LOCUS       NM_001107495            2632 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily s,
            polypeptide 1 (Cyp2s1), mRNA.
ACCESSION   NM_001107495 XM_001077464 XM_218347
VERSION     NM_001107495.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2632)
  AUTHORS   Bui P, Imaizumi S, Beedanagari SR, Reddy ST and Hankinson O.
  TITLE     Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived
            eicosanoids
  JOURNAL   Drug Metab Dispos 39 (2), 180-190 (2011)
   PUBMED   21068195
REFERENCE   2  (bases 1 to 2632)
  AUTHORS   Deb S and Bandiera SM.
  TITLE     Characterization of a new cytochrome P450 enzyme, CYP2S1, in rats:
            its regulation by aryl hydrocarbon receptor agonists
  JOURNAL   Toxicology 267 (1-3), 91-98 (2010)
   PUBMED   19883719
  REMARK    GeneRIF: regulated by aryl hydrocarbon receptor agonists when in
            the presence of 3-methylcholanthrene or
            2,3,7,8-tetrachlorodibenzo-p-dioxin
REFERENCE   3  (bases 1 to 2632)
  AUTHORS   Smith G, Wolf CR, Deeni YY, Dawe RS, Evans AT, Comrie MM, Ferguson
            J and Ibbotson SH.
  TITLE     Cutaneous expression of cytochrome P450 CYP2S1: individuality in
            regulation by therapeutic agents for psoriasis and other skin
            diseases
  JOURNAL   Lancet 361 (9366), 1336-1343 (2003)
   PUBMED   12711469
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_218347.4, XM_001077464.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2632
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2632
                     /gene="Cyp2s1"
                     /note="cytochrome P450, family 2, subfamily s, polypeptide
                     1"
                     /db_xref="GeneID:308445"
                     /db_xref="RGD:1306078"
     exon            1..232
                     /gene="Cyp2s1"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1558
                     /gene="Cyp2s1"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450 2S1"
                     /codon_start=1
                     /product="cytochrome P450, family 2, subfamily s,
                     polypeptide 1 precursor"
                     /protein_id="NP_001100965.1"
                     /db_xref="GeneID:308445"
                     /db_xref="RGD:1306078"
                     /translation="MEAASTWALLLALLLLLLALTLPRTPARGQLPPGPTPLPLLGNL
                     LQLRPGALYSGFLRLSKKYGPVFTVHLGPWRRVVVLVGHDAIREALGGQAEEFSGRGT
                     LATLDKTFDGHGVFFANGERWKQLRKFTLLALRDLGMGKREGEELIQEEVQNLVKAFQ
                     RTEGRPFNPSMLLAQATSNVVCSLIFGIRLPYEDKEFQAVIQAASGTLLGISSPWGQA
                     YEMFSWLLQPLPGPHTQLQHHLGTLAAFTIQQVQRHQGRSHTSGPARDVVDAFLQKMA
                     QEKEDPGTEFTEKNLLMTVTYLLFAGTMTIGATIRYALLLLLKYPQVQKRVREELIQE
                     LGPSRTPSLSDRVRLPYTDAVLHEAQRLLALVPMGMPHTVTKTTSFRGYTLPKGTEVF
                     PLIGSVLHDPAVFRNPEEFHPSRFLDDDGRIRKHEAFLPYSLGKRVCLGEGLARAELW
                     LFFTSILQAFSLDTPCPPGDLSLKPAVRGLFNIPPDFQLQVWPTGDQSR"
     exon            233..398
                     /gene="Cyp2s1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..548
                     /gene="Cyp2s1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..709
                     /gene="Cyp2s1"
                     /inference="alignment:Splign:2.1.0"
     exon            710..889
                     /gene="Cyp2s1"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1031
                     /gene="Cyp2s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1219
                     /gene="Cyp2s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1361
                     /gene="Cyp2s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..2632
                     /gene="Cyp2s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctaactagtc gggccgcgag gagcttctag gaggtgcaga cccagccgac ctgcagagat
       61 ggaggcagcc agcacctggg cgctgctgct ggccctgctg ctgctgctgc tggctctgac
      121 gctgcccagg accccggccc gaggccagct acccccgggg cccacgccgc tgccgttgct
      181 ggggaacctc ctgcagctgc ggcccggggc gctgtactcg gggttcttac ggctaagtaa
      241 gaagtatggg cctgtgttca cggtacacct gggcccctgg cgccgcgtgg tggtcctggt
      301 tggacatgat gctattcgag aagccctggg aggtcaggct gaggaattca gcgggcgggg
      361 aacgttggca actctggaca agacctttga tggtcacgga gttttctttg ccaatgggga
      421 gcggtggaaa cagctgagga aattcaccct gctggctcta cgggacctgg gcatgggcaa
      481 gcgagagggc gaggagctga tccaggagga ggtgcagaat ctggtgaagg ctttccagcg
      541 gacggaagga cgtccattca acccttccat gctgctggcc caggctacct ctaatgttgt
      601 ctgttccctc atctttggca tccgtttgcc ctatgaagat aaagagtttc aggctgtgat
      661 ccaggcagca agtgggacct tgttggggat cagctctcca tggggccagg cctacgagat
      721 gttctcctgg ctactgcagc ccttgccagg cccccacaca cagctccagc accacttggg
      781 caccctggct gccttcacta tccagcaggt acagagacac cagggacgct cccacacctc
      841 aggtcctgct cgtgacgtcg tcgatgcctt cctgcaaaag atggcgcagg agaaagaaga
      901 cccaggtaca gaattcaccg agaagaactt gctgatgaca gtcacatacc tgctgtttgc
      961 tgggactatg accatcggag ccaccatccg ctatgccctt ctgctcctac tgaagtaccc
     1021 tcaagtccaa aagcgtgttc gggaggagct gatccaggag ctgggtccca gcaggactcc
     1081 aagtctcagc gatcgagttc gcctccctta cacggatgct gttttacacg aggcacagcg
     1141 gctcctggcc ctggtaccca tgggaatgcc ccacaccgtc acgaagacca cttccttcag
     1201 aggatatact ctgcccaagg gcactgaggt ctttcctctg attggctccg tactgcacga
     1261 ccctgcggtt ttccggaacc cggaagagtt ccatccaagc cgcttcctgg acgacgacgg
     1321 tcggattaga aaacacgaag ccttcctgcc ctactcctta ggtaagcgag tctgcctagg
     1381 agaaggcctg gctcgggcgg agctgtggct cttcttcact tccatcttgc aagccttctc
     1441 cctggacacc ccgtgcccgc cgggtgactt gagtctgaag ccagctgtcc gtggactttt
     1501 caacatcccc ccggacttcc agctgcaggt ctggcccact ggcgatcagt ccagatgaag
     1561 gaaggaattt ggaaggtggg agccacctgg gacgacacag tgtgtgaagc aggagtctcg
     1621 ggagctaccc cataccacac accatgcacc aaggtagctg tgaagaccag ggggccacat
     1681 ccccaggaca taaccgcacg gcaaccgacg cgtatgcttt tttggagagg gctgtctgaa
     1741 acgggatctt gctatgggac acacgcggat ctcaaaactt gtgatcctcc tgcctcagcg
     1801 ccctggttgc tgtaattaaa ggtatgcacc gccatgaaga agagctgcat aggtttccag
     1861 cctacatcaa tgtaatgtag accatccggc atcacaagca tatagctaga tacccaccat
     1921 ccaccacaca attgcgtatg cacacaacct taatctagcc tacacagacg cgcaaacaac
     1981 ccaaccgcgt tcaggactct tactctccct gtctaacgct ctcagcacca cgttgctggg
     2041 tccctgccat agaaaacagc atgccccagc tggggtcgtg tcacagccag aacgatgttc
     2101 ctgtctactc ccatggaatg acctcaccac catccaggca tctccatcta cggccactag
     2161 ccagaaatcc acacagccaa accttacacg acaacatctt ggctcttcca aacgtcttcc
     2221 cactgagaca caccgtgacg acaaactatt cccccgccgc ctccacaccc ttgcccctca
     2281 aacatgctcc ttccagcaaa tttccccaat ataactgttt cctggtctgt aactgcgctc
     2341 acagaccttg tacagacagg gaccacagac ccagaggaaa aaattcccag tcgtgtttta
     2401 cataattgca ttatcagggg cctgctctca aacacattct gatctcaggc tgcctacaag
     2461 tcctcatggg agtgctggaa atgtacccct cccctggaag gactaactgg tcaaacaggg
     2521 atggagcagg ggagtgctgt tggatgtttc cagccctcct tatcaggaca gaagccatat
     2581 ctgacctctt tgtgtcccca ttttgcaata aaagtttgtc tctggcccgg ga
//
