LOCUS       NM_001401627            1635 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily r,
            polypeptide 1 (Cyp2r1), transcript variant 1, mRNA.
ACCESSION   NM_001401627 XM_006230081
VERSION     NM_001401627.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1635)
  AUTHORS   Varshney,S., Adela,R., Kachhawa,G., Dada,R., Kulshreshtha,V.,
            Kumari,R., Agarwal,R. and Khadgawat,R.
  TITLE     Disrupted placental vitamin D metabolism and calcium signaling in
            gestational diabetes and pre-eclampsia patients
  JOURNAL   Endocrine 80 (1), 191-200 (2023)
   PUBMED   36477942
REFERENCE   2  (bases 1 to 1635)
  AUTHORS   Xie,Y., Acosta,J.N., Ye,Y., Demarais,Z.S., Conlon,C.J., Chen,M.,
            Zhao,H. and Falcone,G.J.
  TITLE     Whole-Exome Sequencing Analyses Support a Role of Vitamin D
            Metabolism in Ischemic Stroke
  JOURNAL   Stroke 54 (3), 800-809 (2023)
   PUBMED   36762557
REFERENCE   3  (bases 1 to 1635)
  AUTHORS   Xu,Z., Zhang,D., Lin,J., Li,X., Liu,Y., Gao,J., Xue,Y., Zhang,Y.,
            Ding,R., Huang,G., Zhao,T., Huang,H., Gu,C. and Li,W.
  TITLE     The influence of CYP2R1 polymorphisms and gene-obesity interaction
            with hypertension risk in a Chinese rural population
  JOURNAL   Nutr Metab Cardiovasc Dis 32 (1), 241-248 (2022)
   PUBMED   34906413
REFERENCE   4  (bases 1 to 1635)
  AUTHORS   Wang,Q., Lin,Z., Chen,H., Ma,T. and Pan,B.
  TITLE     Effect of Cytochrome P450 Family 2 Subfamily R Member 1 Variants on
            the Predisposition of Coronary Heart Disease in the Chinese Han
            Population
  JOURNAL   Front Cardiovasc Med 8, 652729 (2021)
   PUBMED   34262949
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1635)
  AUTHORS   Martin,C.B., Oshiro,B.T., Sands,L.D., Kabir,S., Thorpe,D.,
            Clark,T.C., Yao,R. and Mata-Greenwood,E.
  TITLE     Vitamin-D dysregulation in early- and late-onset preeclampsia: A
            gestational-age matched study
  JOURNAL   J Steroid Biochem Mol Biol 203, 105729 (2020)
   PUBMED   32682061
REFERENCE   6  (bases 1 to 1635)
  AUTHORS   Tissandie,E., Gueguen,Y., Lobaccaro,J.M., Aigueperse,J.,
            Gourmelon,P., Paquet,F. and Souidi,M.
  TITLE     Chronic contamination with 137Cesium affects Vitamin D3 metabolism
            in rats
  JOURNAL   Toxicology 225 (1), 75-80 (2006)
   PUBMED   16806633
REFERENCE   7  (bases 1 to 1635)
  AUTHORS   Tissandie,E., Gueguen,Y., Lobaccaro,J.M., Paquet,F., Aigueperse,J.
            and Souidi,M.
  TITLE     Effects of depleted uranium after short-term exposure on vitamin D
            metabolism in rat
  JOURNAL   Arch Toxicol 80 (8), 473-480 (2006)
   PUBMED   16502312
REFERENCE   8  (bases 1 to 1635)
  AUTHORS   Rahmaniyan,M., Patrick,K. and Bell,N.H.
  TITLE     Characterization of recombinant CYP2C11: a vitamin D 25-hydroxylase
            and 24-hydroxylase
  JOURNAL   Am J Physiol Endocrinol Metab 288 (4), E753-E760 (2005)
   PUBMED   15585593
REFERENCE   9  (bases 1 to 1635)
  AUTHORS   Shinkyo,R., Sakaki,T., Kamakura,M., Ohta,M. and Inouye,K.
  TITLE     Metabolism of vitamin D by human microsomal CYP2R1
  JOURNAL   Biochem Biophys Res Commun 324 (1), 451-457 (2004)
   PUBMED   15465040
REFERENCE   10 (bases 1 to 1635)
  AUTHORS   Cheng,J.B., Motola,D.L., Mangelsdorf,D.J. and Russell,D.W.
  TITLE     De-orphanization of cytochrome P450 2R1: a microsomal vitamin D
            25-hydroxilase
  JOURNAL   J Biol Chem 278 (39), 38084-38093 (2003)
   PUBMED   12867411
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 16, 2022 this sequence version replaced XM_006230081.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.4125.1,
                                           SRR26643292.3454.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676811 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               JAXUCZ010000001.1  178231925-178232174 c
            251-392             JAXUCZ010000001.1  178226086-178226227 c
            393-1025            JAXUCZ010000001.1  178222286-178222918 c
            1026-1355           JAXUCZ010000001.1  178221214-178221543 c
            1356-1635           JAXUCZ010000001.1  178219704-178219983 c
FEATURES             Location/Qualifiers
     source          1..1635
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q34"
     gene            1..1635
                     /gene="Cyp2r1"
                     /note="cytochrome P450, family 2, subfamily r, polypeptide
                     1"
                     /db_xref="GeneID:361631"
                     /db_xref="RGD:1311866"
     exon            1..250
                     /gene="Cyp2r1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1531
                     /gene="Cyp2r1"
                     /EC_number="1.14.14.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     vitamin D 25-hydroxylase"
                     /codon_start=1
                     /product="vitamin D 25-hydroxylase isoform 1"
                     /protein_id="NP_001388556.1"
                     /db_xref="GeneID:361631"
                     /db_xref="RGD:1311866"
                     /translation="MFQLPGVQTCAGALAGAFLLLLLVLVVRQLLRQRRPAGFPPGPP
                     RLPFIGNICSLALSADLPHVYMRKQSRVFGEIFSLDLGGISTVVLNGYDVVKECLVHQ
                     SEIFADRPCLPLFMKMTKMGGLLNSRYGRGWIDHRRLAVNSFHYFGSGQKSFESKILE
                     ETWSLIDAIETYKGRPFDLKQLITNAVSNITNLILFGERFTYEDTDFQHMIELFSENV
                     ELAASAPVFLYNAFPWIGILPFGKHQRLFRNADVVYDFLSKLIEKAAVNRKPHLPQNF
                     VDAYLDEMDKGQNDPLSTFSKENLIFSVGELIIAGTETTTNVLRWAVLFMALYPNIQG
                     QVHKEIDLIMGHDRRPSWEDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGY
                     SIPKGTTVITNLYSVHFDEKYWKDPDMFYPERFLDSSGYFTKKEALIPFSLGRRHCLG
                     EQLARMEMFLFFTSLLQQFHLHFPHELVPNLKPRLGMTLQPQAYLICAERR"
     exon            251..392
                     /gene="Cyp2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..1025
                     /gene="Cyp2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1355
                     /gene="Cyp2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1635
                     /gene="Cyp2r1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggttccca ccccagcctt ggccaatgtt tcagctgccc ggagtccaga cgtgcgctgg
       61 ggcgctcgcg ggcgctttcc ttctgctact actcgtgctg gtggtccgcc agctcctgag
      121 gcagagacgt ccagcgggct tccccccggg tcctccgcgg ctgccattca tcggcaacat
      181 ctgctccctg gccctgtcgg ccgatcttcc ccacgtctac atgaggaagc agagccgggt
      241 gtttggcgag attttcagtt tagatcttgg aggcatatca actgtggttc tcaatggcta
      301 tgatgtagta aaggaatgcc ttgttcatca aagtgaaatt tttgcagata gaccatgcct
      361 tcctttgttc atgaagatga caaaaatggg aggcttactc aattccagat atggcagagg
      421 atggattgat cacagaagat tggctgttaa cagctttcat tattttggaa gtggccaaaa
      481 atcttttgaa tctaaaatct tagaagaaac ttggtcttta attgatgcta ttgaaacata
      541 caaaggtaga ccttttgacc tcaagcaact gataacaaat gctgtttcaa acataactaa
      601 ccttatcctt tttggagaac gattcactta tgaagacact gattttcagc acatgattga
      661 gttattcagt gagaatgtcg aactagctgc cagtgctccg gtcttccttt acaatgcatt
      721 tccatggatt ggcatcttac ctttcggaaa acatcaaagg ctatttagaa atgcagatgt
      781 ggtctatgat ttcctctcca aacttattga aaaagctgca gtaaatagaa agcctcattt
      841 gcctcagaat tttgttgatg cctatttaga tgagatggat aaaggtcaaa atgatccttt
      901 atctacgttc tccaaagaga atctaatttt ctcagtgggt gaactcatca ttgctggaac
      961 tgaaactaca accaatgtgc tccgctgggc agttctgttc atggcccttt atcctaatat
     1021 tcaaggacaa gttcataaag agattgattt aattatggga cacgacagga ggccttcttg
     1081 ggaagacaaa tgcaaaatgc cttatactga agcagttttg catgaagttt taagattctg
     1141 taatatagtt ccactgggga ttttccatgc aacttctgaa gatgcagttg tacgtggcta
     1201 ttccattcct aaaggcacaa cagtcattac aaatctttat tctgttcact ttgatgaaaa
     1261 gtactggaaa gacccagaca tgttctatcc tgagcgattt ctggacagca gtggatattt
     1321 tactaaaaag gaagctttga ttcctttttc tctagggaga agacactgtc ttggagaaca
     1381 gctggctcgg atggaaatgt tcttgttttt tacatcattg cttcagcaat ttcatttgca
     1441 tttcccacac gaactagttc caaacttgaa acccaggttg ggcatgacat tacaacccca
     1501 ggcctacctc atctgtgcag aaagacgctg aaagagcaca aatatattgg gaataacctt
     1561 gttcaatcga taatggtgtt taggccaaag atacagtttt aaaaagccaa ataaacacaa
     1621 atacatcgct taaaa
//
