LOCUS       NM_001399679            2727 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 4, subfamily f,
            polypeptide 39 (Cyp4f39), mRNA.
ACCESSION   NM_001399679 XM_006241090
VERSION     NM_001399679.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2727)
  AUTHORS   Ohno,Y., Nakamichi,S., Ohkuni,A., Kamiyama,N., Naoe,A.,
            Tsujimura,H., Yokose,U., Sugiura,K., Ishikawa,J., Akiyama,M. and
            Kihara,A.
  TITLE     Essential role of the cytochrome P450 CYP4F22 in the production of
            acylceramide, the key lipid for skin permeability barrier formation
  JOURNAL   Proc Natl Acad Sci U S A 112 (25), 7707-7712 (2015)
   PUBMED   26056268
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jan 12, 2022 this sequence version replaced XM_006241090.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210490.1, SRR26643286.21815.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               JAXUCZ010000007.1  12083888-12084012
            126-228             JAXUCZ010000007.1  12124399-12124501
            229-451             JAXUCZ010000007.1  12128428-12128650
            452-596             JAXUCZ010000007.1  12130942-12131086
            597-650             JAXUCZ010000007.1  12139948-12140001
            651-778             JAXUCZ010000007.1  12140627-12140754
            779-903             JAXUCZ010000007.1  12140939-12141063
            904-1171            JAXUCZ010000007.1  12143623-12143890
            1172-1238           JAXUCZ010000007.1  12147373-12147439
            1239-1368           JAXUCZ010000007.1  12147551-12147680
            1369-1502           JAXUCZ010000007.1  12151722-12151855
            1503-1567           JAXUCZ010000007.1  12153888-12153952
            1568-1650           JAXUCZ010000007.1  12154502-12154584
            1651-2727           JAXUCZ010000007.1  12155000-12156076
FEATURES             Location/Qualifiers
     source          1..2727
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2727
                     /gene="Cyp4f39"
                     /gene_synonym="RGD1308796"
                     /note="cytochrome P450, family 4, subfamily f, polypeptide
                     39"
                     /db_xref="GeneID:299566"
                     /db_xref="RGD:1308796"
     exon            1..125
                     /gene="Cyp4f39"
                     /gene_synonym="RGD1308796"
                     /inference="alignment:Splign:2.1.0"
     exon            126..228
                     /gene="Cyp4f39"
                     /gene_synonym="RGD1308796"
                     /inference="alignment:Splign:2.1.0"
     exon            229..451
                     /gene="Cyp4f39"
                     /gene_synonym="RGD1308796"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1882
                     /gene="Cyp4f39"
                     /gene_synonym="RGD1308796"
                     /note="cytochrome P450 4F22"
                     /codon_start=1
                     /product="cytochrome P450, family 4, subfamily f,
                     polypeptide 39"
                     /protein_id="NP_001386608.1"
                     /db_xref="GeneID:299566"
                     /db_xref="RGD:1308796"
                     /translation="MLPITDYLLYLLGLEKTAFRVYVLSALLLFLLFLLFRLLLQAFK
                     LFSDFRITCRRLSCFPEPPGRHWLLGHMSMYLPNEKGLQNEKKVLDTMHHIILAWVGP
                     FLPLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLKPWLGDGLLISKGNKWSRHRRLLT
                     PAFHFDILKPYMKIFNQSVNIMHAKWRRHLAEGSVTSFDMFEHVSLMTLDSLQKCVFS
                     YSSDCQEKLSDYISSIIELSALVVRRQYRLHHYLDFIYYLTADGRRFRQACDTVHNFT
                     TEVIQQRRRALRELGAEAWLKAKQGKTLDFIDVLLLAKDEEGKELSDEDIRAEADTFM
                     FEGHDTTSSGLSWALFNLAKYPEYQDKCREEIQEVMKGRELEELDWDDLTQLPFTTMC
                     IKESLRQFPPVTLISRRCTEDIKLPDGRIIPKGIICLVSIYGTHYNPLVWPDSKVYNP
                     YRFDPDIPQQRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSVDRTRKVR
                     RKPELILRTENGLWLNVEPLPSRAGVPRGPTEPEVQAPPAQA"
     exon            452..596
                     /gene="Cyp4f39"
                     /gene_synonym="RGD1308796"
                     /inference="alignment:Splign:2.1.0"
     exon            597..650
                     /gene="Cyp4f39"
                     /gene_synonym="RGD1308796"
                     /inference="alignment:Splign:2.1.0"
     exon            651..778
                     /gene="Cyp4f39"
                     /gene_synonym="RGD1308796"
                     /inference="alignment:Splign:2.1.0"
     exon            779..903
                     /gene="Cyp4f39"
                     /gene_synonym="RGD1308796"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1171
                     /gene="Cyp4f39"
                     /gene_synonym="RGD1308796"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1238
                     /gene="Cyp4f39"
                     /gene_synonym="RGD1308796"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1368
                     /gene="Cyp4f39"
                     /gene_synonym="RGD1308796"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1502
                     /gene="Cyp4f39"
                     /gene_synonym="RGD1308796"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1567
                     /gene="Cyp4f39"
                     /gene_synonym="RGD1308796"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1650
                     /gene="Cyp4f39"
                     /gene_synonym="RGD1308796"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..2727
                     /gene="Cyp4f39"
                     /gene_synonym="RGD1308796"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttgcacat caggcattcg aagtccacag tctacattag tgtctcctgg tgctgttcac
       61 tcggactcct gtccaggcta ctatttgctg tgtgggcggg tggaacccag ggccctgcac
      121 attaggagct ggcccaaggt caaggatctg agtcccagca acttctctga gaagtggttt
      181 cagcaaatac caggaaagcg agaagaaagt tgagagaatt gaacgcagga tgctacccat
      241 caccgactac ctgctgtacc tgctgggact ggagaagacc gccttccgcg tgtacgtcct
      301 atcggctctg ctgcttttcc tccttttcct cctcttccgc ctgctcctgc aggcattcaa
      361 attattcagt gacttccgca tcacctgtcg ccggctgagc tgcttcccag agcctccagg
      421 ccgccactgg ctactgggcc acatgagcat gtatcttccc aacgagaagg gccttcagaa
      481 tgagaagaaa gtgctggata ccatgcacca catcatcctg gcatgggtcg gacctttcct
      541 gcctctgctg gtgcttgtgc atcctgatta catcaagcct gtgttgggtg cctcagctgc
      601 cattgcgccc aaggatgagt ttttctatag cttcctgaaa ccttggttag gggatgggct
      661 tttgatcagc aaagggaaca aatggagccg gcaccgccgt ctgctcacgc ctgccttcca
      721 ctttgacatc ctgaagccct acatgaagat tttcaaccag agcgtgaaca tcatgcacgc
      781 taaatggcgg cggcatctgg cagagggctc ggtgacctcc tttgacatgt tcgagcacgt
      841 cagcctcatg accctggaca gccttcagaa atgtgtgttc agttacagta gtgactgcca
      901 ggagaaattg agcgattaca tctcctccat tattgaactg agcgctctgg tggtgcggcg
      961 ccaataccgc ttgcatcact atctggattt catctactac ctcactgccg acgggcggcg
     1021 cttccgccag gcctgcgaca cggtgcacaa cttcactact gaagtcatac agcagcggcg
     1081 gcgggcgctg cgcgagctgg gtgccgaggc atggctgaag gccaagcagg gcaagacctt
     1141 ggacttcata gacgtgctgc tgctggccaa ggatgaagag gggaaagaat tatctgacga
     1201 agacatccgg gctgaggcgg atacgttcat gtttgagggt catgacacaa catctagtgg
     1261 gctgtcgtgg gcgctgttca acctggcgaa gtatccggag taccaggaca agtgccggga
     1321 agagatccaa gaagtcatga aaggccgaga gctggaagag ctggactggg atgacctgac
     1381 gcagttgccc ttcaccacca tgtgtatcaa ggagagcctt cgccagttcc cgcccgtgac
     1441 cctcatctct cgtcgctgca cagaggacat caagctgccc gacggacgca tcattcccaa
     1501 aggaattatc tgcttggtca gcatctacgg gacccactac aaccccttag tgtggcctga
     1561 ctctaaggta tacaatccct accgttttga cccagacatt ccacagcagc gctccccgct
     1621 ggcctttgtg cctttctcag caggtcccag gaactgcatc gggcagagct tcgccatggc
     1681 agagatgcga gtggtcgtgg cgctgacact cctgcgcttc cgcctgagcg tggaccgaac
     1741 ccgcaaggtg cggaggaagc cggagcttat tctacgcacg gagaacggcc tttggctcaa
     1801 cgtggagccg ctaccctcgc gggccggagt gccccgaggc cccacggaac ctgaggttca
     1861 ggctccgccc gctcaggcct agaccacgcc tccaaaggcc tggatccgcc cccaagatat
     1921 tgaggacgtt gactacgctc ctcgaaagca caggaggacc aagctttgta gaggagcagc
     1981 ttgttggtgc tgacttcgcc cctcaggaca agaccccatc cttgggattt gggtcaaagt
     2041 tctgtcttga attactccca ccggccctca gcgtgtgggg atcatgctag gccccgcccc
     2101 ctcgggcatg ggctgcgggc cccagtttaa atcagattac cctggccctg cggattccca
     2161 ggcccggccc acagaaactt ccccggacct aagactcacc gctggggttg tatcctcact
     2221 ttcccactgg ctatgcccag gttagcttct aaaccgagga tttagaagct ggagcccgag
     2281 gctgcagtcc tgaatcacag ctccatggaa ggactgttca agctgaacct caggacttag
     2341 gctgtttgct ttgttgccgt tttgtaaacc tagacccttg caaacccctt tctccttggt
     2401 tgcgccgtcc ctttgctgag ttttctcagg ttcaggagag taagagcaag aggatccaca
     2461 caccttctgc ctcaccctgt cccagatgag gagaccaagg tggggaggcg ggcctcttgg
     2521 cggtcgggac gcaactggga catagttgtt tgatctggaa ctaaactcag attttttttt
     2581 tttttgggac aatttgtgcg ctgtttattt ggtcaataat aattcaatgt ctactggcgt
     2641 ggggccaggc atatagccta gcctagttcc tccttctcaa cagagaggag cagaagttga
     2701 acaattatac ctgtaaatga tcattta
//
