LOCUS       NM_031605               2502 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 4, subfamily a,
            polypeptide 8 (Cyp4a8), mRNA.
ACCESSION   NM_031605 XM_213039
VERSION     NM_031605.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2502)
  AUTHORS   Kralova,E., Doka,G., Pivackova,L., Srankova,J., Kuracinova,K.,
            Janega,P., Babal,P., Klimas,J. and Krenek,P.
  TITLE     l-Arginine Attenuates Cardiac Dysfunction, But Further
            Down-Regulates alpha-Myosin Heavy Chain Expression in
            Isoproterenol-Induced Cardiomyopathy
  JOURNAL   Basic Clin Pharmacol Toxicol 117 (4), 251-260 (2015)
   PUBMED   25865156
REFERENCE   2  (bases 1 to 2502)
  AUTHORS   Park,F., Sweeney,W.E. Jr., Jia,G., Akbulut,T., Mueller,B.,
            Falck,J.R., Birudaraju,S., Roman,R.J. and Avner,E.D.
  TITLE     Chronic blockade of 20-HETE synthesis reduces polycystic kidney
            disease in an orthologous rat model of ARPKD
  JOURNAL   Am J Physiol Renal Physiol 296 (3), F575-F582 (2009)
   PUBMED   19129252
  REMARK    Erratum:[Am J Physiol Renal Physiol. 2009 Oct;297(4):F1135]
REFERENCE   3  (bases 1 to 2502)
  AUTHORS   Dunn,K.M., Renic,M., Flasch,A.K., Harder,D.R., Falck,J. and
            Roman,R.J.
  TITLE     Elevated production of 20-HETE in the cerebral vasculature
            contributes to severity of ischemic stroke and oxidative stress in
            spontaneously hypertensive rats
  JOURNAL   Am J Physiol Heart Circ Physiol 295 (6), H2455-H2465 (2008)
   PUBMED   18952718
REFERENCE   4  (bases 1 to 2502)
  AUTHORS   Singh,H. and Schwartzman,M.L.
  TITLE     Renal vascular cytochrome P450-derived eicosanoids in
            androgen-induced hypertension
  JOURNAL   Pharmacol Rep 60 (1), 29-37 (2008)
   PUBMED   18276983
  REMARK    GeneRIF: Increased vascular tone brought about by induction of
            CYP4A8 and enhanced production of 20-HETE may constitute important
            factors in androgen-induced hypertension.
REFERENCE   5  (bases 1 to 2502)
  AUTHORS   Zhou,Y., Huang,H., Chang,H.H., Du,J., Wu,J.F., Wang,C.Y. and
            Wang,M.H.
  TITLE     Induction of renal 20-hydroxyeicosatetraenoic acid by clofibrate
            attenuates high-fat diet-induced hypertension in rats
  JOURNAL   J Pharmacol Exp Ther 317 (1), 11-18 (2006)
   PUBMED   16339392
REFERENCE   6  (bases 1 to 2502)
  AUTHORS   Cowart,L.A., Wei,S., Hsu,M.H., Johnson,E.F., Krishna,M.U.,
            Falck,J.R. and Capdevila,J.H.
  TITLE     The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form
            high affinity peroxisome proliferator-activated receptor ligands
  JOURNAL   J Biol Chem 277 (38), 35105-35112 (2002)
   PUBMED   12124379
REFERENCE   7  (bases 1 to 2502)
  AUTHORS   Hoch,U. and Ortiz De Montellano,P.R.
  TITLE     Covalently linked heme in cytochrome p4504a fatty acid hydroxylases
  JOURNAL   J Biol Chem 276 (14), 11339-11346 (2001)
   PUBMED   11139583
REFERENCE   8  (bases 1 to 2502)
  AUTHORS   Nguyen,X., Wang,M.H., Reddy,K.M., Falck,J.R. and Schwartzman,M.L.
  TITLE     Kinetic profile of the rat CYP4A isoforms: arachidonic acid
            metabolism and isoform-specific inhibitors
  JOURNAL   Am J Physiol 276 (6), R1691-R1700 (1999)
   PUBMED   10362749
REFERENCE   9  (bases 1 to 2502)
  AUTHORS   Kroetz,D.L., Huse,L.M., Thuresson,A. and Grillo,M.P.
  TITLE     Developmentally regulated expression of the CYP4A genes in the
            spontaneously hypertensive rat kidney
  JOURNAL   Mol Pharmacol 52 (3), 362-372 (1997)
   PUBMED   9281597
REFERENCE   10 (bases 1 to 2502)
  AUTHORS   Stromstedt,M., Hayashi,S., Zaphiropoulos,P.G. and Gustafsson,J.A.
  TITLE     Cloning and characterization of a novel member of the cytochrome
            P450 subfamily IVA in rat prostate
  JOURNAL   DNA Cell Biol 9 (8), 569-577 (1990)
   PUBMED   1980193
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081771.1.
            
            On or before Jan 12, 2005 this sequence version replaced
            XM_213039.2, NM_031605.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081771.1, M37828.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5756307
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2502
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..2502
                     /gene="Cyp4a8"
                     /gene_synonym="Cyp4a12"
                     /note="cytochrome P450, family 4, subfamily a, polypeptide
                     8"
                     /db_xref="GeneID:266674"
                     /db_xref="RGD:628846"
     exon            1..203
                     /gene="Cyp4a8"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1541
                     /gene="Cyp4a8"
                     /gene_synonym="Cyp4a12"
                     /EC_number="1.14.14.1"
                     /note="CYPIVA8; CYPIVA12; P450-KP1; P450-PP1; cytochrome
                     P450-KP1; cytochrome P450-PP1; cytochrome P450, 4a12"
                     /codon_start=1
                     /product="cytochrome P450 4A12"
                     /protein_id="NP_113793.2"
                     /db_xref="GeneID:266674"
                     /db_xref="RGD:628846"
                     /translation="MSGSALSFTIFPGSILGFLQIATVLTVLLLLFKTAQFYLHRRWL
                     LRATQQFPSPPSHWFFGHKIPKDQEFQDILTRVKNFPSACPQWLWGSNVRIQVYDPDY
                     MKLILGRSDPKSHHSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDTLKPYVGIM
                     ADSVRIMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSQEGSVQLDRKYKSYIKA
                     VEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARSAWQLAHEHTDQVIKSRKAQLQDEE
                     ELQKVKQKRRLDFLDILLFARIENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYA
                     LATNPEHQQGCRKEIQSLLGDGASITWDDLDKMPYTTMCIKEALRIYPPVTAVSRMLS
                     TPVTFPDGRSLPKGITVMLSFYGLHHNPTVWPNPEVFDPYRFAPESSRHSHSFLPFSG
                     GARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPIPIPRLVLKSKNGIYLRLKKLQ
                     "
     exon            204..345
                     /gene="Cyp4a8"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            346..390
                     /gene="Cyp4a8"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            391..518
                     /gene="Cyp4a8"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            519..643
                     /gene="Cyp4a8"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            644..798
                     /gene="Cyp4a8"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            799..905
                     /gene="Cyp4a8"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1096
                     /gene="Cyp4a8"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1230
                     /gene="Cyp4a8"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1295
                     /gene="Cyp4a8"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1372
                     /gene="Cyp4a8"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..2477
                     /gene="Cyp4a8"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagctgtgg tatcatgagt ggctcggctc tgagcttcac catattccca ggaagtatcc
       61 ttgggttcct ccaaatagcc actgtgctca ctgtgctcct gctgctcttc aagacagccc
      121 agttctacct gcacaggcga tggttactca gagctaccca gcagttccca tccccacctt
      181 ctcactggtt ctttgggcat aagatcccaa aggaccagga gtttcaagat attctaacac
      241 gggtaaagaa tttcccaagt gcctgtccac agtggctctg ggggagcaat gtgcgaatcc
      301 aagtgtatga ccctgactac atgaagctga ttctggggag atcagaccca aaatcccatc
      361 attcgtacag atttctagct ccctggattg ggtatggttt gcttctgctg aatggacaga
      421 catggttcca gcaccgacga atgttgactc cagctttcca ctatgacact ctgaaacctt
      481 atgtgggcat catggcagac tctgttcgta taatgctgga taaatgggaa cagattgttg
      541 gacaggattc caccctggag atcttccaac acatcacctt gatgaccttg gacaccatca
      601 tgaagtgtgc cttcagccaa gagggcagtg tccagttgga cagaaaatac aagtcctaca
      661 tcaaggcagt tgaggacctg aacaatctct cttttttccg tatacggaac atctttcacc
      721 agaatgacat catctatagt ctgtcctcta atggccgcaa ggcccgcagt gcctggcaac
      781 ttgcccatga gcacacagac caagtgatca aatcaaggaa ggctcaactt caggacgagg
      841 aagagttgca aaaggttaag cagaaaagac gattggattt cctggacatc cttctgtttg
      901 ccagaataga aaatggaagc agcttatctg ataaggacct gcgtgctgaa gtggatacct
      961 tcatgttcga gggccatgac accacagcta gcggtatctc ttggatcttc tatgctttgg
     1021 ccacaaatcc tgaacaccag cagggatgca ggaaggagat ccagagtctc ctaggagatg
     1081 gagcttctat cacctgggac gacctggaca agatgcccta caccaccatg tgcatcaagg
     1141 aagctctgag gatctaccca cctgtaacag ctgtgagcag aatgctcagc acacctgtca
     1201 ccttcccgga tggacgctct ttacccaaag gtatcacagt catgctctcc ttctatggcc
     1261 ttcatcacaa cccaactgtg tggccaaatc cagaggtgtt tgacccttat cgatttgcac
     1321 cagagtcttc ccgacacagc cactcattcc tgcccttctc aggaggagca aggaactgca
     1381 ttgggaaaca gtttgccatg aatgaactga aggtggccgt ggccctgacc ctgctccgct
     1441 ttgagctgct gccagatccc accaggatcc caatccccat accaagactc gtgttgaagt
     1501 ccaagaatgg gatctacctg cgtctcaaaa agctccaata atcttgacag cacaagacag
     1561 ctccaacagc atgctgtctg ccatttgtct ttctgtcagt cactcttgtc cccactccat
     1621 ctgctcacat ctcattcttt cttctcacct tgttcacctc cacccacctt ctgctgtgct
     1681 tctggtctcc ttgtctgtca gtctttctat ctcgacttct ggaatttcta cctgcttttc
     1741 tctctacctg gcccctacct gacttcatgt ttgaccttga ccttaatgat ctccctaaat
     1801 tacaccctgc cttctcttct gcatatttcc ttctattcta ctgtttgtct gtgcttaaat
     1861 tgagctttat accaatgtca taattgatta caatagaagt attgccctat gattcgatat
     1921 accaggtgtt tttcatgatt tcattagaat aaagctcagg tcattgcagt accattgccc
     1981 ttggttattt ctgtgactct ttttaccttt tccatcacct atagctgcat tcctaggttg
     2041 caagagcctg tctgagtgtt aaaatccaac attgtcttta agcacgtctt attctgtctc
     2101 taggtcatct cttcatcttg tcaatatgta tgcttacttt gtgcttaagt ggtaatactg
     2161 gtcatgttct tggttctgtc aaagagccat tgttccagca acctaacaca gtccttctct
     2221 gactgtcacc tcatctatcc atataaatct caccttcaaa aactctgcct accagcttta
     2281 agagtcttac catcgcccca gtgaacgtga ttgttgcggg gagggcggca atgggtgaag
     2341 gatggggagg ggaacacccg taaagaaggg gagggggaag agttaggggg atgttggccc
     2401 ggaaaccagg aaagggaata acactcaaaa tgtaaataag aaatactcaa gttaataaaa
     2461 aaaaaagagt cttgtcaaaa aaaaaaaaaa aaaaaaaaaa aa
//
