LOCUS       NM_001044770            2044 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 4, subfamily a,
            polypeptide 2 (Cyp4a2), mRNA.
ACCESSION   NM_001044770 XM_001072959
VERSION     NM_001044770.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2044)
  AUTHORS   Dalmasso,C., Maranon,R., Patil,C., Moulana,M., Romero,D.G. and
            Reckelhoff,J.F.
  TITLE     20-HETE and CYP4A2 omega-hydroxylase contribute to the elevated
            blood pressure in hyperandrogenemic female rats
  JOURNAL   Am J Physiol Renal Physiol 311 (1), F71-F77 (2016)
   PUBMED   27194719
  REMARK    GeneRIF: dihydrotestosterone decreased omega-hydroxylase activity
            in ) female rats (by 50%) but significantly increased
            omega-hydroxylase activity in CYP4A2(-/-) female rats
REFERENCE   2  (bases 1 to 2044)
  AUTHORS   Gebremedhin,D., Zhang,D.X., Carver,K.A., Rau,N., Rarick,K.R.,
            Roman,R.J. and Harder,D.R.
  TITLE     Expression of CYP 4A omega-hydroxylase and formation of
            20-hydroxyeicosatetreanoic acid (20-HETE) in cultured rat brain
            astrocytes
  JOURNAL   Prostaglandins Other Lipid Mediat 124, 16-26 (2016)
   PUBMED   27174801
  REMARK    GeneRIF: Here we report that cultured astrocytes express CYP 4A2/3
            omega-hydroxylase mRNA and CYP 4A protein and produce 20-HETE and
            the CYP epoxygenase metabolites epoxyeicosatrienoic acids (EETs)
            when incubated with AA
REFERENCE   3  (bases 1 to 2044)
  AUTHORS   Inoue,K., Sodhi,K., Puri,N., Gotlinger,K.H., Cao,J., Rezzani,R.,
            Falck,J.R., Abraham,N.G. and Laniado-Schwartzman,M.
  TITLE     Endothelial-specific CYP4A2 overexpression leads to renal injury
            and hypertension via increased production of 20-HETE
  JOURNAL   Am J Physiol Renal Physiol 297 (4), F875-F884 (2009)
   PUBMED   19675180
  REMARK    GeneRIF: Augmentation of vascular endothelial 20-HETE levels by
            CYP4A2 overexpression results in hypertension, endothelial
            dysfunction, and renal injury.
REFERENCE   4  (bases 1 to 2044)
  AUTHORS   Park,F., Sweeney,W.E. Jr., Jia,G., Akbulut,T., Mueller,B.,
            Falck,J.R., Birudaraju,S., Roman,R.J. and Avner,E.D.
  TITLE     Chronic blockade of 20-HETE synthesis reduces polycystic kidney
            disease in an orthologous rat model of ARPKD
  JOURNAL   Am J Physiol Renal Physiol 296 (3), F575-F582 (2009)
   PUBMED   19129252
  REMARK    Erratum:[Am J Physiol Renal Physiol. 2009 Oct;297(4):F1135]
REFERENCE   5  (bases 1 to 2044)
  AUTHORS   Wang,J.S., Singh,H., Zhang,F., Ishizuka,T., Deng,H., Kemp,R.,
            Wolin,M.S., Hintze,T.H., Abraham,N.G., Nasjletti,A. and
            Laniado-Schwartzman,M.
  TITLE     Endothelial dysfunction and hypertension in rats transduced with
            CYP4A2 adenovirus
  JOURNAL   Circ Res 98 (7), 962-969 (2006)
   PUBMED   16543501
  REMARK    GeneRIF: Intravenous injection of adenovirus transfected-CYP4A2
            increased blood pressure and hypertension.
REFERENCE   6  (bases 1 to 2044)
  AUTHORS   Nakamura,M., Imaoka,S., Miura,K., Tanaka,E., Misawa,S. and Funae,Y.
  TITLE     Induction of cytochrome P450 isozymes in rat renal microsomes by
            cyclosporin A
  JOURNAL   Biochem Pharmacol 48 (9), 1743-1746 (1994)
   PUBMED   7980643
REFERENCE   7  (bases 1 to 2044)
  AUTHORS   Imaoka,S., Nakamura,M., Ishizaki,T., Shimojo,N., Ohishi,N.,
            Fujii,S. and Funae,Y.
  TITLE     Regulation of renal cytochrome P450s by thyroid hormone in diabetic
            rats
  JOURNAL   Biochem Pharmacol 46 (12), 2197-2200 (1993)
   PUBMED   8274152
REFERENCE   8  (bases 1 to 2044)
  AUTHORS   Kawashima,H., Kusunose,E., Kubota,I., Maekawa,M. and Kusunose,M.
  TITLE     Purification and NH2-terminal amino acid sequences of human and rat
            kidney fatty acid omega-hydroxylases
  JOURNAL   Biochim Biophys Acta 1123 (2), 156-162 (1992)
   PUBMED   1739747
REFERENCE   9  (bases 1 to 2044)
  AUTHORS   Imaoka,S., Nagashima,K. and Funae,Y.
  TITLE     Characterization of three cytochrome P450s purified from renal
            microsomes of untreated male rats and comparison with human renal
            cytochrome P450
  JOURNAL   Arch Biochem Biophys 276 (2), 473-480 (1990)
   PUBMED   2306108
REFERENCE   10 (bases 1 to 2044)
  AUTHORS   Kimura,S., Hanioka,N., Matsunaga,E. and Gonzalez,F.J.
  TITLE     The rat clofibrate-inducible CYP4A gene subfamily. I. Complete
            intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique
            exon organization, and identification of a conserved 19-bp upstream
            element
  JOURNAL   DNA 8 (7), 503-516 (1989)
   PUBMED   2766932
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078684.1.
            
            On Oct 28, 2007 this sequence version replaced NM_001044770.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2044
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..2044
                     /gene="Cyp4a2"
                     /gene_synonym="Cyp4a11"
                     /note="cytochrome P450, family 4, subfamily a, polypeptide
                     2"
                     /db_xref="GeneID:24306"
                     /db_xref="RGD:2479"
     exon            1..211
                     /gene="Cyp4a2"
                     /gene_synonym="Cyp4a11"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1531
                     /gene="Cyp4a2"
                     /gene_synonym="Cyp4a11"
                     /EC_number="1.14.14.80"
                     /note="cytochrome P450, subfamily IVA, polypeptide 11;
                     CYPIVA2; P450 K-5; P-450 K-2; P450-LA-omega 2; lauric acid
                     omega-hydroxylase; cytochrome P450 K-5; cytochrome P-450
                     K-2; cytochrome P450-LA-omega 2; P-450 IV4AII; cytochrome
                     P450, subfamily 4A, polypeptide 11; long-chain fatty acid
                     omega-monooxygenase; cytochrome P450 4A2-like"
                     /codon_start=1
                     /product="cytochrome P450 4A2"
                     /protein_id="NP_001038235.1"
                     /db_xref="GeneID:24306"
                     /db_xref="RGD:2479"
                     /translation="MGFSVFSPTRSLDGVSGFFQGAFLLSLFLVLFKAVQFYLRRQWL
                     LKALEKFPSTPSHWLWGHNLKDREFQQVLTWVEKFPGACLQWLSGSTARVLLYDPDYV
                     KVVLGRSDPKPYQSLAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSV
                     SIMLDKWEKLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLDVNSRSYTKAVEDL
                     NNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTDGVIKTRKAQLQNEEELQK
                     ARKKRHLDFLDILLFAKMEDGKSLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATH
                     PEHQERCREEVQSILGDGTSVTWDHLDQMPYTTMCIKEALRLYSPVPSVSRELSSPVT
                     FPDGRSIPKGIRVTILIYGLHHNPSYWPNPKVFDPSRFSPDSPRHSHAYLPFSGGARN
                     CIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNGIHLRLKKLR"
     exon            212..344
                     /gene="Cyp4a2"
                     /gene_synonym="Cyp4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            345..380
                     /gene="Cyp4a2"
                     /gene_synonym="Cyp4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            381..508
                     /gene="Cyp4a2"
                     /gene_synonym="Cyp4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            509..633
                     /gene="Cyp4a2"
                     /gene_synonym="Cyp4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            634..788
                     /gene="Cyp4a2"
                     /gene_synonym="Cyp4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            789..895
                     /gene="Cyp4a2"
                     /gene_synonym="Cyp4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1086
                     /gene="Cyp4a2"
                     /gene_synonym="Cyp4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1220
                     /gene="Cyp4a2"
                     /gene_synonym="Cyp4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1285
                     /gene="Cyp4a2"
                     /gene_synonym="Cyp4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1362
                     /gene="Cyp4a2"
                     /gene_synonym="Cyp4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1559
                     /gene="Cyp4a2"
                     /gene_synonym="Cyp4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..2019
                     /gene="Cyp4a2"
                     /gene_synonym="Cyp4a11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagaagcca ttaaccatgg gtttctctgt atttagccct acaagatccc tggatggtgt
       61 ctctgggttc ttccaagggg ccttcttgct cagtctattt ctggtgctgt tcaaggcagt
      121 ccaattctac ttacgaaggc aatggctgct caaggccctc gagaagttcc catccacgcc
      181 ttcccactgg ctttggggcc acaacctgaa ggatagagaa ttccagcagg ttcttacgtg
      241 ggtagagaaa ttcccaggtg cctgcttaca gtggctctca gggagcacag cacgagtcct
      301 gctctatgac cctgactatg tgaaggtggt tctgggaaga tcagatccaa agccttatca
      361 atcccttgct ccctggattg gttatggttt gctcctgttg aatggaaaga aatggttcca
      421 gcatcggcgg atgttgactc cagccttcca ctatgacatc ctcaaaccct atgtcaaaat
      481 catggcggac tctgtcagta taatgctaga caaatgggag aagcttgatg accaggatca
      541 ccctctagag atcttccact atgtctcctt gatgacactg gacactgtta tgaagtgtgc
      601 tttcagccac cagggcagtg ttcagttgga tgtaaattcc aggtcctaca ccaaggctgt
      661 tgaggatcta aacaacctga ttttctttcg tgtgaggagt gccttttatg ggaacagcat
      721 catctacaat atgtcctctg atggccgttt gtcccgccgg gcctgccaga ttgctcatga
      781 gcacacagat ggagtgatca aaacgaggaa ggctcagctg cagaatgagg aagagcttca
      841 gaaggccagg aagaagaggc acttggattt cctggacatc ctgttgtttg ccaaaatgga
      901 ggatgggaag agcttgtcag atgaggacct gcgtgcagag gtggacacat tcatgtttga
      961 gggtcatgac accacagcca gtggaatctc ctgggttttc tatgctctgg ccacccaccc
     1021 tgagcaccaa gagagatgca gagaggaggt gcagagcatt ctgggtgatg gaacctctgt
     1081 cacatgggac cacctggacc agatgcctta caccaccatg tgcatcaagg aggccctgag
     1141 gctctactca cctgtacctt ctgtgagtcg agagctcagc tcccctgtca ccttcccaga
     1201 tggacgttcc atacccaaag gtatcagagt cacaatttta atttatggtc ttcatcataa
     1261 cccaagttac tggccaaacc caaaggtgtt tgacccctct agattctcac cagattctcc
     1321 tcgccatagc catgcttatc tgccattctc aggaggagca aggaactgca ttgggaaaca
     1381 atttgccatg aatgagctga aggtagctgt ggccctgacc ctgcttcgct ttgagttgct
     1441 gccagatccc accaggatcc cggtccccat gccaagactt gtgttgaagt ccaagaatgg
     1501 gatccacctg cgtctcaaga agctaagata attctggtgg agataggaca gctccaaagc
     1561 ttttactcca gacaccttcc cagcttgtgt gtgtacccat ttcccatctg gtttcacctc
     1621 tgaccagcca ctgaacctgc cgccagcagc ccgtcctcca gcctgcttac ccatcatcat
     1681 cattggacta acagagaaag atgtatttta gagggaaact cttgcacttt atctcccttc
     1741 agttctcaga gtcttgggac aatcggcatc atgaattaaa atgttcttag atatcacatg
     1801 ctgggagaaa attaatccta aagattctgg caccagccag aggaaggaag gtgactcaaa
     1861 agaagagatt tctagatatt tctgattgtc tcatggtgaa attaatgtat gcctcatctt
     1921 ttctatgaaa taatagtact gatgcagaac agtagataga aatgaatagt ttttactact
     1981 ttgggccaaa ctgtaaataa atccatttca cttcattaaa aaaaaaaaaa aaaaaaaaaa
     2041 aaaa
//
