LOCUS       NM_173123               2118 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 4, subfamily f,
            polypeptide 4 (Cyp4f4), mRNA.
ACCESSION   NM_173123
VERSION     NM_173123.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2118)
  AUTHORS   Maayah,Z.H., Ansari,M.A., El Gendy,M.A., Al-Arifi,M.N. and
            Korashy,H.M.
  TITLE     Development of cardiac hypertrophy by sunitinib in vivo and in
            vitro rat cardiomyocytes is influenced by the aryl hydrocarbon
            receptor signaling pathway
  JOURNAL   Arch Toxicol 88 (3), 725-738 (2014)
   PUBMED   24247421
REFERENCE   2  (bases 1 to 2118)
  AUTHORS   Aboutabl,M.E., Zordoky,B.N. and El-Kadi,A.O.
  TITLE     3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome
            P450 gene expression and arachidonic acid metabolism in male
            Sprague Dawley rats
  JOURNAL   Br J Pharmacol 158 (7), 1808-1819 (2009)
   PUBMED   19889059
REFERENCE   3  (bases 1 to 2118)
  AUTHORS   Kalsotra,A., Cui,X., Anakk,S., Hinojos,C.A., Doris,P.A. and
            Strobel,H.W.
  TITLE     Renal localization, expression, and developmental regulation of
            P450 4F cytochromes in three substrains of spontaneously
            hypertensive rats
  JOURNAL   Biochem Biophys Res Commun 338 (1), 423-431 (2005)
   PUBMED   16182239
  REMARK    GeneRIF: CYP4Fs are regionally distributed in the spontaneously
            hypertensive rat (SHR) kidney with CYP4F1, 4F4, and 4F5 being more
            highly expressed in the renal cortex than medulla while CYP4F6
            shows higher medullary expression.
REFERENCE   4  (bases 1 to 2118)
  AUTHORS   Xu,F., Falck,J.R., Ortiz de Montellano,P.R. and Kroetz,D.L.
  TITLE     Catalytic activity and isoform-specific inhibition of rat
            cytochrome p450 4F enzymes
  JOURNAL   J Pharmacol Exp Ther 308 (3), 887-895 (2004)
   PUBMED   14634044
REFERENCE   5  (bases 1 to 2118)
  AUTHORS   LeBrun,L.A., Xu,F., Kroetz,D.L. and Ortiz de Montellano,P.R.
  TITLE     Covalent attachment of the heme prosthetic group in the CYP4F
            cytochrome P450 family
  JOURNAL   Biochemistry 41 (18), 5931-5937 (2002)
   PUBMED   11980497
REFERENCE   6  (bases 1 to 2118)
  AUTHORS   Kawashima,H., Kusunose,E., Thompson,C.M. and Strobel,H.W.
  TITLE     Protein expression, characterization, and regulation of CYP4F4 and
            CYP4F5 cloned from rat brain
  JOURNAL   Arch Biochem Biophys 347 (1), 148-154 (1997)
   PUBMED   9344476
REFERENCE   7  (bases 1 to 2118)
  AUTHORS   Kawashima,H. and Strobel,H.W.
  TITLE     cDNA cloning of three new forms of rat brain cytochrome P450
            belonging to the CYP4F subfamily
  JOURNAL   Biochem Biophys Res Commun 217 (3), 1137-1144 (1995)
   PUBMED   8554568
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U39206.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U39206.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2118
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2118
                     /gene="Cyp4f4"
                     /note="cytochrome P450, family 4, subfamily f, polypeptide
                     4"
                     /db_xref="GeneID:286904"
                     /db_xref="RGD:708363"
     exon            1..139
                     /gene="Cyp4f4"
                     /inference="alignment:Splign:2.1.0"
     exon            140..338
                     /gene="Cyp4f4"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1709
                     /gene="Cyp4f4"
                     /EC_number="1.14.14.94"
                     /note="CYPIVF4; leukotriene-B4 20-monooxygenase"
                     /codon_start=1
                     /product="cytochrome P450 4F4"
                     /protein_id="NP_775146.1"
                     /db_xref="GeneID:286904"
                     /db_xref="RGD:708363"
                     /translation="MPQLDLSWLGLRLETSLPWLLLLLIGASWLLVRVLTQTYIFYRT
                     YQHLCDFPQPPKWNWFLGHLGMITPTEQGLKQVTKLVATYPQGFMTWLGPILPIITLC
                     HPDVIRSVLSASASVALKEVIFYSFLKPWLGDGLLLSDGDKWSCHRRMLTPAFHFNIL
                     KPYVKIFNDSTNIMHAKWQDLASGGSARLDMFKNISLMTLDSLQKCVFSFDSNCQEKP
                     SEYISAILELSALVAKRYQQLLLHTDSLYQLTHNGRRFHKACKLVHNFTDAVIQGRRR
                     ALPSQHEDDILKAKARSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMFEGHDTTA
                     SGLSWILYNLARHPEYQERCRQEVRELLRDRESTEIEWDDLAQLPFLTMCIKESLRLH
                     PPVTVISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENI
                     KDRSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFRVLPDDKEPRRKPELILRA
                     EGGLWLRVEPLSTQ"
     exon            339..483
                     /gene="Cyp4f4"
                     /inference="alignment:Splign:2.1.0"
     exon            484..537
                     /gene="Cyp4f4"
                     /inference="alignment:Splign:2.1.0"
     exon            538..665
                     /gene="Cyp4f4"
                     /inference="alignment:Splign:2.1.0"
     exon            666..787
                     /gene="Cyp4f4"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1058
                     /gene="Cyp4f4"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1125
                     /gene="Cyp4f4"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1255
                     /gene="Cyp4f4"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1389
                     /gene="Cyp4f4"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1454
                     /gene="Cyp4f4"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1537
                     /gene="Cyp4f4"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..2101
                     /gene="Cyp4f4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgagagaagg tggctgctta agaccaccca tactaagtta gacagagcac tgaacctggt
       61 tgcttatttc tccataacca actctctgaa gccaaacagc cagagtgatc ctgttggctt
      121 cagacagggg ggtttccagg atgccacagt tggacctgtc ctggctggga ctgaggctgg
      181 agacatcctt accatggctg cttttgctgc tgatcggagc ttcctggctc ttggtccgtg
      241 tcttgactca gacctatatc ttctacagaa catatcaaca tctttgtgat ttccctcaac
      301 cacccaaatg gaattggttc ttgggtcacc tgggcatgat cactcccact gagcaaggtc
      361 tgaagcaggt aactaagctc gtggccacct acccccaggg cttcatgaca tggctgggtc
      421 ctatcctccc tatcatcact ctgtgccacc ctgacgtcat tcgatctgtt ctcagtgcct
      481 cagcttcggt tgccctaaag gaagtaatct tctacagctt tctgaaaccc tggttggggg
      541 atggactcct gttgagcgat ggtgacaagt ggagctgcca ccgccgcatg ctgacacctg
      601 ccttccactt caacatcctg aaaccctatg tgaagatttt caacgacagc accaacatca
      661 tgcacgccaa atggcaggac ctggcctcag gaggcagcgc ccgtctggac atgtttaaga
      721 acatcagcct gatgaccttg gacagtctgc agaaatgtgt cttcagtttt gatagcaact
      781 gccaggagaa gcccagtgag tatatttctg ccatcttgga gctcagtgcc ctagtggcca
      841 aacggtacca gcagctgctt ctacacacag actcactcta tcagctcacc cataatggtc
      901 ggcgcttcca taaggcctgc aaattggtac acaacttcac agacgctgtc atccagggtc
      961 gacgacgcgc tctccccagt cagcatgagg atgatatcct caaggccaag gccaggtcca
     1021 aaactctgga tttcattgat gtgctgctgc tgaccaagga tgaagatgga aaggagctgt
     1081 cagatgaaga cattagagct gaggctgaca ccttcatgtt tgaaggccat gacaccacag
     1141 ccagtgggct ctcctggatc ctgtacaacc ttgcaaggca cccggaatac caggagcgct
     1201 gccggcagga ggtgcgggag ctgctgaggg accgagagtc tacagagatt gaatgggacg
     1261 acctggccca gctgcccttc ctgaccatgt gcatcaagga gagtctgcga ctgcatcccc
     1321 cagtcacggt catctcccgt cgttgtaccc aagacatcgt gctcccagat ggccgggtca
     1381 tccctaaagg tgtcatctgc atcatcaata ttttcgcgac ccatcacaac ccaactgtgt
     1441 ggcccgaccc tgaggtctat gatcccttcc gcttcgaccc agagaatatc aaggacaggt
     1501 cacctctggc ttttattccc ttctccgctg ggcccaggaa ctgcatagga cagacttttg
     1561 ccatgaacga gatgaaggtg gcactggcgc tgacgctgct gcgcttccgc gtcctgccgg
     1621 atgacaagga gccgcgccgg aagccagagc tgatcctgcg tgcggagggc ggactgtggc
     1681 tgcgggtgga gccactgagc acacagtgac tacgtacatc tggacgggtc ccacccaccc
     1741 acataccttt gtagatgtca cctgtgcctg aggctccttg aataccagta gggggctctg
     1801 gaggacaaca gggaaccagc agttgtggca gggagggaga tggggttggt gcccaaattc
     1861 ctgacttcat ctggccgttc gtgggcctct acactgtcct ttagcctagt tggacttact
     1921 ctcttgggcg acagagagct aaggtaagtg tctaagcagg ctcgagctca cagaatcttt
     1981 taaattgagg tacatttcct gccttgacct ccattctaat ctcaaaactc tcatcctggg
     2041 attctgaagt gtttctgtga aaactaaaat tttaggttta ttaaacctaa caagtctgcc
     2101 aaaaaaaaaa aaaaaaaa
//
