LOCUS       NM_145782               2006 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus cytochrome P450, family 3, subfamily a,
            polypeptide 18 (Cyp3a18), mRNA.
ACCESSION   NM_145782
VERSION     NM_145782.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2006)
  AUTHORS   Laine,J.E., Auriola,S., Pasanen,M. and Juvonen,R.O.
  TITLE     Acetaminophen bioactivation by human cytochrome P450 enzymes and
            animal microsomes
  JOURNAL   Xenobiotica 39 (1), 11-21 (2009)
   PUBMED   19219744
REFERENCE   2  (bases 1 to 2006)
  AUTHORS   Kot,M. and Daniel,W.A.
  TITLE     The relative contribution of human cytochrome P450 isoforms to the
            four caffeine oxidation pathways: an in vitro comparative study
            with cDNA-expressed P450s including CYP2C isoforms
  JOURNAL   Biochem Pharmacol 76 (4), 543-551 (2008)
   PUBMED   18619574
REFERENCE   3  (bases 1 to 2006)
  AUTHORS   Korhonen,T., Turpeinen,M., Tolonen,A., Laine,K. and Pelkonen,O.
  TITLE     Identification of the human cytochrome P450 enzymes involved in the
            in vitro biotransformation of lynestrenol and norethindrone
  JOURNAL   J Steroid Biochem Mol Biol 110 (1-2), 56-66 (2008)
   PUBMED   18356043
REFERENCE   4  (bases 1 to 2006)
  AUTHORS   Jeon,S., Kim,K.H., Yun,C.H., Hong,B.W., Chang,Y.S., Han,H.S.,
            Yoon,Y.S., Choi,W.B., Kim,S. and Lee,A.Y.
  TITLE     An NH2-terminal truncated cytochrome P450 CYP3A4 showing catalytic
            activity is present in the cytoplasm of human liver cells
  JOURNAL   Exp Mol Med 40 (2), 254-260 (2008)
   PUBMED   18446064
REFERENCE   5  (bases 1 to 2006)
  AUTHORS   Jiang,Y., He,X. and Ortiz de Montellano,P.R.
  TITLE     Radical intermediates in the catalytic oxidation of hydrocarbons by
            bacterial and human cytochrome P450 enzymes
  JOURNAL   Biochemistry 45 (2), 533-542 (2006)
   PUBMED   16401082
REFERENCE   6  (bases 1 to 2006)
  AUTHORS   Lalovic,B., Phillips,B., Risler,L.L., Howald,W. and Shen,D.D.
  TITLE     Quantitative contribution of CYP2D6 and CYP3A to oxycodone
            metabolism in human liver and intestinal microsomes
  JOURNAL   Drug Metab Dispos 32 (4), 447-454 (2004)
   PUBMED   15039299
REFERENCE   7  (bases 1 to 2006)
  AUTHORS   Lee,A.J., Conney,A.H. and Zhu,B.T.
  TITLE     Human cytochrome P450 3A7 has a distinct high catalytic activity
            for the 16alpha-hydroxylation of estrone but not 17beta-estradiol
  JOURNAL   Cancer Res 63 (19), 6532-6536 (2003)
   PUBMED   14559847
REFERENCE   8  (bases 1 to 2006)
  AUTHORS   Nagata,K., Murayama,N., Miyata,M., Shimada,M., Urahashi,A.,
            Yamazoe,Y. and Kato,R.
  TITLE     Isolation and characterization of a new rat P450 (CYP3A18) cDNA
            encoding P450(6)beta-2 catalyzing testosterone 6 beta- and 16
            alpha-hydroxylations
  JOURNAL   Pharmacogenetics 6 (1), 103-111 (1996)
   PUBMED   8845857
REFERENCE   9  (bases 1 to 2006)
  AUTHORS   Strotkamp,D., Roos,P.H. and Hanstein,W.G.
  TITLE     A novel CYP3 gene from female rats
  JOURNAL   Biochim Biophys Acta 1260 (3), 341-344 (1995)
   PUBMED   7873612
REFERENCE   10 (bases 1 to 2006)
  AUTHORS   Waxman,D.J., Attisano,C., Guengerich,F.P. and Lapenson,D.P.
  TITLE     Human liver microsomal steroid metabolism: identification of the
            major microsomal steroid hormone 6 beta-hydroxylase cytochrome
            P-450 enzyme
  JOURNAL   Arch Biochem Biophys 263 (2), 424-436 (1988)
   PUBMED   3259858
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 15, 2021 this sequence version replaced NM_145782.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D38381.1, X79991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000012.1  13994312-13994460
            150-243             JAXUCZ010000012.1  14004509-14004602
            244-296             JAXUCZ010000012.1  14017100-14017152
            297-396             JAXUCZ010000012.1  14019690-14019789
            397-510             JAXUCZ010000012.1  14023298-14023411
            511-599             JAXUCZ010000012.1  14024826-14024914
            600-748             JAXUCZ010000012.1  14025144-14025292
            749-876             JAXUCZ010000012.1  14027207-14027334
            877-943             JAXUCZ010000012.1  14028833-14028899
            944-1104            JAXUCZ010000012.1  14031817-14031977
            1105-1331           JAXUCZ010000012.1  14034786-14035012
            1332-1494           JAXUCZ010000012.1  14040298-14040460
            1495-2006           JAXUCZ010000012.1  14043673-14044184
FEATURES             Location/Qualifiers
     source          1..2006
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..2006
                     /gene="Cyp3a18"
                     /note="cytochrome P450, family 3, subfamily a, polypeptide
                     18"
                     /db_xref="GeneID:252931"
                     /db_xref="RGD:628709"
     exon            1..149
                     /gene="Cyp3a18"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1572
                     /gene="Cyp3a18"
                     /EC_number="1.14.14.1"
                     /note="CYPIIIA18; cytochrome P450(6)beta-2; cytochrome
                     P450, 3a18"
                     /codon_start=1
                     /product="cytochrome P450 3A18"
                     /protein_id="NP_665725.2"
                     /db_xref="GeneID:252931"
                     /db_xref="RGD:628709"
                     /translation="MEIIPNLSIETWVLLATSLMLFYIYGTYSHGLFKKLGIPGPKPV
                     PLFGTIFNYGDGMWKFDDDCYKKYGKIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVF
                     TNRRCFGPMGFMKKAITMSEDEEWKRLRTILSPTFTSGKLKEMFPLMRQYGDTLLKNL
                     RREEAKGEPINMKDIFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFQIFDP
                     FLLSVVLFPFLTPIYEMLNFSIFPRQSMNFFKKFVKTMKKNRLDSNQKSRVDFLQLMM
                     NTQNSKGQESQKALSDLEMAAQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNE
                     IDRALPNKAPVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKDVEINGVFIPKGT
                     VVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALI
                     SMKLAVIGVLQNFNIQPCEKTQIPLKISRQPIFQPEGPIILKLVSRD"
     exon            150..243
                     /gene="Cyp3a18"
                     /inference="alignment:Splign:2.1.0"
     exon            244..296
                     /gene="Cyp3a18"
                     /inference="alignment:Splign:2.1.0"
     exon            297..396
                     /gene="Cyp3a18"
                     /inference="alignment:Splign:2.1.0"
     exon            397..510
                     /gene="Cyp3a18"
                     /inference="alignment:Splign:2.1.0"
     exon            511..599
                     /gene="Cyp3a18"
                     /inference="alignment:Splign:2.1.0"
     exon            600..748
                     /gene="Cyp3a18"
                     /inference="alignment:Splign:2.1.0"
     exon            749..876
                     /gene="Cyp3a18"
                     /inference="alignment:Splign:2.1.0"
     exon            877..943
                     /gene="Cyp3a18"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1104
                     /gene="Cyp3a18"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1331
                     /gene="Cyp3a18"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1494
                     /gene="Cyp3a18"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..2006
                     /gene="Cyp3a18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcatagca gaggagccct gcaagactgt cagctgggaa ggaaacttgg aggcctgaac
       61 tgctgaagga gagctaagat ggagatcatt cccaaccttt ctatagagac ctgggtgctt
      121 ctagctacta gcttgatgct cttctacata tatgggacct attctcatgg cctgtttaag
      181 aaactaggaa ttcctggacc caaacctgtg cctttatttg gcaccatttt caactacggt
      241 gatggcatgt ggaaatttga tgatgactgc tataaaaagt atggaaaaat atgggggttt
      301 tatgagggcc cacagccttt tttggctatc atggatccag agatcatcaa aatggtgctg
      361 gtgaaagaat gttactcagt cttcacaaac cgtcggtgtt ttgggccaat gggatttatg
      421 aaaaaggcca ttaccatgtc tgaggatgaa gaatggaaga gacttcgaac aatcctgtct
      481 ccaaccttca ccagtggcaa actcaaggag atgttccccc tcatgagaca gtatggagat
      541 acattgttga agaacttgag gcgagaagaa gcaaaagggg agcccatcaa catgaaagac
      601 atctttggag cttatagcat ggacgtgatc actggcacat catttggagt gaacgtcgat
      661 tccctcaaca atccacagga tcccttcgtg cagaaagcca agaagatctt aaaatttcaa
      721 atttttgatc catttcttct ctctgtagtt ctgtttccat ttcttactcc aatatatgag
      781 atgttaaatt tttcaatttt tccaagacag tcaatgaact ttttcaaaaa attcgtaaaa
      841 acaatgaaga aaaatcgcct tgattcaaac cagaagagcc gagtggattt tcttcaactg
      901 atgatgaata ctcagaactc caaaggccaa gagtcccaga aagctctttc tgatctagaa
      961 atggcagcac aagctattat tttcattttt gggggttatg atgccacaag cacctccatt
     1021 tccttcataa tgtatgaact ggccactcgc cccaatgtgc aaaagaaact ccagaatgag
     1081 attgatagag ctctgcccaa taaggcacct gtcacctatg atgctctgat ggaaatggag
     1141 tacctggaca tggtggtgaa tgaaagtcta agattgtacc caattgctac caggctagac
     1201 agagtctcaa aaaaggatgt ggaaatcaat ggagttttta ttcccaaagg gactgtagtt
     1261 acgataccaa tctatcctct tcatcggaac cctgagtact ggctagagcc tgaggaattc
     1321 aaccctgaaa ggttcagcaa ggagaacaag ggcagcattg atccttatgt atatctgccc
     1381 tttggaaatg gacccaggaa ctgcattggc atgaggtttg ctctcatcag catgaaactt
     1441 gctgtcatag gagtcctgca gaacttcaat atccagcctt gtgagaagac acagatccct
     1501 ctgaagatca gtaggcaacc aattttccaa ccagaaggac ccatcatcct aaagcttgtg
     1561 tcaagagatt aaacccagat ttggacagtg aatttccctc aggaaccatg ttataatctt
     1621 caaggagact gtttcacaga acaccagaga atttaattaa cattagaata agagcaatat
     1681 aatataggct tcatcaattt tcctcgatta ctgagtattc agaaattcac tgaacaggct
     1741 cagtggctct gcggtgtatc atctatttta tgattcaaag aaaattatta actcaatggt
     1801 agatgtggag gttcatcata tgattcttgt ggaccatcta tacagattcc agttagttcc
     1861 atcagttctg tattctaact gcagtagctg tttctctaga gttctatcaa tagaaactgt
     1921 tgtattgaca gttagtaaat gtgtagcaaa ttttctcttt gtaaaaatat atgatattaa
     1981 gaatataaat aaatatatct ttcaag
//
