFLKPWLGDGLLMSAGEKWNHHRRLLTPAFHFDIL
                     KSYVKIFNKSVNTMHAKWQRLTAKGSARLDMFEHISLMTLDSLQKCIFSFDSNCQESN
                     SEYIAAILELSSLIVKRQRQPFLYLDFLYYLTADGRRFRKACDVVHNFTDAVIRERRS
                     TLNTQGVDEFLKARAKTKTLDFIDVLLLAKDEHGKGLSDVDIRAEADTFMFGGHDTTA
                     SALSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLRLH
                     PPVLLISRCCSQDIVLPDGRVIPKGNICVISIFGVHHNPSVWPDPEVYNPFRFDPENP
                     QKRSPLAFIPFSAGPRNCIGQTFAMSEIKVALALTLLRFCVLPDDKEPRRKPELILRA
                     EGGLWLRVEPLSTVTSQLPWDLLAHPPTS"
     exon            321..465
                     /gene="Cyp4f6"
                     /inference="alignment:Splign:2.1.0"
     exon            466..519
                     /gene="Cyp4f6"
                     /inference="alignment:Splign:2.1.0"
     exon            520..647
                     /gene="Cyp4f6"
                     /inference="alignment:Splign:2.1.0"
     exon            648..769
                     /gene="Cyp4f6"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1040
                     /gene="Cyp4f6"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1107
                     /gene="Cyp4f6"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1237
                     /gene="Cyp4f6"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1371
                     /gene="Cyp4f6"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1436
                     /gene="Cyp4f6"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1519
                     /gene="Cyp4f6"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1762
                     /gene="Cyp4f6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgattggct ggttcagccc agctcaactt cccgcacagc ttccggcaag tcggaagcca
       61 gggacaaaaa gttttcaaag aagataggag gttgtggagg actcgctgct catgagagaa
      121 ggatgctaca actaagcctg tcccggctgg gaatggggtc cctgacagcc tctccatggc
      181 atctactgct gctgggagga gcctcttgga tactagcccg aattctggcc tggatctata
      241 ccttctatga caactgctgc cgccttcgtt gcttccctca gccccctaaa ccaagttggt
      301 tttggggtca cttgaccttg atgaagaaca acgaggaagg catgcagttc atagcacatc
      361 tgggccgcaa cttccgtgat atccacctct cttgggtggg acccgtgtac ccgatcctgc
      421 gactcgtcca ccctaacgtc attgctcccc tgctccaagc ctcagctgct gttgcaccca
      481 aggaaatgac cctctatggc ttcctgaagc cctggctggg ggatgggctc ctgatgagcg
      541 ctggtgagaa gtggaaccac caccgacgcc tgctgacacc cgccttccac tttgacatcc
      601 tgaagtccta cgtgaagatt tttaacaaga gcgtgaacac catgcatgcc aagtggcagc
      661 gtctgactgc caagggcagt gcccgtctgg acatgttcga gcacatcagc ctgatgacct
      721 tggacagcct gcaaaaatgc atcttcagct tcgacagcaa ctgtcaggag tctaacagtg
      781 aatacatagc tgcgatcctg gaactcagct ccctcatagt gaaacggcaa cgccagccct
      841 tcctgtacct ggacttcctg tattacctca ctgctgatgg gcggcgcttc cgcaaggcct
      901 gcgacgtggt gcacaacttc acagatgctg tcatcaggga gagacgcagc accctcaata
      961 cccagggcgt tgatgaattc ctaaaggcca gggctaagac taaaacttta gactttattg
     1021 atgttctctt gctggccaag gatgagcatg ggaaggggct gtcggatgtg gacatccgag
     1081 cagaggctga caccttcatg ttcggaggtc atgacaccac ggccagcgca ctctcctgga
     1141 tcctgtacaa cctggcaagg cacccggaat accaggagcg ctgccggcag gaggtgcggg
     1201 agctgctgag ggaccgagag cctgaggaga ttgaatggga cgacctggcc cagctgccct
     1261 tcctaaccat gtgcatcaag gagagtctgc ggctgcaccc tccagtctta ttaatctccc
     1321 gctgctgttc ccaggacatt gtgctgccag atggccgggt catccccaaa gggaacatct
     1381 gtgtcatcag catctttggg gttcaccaca atccttcagt gtggccagac cctgaggtct
     1441 acaacccctt ccgctttgac ccagaaaacc cacagaagag gtcacctctg gcttttattc
     1501 ccttctcagc gggacccagg aactgcatag gacagacttt cgccatgagc gagataaagg
     1561 tggcgctggc gctgacgctg ctgcgcttct gcgtcctgcc agatgacaag gagccgcgcc
     1621 ggaagccgga gctgatcctg cgtgcggagg gcggactgtg gctgcgggtg gaaccgctga
     1681 gcacagtgac ctcacagctg ccttgggacc tcctcgccca ccctcctacc tcttgagatc
     1741 tctgaataaa gaattaaata agaaaaaaaa aaaaaaaaaa aa
//
