LOCUS       NM_001024232            1796 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus cytochrome P450, family 3, subfamily a,
            polypeptide 62 (Cyp3a62), mRNA.
ACCESSION   NM_001024232
VERSION     NM_001024232.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1796)
  AUTHORS   Alshammari N, Chandrashekar DV, Rashid M and Mehvar R.
  TITLE     Differential expression and activities of cytochrome P450 3A in the
            rat brain microsomes and mitochondria
  JOURNAL   Fundam Clin Pharmacol 37 (2), 359-368 (2023)
   PUBMED   36345268
  REMARK    GeneRIF: Differential expression and activities of cytochrome P450
            3A in the rat brain microsomes and mitochondria.
REFERENCE   2  (bases 1 to 1796)
  AUTHORS   Salmin SF, Giroux MC, Vachon P and Beaudry F.
  TITLE     In vitro metabolism of specific CYP2D and CYP3A opioid substrates
            using rat liver S9 fractions and mass spectrometry reveal a severe
            metabolic impairment with increasing age
  JOURNAL   Biomed Chromatogr 31 (2) (2017)
   PUBMED   27390106
  REMARK    GeneRIF: This study suggests that there is an impairment of CYP2D
            and CYP3A metabolism in aging rats.
REFERENCE   3  (bases 1 to 1796)
  AUTHORS   Xiong S, Li J, Zhang W, Wang X and Zhang Z.
  TITLE     Induction of CYP3A by morroniside in rats
  JOURNAL   J Pharmacol Sci 127 (4), 414-418 (2015)
   PUBMED   25953268
  REMARK    GeneRIF: mRNA and protein expression of CYP3A were significantly
            induced and the absorbance and bioavailability of midazolam in rats
            were reduced
REFERENCE   4  (bases 1 to 1796)
  AUTHORS   Mate ML, Ballent M, Larsen K, Lifschitz A, Lanusse C and Virkel G.
  TITLE     Gene expression and enzyme function of two cytochrome P450 3A
            isoenzymes in rat and cattle precision cut liver slices
  JOURNAL   Xenobiotica 45 (7), 563-570 (2015)
   PUBMED   25630049
  REMARK    GeneRIF: The aim of the current work was to study the effect of
            dexamethasone (DEX) on the gene expression and function of CYP3A23
            (in rat), CYP3A28 (in cattle) and the transcriptional factors
            involved in their regulation.
REFERENCE   5  (bases 1 to 1796)
  AUTHORS   Dogruer D, Tug E, Bes C and Soy M.
  TITLE     Lack of an effect of CYP3A4 and MDR1 gene polymorphisms on
            colchicine pharmacogenetics in the treatment of Familial
            Mediterranean fever
  JOURNAL   Genet Mol Res 12 (3), 3521-3528 (2013)
   PUBMED   23408444
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1796)
  AUTHORS   Zhu Z, Hotchkiss SA, Boobis AR and Edwards RJ.
  TITLE     Expression of P450 enzymes in rat whole skin and cultured epidermal
            keratinocytes
  JOURNAL   Biochem Biophys Res Commun 297 (1), 65-70 (2002)
   PUBMED   12220509
REFERENCE   7  (bases 1 to 1796)
  AUTHORS   Miyazawa M, Shindo M and Shimada T.
  TITLE     Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of
            1,4-cineole, a monoterpene cyclic ether, by rat and human liver
            microsomes
  JOURNAL   Xenobiotica 31 (10), 713-723 (2001)
   PUBMED   11695850
  REMARK    GeneRIF: a major enzyme involved in the 2-hydroxylation of
            1,4-cineole
REFERENCE   8  (bases 1 to 1796)
  AUTHORS   Ourlin JC, Baader M, Fraser D, Halpert JR and Meyer UA.
  TITLE     Cloning and functional expression of a first inducible avian
            cytochrome P450 of the CYP3A subfamily (CYP3A37)
  JOURNAL   Arch Biochem Biophys 373 (2), 375-384 (2000)
   PUBMED   10620362
REFERENCE   9  (bases 1 to 1796)
  AUTHORS   Remmers EF, Griffiths MM, Longman RE, Gulko PS, Kawahito Y, Chen S,
            Chang L, Shepard J, Ge L, Dracheva S, Wang JP, Joe B, Cannon GW and
            Wilder RL.
  TITLE     An integrated rat genetic map: analysis of linkage conservation
            with the mouse and human maps
  JOURNAL   Transplant Proc 31 (3), 1549-1554 (1999)
   PUBMED   10330996
REFERENCE   10 (bases 1 to 1796)
  AUTHORS   Waxman DJ, Attisano C, Guengerich FP and Lapenson DP.
  TITLE     Human liver microsomal steroid metabolism: identification of the
            major microsomal steroid hormone 6 beta-hydroxylase cytochrome
            P-450 enzyme
  JOURNAL   Arch Biochem Biophys 263 (2), 424-436 (1988)
   PUBMED   3259858
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB084894.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB084894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..1796
                     /gene="Cyp3a62"
                     /gene_synonym="CYP3; Cyp3a"
                     /note="cytochrome P450, family 3, subfamily a, polypeptide
                     62"
                     /db_xref="GeneID:170509"
                     /db_xref="RGD:1595919"
     exon            1..164
                     /gene="Cyp3a62"
                     /gene_synonym="CYP3; Cyp3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1587
                     /gene="Cyp3a62"
                     /gene_synonym="CYP3; Cyp3a"
                     /note="cytochrome P450, subfamily IIA (niphedipine
                     oxidase); cytochrome P450, subfamily IIIA (niphedipine
                     oxidase); cytochrome P450, subfamily 3A, polypeptide 62"
                     /codon_start=1
                     /product="cytochrome P450, family 3, subfamily a,
                     polypeptide 62"
                     /protein_id="NP_001019403.1"
                     /db_xref="GeneID:170509"
                     /db_xref="RGD:1595919"
                     /translation="MDLIPNISLETWMLLATILVLLYLYGTSTHGNFKKLGISGPKPL
                     PFVGNILAYRHGFWEFDRHCHKKYGDIWGFYEGRQPILAITDPDIIKTVLVKECYSTF
                     TNRRSFGPAGILKKAITLSEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNV
                     KHEAEKGNPITMKDIFGAYSMDVITGTSFGVNVDSLNNPQNPFVQKVKKLLKFNFLDP
                     FFLSVILFPFLTPVFEAFDITVFPKDVMKFFRTSVERMKENRMQEKVKQRLDFLQLMI
                     NSQSSGDKESHQGLTDVEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDE
                     IDAALPNKAPVTYDVLVEMEYLDMVLNETLRLFPVGGRLERVCKKDVEINGVFIPKGT
                     VVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINPYIYLPFGNGPRNCIGMRFALM
                     NMKIALVRVLQNFSFGLCKETQIPLKLRKKGFFQPEKPIILRAVSRD"
     exon            165..258
                     /gene="Cyp3a62"
                     /gene_synonym="CYP3; Cyp3a"
                     /inference="alignment:Splign:2.1.0"
     exon            259..311
                     /gene="Cyp3a62"
                     /gene_synonym="CYP3; Cyp3a"
                     /inference="alignment:Splign:2.1.0"
     exon            312..411
                     /gene="Cyp3a62"
                     /gene_synonym="CYP3; Cyp3a"
                     /inference="alignment:Splign:2.1.0"
     exon            412..525
                     /gene="Cyp3a62"
                     /gene_synonym="CYP3; Cyp3a"
                     /inference="alignment:Splign:2.1.0"
     exon            526..614
                     /gene="Cyp3a62"
                     /gene_synonym="CYP3; Cyp3a"
                     /inference="alignment:Splign:2.1.0"
     exon            615..763
                     /gene="Cyp3a62"
                     /gene_synonym="CYP3; Cyp3a"
                     /inference="alignment:Splign:2.1.0"
     exon            764..891
                     /gene="Cyp3a62"
                     /gene_synonym="CYP3; Cyp3a"
                     /inference="alignment:Splign:2.1.0"
     exon            892..958
                     /gene="Cyp3a62"
                     /gene_synonym="CYP3; Cyp3a"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1119
                     /gene="Cyp3a62"
                     /gene_synonym="CYP3; Cyp3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1346
                     /gene="Cyp3a62"
                     /gene_synonym="CYP3; Cyp3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1509
                     /gene="Cyp3a62"
                     /gene_synonym="CYP3; Cyp3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1796
                     /gene="Cyp3a62"
                     /gene_synonym="CYP3; Cyp3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagggaggag actcggcaag ctcagccata aaggtgcagc acacacagct aagaataaag
       61 gacaaaggag agacttgatt aaagaaagca gcaatggacc tgatcccaaa catttccttg
      121 gaaacctgga tgctcctggc taccatcctc gtgctcctgt atctgtatgg aacctccaca
      181 catggaaatt ttaagaaatt agggatttct ggacctaaac cactgccttt tgtgggaaat
      241 attcttgcat accgccatgg attttgggag tttgatagac actgccataa aaaatatggg
      301 gatatatggg ggttttatga gggacgacaa cctattttgg ctataacaga tccagatata
      361 ataaaaacag tgctggtaaa ggaatgttat tctaccttca caaaccgtcg gagctttggt
      421 ccagcgggaa ttttgaaaaa agctatcacc ttatctgagg atgaagaatg gaagagatta
      481 agaacattgc tatctcccac cttcaccagt gggaagctca aggagatgtt ccccatcatt
      541 aaccagtatg cagatttgct ggtgaaaaac gtgaaacatg aagcagaaaa aggcaatcct
      601 atcaccatga aagacatctt tggggcctat agcatggatg tgatcacagg cacatcattt
      661 ggagtaaacg tggattccct caacaaccca cagaatccct ttgtacaaaa agtgaagaaa
      721 ctcttaaaat ttaatttctt ggacccattc tttctctcag tgatactctt tccattcctt
      781 accccagttt ttgaagcatt tgacataact gtgtttccaa aagatgttat gaagtttttt
      841 aggacttctg tagaacgaat gaaagagaac cgcatgcaag agaaagtaaa gcaaagatta
      901 gattttcttc aactgatgat aaactcccaa agttctggag ataaagagtc tcaccaaggt
      961 ttaactgatg tggagattgt ggctcagtcc attttcttta tttttgccgg ctatgagacc
     1021 actagcagtg ctctttcctt tgctttgtat ttgctggcca cacaccctga tctccagaag
     1081 aaactgcagg atgaaattga tgcagctctg cccaataagg cacctgtgac ctatgatgtc
     1141 ctggtagaga tggagtactt ggacatggtg ttaaatgaaa ctctcagatt atttccagtt
     1201 ggtggaagac tcgagagggt ctgtaagaaa gatgttgaaa tcaatggggt ttttataccc
     1261 aaagggactg tggtgatggt accaaccttt gctcttcaca aagacccaaa gtgctggcca
     1321 gagcctgagg aattttgtcc tgaaaggttc agaaagaaga atcaggacag catcaatcct
     1381 tacatatacc tgccctttgg taatggaccc aggaactgta ttggcatgag gtttgctctc
     1441 atgaacatga aaattgctct tgtcagagtc ctgcagaact tctcctttgg actttgtaaa
     1501 gaaactcaga ttcctttaaa actaagaaag aaaggatttt ttcaaccaga aaaacccatc
     1561 attctaaggg ctgtatcaag agattgaacc atgagtggag cttgatatta tgcctactct
     1621 agccccatga cacatggcat cagaaaccaa attatttgtg aagaaaatgc agcgatgaag
     1681 acgggattga ttctcttcat gtatggtgga ctctgggcct tcatcaagat gctcacctcc
     1741 tctagccacc aaagttcagc aatcacatgc ttcccaaaat agaaaaaagc aagggt
//
