LOCUS       NM_016999               1920 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 4, subfamily b,
            polypeptide 1 (Cyp4b1), mRNA.
ACCESSION   NM_016999
VERSION     NM_016999.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1920)
  AUTHORS   Genter,M.B., Yost,G.S. and Rettie,A.E.
  TITLE     Localization of CYP4B1 in the rat nasal cavity and analysis of CYPs
            as secreted proteins
  JOURNAL   J Biochem Mol Toxicol 20 (3), 139-141 (2006)
   PUBMED   16788951
  REMARK    GeneRIF: Examination of high-power photomicrographs suggests that
            CYP4B1 may be a secreted protein, based on the fact that
            immunoreactivity appears to be present in the lumens of ducts of
            Bowman's glands and in secretory granules in respiratory mucosa.
REFERENCE   2  (bases 1 to 1920)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   3  (bases 1 to 1920)
  AUTHORS   Imaoka,S., Yoneda,Y., Sugimoto,T., Ikemoto,S., Hiroi,T.,
            Yamamoto,K., Nakatani,T. and Funae,Y.
  TITLE     Androgen regulation of CYP4B1 responsible for mutagenic activation
            of bladder carcinogens in the rat bladder: detection of CYP4B1 mRNA
            by competitive reverse transcription-polymerase chain reaction
  JOURNAL   Cancer Lett 166 (2), 119-123 (2001)
   PUBMED   11311483
REFERENCE   4  (bases 1 to 1920)
  AUTHORS   Imaoka,S., Yoneda,Y., Matsuda,T., Degawa,M., Fukushima,S. and
            Funae,Y.
  TITLE     Mutagenic activation of urinary bladder carcinogens by CYP4B1 and
            the presence of CYP4B1 in bladder mucosa
  JOURNAL   Biochem Pharmacol 54 (6), 677-683 (1997)
   PUBMED   9310344
REFERENCE   5  (bases 1 to 1920)
  AUTHORS   Verschoyle,R.D., Philpot,R.M., Wolf,C.R. and Dinsdale,D.
  TITLE     CYP4B1 activates 4-ipomeanol in rat lung
  JOURNAL   Toxicol Appl Pharmacol 123 (2), 193-198 (1993)
   PUBMED   8248926
REFERENCE   6  (bases 1 to 1920)
  AUTHORS   Imaoka,S. and Funae,Y.
  TITLE     Purification and characterization of rat pulmonary cytochrome P-450
  JOURNAL   J Biochem 108 (1), 33-36 (1990)
   PUBMED   2229008
REFERENCE   7  (bases 1 to 1920)
  AUTHORS   Kimura,S., Hanioka,N., Matsunaga,E. and Gonzalez,F.J.
  TITLE     The rat clofibrate-inducible CYP4A gene subfamily. I. Complete
            intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique
            exon organization, and identification of a conserved 19-bp upstream
            element
  JOURNAL   DNA 8 (7), 503-516 (1989)
   PUBMED   2766932
REFERENCE   8  (bases 1 to 1920)
  AUTHORS   Gasser,R. and Philpot,R.M.
  TITLE     Primary structures of cytochrome P-450 isozyme 5 from rabbit and
            rat and regulation of species-dependent expression and induction in
            lung and liver: identification of cytochrome P-450 gene subfamily
            IVB
  JOURNAL   Mol Pharmacol 35 (5), 617-625 (1989)
   PUBMED   2725471
REFERENCE   9  (bases 1 to 1920)
  AUTHORS   Hardwick,J.P., Song,B.J., Huberman,E. and Gonzalez,F.J.
  TITLE     Isolation, complementary DNA sequence, and regulation of rat
            hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega).
            Identification of a new cytochrome P-450 gene family
  JOURNAL   J Biol Chem 262 (2), 801-810 (1987)
   PUBMED   3027069
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M29853.1.
            
            On Oct 1, 2002 this sequence version replaced NM_016999.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M29853.1, BC074012.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788, SAMN16676806
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1920
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..1920
                     /gene="Cyp4b1"
                     /note="cytochrome P450, family 4, subfamily b, polypeptide
                     1"
                     /db_xref="GeneID:24307"
                     /db_xref="RGD:2480"
     exon            1..182
                     /gene="Cyp4b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..1538
                     /gene="Cyp4b1"
                     /EC_number="1.14.14.1"
                     /note="CYPIVB1; P450 L-2; P450-isozyme 5; cytochrome P450
                     L-2; cytochrome P450 isozyme 5; cytochrome P450, subfamily
                     4B, polypeptide 1"
                     /codon_start=1
                     /product="cytochrome P450 4B1"
                     /protein_id="NP_058695.2"
                     /db_xref="GeneID:24307"
                     /db_xref="RGD:2480"
                     /translation="MVLNFLSPSLSRLGLWASVVILMVIVLKLFSLLLRRQKLARAMD
                     SFPGPPTHWLFGHALEIQKLGSLDKVVSWAQQFPHAHPLWFGQFVGFLNIYEPDYAKA
                     VYSRGDPKAADVYDFFLQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVLKPYVAIFAES
                     TRMMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGDSGLGHRDNSYYLAVSDL
                     TLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACKIAHDHTDEVIRQRKAALQDEKERKK
                     IQQRRHLDFLDILLGVRDESGIKLSDAELRAEVDTFMFEGHDTTTSGISWFLYCMALY
                     PEHQQLCREEVRGILGDQDSFQWDDLAKMTYLTMCMKECFRLYPPVPQVYRQLNKPVT
                     FVDGRSLPAGSLISLHIYALHRNSTVWPDPEVFDPLRFSPENAAGRHPFAFMPFSAGP
                     RNCIGQQFAMNEMKVVTALCLLRFEFSLDPSKMPIKVPQLILRSKNGIHLYLKPLASR
                     SGK"
     exon            183..324
                     /gene="Cyp4b1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..369
                     /gene="Cyp4b1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..497
                     /gene="Cyp4b1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..622
                     /gene="Cyp4b1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..774
                     /gene="Cyp4b1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..881
                     /gene="Cyp4b1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1072
                     /gene="Cyp4b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1206
                     /gene="Cyp4b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1271
                     /gene="Cyp4b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1354
                     /gene="Cyp4b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1920
                     /gene="Cyp4b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccatggtcct caatttcctc tccccgagcc tttcccggct cggcttgtgg gcttctgtag
       61 tgatcctgat ggtaatcgtt ctcaagctct tcagcctgct gcttcggagg cagaagctgg
      121 ccagggctat ggacagtttc ccagggcccc ccacacactg gctttttggt catgcccttg
      181 agatccagaa gttagggagc ctggacaagg tggtatcctg ggcccaacag ttcccccatg
      241 cccacccact ttggtttgga caattcgttg gtttcctgaa catctatgag cccgactatg
      301 cgaaagctgt atacagccgc ggggatccga aggctgcaga tgtgtatgac ttcttcctcc
      361 agtggatcgg gaaaggccta ctagttctgg atgggccaaa atggttccag caccgcaagc
      421 tgctcacacc tggcttccat tatgatgtgc tgaagcccta tgtggccata tttgctgagt
      481 ccacacgtat gatgctggac aagtgggaga aaaaggctag tgaaaataag agctttgaca
      541 tcttctgtga cgtaggccac atggccctgg acaccctcat gaagtgcacc ttcggcaaag
      601 gagacagcgg cctaggccac agagacaaca gctactacct ggcggtcagt gacctcacac
      661 tgctgatgca gcagcgcatc gactccttcc agtaccataa tgacttcatt tactggctca
      721 ctccacatgg ccgccgcttc ctgcgggcct gcaagatagc ccatgaccat acagatgagg
      781 tcatcaggca gcggaaggca gcactgcagg atgagaaaga gcggaaaaag attcagcagc
      841 ggaggcacct ggacttcctg gacattctcc tgggtgtccg ggatgaaagt gggatcaagc
      901 tgtcagatgc agagctccgg gctgaagtgg acacattcat gtttgaaggc catgacacca
      961 ccactagtgg tatctcttgg tttctctact gcatggccct ttaccctgag caccagcagc
     1021 tatgtaggga ggaggtccgt gggatcctag gagaccaaga ctccttccaa tgggatgatc
     1081 tggccaagat gacctacctg accatgtgca tgaaggagtg cttccgcctc tacccacctg
     1141 taccccaagt ataccgccag ctcaacaagc cagtcacctt cgtggatggc cgctctctac
     1201 ctgcaggcag cctgatctct ctgcacatct acgccctcca caggaacagt actgtgtggc
     1261 ctgatccaga ggtctttgac ccactgcgct tttctcctga gaatgctgca ggacggcatc
     1321 cctttgcctt catgcctttt tctgcagggc ccaggaattg catcgggcag cagtttgcca
     1381 tgaacgagat gaaggtggtc acagcccttt gtttactgcg ctttgagttc tccctggatc
     1441 cctcaaagat gcccattaag gtcccccagc tgatcttgcg ctccaaaaat ggtatccacc
     1501 tctacctgaa gccgctggct tctaggtctg gaaagtaggt cttcagagaa ctaggcctgg
     1561 gcagcacaag ccgtgactct tcctgggatg ttgccctcct agatagaatg tggagtcatc
     1621 atggatccct gcctgtggga ggctttggag gcaaaagcat ggacactgac agtctcctgg
     1681 aagacattct cttgtaaaca tgtgtgtgga atgattcaac gcccaggctc cagaacttat
     1741 ttcttcactc cacaacattt gctgaacgtt ttgctgcctt gagaaactcc attgatttca
     1801 catagctaca tttatttaac catcttggtg tgtatttgga atacgatgga catgaggaaa
     1861 attgctcaaa ctaaaactgt acaaaataaa taatacttta aaaagcaaac tcccaccacc
//
