LOCUS       NM_001393813            3947 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily u,
            polypeptide 1 (Cyp2u1), transcript variant 1, mRNA.
ACCESSION   NM_001393813 XM_006233310
VERSION     NM_001393813.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3947)
  AUTHORS   Siller,M., Goyal,S., Yoshimoto,F.K., Xiao,Y., Wei,S. and
            Guengerich,F.P.
  TITLE     Oxidation of endogenous N-arachidonoylserotonin by human cytochrome
            P450 2U1
  JOURNAL   J Biol Chem 289 (15), 10476-10487 (2014)
   PUBMED   24563460
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000079.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001393813.2.
            
            On Mar 16, 2021 this sequence version replaced XM_006233310.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               JACYVU010000079.1  6965889-6966412     c
            525-1160            JACYVU010000079.1  6960800-6961435     c
            1161-1322           JACYVU010000079.1  6955410-6955571     c
            1323-1490           JACYVU010000079.1  6953559-6953726     c
            1491-3947           JACYVU010000079.1  6948935-6951391     c
FEATURES             Location/Qualifiers
     source          1..3947
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..3947
                     /gene="Cyp2u1"
                     /note="cytochrome P450, family 2, subfamily u, polypeptide
                     1"
                     /db_xref="GeneID:310848"
                     /db_xref="RGD:1309433"
     exon            1..524
                     /gene="Cyp2u1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1669
                     /gene="Cyp2u1"
                     /EC_number="1.14.14.80"
                     /note="long-chain fatty acid omega-monooxygenase"
                     /codon_start=1
                     /product="cytochrome P450 2U1"
                     /protein_id="NP_001380742.1"
                     /db_xref="GeneID:310848"
                     /db_xref="RGD:1309433"
                     /translation="MSSIGGLRPAAGEQPGVGPHLQAVGGALLLCGLAVLLDWVWLQR
                     QRAGGIPPGPKPRPLVGNFGYLLLPRFLRLHFWLGSGSQTDTVGRHVYLARLARVYGN
                     IFSFFIGHRLVVVLSDFQSVREALVQQAEVFSDRPRMPLISILTKEKGIVFAHYGPIW
                     KQQRRFSHSTLRHFGLGKLSLEPRIIEEFAYVKAEMQKHGEAPFSPFPVISNAVSNII
                     CSLCFGQRFDYTNKEFKKVLDFMSRGLEICLHSQLFLINLCPWFYYLPFGPFKELRQI
                     ERDITCFLKNIIKEHQESLDANNPQDFIDMYLLHTQEEKDKCKGTNFDEDYLFYIIGD
                     LFIAGTDTTTNSLLWCLLYMSLNPGVQKKVHEEIERVIGRDRAPSLTDKAQMPYTEAT
                     IMEVQRLSMVVPLAIPHMTSEKTVLQGYSIPKGTVVLPNLWSIHRDPVIWEKPDDFCP
                     HRFLDDQGQLLKRETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFTFALPEGSEKP
                     IMTGRFGLTLAPHPFNVTVSKR"
     exon            525..1160
                     /gene="Cyp2u1"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1322
                     /gene="Cyp2u1"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1490
                     /gene="Cyp2u1"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..3947
                     /gene="Cyp2u1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctgcaac ccgcaactgt cgccggtgct gccggcgcat ctgcggcgga gctagagtct
       61 ggcggccaca tagagcatgt cctcgatcgg gggcctgcgt cccgcggccg gggagcagcc
      121 gggagttggg ccgcacctac aggcggtggg aggcgcgctg ctgctttgcg ggctggcggt
      181 cctgctggac tgggtttggc tgcagcggca gcgcgccggc ggcatccctc cggggcccaa
      241 gcctcggcca ctcgtgggta acttcgggta cttgctgctg ccgcgcttcc tacggctgca
      301 cttctggctg ggctcgggca gccagaccga cacagtaggc cggcatgtgt acctggccag
      361 gctggcccgt gtctatggca acatcttcag cttcttcatc ggccaccgtc tggtggtggt
      421 cctcagcgac ttccagagcg tgcgcgaggc gcttgtgcag caggccgaag tgttcagtga
      481 ccgcccgcgg atgccgctca tctccatctt gaccaaggag aagggaatcg tgttcgcaca
      541 ctatggtccg atctggaagc agcagagaag attctcccac tcaacccttc gtcacttcgg
      601 cctgggcaag cttagcctgg agcccaggat catcgaggag ttcgcgtacg tgaaagcaga
      661 gatgcagaag cacggggagg cccccttcag ccccttccca gtcatcagca atgccgtctc
      721 caacatcatc tgctccctgt gcttcggcca gcgcttcgac tacaccaaca aggagtttaa
      781 aaaggtgctg gacttcatgt ctcgagggct agaaatctgc ttgcacagcc agctcttcct
      841 gatcaaccta tgtccctggt tttactacct tccctttggg ccgtttaagg aactgaggca
      901 aatcgaaagg gacataacct gcttccttaa aaacatcatc aaagagcacc aagagtctct
      961 ggatgccaac aacccccagg acttcataga catgtacctt ctgcacacgc aggaggagaa
     1021 ggacaagtgc aagggcacca acttcgatga ggactacctg ttctacatca tcggggacct
     1081 cttcatcgcg ggcacggaca ccacaaccaa ctctttgctc tggtgcctgc tgtacatgtc
     1141 actgaacccc ggcgtgcaaa aaaaggttca tgaagaaatt gaaagggtca ttggccgtga
     1201 ccgtgcacct tccctcacag acaaggccca gatgccatac acagaagcca ccatcatgga
     1261 ggtacagcgg ttatccatgg tggtaccact tgccattcct cacatgacct cggagaaaac
     1321 agtcctccaa gggtacagta ttcctaaagg cacagtggtc ctacccaatt tgtggtccat
     1381 acacagagac ccagtcattt gggagaagcc agacgacttc tgtcctcatc gatttctgga
     1441 tgaccaggga caacttttga aaagagaaac gtttatccct tttgggatag ggaagcgggt
     1501 gtgtatggga gagcagctgg ccaagatgga gctattcctg atgtttgtga gcctgatgca
     1561 gagtttcacc tttgctttac ctgagggctc cgagaagccc atcatgaccg gcagatttgg
     1621 tctaacattg gccccacatc cctttaatgt aaccgtctca aagagatgaa gaaaccgcga
     1681 ggagtaagga gggagccggc tccacgtacc cgtcccacac agtcttcctg ttgctcttga
     1741 acatgggcca agcagttccg cagccgggag aggctccaga cgagagaccc agagggtaag
     1801 ggtgccacac gtggaggcct cctccgcagg gtcctcgagt ggctggtggt gtccactgtc
     1861 cacggggaag cgtggacact caatttagtt gtatgggtcc tatcgggaag cagagcttct
     1921 cacctctcag ccttcgtcat cacgtggtaa aatgagttaa tgaaatttct ctcaactctg
     1981 aggagaacca aatgcttcgt gacgtctgtg ctgtgggtgg atgctgggca gttcggtagc
     2041 tctgccttca gacctcccaa ggcccctgac aacaatgaag tatcatcatg gacacttggt
     2101 cagagaggga tgcaggtcta ggttatattg aggagacatt tttctttgtg cgttttttga
     2161 tttttttttt tttttttttt tttttttttt ttttttttgt gcctagattc aatgtcagtt
     2221 tctttgggct tgtgtcttac gagtatcatt tttgtttagg gatgggtcct ttttatagag
     2281 ctaagatgga tgtccccttg ccctgtatgt tgaggaaaaa gaaaagcatc ctcttgagct
     2341 tattgtccac atgtgtctac tgtctttagc cacatgagcg gtgagccagg ctgcacagca
     2401 caggtctgcc ctgctcaggt gagtgcagag cccctaatca gggcctggat gctgggccgg
     2461 gactgtaata gaattgtgga cctggcccag aagggacttc tcattcaagt gattcagaac
     2521 ctcctctcct gccgtgccat cagccattgt gtgactgact tactctgcaa gacaagaagc
     2581 catttcgtga taagagggcc ctctagtggc tcctccaagg accactggga atgggagaat
     2641 gcacttctca taatggtgga ggactgcaca gccaacagtg tgcttctcag tgtgcctgtg
     2701 tccggcccct ccctcgggtc tccctgctct gaaggagccg tggtaatgct gagactttct
     2761 tagaagagcc tgccccggat tcgtttgtgt gcctgaaatc ctcacactga ggagctgaga
     2821 tttccaatgc caaggtccat aattagaaag tgccaccgtc actgggtctc taagctactt
     2881 ggccttgtga ctggaaagca ctttctgatc cccttcccag tattgcccca catggcctcc
     2941 gttacctgtg cccctctttg tcccagttga ttccttgggg caggctccac gctgcctcct
     3001 caccatgcct gattcttggt ggatgcccag gtaacttagg agtgagttgg ggaaagcgat
     3061 taaggggaaa agcctgccca ggctttatta cagtctgttc aagatagctt caaaacacag
     3121 cattatgtgt cctacttgac taagcaaacc agtgttcaaa aatgcactcg acttttgttt
     3181 atcatttaaa gtaatcattt taggcaaatt taagatggtg ccttggctgc caaaacaata
     3241 cagaatgaaa gcttccggca gctgcctgct gtctgcacac aggcgcttgc tgggctagcc
     3301 agacagactc ttaaatgctt actgcaggaa aatagcagct gccgaataaa aatctaatat
     3361 gaggacaagg ggaaatggac attgtataac caagtactga ttaactttga gtctgtattc
     3421 tttatgtcat ccacattggt gttttctttt tcataaatta ctttacaaca gatgttgtac
     3481 aggctaatct ttaggttccc tgagcgctgg tgtctaggcc gagatgctga agtagggtag
     3541 ctgaggtgca tgaatggtga cactgctcgc tgagcaggtg gtctgtcctg atctggcctt
     3601 cacgtttgca ggccccccta ctctctgact cgcacatgga tctctggacc tactaaccaa
     3661 agatttcaca tcatacttga agaagcctct gccttctctg agacgacatc agaatcccac
     3721 gattatccgg cagtgtaaca ccgtgcctca agctggtgaa aacccctttc cacacgctgc
     3781 cacagaggga ctgcacgtct tcccagccga ctgctatttg aagactttgc acttcctgtc
     3841 ccatctgaaa tgtgaaatta actgtggtca gttttctaat aacgaggtct ggacttcgtc
     3901 tgtactggag ctcttggtgc tcctattaaa cctcttattt tactgaa
//
