LOCUS       NM_153312               2049 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 3, subfamily a,
            polypeptide 2 (Cyp3a2), mRNA.
ACCESSION   NM_153312
VERSION     NM_153312.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2049)
  AUTHORS   Qin,X., Zhang,Y., Lu,J., Huang,S., Liu,Z. and Wang,X.
  TITLE     CYP3A deficiency alters bile acid homeostasis and leads to changes
            in hepatic susceptibility in rats
  JOURNAL   Toxicol Appl Pharmacol 429, 115703 (2021)
   PUBMED   34461081
  REMARK    GeneRIF: CYP3A deficiency alters bile acid homeostasis and leads to
            changes in hepatic susceptibility in rats.
REFERENCE   2  (bases 1 to 2049)
  AUTHORS   Xun,T., Lin,Z., Wang,X., Zhan,X., Feng,H., Gan,D. and Yang,X.
  TITLE     Advanced oxidation protein products downregulate CYP1A2 and CYP3A4
            expression and activity via the NF-kappaB-mediated signaling
            pathway in vitro and in vivo
  JOURNAL   Lab Invest 101 (9), 1197-1209 (2021)
   PUBMED   34031539
  REMARK    GeneRIF: Advanced oxidation protein products downregulate CYP1A2
            and CYP3A4 expression and activity via the NF-kappaB-mediated
            signaling pathway in vitro and in vivo.
REFERENCE   3  (bases 1 to 2049)
  AUTHORS   Iwaki,M., Niwa,T., Nakamura,Y., Kawase,A. and Komura,H.
  TITLE     Relative contribution of rat CYP isoforms responsible for
            stereoselective metabolism of carvedilol
  JOURNAL   J Toxicol Sci 43 (1), 59-63 (2018)
   PUBMED   29415952
  REMARK    GeneRIF: It shows the highest metabolic activities against
            enantiomers of carvedilol.
REFERENCE   4  (bases 1 to 2049)
  AUTHORS   Gabbia,D., Pozza,A.D., Albertoni,L., Lazzari,R., Zigiotto,G.,
            Carrara,M., Baldo,V., Baldovin,T., Floreani,A. and Martin,S.
  TITLE     Pregnane X receptor and constitutive androstane receptor modulate
            differently CYP3A-mediated metabolism in early- and late-stage
            cholestasis
  JOURNAL   World J Gastroenterol 23 (42), 7519-7530 (2017)
   PUBMED   29204052
REFERENCE   5  (bases 1 to 2049)
  AUTHORS   Xu,M., Tang,H., Rong,Q., Zhang,Y., Li,Y., Zhao,L., Ye,G., Shi,F.
            and Lv,C.
  TITLE     The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in
            Rats
  JOURNAL   Biomed Res Int 2017, 6525474 (2017)
   PUBMED   28555194
  REMARK    GeneRIF: acute Formaldehyde (FA) poisoning suppressed the
            activities of CYP2C11, CYP2E1, and CYP3A2 and induced the activity
            of CYP1A2 in rats. And the change of CYP450 activity caused by
            acute FA poisoning may be associated with FA potential carcinogenic
            effects on the airways.
REFERENCE   6  (bases 1 to 2049)
  AUTHORS   Cooper,K.O., Reik,L.M., Jayyosi,Z., Bandiera,S., Kelley,M.,
            Ryan,D.E., Daniel,R., McCluskey,S.A., Levin,W. and Thomas,P.E.
  TITLE     Regulation of two members of the steroid-inducible cytochrome P450
            subfamily (3A) in rats
  JOURNAL   Arch Biochem Biophys 301 (2), 345-354 (1993)
   PUBMED   7681660
REFERENCE   7  (bases 1 to 2049)
  AUTHORS   Telhada,M.B., Pereira,T.M. and Lechner,M.C.
  TITLE     Effect of dexamethasone and phenobarbital on run-on transcription
            rate and CYP3A mRNA concentration in rat liver: changes during
            development
  JOURNAL   Arch Biochem Biophys 298 (2), 715-725 (1992)
   PUBMED   1417000
REFERENCE   8  (bases 1 to 2049)
  AUTHORS   Miyata,M., Nagata,K., Yamazoe,Y. and Kato,R.
  TITLE     A gene structure of testosterone 6 beta-hydroxylase (P450IIIA)
  JOURNAL   Biochem Biophys Res Commun 177 (1), 68-73 (1991)
   PUBMED   2043144
REFERENCE   9  (bases 1 to 2049)
  AUTHORS   Nagata,K., Gonzalez,F.J., Yamazoe,Y. and Kato,R.
  TITLE     Purification and characterization of four catalytically active
            testosterone 6 beta-hydroxylase P-450s from rat liver microsomes:
            comparison of a novel form with three structurally and functionally
            related forms
  JOURNAL   J Biochem 107 (5), 718-725 (1990)
   PUBMED   2398038
REFERENCE   10 (bases 1 to 2049)
  AUTHORS   Gonzalez,F.J., Song,B.J. and Hardwick,J.P.
  TITLE     Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family:
            gene conversion and differential regulation
  JOURNAL   Mol Cell Biol 6 (8), 2969-2976 (1986)
   PUBMED   3785219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 15, 2021 this sequence version replaced NM_153312.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089765.1, X79320.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               JAXUCZ010000012.1  14343695-14343857   c
            164-257             JAXUCZ010000012.1  14343231-14343324   c
            258-310             JAXUCZ010000012.1  14339298-14339350   c
            311-410             JAXUCZ010000012.1  14337074-14337173   c
            411-524             JAXUCZ010000012.1  14333971-14334084   c
            525-613             JAXUCZ010000012.1  14333803-14333891   c
            614-762             JAXUCZ010000012.1  14333359-14333507   c
            763-890             JAXUCZ010000012.1  14330833-14330960   c
            891-960             JAXUCZ010000012.1  14329866-14329935   c
            961-1121            JAXUCZ010000012.1  14327522-14327682   c
            1122-1348           JAXUCZ010000012.1  14326496-14326722   c
            1349-1511           JAXUCZ010000012.1  14325069-14325231   c
            1512-2049           JAXUCZ010000012.1  14321771-14322308   c
FEATURES             Location/Qualifiers
     source          1..2049
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..2049
                     /gene="Cyp3a2"
                     /gene_synonym="Cyp3a11"
                     /note="cytochrome P450, family 3, subfamily a, polypeptide
                     2"
                     /db_xref="GeneID:266682"
                     /db_xref="RGD:708379"
     exon            1..163
                     /gene="Cyp3a2"
                     /gene_synonym="Cyp3a11"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1607
                     /gene="Cyp3a2"
                     /gene_synonym="Cyp3a11"
                     /EC_number="1.14.14.1"
                     /note="CYPIIIA2; P450-PCN2; P450/6-beta-A; cytochrome
                     P450-PCN2; cytochrome P450/6-beta-A; cytochrome P450,
                     family 3, subfamily a, polypeptide 11; testosterone
                     6-beta-hydroxylase"
                     /codon_start=1
                     /product="cytochrome P450 3A2"
                     /protein_id="NP_695224.3"
                     /db_xref="GeneID:266682"
                     /db_xref="RGD:708379"
                     /translation="MDLLSALTLETWVLLAVILVLLYRLGTHRHGIFKKQGIPGPKPL
                     PFLGTVLNYYKGLGRFDMECYKKYGKIWGLFDGQTPVFAIMDTEMIKNVLVKECFSVF
                     TNRRDFGPVGIMGKAVSVAKDEEWKRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYL
                     KQEAETGKPVTMKKVFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDP
                     LFLSVVLFPFLTPIYEMLNICMFPKDSIAFFQKFVHRIKETRLDSKHKHRVDFLQLML
                     NAHNNSKDEVSHKALSDVEIIAQSVIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQE
                     EIDGALPSKAPPTYDIVMEMEYLDMVLNETLRLYPIGNRLERVCKKDIELDGLFIPKG
                     SVVTIPTYALHHDPQHWPKPEEFHPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFAL
                     MNMKLALTKVLQNFSFQPCKETQIPLKLSRQAILEPEKPIVLKVLPRDAVINGA"
     exon            164..257
                     /gene="Cyp3a2"
                     /gene_synonym="Cyp3a11"
                     /inference="alignment:Splign:2.1.0"
     exon            258..310
                     /gene="Cyp3a2"
                     /gene_synonym="Cyp3a11"
                     /inference="alignment:Splign:2.1.0"
     exon            311..410
                     /gene="Cyp3a2"
                     /gene_synonym="Cyp3a11"
                     /inference="alignment:Splign:2.1.0"
     exon            411..524
                     /gene="Cyp3a2"
                     /gene_synonym="Cyp3a11"
                     /inference="alignment:Splign:2.1.0"
     exon            525..613
                     /gene="Cyp3a2"
                     /gene_synonym="Cyp3a11"
                     /inference="alignment:Splign:2.1.0"
     exon            614..762
                     /gene="Cyp3a2"
                     /gene_synonym="Cyp3a11"
                     /inference="alignment:Splign:2.1.0"
     exon            763..890
                     /gene="Cyp3a2"
                     /gene_synonym="Cyp3a11"
                     /inference="alignment:Splign:2.1.0"
     exon            891..960
                     /gene="Cyp3a2"
                     /gene_synonym="Cyp3a11"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1121
                     /gene="Cyp3a2"
                     /gene_synonym="Cyp3a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1348
                     /gene="Cyp3a2"
                     /gene_synonym="Cyp3a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1511
                     /gene="Cyp3a2"
                     /gene_synonym="Cyp3a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..2049
                     /gene="Cyp3a2"
                     /gene_synonym="Cyp3a11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgtgtgg tcaggaggga agacctgcag agtatcagag gcccagctag agggagaaca
       61 ccgaggagta atttgctgac agacaagcag ggatggacct gctttcagct ctcacactgg
      121 aaacctgggt cctcctggca gtcatcctgg tgcttctcta ccgacttgga acccatagac
      181 atggaatttt taagaaacaa ggaattcctg ggccaaaacc tctgcctttt ttaggcactg
      241 tgctgaatta ctacaagggc ttagggagat ttgacatgga gtgctataaa aagtatggaa
      301 aaatatgggg gttgtttgat ggtcaaacgc ctgtgtttgc catcatggac acagagatga
      361 ttaagaatgt actagtgaag gaatgctttt ctgtcttcac aaaccggcgg gattttggcc
      421 cagtggggat tatggggaaa gctgtctctg tagctaagga tgaggagtgg aagagatata
      481 gagccttgct gtcccccacg ttcaccagtg gaagactcaa ggagatgttc cccatcattg
      541 aacagtatgg agacattttg gtaaagtact tgaagcaaga ggcggagaca ggcaagcctg
      601 tcaccatgaa aaaagtgttt ggtgcctaca gcatggatgt gatcaccagc acatcatttg
      661 gagtgaacgt cgattccctt aacaacccaa aggatccttt tgtggagaaa accaagaaat
      721 tgttaagatt tgactttttt gatccgttgt tcttgtcagt agtactcttt ccattcctca
      781 ccccaatata tgagatgcta aatatctgca tgttcccaaa ggattcaata gcatttttcc
      841 aaaaatttgt gcacagaata aaggaaaccc gtctggattc taagcataag caccgagtgg
      901 attttctcca gctgatgctg aacgctcata ataattccaa agacgaagtg tctcataaag
      961 ccctgtctga tgttgaaatc atagcccagt cagttatctt tatttttgct ggctatgaaa
     1021 ccaccagcag cacactctcc tttgtcttgt atttcctggc cactcaccct gatattcaga
     1081 agaaactgca ggaggagatc gatggggccc tgccgagtaa ggcacctcct acctacgata
     1141 ttgtgatgga aatggaatac ctggatatgg tgttgaatga aactctcaga ttgtatccaa
     1201 ttggtaatag acttgagaga gtctgtaaaa aagatataga acttgatggt ttgtttatac
     1261 ccaaagggtc agtagtgacg attccaacat atgctcttca tcatgaccca cagcactggc
     1321 caaagcctga ggaatttcat ccagaaaggt ttagcaagga gaacaaggga agcattgatc
     1381 cttatgtata tctgcccttt ggaaatggac ccaggaactg cattggcatg aggtttgctc
     1441 tcatgaatat gaaactcgct ctcactaaag ttctgcaaaa cttctccttc cagccttgca
     1501 aggaaacaca gatacctctg aaattgagta gacaagcaat tcttgaacca gaaaaaccca
     1561 ttgttctaaa ggttctgcca cgggatgcag tcataaatgg agcctgactt tccctcaagg
     1621 aattttattg ggatcttcac aaaggcagtg tctaagaaca ttgaaccttt taatttactt
     1681 catgaatgaa ttccagataa aactgggact taattgactg ctcttgatgc atggttaaag
     1741 atttggtaca tttatggatc tttctaagtg tctatacgaa gtaccacata ataaaaagga
     1801 gttggcaagt ctgtgatgga acaggaaatt cacctttgct gattctcatg ggaccatctc
     1861 catccacatc tggtggtctc tgttaatttc ttttgagctc ttttgatagt aaccatgtct
     1921 ctgtaatttg atcaataata ctttgatgta aaggtgaact attgtggtaa ttctatttgt
     1981 agatttggta tcagatgttt ttcatttgca atattctaga ataaatgcta catggaaagt
     2041 atcctttaa
//
