LOCUS       NM_173124               2440 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 4, subfamily f,
            polypeptide 5 (Cyp4f5), mRNA.
ACCESSION   NM_173124
VERSION     NM_173124.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2440)
  AUTHORS   Aboutabl,M.E., Zordoky,B.N. and El-Kadi,A.O.
  TITLE     3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome
            P450 gene expression and arachidonic acid metabolism in male
            Sprague Dawley rats
  JOURNAL   Br J Pharmacol 158 (7), 1808-1819 (2009)
   PUBMED   19889059
REFERENCE   2  (bases 1 to 2440)
  AUTHORS   Andersson,K.B., Florholmen,G., Winer,L.H., Tonnessen,T. and
            Christensen,G.
  TITLE     Regulation of neuronal type genes in congestive heart failure rats
  JOURNAL   Acta Physiol (Oxf) 186 (1), 17-27 (2006)
   PUBMED   16497176
REFERENCE   3  (bases 1 to 2440)
  AUTHORS   Kalsotra,A., Cui,X., Anakk,S., Hinojos,C.A., Doris,P.A. and
            Strobel,H.W.
  TITLE     Renal localization, expression, and developmental regulation of
            P450 4F cytochromes in three substrains of spontaneously
            hypertensive rats
  JOURNAL   Biochem Biophys Res Commun 338 (1), 423-431 (2005)
   PUBMED   16182239
  REMARK    GeneRIF: CYP4Fs are regionally distributed in the spontaneously
            hypertensive rat (SHR) kidney with CYP4F1, 4F4, and 4F5 being
            expressed more highly in the renal cortex than medulla while CYP4F6
            shows higher medullary expression.
REFERENCE   4  (bases 1 to 2440)
  AUTHORS   Bylund,J., Harder,A.G., Maier,K.G., Roman,R.J. and Harder,D.R.
  TITLE     Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6
  JOURNAL   Arch Biochem Biophys 412 (1), 34-41 (2003)
   PUBMED   12646265
  REMARK    GeneRIF: CYP4F5 and CYP4F6, due to their capacities to metabolize
            LTB(4), may play important roles in modulating inflammatory
            response in the lung and to some extent in the brain, kidney, and
            testis
REFERENCE   5  (bases 1 to 2440)
  AUTHORS   Kawashima,H. and Strobel,H.W.
  TITLE     cDNA cloning of three new forms of rat brain cytochrome P450
            belonging to the CYP4F subfamily
  JOURNAL   Biochem Biophys Res Commun 217 (3), 1137-1144 (1995)
   PUBMED   8554568
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U39207.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U39207.1, BC129085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132297, SAMD00132306
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2440
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2440
                     /gene="Cyp4f5"
                     /note="cytochrome P450, family 4, subfamily f, polypeptide
                     5"
                     /db_xref="GeneID:286905"
                     /db_xref="RGD:708364"
     exon            1..69
                     /gene="Cyp4f5"
                     /inference="alignment:Splign:2.1.0"
     exon            70..271
                     /gene="Cyp4f5"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1654
                     /gene="Cyp4f5"
                     /EC_number="1.14.14.1"
                     /note="CYPIVF5; cytochrome P450 4F5-like"
                     /codon_start=1
                     /product="cytochrome P450 4F5"
                     /protein_id="NP_775147.1"
                     /db_xref="GeneID:286905"
                     /db_xref="RGD:708364"
                     /translation="MPWLTVSGLDLGSVVTSTWHLLLLGAASWILARILAWTYSFCEN
                     CSRLRCFPQSPKRNWFLGHLGTIQSNEEGMRLVTEMGQTFRDIHLCWLGPVIPVLRLV
                     DPAFVAPLLQAPALVAPKDTTFLRFLKPWLGDGLFLSSGDKWSRHRRLLTPAFHFDIL
                     KPYVKIFNQSVNIMHAKWKHLCLEGSARLEMFENISLMTLDSLQKCLFGFDSNCQESP
                     SEYISAILELSSLIIKRSQQLFLYLDFLYYRTADGRRFRKACDLVHNFTDAVIRERRR
                     LLSSQGTDEFLESKTKSKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHDT
                     TASALSWILYNLARHPEYQERCRQEVWELLRDREPEEIEWDDLAQLPFLTMCIKESLR
                     LHPPAIDLLRRCTQDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVFDPFRFDSE
                     NRQKRSPLSFIPFSAGPRNCIGQTFAMNEMKVVVALTLLRFRVLPDDKEPRRKPEIIL
                     RAEGGLWLRMEPLSTDTQ"
     exon            272..416
                     /gene="Cyp4f5"
                     /inference="alignment:Splign:2.1.0"
     exon            417..470
                     /gene="Cyp4f5"
                     /inference="alignment:Splign:2.1.0"
     exon            471..598
                     /gene="Cyp4f5"
                     /inference="alignment:Splign:2.1.0"
     exon            599..720
                     /gene="Cyp4f5"
                     /inference="alignment:Splign:2.1.0"
     exon            721..997
                     /gene="Cyp4f5"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1064
                     /gene="Cyp4f5"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1194
                     /gene="Cyp4f5"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1328
                     /gene="Cyp4f5"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1393
                     /gene="Cyp4f5"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1476
                     /gene="Cyp4f5"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..2401
                     /gene="Cyp4f5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcagata aatgcgtttt tgcaggagtg gggagaaggt cttagaggac aggctgctcc
       61 tgagataagc aggatgccgt ggctaactgt gtctgggctg gacctaggct ctgtggtgac
      121 ctcgacatgg catcttctgc tgcttggagc cgcttcttgg attttggcca gaattcttgc
      181 ctggacttac tcattctgtg agaactgctc ccgcctcaga tgtttccctc agtcccctaa
      241 aagaaactgg tttttgggcc acttgggcac gatccagagc aatgaggaag gcatgcggct
      301 ggtgactgaa atgggccaga ctttccgaga tatccatctc tgttggctgg gacccgtcat
      361 ccctgtgctg aggcttgttg accctgcatt tgttgcccct ctgctccagg ccccagcttt
      421 ggtggcccca aaggacacga ctttcttacg cttcctgaag ccctggcttg gagatggtct
      481 atttctgagt tctggtgaca agtggagccg ccatcgccgt ctgctgacac ctgccttcca
      541 ttttgacatc ctgaagccct atgtgaagat tttcaaccag agcgtgaaca tcatgcacgc
      601 caagtggaag catctatgcc tggaaggcag tgcccgtctg gaaatgtttg agaacatcag
      661 cctcatgacc ctggacagtc tgcagaaatg cctctttggc tttgacagca actgtcagga
      721 gtctcccagt gaatacattt ctgccatatt ggaactgagt tccctcatca taaaaaggtc
      781 acagcagctc ttcctgtacc tggacttcct gtattaccgc actgctgatg gacggcgctt
      841 ccgcaaggcc tgtgacctgg tgcacaactt cacggatgct gtcatcaggg agagacgtcg
      901 acttctctcc agccaaggca ctgatgagtt cttggagtcc aagactaagt ctaagtctaa
      961 gactttggac ttcatcgatg tactcttgtt ggctaaggat gaacatggaa aggagctgtc
     1021 agatgaggac atccgggcag aggctgacac cttcatgttt ggaggccatg acaccacagc
     1081 cagcgcactg tcctggatcc tgtacaacct ggcaaggcac ccagaatacc aggagcgctg
     1141 ccgtcaggag gtgtgggagc tgctgaggga ccgagagcct gaggagattg aatgggacga
     1201 cctagcccag ctgcccttcc tgaccatgtg catcaaggag agtctccggc tgcacccccc
     1261 agctatagac ctcctgcgcc gctgcaccca ggacattgtg ctacctgatg gccgggtcat
     1321 ccctaaaggg aacatctgtg tcatcagcat ctttggtatt catcacaatc cttcagtgtg
     1381 gccagaccct gaggtcttcg accccttccg ctttgactca gaaaatcgtc agaagaggtc
     1441 acctctgtct tttattccct tctccgcagg gcccaggaac tgcataggac agactttcgc
     1501 tatgaacgag atgaaagtgg tggtggcgct gacgctgctg cgcttccgtg tcctgccgga
     1561 tgacaaggag ccgcgccgga agccagagat aatcctgcgc gcggagggcg ggctgtggct
     1621 gcggatggag cccctgagca cagacactca gtaaccctgt gtaaactccc cgtcactctc
     1681 ctctgcacaa tgcagaaaaa gcggagcctc accaagagcc agcagggggc gcggaaggac
     1741 aacagaccct gggagcctgg gcagggccgc tgtctgagtc caagagcctt tctaggtgac
     1801 ccacagggcc cgcagactga tgagtgttgc acccaagctg aaggaaggcc tttattcttt
     1861 tggccatagg gaggcaccat agatgcttag gtttattggc agatttgagg cagttttctt
     1921 cttttcttgt ttttgagata gggtctcaaa ttttagtgga tacagcaggc tggcctttaa
     1981 cttgcagcaa atctctggcc tgaccacccg agtggcaatt agaaagtgca ccactgtgcc
     2041 tgtcgtattc gaaggtattt tttattagaa tgatgggaag tttcccagga gagaagtctg
     2101 ggagcccttc aaaatgatgt taaatgatgt ccaaggcttg tgatgtctaa gaccattgag
     2161 gcagcttaaa tttaaaatga catcacattg caggctccct gtgtggtgat gtcctttcag
     2221 gttcccactt gttcttcctt gggctgggga ggtggcttag tggggagaca ggaggatccc
     2281 agggcctcag tggccaacca gtcctgctga atcagagctc caggttgtaa gagacactgt
     2341 ctcaggaaat aaggtggata gtgatgactg aagacacctg aataaacctc tggcctcctc
     2401 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
