LOCUS       NM_013105               1716 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 3, subfamily a,
            polypeptide 23-polypeptide 1 (Cyp3a23-3a1), mRNA.
ACCESSION   NM_013105 NM_173144
VERSION     NM_013105.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1716)
  AUTHORS   Qin,X., Zhang,Y., Lu,J., Huang,S., Liu,Z. and Wang,X.
  TITLE     CYP3A deficiency alters bile acid homeostasis and leads to changes
            in hepatic susceptibility in rats
  JOURNAL   Toxicol Appl Pharmacol 429, 115703 (2021)
   PUBMED   34461081
  REMARK    GeneRIF: CYP3A deficiency alters bile acid homeostasis and leads to
            changes in hepatic susceptibility in rats.
REFERENCE   2  (bases 1 to 1716)
  AUTHORS   Yijie,Q., Xuejun,W., Yuanyao,X., Yongqiong,N., Jianxin,Y., Yabin,D.
            and Xiangyang,L.
  TITLE     Effect of X-ray irradiation on pharmacokinetics of irinotecan
            hydrochloride and expression of CES1 and CYP3A1 in rats
  JOURNAL   Fundam Clin Pharmacol 33 (5), 558-566 (2019)
   PUBMED   30811654
  REMARK    GeneRIF: Due to significant increases in the expressions of CYP3A1
            and CES1.
REFERENCE   3  (bases 1 to 1716)
  AUTHORS   Gabbia,D., Pozza,A.D., Albertoni,L., Lazzari,R., Zigiotto,G.,
            Carrara,M., Baldo,V., Baldovin,T., Floreani,A. and Martin,S.
  TITLE     Pregnane X receptor and constitutive androstane receptor modulate
            differently CYP3A-mediated metabolism in early- and late-stage
            cholestasis
  JOURNAL   World J Gastroenterol 23 (42), 7519-7530 (2017)
   PUBMED   29204052
  REMARK    GeneRIF: Early- and late-stage cholestasis affect CYP3A-mediated
            drug metabolism differently.
REFERENCE   4  (bases 1 to 1716)
  AUTHORS   Abdelhadya,D.H., El-Magd,M.A., Elbialy,Z.I. and Saleh,A.A.
  TITLE     Bromuconazole-induced hepatotoxicity is accompanied by upregulation
            of PXR/CYP3A1 and downregulation of CAR/CYP2B1 gene expression
  JOURNAL   Toxicol Mech Methods 27 (7), 544-550 (2017)
   PUBMED   28532222
  REMARK    GeneRIF: Data suggest that liver oxidative damage induced by
            industrial fungicide bromuconazole is due, in part, to
            up-regulation of PXR/CYP3A1 expression and down-regulation of
            CAR/CYP2B1 expression. (PXR = pregnane X receptor; CYP3A1 =
            cytochrome P-450 3A1; CAR = constitutive androstane receptor;
            CYP2B1 = cytochrome P-450 2B1)
REFERENCE   5  (bases 1 to 1716)
  AUTHORS   Balakina,A.S., Trusov,N.V., Aksenov,I.V., Guseva,G.V.,
            Kravchenko,L.V. and Tutelyan,V.A.
  TITLE     [The effect of rutin and hesperidin on the expression of Nrf2- and
            AhR-regulated genes and CYP3A1 gene in rats intoxicated with carbon
            tetrachloride]
  JOURNAL   Vopr Pitan 85 (5), 28-35 (2016)
   PUBMED   29381299
  REMARK    GeneRIF: The effect of rutin and hesperidin on the expression of
            Nrf2- and AhR-regulated genes and CYP3A1 gene in rats intoxicated
            with carbon tetrachloride.
REFERENCE   6  (bases 1 to 1716)
  AUTHORS   Telhada,M.B., Pereira,T.M. and Lechner,M.C.
  TITLE     Effect of dexamethasone and phenobarbital on run-on transcription
            rate and CYP3A mRNA concentration in rat liver: changes during
            development
  JOURNAL   Arch Biochem Biophys 298 (2), 715-725 (1992)
   PUBMED   1417000
REFERENCE   7  (bases 1 to 1716)
  AUTHORS   Rowland,A.S., Baird,D.D., Weinberg,C.R., Shore,D.L., Shy,C.M. and
            Wilcox,A.J.
  TITLE     Reduced fertility among women employed as dental assistants exposed
            to high levels of nitrous oxide
  JOURNAL   N Engl J Med 327 (14), 993-997 (1992)
   PUBMED   1298226
REFERENCE   8  (bases 1 to 1716)
  AUTHORS   Burger,H.J., Schuetz,J.D., Schuetz,E.G. and Guzelian,P.S.
  TITLE     Paradoxical transcriptional activation of rat liver cytochrome
            P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone
            16 alpha-carbonitrile: analysis by transient transfection into
            primary monolayer cultures of adult rat hepatocytes
  JOURNAL   Proc Natl Acad Sci U S A 89 (6), 2145-2149 (1992)
   PUBMED   1372436
REFERENCE   9  (bases 1 to 1716)
  AUTHORS   Ribeiro,V. and Lechner,M.C.
  TITLE     Cloning and characterization of a novel CYP3A1 allelic variant:
            analysis of CYP3A1 and CYP3A2 sex-hormone-dependent expression
            reveals that the CYP3A2 gene is regulated by testosterone
  JOURNAL   Arch Biochem Biophys 293 (1), 147-152 (1992)
   PUBMED   1731631
REFERENCE   10 (bases 1 to 1716)
  AUTHORS   Nagata,K., Gonzalez,F.J., Yamazoe,Y. and Kato,R.
  TITLE     Purification and characterization of four catalytically active
            testosterone 6 beta-hydroxylase P-450s from rat liver microsomes:
            comparison of a novel form with three structurally and functionally
            related forms
  JOURNAL   J Biochem 107 (5), 718-725 (1990)
   PUBMED   2398038
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088163.1.
            
            On or before Sep 28, 2007 this sequence version replaced
            NM_173144.1, NM_013105.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088163.1, FQ211106.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1716
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..1716
                     /gene="Cyp3a23-3a1"
                     /gene_synonym="AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23;
                     Cyp3a23/3a1; Cyp3a3; RL33"
                     /note="cytochrome P450, family 3, subfamily a, polypeptide
                     23-polypeptide 1"
                     /db_xref="GeneID:25642"
                     /db_xref="RGD:628626"
     exon            1..150
                     /gene="Cyp3a23-3a1"
                     /gene_synonym="AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23;
                     Cyp3a23/3a1; Cyp3a3; RL33"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1588
                     /gene="Cyp3a23-3a1"
                     /gene_synonym="AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23;
                     Cyp3a23/3a1; Cyp3a3; RL33"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450/6 beta B; CYPIIIA1; P450-PCN1;
                     cytochrome P450-PCN1; Cytochrome P450, subfamily IIIA,
                     polypeptide 3; P450 IIIA; cytochrome P450, subfamily 3A,
                     polypeptide 3; cytochrome P450 3A1-like; cytochrome P450,
                     family 3, subfamily a, polypeptide 1; cytochrome P-450PCN
                     (PNCN inducible)"
                     /codon_start=1
                     /product="cytochrome P450 3A1"
                     /protein_id="NP_037237.2"
                     /db_xref="GeneID:25642"
                     /db_xref="RGD:628626"
                     /translation="MDLLSALTLETWVLLAVVLVLLYGFGTRTHGLFKKQGIPGPKPL
                     PFFGTVLNYYMGLWKFDVECHKKYGKIWGLFDGQMPLFAITDTEMIKNVLVKECFSVF
                     TNRRDFGPVGIMGKAISVSKDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYL
                     RQEKGKPVPVKEVFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPLF
                     LSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVYRMKETRLDSVQKHRVDFLQLMMNA
                     HNDSKDKESHTALSDMEITAQSIIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEI
                     DRALPNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKKDVEINGVFMPKGSV
                     VMIPSYALHRDPQHWPEPEEFRPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMN
                     MKLALTKVLQNFSFQPCKETQIPLKLSRQGLLQPTKPIILKVVPRDEIITGS"
     exon            151..244
                     /gene="Cyp3a23-3a1"
                     /gene_synonym="AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23;
                     Cyp3a23/3a1; Cyp3a3; RL33"
                     /inference="alignment:Splign:2.1.0"
     exon            245..297
                     /gene="Cyp3a23-3a1"
                     /gene_synonym="AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23;
                     Cyp3a23/3a1; Cyp3a3; RL33"
                     /inference="alignment:Splign:2.1.0"
     exon            298..397
                     /gene="Cyp3a23-3a1"
                     /gene_synonym="AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23;
                     Cyp3a23/3a1; Cyp3a3; RL33"
                     /inference="alignment:Splign:2.1.0"
     exon            398..511
                     /gene="Cyp3a23-3a1"
                     /gene_synonym="AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23;
                     Cyp3a23/3a1; Cyp3a3; RL33"
                     /inference="alignment:Splign:2.1.0"
     exon            512..594
                     /gene="Cyp3a23-3a1"
                     /gene_synonym="AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23;
                     Cyp3a23/3a1; Cyp3a3; RL33"
                     /inference="alignment:Splign:2.1.0"
     exon            595..743
                     /gene="Cyp3a23-3a1"
                     /gene_synonym="AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23;
                     Cyp3a23/3a1; Cyp3a3; RL33"
                     /inference="alignment:Splign:2.1.0"
     exon            744..871
                     /gene="Cyp3a23-3a1"
                     /gene_synonym="AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23;
                     Cyp3a23/3a1; Cyp3a3; RL33"
                     /inference="alignment:Splign:2.1.0"
     exon            872..941
                     /gene="Cyp3a23-3a1"
                     /gene_synonym="AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23;
                     Cyp3a23/3a1; Cyp3a3; RL33"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1102
                     /gene="Cyp3a23-3a1"
                     /gene_synonym="AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23;
                     Cyp3a23/3a1; Cyp3a3; RL33"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1329
                     /gene="Cyp3a23-3a1"
                     /gene_synonym="AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23;
                     Cyp3a23/3a1; Cyp3a3; RL33"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1492
                     /gene="Cyp3a23-3a1"
                     /gene_synonym="AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23;
                     Cyp3a23/3a1; Cyp3a3; RL33"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1689
                     /gene="Cyp3a23-3a1"
                     /gene_synonym="AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23;
                     Cyp3a23/3a1; Cyp3a3; RL33"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaaggaagc cctgcagagc atcagaggcc cagctagagg gacaacacag aggagtaatt
       61 tgctgacaga cctgcaggga tggacctgct ttcagctctc acactggaaa cctgggtcct
      121 cctggcagtc gtcctggtgc tcctctacgg atttgggacc cgcacacatg gacttttcaa
      181 gaaacagggg attcctgggc ccaaacctct gccttttttt ggcactgtgc tgaattacta
      241 tatgggttta tggaaattcg atgtggagtg ccataaaaag tatggaaaaa tatgggggtt
      301 gtttgatggt caaatgcctc tgtttgccat cacggacaca gaaatgatca agaatgtgct
      361 agtgaaggaa tgcttttctg tcttcacaaa ccggcgggat tttggcccag tggggattat
      421 ggggaaagcc atctctgtat ctaaggatga ggagtggaag agatatagag ccttgctgtc
      481 acccacgttc accagtggaa gactcaagga gatgttccct gtcatcgaac agtatggaga
      541 cattttggta aaatacttga ggcaagagaa aggcaaacct gtccctgtga aagaagtgtt
      601 tggtgcctac agcatggatg tgatcaccag cacatcattt ggagtgaatg ttgattccct
      661 caacaacccg aaggatcctt ttgtggagaa agccaagaag ctcttaagaa ttgatttttt
      721 tgatccgttg ttcttgtcag tagtactctt tccattcctc acgccagtat atgagatgtt
      781 aaacatctgc atgttcccaa aagattcaat agaatttttc aaaaaatttg tgtacagaat
      841 gaaggaaacc cgcctggatt ctgtgcagaa gcatcgagtg gattttcttc agctgatgat
      901 gaatgctcat aatgattcta aagacaaaga atctcataca gccctatccg atatggagat
      961 cacagcccag tcaatcattt ttatttttgc tggatatgaa cccaccagca gcacactttc
     1021 ctttgtcctg cattccctgg ccactcaccc agatacacag aagaaactgc aggaggagat
     1081 cgacagggct ctgcccaata aggcacctcc cacctatgat actgtgatgg aaatggaata
     1141 cctggatatg gtgttgaatg aaaccctcag attgtatcca attggtaata gacttgagag
     1201 agtctgtaaa aaagatgttg aaatcaatgg tgtgtttatg cccaaagggt cagtggtcat
     1261 gattccatct tatgctcttc accgtgatcc acagcactgg ccagagcctg aggaatttcg
     1321 cccagaaagg ttcagcaagg agaacaaggg cagcattgat ccttatgtat atctgccctt
     1381 tggaaatgga cccaggaact gcattggcat gaggtttgct ctcatgaata tgaaactcgc
     1441 tctcactaaa gttctgcaaa acttctcctt ccagccttgt aaggaaacac agatacctct
     1501 gaaattaagc agacaaggac ttcttcaacc aacaaaaccc attattctaa aggttgtgcc
     1561 acgggatgaa atcataactg gatcatgatt ttccctcaag gagttctgct gaattcttca
     1621 gaaatgtggt gtctaagaac accagaccct ttaatttatg tcatgaataa aattcagatg
     1681 aaattaggga aaaaaaaaaa aaaaaaaaaa aaaaaa
//
