LOCUS       NM_001393771            2777 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 4, subfamily f,
            polypeptide 18 (Cyp4f18), transcript variant 2, mRNA.
ACCESSION   NM_001393771 XM_039094276
VERSION     NM_001393771.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2777)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2777)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
REFERENCE   3  (bases 1 to 2777)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000275.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001393771.2.
            
            On Mar 11, 2021 this sequence version replaced XM_039094276.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351,
                              SAMN06680412 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                JACYVU010000275.1  1126676-1126723
            49-247              JACYVU010000275.1  1127019-1127217
            248-392             JACYVU010000275.1  1131831-1131975
            393-446             JACYVU010000275.1  1132915-1132968
            447-574             JACYVU010000275.1  1133055-1133182
            575-696             JACYVU010000275.1  1135905-1136026
            697-967             JACYVU010000275.1  1137993-1138263
            968-1034            JACYVU010000275.1  1140415-1140481
            1035-1164           JACYVU010000275.1  1140656-1140785
            1165-1298           JACYVU010000275.1  1151580-1151713
            1299-1363           JACYVU010000275.1  1151795-1151859
            1364-1446           JACYVU010000275.1  1152546-1152628
            1447-2777           JACYVU010000275.1  1152947-1154277
FEATURES             Location/Qualifiers
     source          1..2777
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2777
                     /gene="Cyp4f18"
                     /gene_synonym="Cyp4f3; CYPIVF3"
                     /note="cytochrome P450, family 4, subfamily f, polypeptide
                     18"
                     /db_xref="GeneID:290623"
                     /db_xref="RGD:1305261"
     exon            1..48
                     /gene="Cyp4f18"
                     /gene_synonym="Cyp4f3; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            49..247
                     /gene="Cyp4f18"
                     /gene_synonym="Cyp4f3; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1624
                     /gene="Cyp4f18"
                     /gene_synonym="Cyp4f3; CYPIVF3"
                     /EC_number="1.14.14.94"
                     /note="leukotriene-B(4) omega-hydroxylase 2; cytochrome
                     P450-LTB-omega; leukotriene-B(4) 20-monooxygenase 2;
                     leukotriene-B(4) omega-1/omega-2 hydroxylase"
                     /codon_start=1
                     /product="cytochrome P450 4F3"
                     /protein_id="NP_001380700.1"
                     /db_xref="GeneID:290623"
                     /db_xref="RGD:1305261"
                     /translation="MPLLSLSWLGLGHTAASPWLLLLLVGASCLLAYILPQVYAVFEN
                     SRRLRRFPQPPTRNWLFGHLGLIQSSEEGLLYIQSLSRTFRDVCCWWVGPWHPVIRIF
                     HPAFIKPVILAPASVAPKDRVFYRFLKPWLGDGLLLSTGDKWSRHRHMLTPAFHFNIL
                     KPYVKIFNDSTNIMHAKWQRLASQGSARLDMFEHISLMTLDSLQKCVFSFDSNCQEKP
                     SEYITAILELSALVARRHQSLLLYVDLFYHLTRDGMRFRKACRLVHDFTDAVIRERRR
                     TLPDQGGDDALKAKAKAKTLDFIDVLLLSKDEHGEALSDEDIRAEADTFMFGGHDTTA
                     SGLSWILYNLAKHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLRLH
                     PPATAISRCCTQDIMLPDGRVIPKGVICRISIFGTHHNPAVWPDPEVYNPFRFDADNG
                     EGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLPDDKEPRRKPELILRA
                     EGGLWLRVEPLSAGAH"
     exon            248..392
                     /gene="Cyp4f18"
                     /gene_synonym="Cyp4f3; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            393..446
                     /gene="Cyp4f18"
                     /gene_synonym="Cyp4f3; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            447..574
                     /gene="Cyp4f18"
                     /gene_synonym="Cyp4f3; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            575..696
                     /gene="Cyp4f18"
                     /gene_synonym="Cyp4f3; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            697..967
                     /gene="Cyp4f18"
                     /gene_synonym="Cyp4f3; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1034
                     /gene="Cyp4f18"
                     /gene_synonym="Cyp4f3; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1164
                     /gene="Cyp4f18"
                     /gene_synonym="Cyp4f3; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1298
                     /gene="Cyp4f18"
                     /gene_synonym="Cyp4f3; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1363
                     /gene="Cyp4f18"
                     /gene_synonym="Cyp4f3; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1446
                     /gene="Cyp4f18"
                     /gene_synonym="Cyp4f3; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..2777
                     /gene="Cyp4f18"
                     /gene_synonym="Cyp4f3; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagaagggg agagacagac ctgagaaaca cagtgttcct aagagaagga tgccactgct
       61 gagcctgtcc tggctgggcc tggggcacac agcagcctct ccatggctgt tgctgctgct
      121 ggttggggcc tcctgtctcc tggcttacat cctgcctcag gtttatgctg tctttgagaa
      181 ctctcgtcgc ctccgccgtt ttccgcagcc ccccacacga aactggctct ttggacacct
      241 aggcctgatc cagagctcag aggaagggct cctgtacatc cagagcctgt cgagaacctt
      301 cagggatgtt tgctgctggt gggtggggcc gtggcacccc gttatccgca tattccaccc
      361 tgccttcatc aagcccgtga tcttggctcc agcttcagtt gcccccaagg acagagtctt
      421 ctaccgtttc ctgaagccgt ggctggggga tggcctccta ttgagtactg gtgacaagtg
      481 gagccgccac cgtcacatgc tgacacctgc cttccatttc aacatcctga agccctatgt
      541 gaagattttt aacgacagca ccaacatcat gcacgccaag tggcagcgcc tggcctccca
      601 gggcagtgcc cgtttggaca tgtttgagca catcagcctc atgaccctgg acagtctgca
      661 gaagtgcgtc ttcagctttg acagcaattg ccaggagaag cctagtgaat atatcactgc
      721 catcttagaa cttagtgcct tagtggccag acggcaccag agtctgcttc tgtatgtgga
      781 cctgttttat cacctcaccc gtgatgggat gcgcttccgg aaggcctgcc gcctagtgca
      841 tgacttcacg gatgctgtca tccgggagcg gcgccgtacc ctccctgatc agggtggtga
      901 tgatgccctt aaagccaagg ccaaggccaa gactttggac ttcattgacg tgctactgct
      961 gagcaaggat gaacatggcg aggctctgtc cgatgaggac atccgagcag aggctgacac
     1021 cttcatgttt ggaggccacg acaccacggc cagtgggctc tcctggatcc tgtacaacct
     1081 ggcgaagcac ccggaatacc aggagcgctg ccggcaggag gtgcgggagc tcctgaggga
     1141 ccgtgagcct gaggagattg aatgggacga cctggcccag ctgccattcc tcaccatgtg
     1201 cattaaggag agcctgcgac tgcatcctcc ggccacggca atctcccgct gctgcactca
     1261 agacattatg ctcccagatg gccgggtcat ccctaaaggc gtcatctgcc gaataagtat
     1321 tttcgggacc catcacaatc cagctgtgtg gccagacccg gaggtgtata accccttccg
     1381 ctttgatgca gacaacggcg agggcaggtc acccctggct tttattcctt tttcggctgg
     1441 gcccaggaac tgcataggac agactttcgc catgagtgag atgaaagtgg ctttggcgct
     1501 gactctgcta cgcttccgtg tcctgcctga tgacaaggaa ccacgcagga agccagagct
     1561 gatcctgcgt gcagagggtg ggctgtggct gcgggtggag cctctcagcg caggagcgca
     1621 ttgaccccac agctggcctg gaaactgccc cattcaccca cccggcctgc gcttttccag
     1681 gaataaaaat ctcttgtgtg agcttcacca aacatccagg ttacacgcct catgtgagcc
     1741 acagggagct gtggaaggtg tttgagcggt agaaggattt aaggaacatg aaaattaata
     1801 ttgtcacccg ggaggcaagg cacacccgtg agggattatc tgaataaatt aactgaagtg
     1861 gaatgatccg tcctaatcct aactgtaggt ggaattctgg gttgaatttc aaaaaagtgt
     1921 ggcctagatt agagatggct cttctcagct cagatgatct aatcaagaaa attttcttag
     1981 cggtatgtca aacagcttgg gttttagtta attacagatg tagtcaaatt gaaaaccaag
     2041 aatggccacc acagccagac tacctaaccc ttcccaaacg tttccaacac atgagcctat
     2101 gtggtcatcc tcacccaaat caccacaggc ttacttttga ggatgtgcca ttacagcaac
     2161 tgggcatgcg tgttagtcag ggctctctag acttacagaa cctacggaat gtctctatat
     2221 attaagggga tttattggaa tgacttacag tctgtagtcc taaggccaag tcttttaagt
     2281 tcagactcca ttttagagaa cctgacctaa gtctgaactc aggtaaacta acaggccggt
     2341 acccagcatt agtttccaag tcgccccccc ccccccccca aaaacaaaac ctagctccag
     2401 cctctaggct aatccccact aagaccagca ttttcaggtt acaccctcaa caagaccagc
     2461 gtctccaagt tcttccccca acaaacttac acccacaggt tacaagccca ccccctgggt
     2521 aatgaccacc ggtgcagaag gcagcagaaa ttaggttttt cccaatacca gacaattatg
     2581 tcaaaggccg cagtagcttt ccaattagat gtttgcacac tcaccactcc cctcgcttac
     2641 tacaagttac tacaaagcct tgccctatag atattcagcc cctccacccc catcgaaact
     2701 gtcctgcgtg acagcggtgc attggagggg cccgagctag ctccaatgaa ataaagaccc
     2761 tgctgtgtgt tgcatca
//
