LOCUS       NM_175760               2140 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus cytochrome P450, family 4, subfamily a,
            polypeptide 3 (Cyp4a3), mRNA.
ACCESSION   NM_175760 XM_575886
VERSION     NM_175760.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2140)
  AUTHORS   Zhang,X., Li,S., Zhou,Y., Su,W., Ruan,X., Wang,B., Zheng,F.,
            Warner,M., Gustafsson,J.A. and Guan,Y.
  TITLE     Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates
            hepatic steatosis and fibrosis
  JOURNAL   Proc Natl Acad Sci U S A 114 (12), 3181-3185 (2017)
   PUBMED   28270609
  REMARK    GeneRIF: this study provides a link between CYP4A14 and NAFLD.
            Overexpression of CYP4A14 promotes, whereas gene disruption of
            CYP4A14 attenuates, HFD- and MCD-induced liver lipid accumulation.
            Ablation of CYP4A14 gene markedly attenuates liver damage,
            inflammation, and fibrosis in MCD-induced NASH.
            Erratum:[Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2315591120.
            doi: 10.1073/pnas.2315591120.. PMID: 37824533]
REFERENCE   2  (bases 1 to 2140)
  AUTHORS   Maayah,Z.H., Ansari,M.A., El Gendy,M.A., Al-Arifi,M.N. and
            Korashy,H.M.
  TITLE     Development of cardiac hypertrophy by sunitinib in vivo and in
            vitro rat cardiomyocytes is influenced by the aryl hydrocarbon
            receptor signaling pathway
  JOURNAL   Arch Toxicol 88 (3), 725-738 (2014)
   PUBMED   24247421
REFERENCE   3  (bases 1 to 2140)
  AUTHORS   Aboutabl,M.E., Zordoky,B.N. and El-Kadi,A.O.
  TITLE     3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome
            P450 gene expression and arachidonic acid metabolism in male
            Sprague Dawley rats
  JOURNAL   Br J Pharmacol 158 (7), 1808-1819 (2009)
   PUBMED   19889059
REFERENCE   4  (bases 1 to 2140)
  AUTHORS   Park,F., Sweeney,W.E. Jr., Jia,G., Akbulut,T., Mueller,B.,
            Falck,J.R., Birudaraju,S., Roman,R.J. and Avner,E.D.
  TITLE     Chronic blockade of 20-HETE synthesis reduces polycystic kidney
            disease in an orthologous rat model of ARPKD
  JOURNAL   Am J Physiol Renal Physiol 296 (3), F575-F582 (2009)
   PUBMED   19129252
  REMARK    Erratum:[Am J Physiol Renal Physiol. 2009 Oct;297(4):F1135]
REFERENCE   5  (bases 1 to 2140)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   6  (bases 1 to 2140)
  AUTHORS   Kawashima,H., Kusunose,E., Kubota,I., Maekawa,M. and Kusunose,M.
  TITLE     Purification and NH2-terminal amino acid sequences of human and rat
            kidney fatty acid omega-hydroxylases
  JOURNAL   Biochim Biophys Acta 1123 (2), 156-162 (1992)
   PUBMED   1739747
REFERENCE   7  (bases 1 to 2140)
  AUTHORS   Imaoka,S., Nagashima,K. and Funae,Y.
  TITLE     Characterization of three cytochrome P450s purified from renal
            microsomes of untreated male rats and comparison with human renal
            cytochrome P450
  JOURNAL   Arch Biochem Biophys 276 (2), 473-480 (1990)
   PUBMED   2306108
REFERENCE   8  (bases 1 to 2140)
  AUTHORS   Kimura,S., Hardwick,J.P., Kozak,C.A. and Gonzalez,F.J.
  TITLE     The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of
            IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and
            coordinate and tissue-specific regulation of the CYP4A genes
  JOURNAL   DNA 8 (7), 517-525 (1989)
   PUBMED   2766933
REFERENCE   9  (bases 1 to 2140)
  AUTHORS   Kimura,S., Hanioka,N., Matsunaga,E. and Gonzalez,F.J.
  TITLE     The rat clofibrate-inducible CYP4A gene subfamily. I. Complete
            intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique
            exon organization, and identification of a conserved 19-bp upstream
            element
  JOURNAL   DNA 8 (7), 503-516 (1989)
   PUBMED   2766932
REFERENCE   10 (bases 1 to 2140)
  AUTHORS   Imaoka,S., Shimojo,N. and Funae,Y.
  TITLE     Induction of renal cytochrome P-450 in hepatic microsomes of
            diabetic rats
  JOURNAL   Biochem Biophys Res Commun 152 (2), 680-687 (1988)
   PUBMED   3365247
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M33936.1.
            
            On or before Jun 29, 2005 this sequence version replaced
            XM_575886.1, NM_175760.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M33936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2140
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..2140
                     /gene="Cyp4a3"
                     /gene_synonym="Cyp4a14; CYPIVA3"
                     /note="cytochrome P450, family 4, subfamily a, polypeptide
                     3"
                     /db_xref="GeneID:298423"
                     /db_xref="RGD:631356"
     exon            1..207
                     /gene="Cyp4a3"
                     /gene_synonym="Cyp4a14; CYPIVA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1536
                     /gene="Cyp4a3"
                     /gene_synonym="Cyp4a14; CYPIVA3"
                     /EC_number="1.14.14.80"
                     /note="CYPIVA14; P450-LA-omega 3; cytochrome P450-LA-omega
                     3; cytochrome P450, family 4, subfamily a, polypeptide 14;
                     cytochrome P450 4A3; long-chain fatty acid
                     omega-monooxygenase"
                     /codon_start=1
                     /product="cytochrome P450 4A14"
                     /protein_id="NP_786936.1"
                     /db_xref="GeneID:298423"
                     /db_xref="RGD:631356"
                     /translation="MGFSVFTPTRSLDGVSGFFQGAFLLSLFLVLFKAVQFYLRRQWL
                     LKALEKFPSTPSHWLWGHDLKDREFQQVLTWVEKFPGACLQWLSGSKTRVLLYDPDYV
                     KVVLGRSDPKASGIYQFLAPWIGYGLLLLNGKKWFQHRRMLTPAFHYGILKPYVKIMA
                     DSVNIMLDKWEKLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLDVNSRSYTKAV
                     EDLNNLTFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTDGVIKMRKAQLQNEEE
                     LQKARKKRHLDFLDILLFAKMEDGKSLSDEDLRAEVDTFMFEGHDTTASGISWVFYAL
                     ATHPEHQERCREEVQSILGDGTSVTWDHLDQIPYTTMCIKEALRLYPPVPSVSRELSS
                     PVTFPDGRSIPKGITTTILIYGLHHNPSYWPNPKVFDPSRFSPDSPRHSHAYLPFSGG
                     ARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMARLVLKSKNGIHLRLKKLR"
     exon            208..340
                     /gene="Cyp4a3"
                     /gene_synonym="Cyp4a14; CYPIVA3"
                     /inference="alignment:Splign:2.1.0"
     exon            341..385
                     /gene="Cyp4a3"
                     /gene_synonym="Cyp4a14; CYPIVA3"
                     /inference="alignment:Splign:2.1.0"
     exon            386..513
                     /gene="Cyp4a3"
                     /gene_synonym="Cyp4a14; CYPIVA3"
                     /inference="alignment:Splign:2.1.0"
     exon            514..638
                     /gene="Cyp4a3"
                     /gene_synonym="Cyp4a14; CYPIVA3"
                     /inference="alignment:Splign:2.1.0"
     exon            639..793
                     /gene="Cyp4a3"
                     /gene_synonym="Cyp4a14; CYPIVA3"
                     /inference="alignment:Splign:2.1.0"
     exon            794..900
                     /gene="Cyp4a3"
                     /gene_synonym="Cyp4a14; CYPIVA3"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1091
                     /gene="Cyp4a3"
                     /gene_synonym="Cyp4a14; CYPIVA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1225
                     /gene="Cyp4a3"
                     /gene_synonym="Cyp4a14; CYPIVA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1290
                     /gene="Cyp4a3"
                     /gene_synonym="Cyp4a14; CYPIVA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1367
                     /gene="Cyp4a3"
                     /gene_synonym="Cyp4a14; CYPIVA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..2140
                     /gene="Cyp4a3"
                     /gene_synonym="Cyp4a14; CYPIVA3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaccattaa ccatgggttt ctctgtattt acccctacaa gatccctgga tggtgtctct
       61 gggttcttcc aaggggcctt cctgctcagt ctatttctgg tgctgttcaa ggcagtccaa
      121 ttctacttac gaaggcaatg gctgctcaag gccctcgaga agttcccatc cacgccttcc
      181 cactggcttt ggggccacga cctgaaggac agagaattcc agcaggttct tacgtgggta
      241 gagaaattcc caggtgcctg cttacagtgg ctctcaggga gcaaaacacg agtcctgctc
      301 tatgaccctg actatgtgaa ggtggttctg ggaagatcag atccaaaggc ttctggaatt
      361 tatcaattcc ttgctccctg gattggttat ggtttgctcc tgttgaatgg gaagaaatgg
      421 ttccagcatc ggcggatgtt gactccagcc ttccactatg gcatcctcaa accctatgtc
      481 aaaatcatgg cggactctgt caatataatg ctagacaaat gggagaagct tgatgaccag
      541 gatcaccctc tagagatctt ccactatgtc tccttgatga cactggacac tgttatgaag
      601 tgtgctttca gccatcaggg cagtgttcag ttggatgtaa attccaggtc ctacaccaag
      661 gctgtcgagg atctaaacaa cctgactttc tttcgtgtga ggagtgcctt ttatgggaac
      721 agcatcatct acaatatgtc ctctgatggc cgtttgtccc gccgggcctg ccagattgct
      781 catgagcaca cagatggagt gatcaaaatg aggaaggctc agctgcagaa tgaggaagag
      841 cttcagaagg ccaggaagaa gaggcacttg gatttcctgg acatcctgtt gtttgccaaa
      901 atggaggatg ggaagagctt gtctgatgag gacctgcgtg cagaggtgga cacattcatg
      961 tttgagggtc atgacaccac agccagtgga atctcctggg ttttctatgc tctggccacc
     1021 caccctgagc accaagagag atgcagagag gaggtgcaga gcattctggg tgatggaacc
     1081 tctgtcacat gggaccacct ggaccagata ccttacacca ccatgtgcat caaggaggcc
     1141 ctgaggctct acccaccagt accttctgtg agtcgagagc tcagctcccc tgtcaccttc
     1201 ccagatggac gttccatacc caaaggtatc acaaccacaa ttttaattta tggccttcat
     1261 cataacccaa gttactggcc aaacccaaag gtgtttgacc cctctagatt ctcaccagat
     1321 tctcctcgcc atagccatgc ttatctgcca ttctcaggag gagcaaggaa ctgcattggg
     1381 aaacagtttg ccatgaatga gctgaaggtg gctgtggccc tgaccctgct tcgctttgag
     1441 ttgctgccag atcccaccag gatcccggtc cctatggcaa gacttgtgtt gaagtccaag
     1501 aatgggatcc acctgcgtct caagaagcta agataaatct ggtggagata ggacagctcc
     1561 agaggtctgc tgcctgcaat acctgcattt gttactggct aatttatact cattttgctt
     1621 tctctttgat tcccatcctc tgctgagtgt cccgtcatct catttttttg ccctcatttc
     1681 tgtagctttt cctccagact ccatcccagt ttgtgcgtgg acccatttcc catctgtttt
     1741 cacctctgac cagccactga acttgccgcc agcagcctgt cctccagcct gcttacccct
     1801 cattatcatt ggactaacag agaaagatgt attttagagg gaaactcttg cactttatct
     1861 ctcttcagtt ctcagagtct tgggacaatg gacatcatga attaaaatgt tcttaaaaat
     1921 cacatgctgg gagaaaatta atcctaaaaa ttctggcacc agccagagga aggatgttgg
     1981 ctgaaaagaa aagatttcta gatatttatg tttgtctcat ggtgaaatta atgtatgcct
     2041 catcttttct atgaaataat aattctgata cagaacagta gagagaaatg aatagttttt
     2101 gctactttgg gccaaactgt aaataaatcc atttcacttc
//
