LOCUS       NM_001106893            3195 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 39, subfamily a,
            polypeptide 1 (Cyp39a1), mRNA.
ACCESSION   NM_001106893 XM_001068520 XM_236983
VERSION     NM_001106893.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3195)
  AUTHORS   Li-Hawkins,J., Lund,E.G., Bronson,A.D. and Russell,D.W.
  TITLE     Expression cloning of an oxysterol 7alpha-hydroxylase selective for
            24-hydroxycholesterol
  JOURNAL   J Biol Chem 275 (22), 16543-16549 (2000)
   PUBMED   10748047
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473987.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_236983.4, XM_001068520.1.
FEATURES             Location/Qualifiers
     source          1..3195
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..3195
                     /gene="Cyp39a1"
                     /note="cytochrome P450, family 39, subfamily a,
                     polypeptide 1"
                     /db_xref="GeneID:301264"
                     /db_xref="RGD:1307471"
     exon            1..498
                     /gene="Cyp39a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..1710
                     /gene="Cyp39a1"
                     /EC_number="1.14.14.26"
                     /codon_start=1
                     /product="24-hydroxycholesterol 7-alpha-hydroxylase"
                     /protein_id="NP_001100363.1"
                     /db_xref="GeneID:301264"
                     /db_xref="RGD:1307471"
                     /translation="MGIMELFSPIAIAVLGSCVLFLFSRWKNLRGPPCIQGWIPWIGA
                     GFEFGKAPLEFIEKARIKYGPVFTVFAVGKRMTFVTEEEGINVLLKSKHVDFELAVQR
                     PLYHTAWIPKNIFFALHEKLYVLMKGKMGTFNTHHFTGQLTEEFHDQLEGLGTHGTMD
                     LNDFVRYLLYPATLNTLFMKGLFLTDKRKIKEFYQHFKTYDEGFEYGSQLPEWLLRNW
                     SKSKRWLLALFEKNIGDIKTHGSAGHSETLLQAVLGMVETETRLHSPNYGLVMLWASL
                     ANAAPIAFWTLAYILSHPDLHRTIVESISSVFGTAGKDKIQVSENDLKKLLLIKWCIL
                     ESIRLRAPGVITRKVVKPVKILNHTVPSGDLLMLSPFWLHRNPKYFPEPESFKPERWK
                     EANLDKYIFLDYFMAFGGGKFQCPGRWFALLEIQLCIILVLYKYECSLLDPLPKQAKF
                     SSFGGCPPASREMPN"
     exon            499..634
                     /gene="Cyp39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..809
                     /gene="Cyp39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..959
                     /gene="Cyp39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1050
                     /gene="Cyp39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1155
                     /gene="Cyp39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1246
                     /gene="Cyp39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1380
                     /gene="Cyp39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1476
                     /gene="Cyp39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1565
                     /gene="Cyp39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1657
                     /gene="Cyp39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..3195
                     /gene="Cyp39a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttactccg gctccaccgc cacagggcgt gttcccgccc accggtccca gcccaggcca
       61 gcccagttca actcattgct tttttttttt cccctcagaa tttgaaagca atgcgaaggt
      121 ggaaggcagc cacaatgcaa aaatcacaca aacactgggg cggggcaaag gagctacagt
      181 tacgcaagag aattggtttc caaagtttct cggctcaaag tttggaggac tgggtgcatt
      241 ttcctcagtc ggcaggggag caggaattgc ccctggagaa ggacgttttc aaacgtctgt
      301 tgattctgga agatgggcat tatggagtta ttctcaccaa tagcaatagc cgtcctagga
      361 agctgcgttc ttttcttatt ctctcggtgg aagaatttgc gtggaccccc gtgcatccag
      421 ggttggattc cctggatcgg agctggcttt gagtttggga aagcccctct tgaatttata
      481 gaaaaagcaa gaatcaagta tggaccagtg tttactgtct ttgctgtggg aaaacgaatg
      541 acctttgtta ctgaagaaga aggaatcaat gtgcttctaa agtctaagca tgtagatttt
      601 gaattagcag tacaacgccc tctctaccac acagcatgga tcccaaagaa tattttcttc
      661 gcactgcatg aaaaactgta tgtcttgatg aaagggaaga tgggaacttt caacacacat
      721 cactttactg ggcagctgac tgaagaattt catgatcaac tggaaggttt aggcactcat
      781 gggactatgg acctgaatga ctttgtacgg tatctacttt atccagccac actcaatact
      841 ctctttatga aagggctgtt tctcacagac aagaggaaga tcaaggagtt ctaccagcat
      901 tttaaaacct atgatgaggg ctttgagtat ggctcccagc tgcccgaatg gcttctgaga
      961 aactggtcaa aatccaaaag atggctcttg gcactgtttg agaaaaatat tggagacata
     1021 aaaactcatg gatctgcagg tcattccgaa acccttttgc aggccgtgct gggaatggtg
     1081 gagacagaga cacgtctaca cagtccaaat tacggactgg tcatgctttg ggcttctctg
     1141 gccaatgctg ctcctattgc gttctggaca cttgcatata tcctgtctca tcccgatctg
     1201 cacaggacaa ttgtagaaag catatcttct gtgtttggca ctgcaggtaa agacaagatt
     1261 caagtgtctg aaaatgactt gaagaagctt cttctaatta agtggtgtat tctggaatcc
     1321 atccgcttga gagcccctgg ggtcattact aggaaggtag tgaagccagt taaaattctg
     1381 aatcacacag ttccttctgg agatctgctg atgctgtctc cattctggct acacagaaat
     1441 ccaaaatatt tccctgaacc agagtctttc aaacctgaac gctggaaaga ggcaaattta
     1501 gataagtaca ttttcttgga ctacttcatg gctttcggag gcgggaagtt tcagtgtcct
     1561 ggaaggtggt ttgctctctt agagattcaa ctgtgtatta tcttagtgct ttataagtat
     1621 gagtgcagtc ttctggatcc attaccaaag caggcaaagt tctcttcatt tggtgggtgt
     1681 cccccagcca gcagggaaat gccgaattga atataaacaa agagtatgac cttcgttggg
     1741 actcaagaga ttcagaaact tccagaggag tgaggtcacc gacagagcta cagtcctccc
     1801 agcaccttga cctgaagaca tcctagtggc acatgcattt caaatctgaa gaccgtgcac
     1861 cgtggttcac tctcaggaac acagaaaccc caattcaagg tttacagaaa gggtgcagat
     1921 gatttggaaa agttgataaa agattagaat ttggctccat acataggcgt atcaaaactt
     1981 caagtaaaat tgtcacttta atcaaaatat tggtatgtta agttcactgt gaaaacaaca
     2041 tacttacaat ttccctttcg caaaataact acagtgcagg acaatgaaag attagatcat
     2101 ttctagatat tttgtagttt aaaaatgtga tacttaacta gaccttggac atgttaggct
     2161 tattgatacc aatcattgca gaatgcgtag tgctcaaaat gtgaataaaa ccgtgcttta
     2221 tgacgctggg aatgggtccc catgctgcgt tcattcctgc actctcttat gtccagggta
     2281 gtatcttcct cttggggata ctaatcagta cacattgact gaagtatcaa tttgtatttt
     2341 agttaagggg gaagcactct tttgactcaa agtatcttta cttatccttt gacagagata
     2401 atatttttta ctcctgtgta aaatgcacag tcttattata tcttatgtct ttgcgatatc
     2461 cctgggagac ctgctttttt cagaaatgaa acagaggagc agtggctctg tgggagagag
     2521 aaggtgggga ggggagtgga gggaggggga actggggtcg gaatgtattg tatgagagat
     2581 gagtaaataa atggatgaat aaaataaata cacatctggt tttgtgccaa gtaaataact
     2641 acacatgagt ctgtttttcg agtcttagga cagtgggata tttgccatta agttctggag
     2701 agaaaaccca gtaggtccac gggaacatat ggttttccta acaatggtgt catcctttac
     2761 ccgccagaat ccaaaactaa gttcatttct gatgttgcat agctgtatag ctcttcttag
     2821 gcttcttccc ttacctgtcc cagccccagc tccggaagtt ggaaattgtt gactcttctt
     2881 tccttcacca acaaggacgc aggtctccag aagactggtg ggtgctttca aagagctttc
     2941 actctttgca gggagtgatt gcatttgaag ctcacctagc tgcccatagc ttccctcagc
     3001 aggctcagcg gtcgggagaa ggcagtgccg ggagtccaca gcagctcagc tttgcagccc
     3061 agcctggaag gttctgctgc agtaacagtt gtgttctgag ggaaggtgta ttcactatcc
     3121 aacagccaag gcccacaata aagtgctgta tttgcatata tttgcatata tttgcataca
     3181 gctgaactaa atttc
//
