LOCUS       NM_019623               2119 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 4, subfamily f,
            polypeptide 1 (Cyp4f1), mRNA.
ACCESSION   NM_019623
VERSION     NM_019623.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2119)
  AUTHORS   Takitani,K., Inoue,K., Koh,M., Miyazaki,H., Kishi,K., Inoue,A. and
            Tamai,H.
  TITLE     alpha-Tocopherol status and altered expression of
            alpha-tocopherol-related proteins in streptozotocin-induced type 1
            diabetes in rat models
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 60 (6), 380-386 (2014)
   PUBMED   25866300
  REMARK    GeneRIF: The reduced expression of hepatic alpha-TTP and CYP4F2
            genes probably leads to decreased plasma alpha-tocopherol levels
            and elevated alpha-tocopherol levels in the liver of streptozotocin
            rats.
REFERENCE   2  (bases 1 to 2119)
  AUTHORS   Wang,Y., Zhao,J., Kalsotra,A., Turman,C.M., Grill,R.J., Dash,P.K.
            and Strobel,H.W.
  TITLE     CYP4Fs expression in rat brain correlates with changes in LTB4
            levels after traumatic brain injury
  JOURNAL   J Neurotrauma 25 (10), 1187-1194 (2008)
   PUBMED   18847377
REFERENCE   3  (bases 1 to 2119)
  AUTHORS   Donelson,E., Chen,L., Zhang,X., Goswami,P., Song,B.J. and
            Hardwick,J.P.
  TITLE     Genomic structure and regulation of the rat hepatic CYP4F1 gene by
            peroxisome proliferators
  JOURNAL   Arch Biochem Biophys 472 (1), 1-16 (2008)
   PUBMED   18262487
  REMARK    GeneRIF: In clofibrate treated rats HNF4alpha binds during gene
            repression, suggesting differential regulation of the CYP4F1 gene
            in vivo and in cell lines.
REFERENCE   4  (bases 1 to 2119)
  AUTHORS   Kalsotra,A., Cui,X., Anakk,S., Hinojos,C.A., Doris,P.A. and
            Strobel,H.W.
  TITLE     Renal localization, expression, and developmental regulation of
            P450 4F cytochromes in three substrains of spontaneously
            hypertensive rats
  JOURNAL   Biochem Biophys Res Commun 338 (1), 423-431 (2005)
   PUBMED   16182239
  REMARK    GeneRIF: CYP4F1 is more highly expressed in the renal cortex than
            medulla of the spontaneously hypertensive (SHR) rat and may be a
            critical enzyme in the development of this rat strain.
REFERENCE   5  (bases 1 to 2119)
  AUTHORS   Imaoka,S., Hashizume,T. and Funae,Y.
  TITLE     Localization of rat cytochrome P450 in various tissues and
            comparison of arachidonic acid metabolism by rat P450 with that by
            human P450 orthologs
  JOURNAL   Drug Metab Pharmacokinet 20 (6), 478-484 (2005)
   PUBMED   16415532
REFERENCE   6  (bases 1 to 2119)
  AUTHORS   Xu,F., Falck,J.R., Ortiz de Montellano,P.R. and Kroetz,D.L.
  TITLE     Catalytic activity and isoform-specific inhibition of rat
            cytochrome p450 4F enzymes
  JOURNAL   J Pharmacol Exp Ther 308 (3), 887-895 (2004)
   PUBMED   14634044
REFERENCE   7  (bases 1 to 2119)
  AUTHORS   LeBrun,L.A., Xu,F., Kroetz,D.L. and Ortiz de Montellano,P.R.
  TITLE     Covalent attachment of the heme prosthetic group in the CYP4F
            cytochrome P450 family
  JOURNAL   Biochemistry 41 (18), 5931-5937 (2002)
   PUBMED   11980497
REFERENCE   8  (bases 1 to 2119)
  AUTHORS   Kikuta,Y., Kusunose,E., Ito,M. and Kusunose,M.
  TITLE     Purification and characterization of recombinant rat hepatic CYP4F1
  JOURNAL   Arch Biochem Biophys 369 (2), 193-196 (1999)
   PUBMED   10486137
REFERENCE   9  (bases 1 to 2119)
  AUTHORS   Harris,A.J., Shaddock,J.G., Manjanatha,M.G., Lisenbey,J.A. and
            Casciano,D.A.
  TITLE     Identification of differentially expressed genes in aflatoxin
            B1-treated cultured primary rat hepatocytes and Fischer 344 rats
  JOURNAL   Carcinogenesis 19 (8), 1451-1458 (1998)
   PUBMED   9744542
REFERENCE   10 (bases 1 to 2119)
  AUTHORS   Chen,L. and Hardwick,J.P.
  TITLE     Identification of a new P450 subfamily, CYP4F1, expressed in rat
            hepatic tumors
  JOURNAL   Arch Biochem Biophys 300 (1), 18-23 (1993)
   PUBMED   8424651
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081808.1.
            
            On Sep 16, 2004 this sequence version replaced NM_019623.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081808.1, M94548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2119
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2119
                     /gene="Cyp4f1"
                     /gene_synonym="Cyp4f14; Cyp4f2"
                     /note="cytochrome P450, family 4, subfamily f, polypeptide
                     1"
                     /db_xref="GeneID:56266"
                     /db_xref="RGD:70926"
     exon            1..328
                     /gene="Cyp4f1"
                     /gene_synonym="Cyp4f14; Cyp4f2"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1705
                     /gene="Cyp4f1"
                     /gene_synonym="Cyp4f14; Cyp4f2"
                     /EC_number="1.14.14.94"
                     /note="CYPIVF1; P450-A3; leukotriene-B4 20-monooxygenase;
                     cytochrome P450-A3; cytochrome P450, subfamily IVF,
                     polypeptide 14 (leukotriene B4 omega hydroxylase);
                     cytochrome P450, family 4, subfamily F, polypeptide 2"
                     /codon_start=1
                     /product="cytochrome P450 4F1"
                     /protein_id="NP_062569.2"
                     /db_xref="GeneID:56266"
                     /db_xref="RGD:70926"
                     /translation="MSQLSLSWLGLGPEVAFPWQTLLLFGASWILAQILTQIYAAYRN
                     FRRLRGFPQPPKRNWLMGHVGMVTPTEQGLKELTRLVGTYPQGFLMWIGPMVPVITLC
                     HSDIVRSILNASAAVALKDVIFYTILKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNIL
                     KPYVKIFNDSTNIMHAKWKRLISEGSSRLDMFEHVSLMTLDSLQKCVFSFDSNCQEKS
                     SEYIAAILELSALVAKRHQQPLLFMDLLYNLTPDGMRFHKACNLVHEFTDAVIRERRR
                     TLPDQGLDEFLKSKAKSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMFEGHDTTA
                     SGLSWILYNLAKHPEYQERCRQEVQELLRDRDPEEIEWDDLAQLPFLTMCIKESLRLH
                     PPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVWPDPEVYNPFRFDPENI
                     KDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLPDDKEPRRQPELILRA
                     EGGLWLRVEPLSAGAQ"
     exon            329..473
                     /gene="Cyp4f1"
                     /gene_synonym="Cyp4f14; Cyp4f2"
                     /inference="alignment:Splign:2.1.0"
     exon            474..527
                     /gene="Cyp4f1"
                     /gene_synonym="Cyp4f14; Cyp4f2"
                     /inference="alignment:Splign:2.1.0"
     exon            528..655
                     /gene="Cyp4f1"
                     /gene_synonym="Cyp4f14; Cyp4f2"
                     /inference="alignment:Splign:2.1.0"
     exon            656..777
                     /gene="Cyp4f1"
                     /gene_synonym="Cyp4f14; Cyp4f2"
                     /inference="alignment:Splign:2.1.0"
     exon            778..1048
                     /gene="Cyp4f1"
                     /gene_synonym="Cyp4f14; Cyp4f2"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1115
                     /gene="Cyp4f1"
                     /gene_synonym="Cyp4f14; Cyp4f2"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1245
                     /gene="Cyp4f1"
                     /gene_synonym="Cyp4f14; Cyp4f2"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1379
                     /gene="Cyp4f1"
                     /gene_synonym="Cyp4f14; Cyp4f2"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1444
                     /gene="Cyp4f1"
                     /gene_synonym="Cyp4f14; Cyp4f2"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1527
                     /gene="Cyp4f1"
                     /gene_synonym="Cyp4f14; Cyp4f2"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..2093
                     /gene="Cyp4f1"
                     /gene_synonym="Cyp4f14; Cyp4f2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttatacctc ttccccaacc ttcccttagt tctcgcacct cctttctgct ctgtcctctg
       61 tccagtgtct tgagattcct gtcccctccc ggacctcagt aactcactgc ccgtttattc
      121 acccagcagg atgtcacagc tgagcctctc ctggctggga ctggggcctg aggtggcctt
      181 cccatggcag accctgctac tgtttggagc ctcctggatc ctggcccaaa ttctgaccca
      241 gatctacgct gcctatagga actttcgtcg cctccgtggc ttccctcagc cccccaaacg
      301 gaactggctt atgggtcatg tgggcatggt cactcctaca gagcagggct tgaaggaatt
      361 gactcggttg gtgggtacct acccccaagg ctttttgatg tggattgggc caatggtccc
      421 cgttattact ctgtgccact ctgacatcgt ccgatctatc ctcaatgcct cagctgccgt
      481 tgcgctcaag gatgtgatat tctacaccat cctcaagcct tggctggggg atgggctcct
      541 ggtgagtgct ggtgacaagt ggagccgcca ccgccgcatg ctgacacctg ccttccactt
      601 caacatcctg aaaccctatg tgaagatttt caacgacagc accaacatca tgcacgccaa
      661 gtggaaacgg ttgatttcag aaggcagttc ccgtctggac atgtttgagc acgtcagcct
      721 catgactctg gacagtctgc agaaatgtgt cttcagcttt gacagcaact gccaggagaa
      781 gtccagtgaa tatattgctg ccatcctgga gctcagtgcc ctagtggcca aaaggcacca
      841 gcagcctttg ctgttcatgg acctgctgta caatctcacc cctgatggga tgcgcttcca
      901 taaggcctgc aacctggtgc atgaattcac tgatgccgtc atccgggagc ggcgccgcac
      961 cctcccagat cagggtttgg atgagtttct caagtctaag gccaagtcca agactttgga
     1021 tttcattgat gtgctgctcc tgaccaagga tgaagatgga aaggagctgt cggatgagga
     1081 catcagagca gaggccgaca ccttcatgtt tgagggccat gacaccacag ccagtgggct
     1141 ctcctggatt ctatacaacc tggcgaagca cccagagtac caggagcgct gccggcagga
     1201 agttcaggag cttctgaggg accgagatcc tgaggagatt gaatgggacg acctggccca
     1261 gctgcccttc ctgaccatgt gcatcaagga gagtctgcgg ctgcaccccc cagtcacggt
     1321 catctcccga tgctgcaccc aggacattct gctcccagat ggcaggacca ttcccaaagg
     1381 tatcatctgc cttatcagta tctttggaat tcatcacaac ccgtctgtgt ggccggaccc
     1441 tgaggtctac aaccccttcc gctttgaccc tgaaaacatc aaagacagct cacctctggc
     1501 atttattccc ttctcggcgg ggcccaggaa ctgcataggt cagactttcg ccatgagcga
     1561 gatgaaggtg gcgctggcac taacactgct gcgcttccga ctcctaccgg acgacaagga
     1621 accgcgcagg cagccagagc tgatcctgcg tgccgagggc ggactgtggc tgcgggtgga
     1681 gccgctgagc gcgggcgcgc agtgacctca cagttggtct ggagcacccc caccatccta
     1741 cctctgagga tcccagaatg aacagaactg tcacccatac cagaatctta cggagggcca
     1801 gcagggggcg ctgtgaatcc agtgagtggg tgagagaggc cagttagtgt ctgagccaaa
     1861 gacctttgac ttcgtctaac tgatcgccag cctttatcat aaggtgcatt cttctccaac
     1921 caacctggac tattctctgg acaataggaa gccaaagaaa cgtctgagca agagaccaga
     1981 atgaaacgca aatttgagct cttattctcg cagcaaatcc cttattcagc tccatttcca
     2041 ttattttgac ctacattcaa atcatctaat aaatacattc tctcacctcg gaaaaaaaaa
     2101 aaaaaaaaaa aaaaaaaaa
//
