LOCUS       NM_147206               1976 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 3, subfamily a,
            polypeptide 9 (Cyp3a9), mRNA.
ACCESSION   NM_147206
VERSION     NM_147206.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Li,X., Jin,X., Zhou,X., Wang,X., Shi,D., Xiao,Y. and Bi,D.
  TITLE     Pregnane X receptor is required for IFN-alpha-mediated CYP3A29
            expression in pigs
  JOURNAL   Biochem Biophys Res Commun 445 (2), 469-474 (2014)
   PUBMED   24525126
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Bedewy,A.M. and El-Maghraby,S.M.
  TITLE     Do SLCO1B3 (T334G) and CYP3A5*3 polymorphisms affect response in
            Egyptian chronic myeloid leukemia patients receiving imatinib
            therapy?
  JOURNAL   Hematology 18 (4), 211-216 (2013)
   PUBMED   23394475
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   Xie,H., Liu,J. and Ling,T.Y.
  TITLE     [Expression of cytochrome P450 related genes in oral submucous
            fibrosis tissue]
  JOURNAL   Zhonghua Kou Qiang Yi Xue Za Zhi 47 (12), 743-747 (2012)
   PUBMED   23328101
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Silveira,V.S., Canalle,R., Scrideli,C.A., Queiroz,R.G., Lopes,L.F.
            and Tone,L.G.
  TITLE     CYP3A5 and NAT2 gene polymorphisms: role in childhood acute
            lymphoblastic leukemia risk and treatment outcome
  JOURNAL   Mol Cell Biochem 364 (1-2), 217-223 (2012)
   PUBMED   22215203
REFERENCE   5  (bases 1 to 1976)
  AUTHORS   Green,H., Khan,M.S., Jakobsen-Falk,I., Avall-Lundqvist,E. and
            Peterson,C.
  TITLE     Impact of CYP3A5*3 and CYP2C8-HapC on
            paclitaxel/carboplatin-induced myelosuppression in patients with
            ovarian cancer
  JOURNAL   J Pharm Sci 100 (10), 4205-4209 (2011)
   PUBMED   21702053
REFERENCE   6  (bases 1 to 1976)
  AUTHORS   Rowlands,J.C., Wang,H., Hakkak,R., Ronis,M.J., Strobel,H.W. and
            Badger,T.M.
  TITLE     Chronic intragastric infusion of ethanol-containing diets induces
            CYP3A9 while decreasing CYP3A2 in male rats
  JOURNAL   J Pharmacol Exp Ther 295 (2), 747-752 (2000)
   PUBMED   11046114
REFERENCE   7  (bases 1 to 1976)
  AUTHORS   Jager,W., Correia,M.A., Bornheim,L.M., Mahnke,A., Hanstein,W.G.,
            Xue,L. and Benet,L.Z.
  TITLE     Ethynylestradiol-mediated induction of hepatic CYP3A9 in female
            rats: implication for cyclosporine metabolism
  JOURNAL   Drug Metab Dispos 27 (12), 1505-1511 (1999)
   PUBMED   10570034
REFERENCE   8  (bases 1 to 1976)
  AUTHORS   Wang,H. and Strobel,H.W.
  TITLE     Regulation of CYP3A9 gene expression by estrogen and catalytic
            studies using cytochrome P450 3A9 expressed in Escherichia coli
  JOURNAL   Arch Biochem Biophys 344 (2), 365-372 (1997)
   PUBMED   9264551
REFERENCE   9  (bases 1 to 1976)
  AUTHORS   Mahnke,A., Strotkamp,D., Roos,P.H., Hanstein,W.G., Chabot,G.G. and
            Nef,P.
  TITLE     Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and
            other members of the CYP3A subfamily in rat liver
  JOURNAL   Arch Biochem Biophys 337 (1), 62-68 (1997)
   PUBMED   8990268
REFERENCE   10 (bases 1 to 1976)
  AUTHORS   Wang,H., Kawashima,H. and Strobel,H.W.
  TITLE     cDNA cloning of a novel CYP3A from rat brain
  JOURNAL   Biochem Biophys Res Commun 221 (1), 157-162 (1996)
   PUBMED   8660328
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086985.1.
            
            On Apr 4, 2007 this sequence version replaced NM_147206.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086985.1, U60085.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..1976
                     /gene="Cyp3a9"
                     /gene_synonym="Cyp3a13; P450olf3"
                     /note="cytochrome P450, family 3, subfamily a, polypeptide
                     9"
                     /db_xref="GeneID:171352"
                     /db_xref="RGD:708392"
     exon            1..163
                     /gene="Cyp3a9"
                     /gene_synonym="Cyp3a13; P450olf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1604
                     /gene="Cyp3a9"
                     /gene_synonym="Cyp3a13; P450olf3"
                     /EC_number="1.14.14.1"
                     /note="olfactory cytochrome P450olf3; 3AH15; CYPIIIA9;
                     P450-OLF3; olfactive; cytochrome P450-OLF3; cytochrome
                     P450 olfactive 3; cytochrome P450, family 3, subfamily a,
                     polypeptide 13"
                     /codon_start=1
                     /product="cytochrome P450 3A9"
                     /protein_id="NP_671739.2"
                     /db_xref="GeneID:171352"
                     /db_xref="RGD:708392"
                     /translation="MDLIPNFSMETWLLLVISLVLLYLYGTHSHGIFKKLGIPGPKPL
                     PFLGTILAYRKGFWEFDKYCHKKYGKLWGLYDGRQPVLAITDPDIIKTVLVKECYSTF
                     TNRRNFGPVGILKKAISISEDEEWKRIRALLSPTFTSGKLKEMFPIINQYTDMLVRNM
                     RQGSEEGKPTSMKDIFGAYSMDVITATSFGVNVDSLNNPQDPFVEKIKKLLKFDIFDP
                     LFLSVTLFPFLTPLFEALNVSMFPRDVIDFFKTSVERMKENRMKEKEKQRMDFLQLMI
                     NSQNSKVKDSHKALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDE
                     IDAALPNKAHATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEINGVFIPKGT
                     VVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNINPYMYLPFGNGPRNCIGMRFALM
                     NMKVALVRVLQNFSFQPCKETQIPLKLSKQGLLQPEKPLLLKVVSRDETVNGA"
     exon            164..257
                     /gene="Cyp3a9"
                     /gene_synonym="Cyp3a13; P450olf3"
                     /inference="alignment:Splign:2.1.0"
     exon            258..310
                     /gene="Cyp3a9"
                     /gene_synonym="Cyp3a13; P450olf3"
                     /inference="alignment:Splign:2.1.0"
     exon            311..410
                     /gene="Cyp3a9"
                     /gene_synonym="Cyp3a13; P450olf3"
                     /inference="alignment:Splign:2.1.0"
     exon            411..524
                     /gene="Cyp3a9"
                     /gene_synonym="Cyp3a13; P450olf3"
                     /inference="alignment:Splign:2.1.0"
     exon            525..613
                     /gene="Cyp3a9"
                     /gene_synonym="Cyp3a13; P450olf3"
                     /inference="alignment:Splign:2.1.0"
     exon            614..762
                     /gene="Cyp3a9"
                     /gene_synonym="Cyp3a13; P450olf3"
                     /inference="alignment:Splign:2.1.0"
     exon            763..890
                     /gene="Cyp3a9"
                     /gene_synonym="Cyp3a13; P450olf3"
                     /inference="alignment:Splign:2.1.0"
     exon            891..957
                     /gene="Cyp3a9"
                     /gene_synonym="Cyp3a13; P450olf3"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1118
                     /gene="Cyp3a9"
                     /gene_synonym="Cyp3a13; P450olf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1345
                     /gene="Cyp3a9"
                     /gene_synonym="Cyp3a13; P450olf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1508
                     /gene="Cyp3a9"
                     /gene_synonym="Cyp3a13; P450olf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1899
                     /gene="Cyp3a9"
                     /gene_synonym="Cyp3a13; P450olf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaagggag ctcagcacgt tcagccctgc aaagggcagt acacaaaatt gagagtaaag
       61 ctcgaagaga gacttgttta aagaaaacgg caatggattt gatcccaaac ttttccatgg
      121 aaacctggct gctcctggtt atcagcctgg tgctcctcta cctatatgga actcattcac
      181 atggaatttt taaaaagttg ggaattcctg ggcccaaacc tttgcctttc ttggggacga
      241 ttcttgctta caggaagggc ttctgggaat ttgacaaata ctgccataaa aaatatggga
      301 aattatgggg gttgtacgat ggtcgacagc ctgtgctagc gatcacggat ccagacataa
      361 tcaaaacagt gctggtgaag gaatgttact ctaccttcac aaaccgacgg aactttggtc
      421 cagtgggtat tttgaaaaaa gccatctcca tctctgagga tgaagaatgg aagagaattc
      481 gagccctgct gtctccaacc ttcaccagtg ggaagctcaa ggagatgttc cccatcatta
      541 accagtatac agatatgttg gtgagaaaca tgaggcaggg atcggaggaa ggcaagccca
      601 ccagcatgaa agacatcttt ggggcctaca gcatggatgt gatcacagcc acctcatttg
      661 gagtgaatgt tgattccctt aacaacccac aggacccttt tgtggaaaaa atcaagaagc
      721 tcttaaaatt tgatatcttt gatccattgt tcctctcagt gacacttttt ccattcctta
      781 ccccactatt tgaagcacta aatgtctcca tgtttccaag agatgtcatt gactttttta
      841 aaacttcagt agaacgaatg aaagagaatc gcatgaaaga gaaagaaaag caaagaatgg
      901 actttcttca gctgatgata aactcccaga attccaaagt caaagactct cataaagcat
      961 tatccgatgt ggagattgtg gcccagtcag ttatcttcat ttttgccggc tatgagacca
     1021 ctagcagtgc tctttccttt gttttgtatt tgctggccat tcaccctgat atacagaaga
     1081 aactgcagga tgaaattgat gcagctctcc ccaataaggc acatgccacc tatgataccc
     1141 tgctacaaat ggagtatcta gatatggtgg tgaatgaaac cctcagatta tatccaattg
     1201 ctggaaggct tgagagggtc tgtaagacag atgttgaaat caatggggtg ttcattccca
     1261 aagggactgt ggtgatgata ccaacctttg ctcttcacaa agacccgcat tactggccag
     1321 agcctgagga attccgccct gaaaggttca gcaagaagaa tcaggataac atcaatcctt
     1381 atatgtacct gccctttggg aatggaccca ggaactgtat tggcatgagg tttgctctca
     1441 tgaacatgaa agttgctctt gtcagagtcc tgcagaactt ctccttccaa ccttgtaagg
     1501 aaactcagat ccctttaaaa ttgagcaaac aaggacttct tcaaccagaa aagccactgc
     1561 ttctaaaagt tgtgtccaga gatgagactg tgaatggagc ttgatgtaga atggcctata
     1621 gtggtgttgt atcacatgga ccagaaacca gttcatattg tgaatgaatc cagagatgaa
     1681 gattgcagta attttgttca ctcctgggga ttttgggtgt tctttgagct ttctcagcct
     1741 ctgtgcaagt tgttttctgt ggaacatatg gatctaatga cataaatcca agataaatat
     1801 attcaactcg tggttcttgt gggatggcct atgttacctt cattgttacc accaaatact
     1861 ctgatttctg atgagaaaat aaataaacat caattactaa aaaaaaaaaa aaaaaaaaaa
     1921 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
