LOCUS       NM_175837               2089 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 4, subfamily a,
            polypeptide 1 (Cyp4a1), mRNA.
ACCESSION   NM_175837 NM_153307
VERSION     NM_175837.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2089)
  AUTHORS   Rong,R., Hu,G., Wang,W., Muroya,Y., Miura,T., Ogawa,Y., Kohzuki,M.
            and Ito,O.
  TITLE     Angiotensin II upregulates CYP4A isoform expression in the rat
            kidney through angiotensin II type 1 receptor
  JOURNAL   Prostaglandins Other Lipid Mediat 139, 80-86 (2018)
   PUBMED   30227249
  REMARK    GeneRIF: These results indicated that AngII chronically increased
            the CYP4A isoform expression in the rat kidney. The AngII-induced
            CYP4A isoform expression was mediated by AT1-R.
REFERENCE   2  (bases 1 to 2089)
  AUTHORS   Lukaszewicz,K.M., Paudyal,M.P., Falck,J.R. and Lombard,J.H.
  TITLE     Role of vascular reactive oxygen species in regulating cytochrome
            P450-4A enzyme expression in Dahl salt-sensitive rats
  JOURNAL   Microcirculation 23 (7), 540-548 (2016)
   PUBMED   27537772
  REMARK    GeneRIF: The CYP4A pathway plays a role in vascular dysfunction in
            SS rats and there appears to be a direct role of reduced NO
            availability due to salt-induced oxidant stress in upregulating
            CYP4A enzyme expression.
REFERENCE   3  (bases 1 to 2089)
  AUTHORS   Fan,F., Geurts,A.M., Murphy,S.R., Pabbidi,M.R., Jacob,H.J. and
            Roman,R.J.
  TITLE     Impaired myogenic response and autoregulation of cerebral blood
            flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 308 (5), R379-R390 (2015)
   PUBMED   25540098
  REMARK    GeneRIF: In CYP4A1 transgenic Dahl salt-sensitive rat formation of
            20-HETE in the cerebral vasculature was elevated rescuing impaired
            myogenic response/autoregulation of cerebrovascular blood flow.
REFERENCE   4  (bases 1 to 2089)
  AUTHORS   Li,D.B., Xu,H.W., Yang,G.J., Yang,J.M., Fang,H. and Tang,J.Y.
  TITLE     Effects of rosuvastatin correlated with the down-regulation of
            CYP4A1 in spontaneously hypertensive rats
  JOURNAL   Microvasc Res 98, 88-93 (2015)
   PUBMED   25636742
  REMARK    GeneRIF: rosuvastatin downregulates CYP4A1 in spontaneously
            hypertensive rats
REFERENCE   5  (bases 1 to 2089)
  AUTHORS   Lukaszewicz,K.M., Falck,J.R., Manthati,V.L. and Lombard,J.H.
  TITLE     Introgression of Brown Norway CYP4A genes on to the Dahl
            salt-sensitive background restores vascular function in SS-5(BN)
            consomic rats
  JOURNAL   Clin Sci (Lond) 124 (5), 333-342 (2013)
   PUBMED   22938512
  REMARK    GeneRIF: Salt sensitive rats have an up-regulation of the
            CYP4A/20-HETE pathway resulting in elevated reactive oxygen species
            and reduced NO bioavailability causing vascular dysfunction.
REFERENCE   6  (bases 1 to 2089)
  AUTHORS   Okita,R.T. and Okita,J.R.
  TITLE     Characterization of a cytochrome P450 from di(2-ethylhexyl)
            phthalate-treated rats which hydroxylates fatty acids
  JOURNAL   Arch Biochem Biophys 294 (2), 475-481 (1992)
   PUBMED   1567203
REFERENCE   7  (bases 1 to 2089)
  AUTHORS   Stromstedt,M., Hayashi,S., Zaphiropoulos,P.G. and Gustafsson,J.A.
  TITLE     Cloning and characterization of a novel member of the cytochrome
            P450 subfamily IVA in rat prostate
  JOURNAL   DNA Cell Biol 9 (8), 569-577 (1990)
   PUBMED   1980193
REFERENCE   8  (bases 1 to 2089)
  AUTHORS   Kimura,S., Hanioka,N., Matsunaga,E. and Gonzalez,F.J.
  TITLE     The rat clofibrate-inducible CYP4A gene subfamily. I. Complete
            intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique
            exon organization, and identification of a conserved 19-bp upstream
            element
  JOURNAL   DNA 8 (7), 503-516 (1989)
   PUBMED   2766932
REFERENCE   9  (bases 1 to 2089)
  AUTHORS   Earnshaw,D., Dale,J.W., Goldfarb,P.S. and Gibson,G.G.
  TITLE     Differential splicing in the 3' non-coding region of rat cytochrome
            P-452 (P450 IVA1) mRNA
  JOURNAL   FEBS Lett 236 (2), 357-361 (1988)
   PUBMED   3410047
REFERENCE   10 (bases 1 to 2089)
  AUTHORS   Hardwick,J.P., Song,B.J., Huberman,E. and Gonzalez,F.J.
  TITLE     Isolation, complementary DNA sequence, and regulation of rat
            hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega).
            Identification of a new cytochrome P-450 gene family
  JOURNAL   J Biol Chem 262 (2), 801-810 (1987)
   PUBMED   3027069
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M57718.1.
            
            On Sep 1, 2011 this sequence version replaced NM_153307.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089761.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2089
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..2089
                     /gene="Cyp4a1"
                     /gene_synonym="Cyp4a10; Cyp4a22; CYPIVA10"
                     /note="cytochrome P450, family 4, subfamily a, polypeptide
                     1"
                     /db_xref="GeneID:50549"
                     /db_xref="RGD:68945"
     exon            1..228
                     /gene="Cyp4a1"
                     /gene_synonym="Cyp4a10; Cyp4a22; CYPIVA10"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1569
                     /gene="Cyp4a1"
                     /gene_synonym="Cyp4a10; Cyp4a22; CYPIVA10"
                     /EC_number="1.14.14.80"
                     /note="cytochrome P450, 4a10; cytochrome P450, family 4,
                     subfamily a, polypeptide 10; cytochrome P450, 4A1; lauric
                     acid omega-hydroxylase; cytochrome P452; cytochrome P450,
                     IVA1; cytochrome P450, family 4, subfamily A, polypeptide
                     22; cytochrome P450-LA-omega 1; long-chain fatty acid
                     omega-monooxygenase"
                     /codon_start=1
                     /product="cytochrome P450 4A10"
                     /protein_id="NP_787031.1"
                     /db_xref="GeneID:50549"
                     /db_xref="RGD:68945"
                     /translation="MSVSALSSTRFTGSISGFLQVASVLGLLLLLVKAVQFYLQRQWL
                     LKAFQQFPSPPFHWFFGHKQFQGDKELQQIMTCVENFPSAFPRWFWGSKAYLIVYDPD
                     YMKVILGRSDPKANGVYRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKN
                     MADSIRLMLDKWEQLAGQDSSIEIFQHISLMTLDTVMKCAFSHNGSVQVDGNYKSYIQ
                     AIGNLNDLFHSRVRNIFHQNDTIYNFSSNGHLFNRACQLAHDHTDGVIKLRKDQLQNA
                     GELEKVKKKRRLDFLDILLLARMENGDSLSDKDLRAEVDTFMFEGHDTTASGVSWIFY
                     ALATHPEHQQRCREEVQSVLGDGSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVREL
                     STSVTFPDGRSLPKGIQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPRHSHSFLPFS
                     GGARNCIGKQFAMSEMKVIVALTLLRFELLPDPTKVPIPLPRLVLKSKNGIYLYLKKL
                     H"
     exon            229..373
                     /gene="Cyp4a1"
                     /gene_synonym="Cyp4a10; Cyp4a22; CYPIVA10"
                     /inference="alignment:Splign:2.1.0"
     exon            374..418
                     /gene="Cyp4a1"
                     /gene_synonym="Cyp4a10; Cyp4a22; CYPIVA10"
                     /inference="alignment:Splign:2.1.0"
     exon            419..546
                     /gene="Cyp4a1"
                     /gene_synonym="Cyp4a10; Cyp4a22; CYPIVA10"
                     /inference="alignment:Splign:2.1.0"
     exon            547..671
                     /gene="Cyp4a1"
                     /gene_synonym="Cyp4a10; Cyp4a22; CYPIVA10"
                     /inference="alignment:Splign:2.1.0"
     exon            672..826
                     /gene="Cyp4a1"
                     /gene_synonym="Cyp4a10; Cyp4a22; CYPIVA10"
                     /inference="alignment:Splign:2.1.0"
     exon            827..933
                     /gene="Cyp4a1"
                     /gene_synonym="Cyp4a10; Cyp4a22; CYPIVA10"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1124
                     /gene="Cyp4a1"
                     /gene_synonym="Cyp4a10; Cyp4a22; CYPIVA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1258
                     /gene="Cyp4a1"
                     /gene_synonym="Cyp4a10; Cyp4a22; CYPIVA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1323
                     /gene="Cyp4a1"
                     /gene_synonym="Cyp4a10; Cyp4a22; CYPIVA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1400
                     /gene="Cyp4a1"
                     /gene_synonym="Cyp4a10; Cyp4a22; CYPIVA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1574
                     /gene="Cyp4a1"
                     /gene_synonym="Cyp4a10; Cyp4a22; CYPIVA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..2089
                     /gene="Cyp4a1"
                     /gene_synonym="Cyp4a10; Cyp4a22; CYPIVA10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtgagagt gagggcagct actgaggagt ggctgcacca tgagcgtctc tgcactgagc
       61 tccacccgct tcacgggcag catctctggc ttcctccaag tggcctccgt gcttggtctg
      121 cttctgctgc tggtcaaagc agtccagttc tacctgcaaa ggcaatggct actcaaggct
      181 ttccagcagt tcccatcacc tcccttccac tggttctttg ggcacaagca gtttcaaggt
      241 gacaaagaac tacagcaaat tatgacatgt gtggagaatt tcccaagtgc ctttcctcga
      301 tggttctggg gaagcaaagc ctacttaatt gtctatgacc ctgactacat gaaggtgatt
      361 ctcgggcgat cagatccaaa ggccaatggc gtctacagat tgctagctcc ttggatcgga
      421 tatggtttgc tcttgctgaa tggacaaccg tggttccagc accggcgaat gctaacccca
      481 gccttccact atgacattct gaaaccctat gtaaaaaaca tggctgactc cattcgactg
      541 atgctagaca aatgggaaca gctggcaggt caagactcct ctatagaaat ctttcaacat
      601 atctccttaa tgaccctaga cactgtcatg aagtgtgcct tcagccacaa tggcagtgtt
      661 caggtggatg gaaattacaa gagctatatc caggccattg ggaacttgaa tgacctcttt
      721 cactcccgtg tgaggaacat ctttcatcag aatgatacca tctataattt ttcttccaat
      781 ggccacttgt tcaaccgtgc ttgtcaactt gcccatgatc acacagatgg tgtgatcaag
      841 ctaaggaagg atcagctgca gaatgcggga gagctggaaa aggtcaagaa gaaaagacgt
      901 ttggattttc tggacatcct cttacttgcc agaatggaga atggggacag cttgtctgac
      961 aaggacctac gtgctgaggt ggacacattt atgttcgagg gtcatgacac cacagccagt
     1021 ggagtctcct ggatcttcta tgctctggcc acacaccctg agcaccaaca aagatgcaga
     1081 gaggaagttc agagtgtcct gggggatggg tcctccatta cctgggatca cctggaccag
     1141 attccctaca ccaccatgtg tatcaaggag gccctgaggc tttacccacc tgttccaggc
     1201 attgtcagag aactcagcac atctgtcacc ttccctgatg ggcgctcttt acccaagggt
     1261 atccaagtca cactctccat ttatggtctc caccacaacc cgaaggtgtg gccaaaccca
     1321 gaggtgtttg acccttccag gtttgcacca gactctcccc gacacagcca ctcattcctg
     1381 cccttctcag gaggagcgag gaactgcatt gggaaacaat ttgctatgag tgagatgaag
     1441 gtgattgtgg ccctgaccct gctccgcttt gagctactgc cagatcccac caaggtcccc
     1501 atccccttac cacgacttgt gctgaagtcc aaaaatggga tctacctgta tctcaagaag
     1561 ctccactaat tccgttgtgg agctccgaaa tctgaaatga gtttcactgg cagaaagctg
     1621 agttggtggt gtgactagcc ttcttcagaa gagtgcttca gagagtcctc tcctcctctc
     1681 ttcagtacag atcacccttc tcagcactgg aatattcctc tgctttaaag ccagcaccct
     1741 tcccataccc cctcttctaa aagccttccc ttttacaaat gttcttatga catcatcaag
     1801 accactgaaa aactccaaga taatttccca tctcaatatt ccttactcca tctaacctac
     1861 taagtccctt ttgaattatg aggaataatt caatttgttc catgggctcc aaaactcaag
     1921 gcctgagcat tattgtgaaa cctttattca gcctaatatc atcttcacaa gactgttacc
     1981 tggtacgttc atctaaatct cccctgcata gtctctctac ctgactattc ctcacacaag
     2041 tttctttacc ttccctcctt tctccaataa agtgtccagt gtcctgcac
//
