LOCUS       NM_023025               2223 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily j,
            polypeptide 4 (Cyp2j4), mRNA.
ACCESSION   NM_023025
VERSION     NM_023025.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2223)
  AUTHORS   Zhang,Y., Lu,J., Huang,S., Zhang,Y., Liu,J., Xu,Y., Yao,B. and
            Wang,X.
  TITLE     CYP2J deficiency leads to cardiac injury and presents dual
            regulatory effects on cardiac function in rats
  JOURNAL   Toxicol Appl Pharmacol 473, 116610 (2023)
   PUBMED   37385478
  REMARK    GeneRIF: CYP2J deficiency leads to cardiac injury and presents dual
            regulatory effects on cardiac function in rats.
REFERENCE   2  (bases 1 to 2223)
  AUTHORS   Zhao,B., Huang,J., Lou,X., Yao,K., Ye,M., Mou,Q., Wen,Z., Duan,Q.,
            Zhang,H. and Zhao,Y.
  TITLE     Endothelial CYP2J2 overexpression restores the BRB via
            METTL3-mediated ANXA1 upregulation
  JOURNAL   FASEB J 36 (11), e22619 (2022)
   PUBMED   36269280
  REMARK    GeneRIF: Endothelial CYP2J2 overexpression restores the BRB via
            METTL3-mediated ANXA1 upregulation.
REFERENCE   3  (bases 1 to 2223)
  AUTHORS   Zhao,Q., Huang,J., Wang,D., Chen,L., Sun,D. and Zhao,C.
  TITLE     Endothelium-specific CYP2J2 overexpression improves cardiac
            dysfunction by promoting angiogenesis via Jagged1/Notch1 signaling
  JOURNAL   J Mol Cell Cardiol 123, 118-127 (2018)
   PUBMED   30219518
  REMARK    GeneRIF: Our findings demonstrate that CYP2J2 improves cardiac
            function by increasing the concentration of circulating EETs, and
            boosting angiogenesis via the Jagged1/Notch1 signaling pathway in
            MI-induced heart failure.
REFERENCE   4  (bases 1 to 2223)
  AUTHORS   Olona,A., Terra,X., Ko,J.H., Grau-Bove,C., Pinent,M., Ardevol,A.,
            Diaz,A.G., Moreno-Moral,A., Edin,M., Bishop-Bailey,D., Zeldin,D.C.,
            Aitman,T.J., Petretto,E., Blay,M. and Behmoaras,J.
  TITLE     Epoxygenase inactivation exacerbates diet and aging-associated
            metabolic dysfunction resulting from impaired adipogenesis
  JOURNAL   Mol Metab 11, 18-32 (2018)
   PUBMED   29656108
REFERENCE   5  (bases 1 to 2223)
  AUTHORS   Behmoaras,J., Diaz,A.G., Venda,L., Ko,J.H., Srivastava,P.,
            Montoya,A., Faull,P., Webster,Z., Moyon,B., Pusey,C.D.,
            Abraham,D.J., Petretto,E., Cook,T.H. and Aitman,T.J.
  TITLE     Macrophage epoxygenase determines a profibrotic transcriptome
            signature
  JOURNAL   J Immunol 194 (10), 4705-4716 (2015)
   PUBMED   25840911
REFERENCE   6  (bases 1 to 2223)
  AUTHORS   Yu,Z., Huse,L.M., Adler,P., Graham,L., Ma,J., Zeldin,D.C. and
            Kroetz,D.L.
  TITLE     Increased CYP2J expression and epoxyeicosatrienoic acid formation
            in spontaneously hypertensive rat kidney
  JOURNAL   Mol Pharmacol 57 (5), 1011-1020 (2000)
   PUBMED   10779386
REFERENCE   7  (bases 1 to 2223)
  AUTHORS   Zhang,Q.Y., Ding,X., Dunbar,D., Cao,L. and Kaminsky,L.S.
  TITLE     Induction of rat small intestinal cytochrome P-450 2J4
  JOURNAL   Drug Metab Dispos 27 (10), 1123-1127 (1999)
   PUBMED   10497137
REFERENCE   8  (bases 1 to 2223)
  AUTHORS   Zhang,Q.Y., Raner,G., Ding,X., Dunbar,D., Coon,M.J. and
            Kaminsky,L.S.
  TITLE     Characterization of the cytochrome P450 CYP2J4: expression in rat
            small intestine and role in retinoic acid biotransformation from
            retinal
  JOURNAL   Arch Biochem Biophys 353 (2), 257-264 (1998)
   PUBMED   9606960
REFERENCE   9  (bases 1 to 2223)
  AUTHORS   Zhang,Q.Y., Ding,X. and Kaminsky,L.S.
  TITLE     CDNA cloning, heterologous expression, and characterization of rat
            intestinal CYP2J4
  JOURNAL   Arch Biochem Biophys 340 (2), 270-278 (1997)
   PUBMED   9143331
REFERENCE   10 (bases 1 to 2223)
  AUTHORS   Wu,S., Moomaw,C.R., Tomer,K.B., Falck,J.R. and Zeldin,D.C.
  TITLE     Molecular cloning and expression of CYP2J2, a human cytochrome P450
            arachidonic acid epoxygenase highly expressed in heart
  JOURNAL   J Biol Chem 271 (7), 3460-3468 (1996)
   PUBMED   8631948
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091149.1.
            
            On Mar 27, 2005 this sequence version replaced NM_023025.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091149.1, L81170.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2223
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..2223
                     /gene="Cyp2j4"
                     /gene_synonym="CYP2J2; CYPIIJ4"
                     /note="cytochrome P450, family 2, subfamily j, polypeptide
                     4"
                     /db_xref="GeneID:65210"
                     /db_xref="RGD:620007"
     exon            1..256
                     /gene="Cyp2j4"
                     /gene_synonym="CYP2J2; CYPIIJ4"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1552
                     /gene="Cyp2j4"
                     /gene_synonym="CYP2J2; CYPIIJ4"
                     /EC_number="1.14.14.1"
                     /codon_start=1
                     /product="cytochrome P450 2J4"
                     /protein_id="NP_075414.2"
                     /db_xref="GeneID:65210"
                     /db_xref="RGD:620007"
                     /translation="MLATAGSLVATIWAALHLRTLLVAALTFLLLADYFKTRRPKNYP
                     PGPWGLPFVGNIFQLDFGQPHLSIQPFVKKYGNIFSLNLGDITSVVITGLPLIKETFT
                     HIEQNILNRPLSVMQERITNKNGLIFSSGQTWKEQRRFALMTLRNFGLGKKSLEQRMQ
                     EEAHYLVEAIREEKGKPFNPHFSINNAVSNIICSVTFGERFEYHDSRFQEMLRLLDEV
                     MYLETTMISQLYNIFPWIMKYIPGSHQTVFRNWEKLKLFVSSMIDDHRKDWNPEEPRD
                     FIDAFLKEMSKYPEKTTSFNEENLICSTLDLFFAGTETTSTTLRWALLYMALYAEVQE
                     KVQAEIDRVIGQKRAASLADRESMPYTNAVIHEVQRMGNIIPLNVPREVAMDTTLNGF
                     HLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFLENGQFKKRESFLPFSMGKRACLGE
                     QLARSELFIFFTSLMQKFTFKPPTNEKLSLKFRNGLTLSPVTHRICAVPRE"
     exon            257..419
                     /gene="Cyp2j4"
                     /gene_synonym="CYP2J2; CYPIIJ4"
                     /inference="alignment:Splign:2.1.0"
     exon            420..569
                     /gene="Cyp2j4"
                     /gene_synonym="CYP2J2; CYPIIJ4"
                     /inference="alignment:Splign:2.1.0"
     exon            570..730
                     /gene="Cyp2j4"
                     /gene_synonym="CYP2J2; CYPIIJ4"
                     /inference="alignment:Splign:2.1.0"
     exon            731..907
                     /gene="Cyp2j4"
                     /gene_synonym="CYP2J2; CYPIIJ4"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1046
                     /gene="Cyp2j4"
                     /gene_synonym="CYP2J2; CYPIIJ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1234
                     /gene="Cyp2j4"
                     /gene_synonym="CYP2J2; CYPIIJ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1373
                     /gene="Cyp2j4"
                     /gene_synonym="CYP2J2; CYPIIJ4"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..2189
                     /gene="Cyp2j4"
                     /gene_synonym="CYP2J2; CYPIIJ4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctcggac cttcattcca caaaagaacc agctccagtc ctagccatgc tcgccaccgc
       61 gggctctctg gtagccacga tctgggcagc gctccatctc aggactctgc tggtggctgc
      121 actcaccttc ctactcctgg ctgactactt caaaacccgg cgccccaaga actatccccc
      181 ggggccttgg ggtctcccat tcgtgggcaa catattccag ttggactttg ggcagcccca
      241 cctctcaatc cagccgtttg tgaagaaata tgggaatatt tttagcctga atcttggtga
      301 cataacatcc gtggtcataa ctggactgcc cttaatcaaa gaaaccttta ctcacataga
      361 acaaaacatt ttgaatcgcc ctctcagtgt tatgcaagaa cgcatcacca ataaaaatgg
      421 attgatcttc tccagtggtc agacatggaa ggagcaaaga aggtttgccc tgatgacact
      481 caggaatttt ggcttgggaa agaagagctt agagcagcgc atgcaggagg aggcccacta
      541 cctcgtggaa gccataagag aggagaaagg aaaacctttc aaccctcact tcagtatcaa
      601 caatgcagtt tccaatatca tttgctctgt cacctttggg gagcgctttg agtaccatga
      661 cagtagattt caggagatgc tgaggttgct ggatgaggtc atgtatttgg agacaacaat
      721 gataagccag ctctataata tttttccatg gataatgaag tatattcctg gatcacatca
      781 aacagttttc agaaactggg aaaaactgaa attgtttgtc tcttctatga tcgatgatca
      841 ccggaaagac tggaaccctg aggagccaag agacttcatt gatgctttcc tcaaggaaat
      901 gtcaaagtac ccagagaaga ctacaagttt caatgaagaa aacctcatct gcagcaccct
      961 ggacctcttc tttgcgggaa cagagacaac atccactaca ctgcgctggg ctctgctcta
     1021 catggccctc tacgcagaag tgcaagaaaa agtacaggca gagattgaca gagtcattgg
     1081 ccagaagagg gcagcaagcc tggccgatcg agaatccatg ccctatacca atgccgtcat
     1141 ccatgaggtg cagaggatgg gcaacatcat ccccctgaat gttcccaggg aagtagcaat
     1201 ggataccact ttgaatggat tccacctgcc aaagggtacc atggttctaa ccaacctaac
     1261 tgcactgcac agggacccaa aagagtgggc caccccagat gtgttcaacc cagagcactt
     1321 tttggagaat ggacagttta agaagagaga atcttttctg ccattctcaa tgggaaagag
     1381 agcttgcctt ggagaacaac tggccaggtc tgaactgttc attttcttca cttctcttat
     1441 gcaaaaattt accttcaagc ccccaaccaa tgagaagctg agcctgaagt tcagaaatgg
     1501 cctcacactt tctccagtca cgcaccgcat ctgtgctgtc cctagagaat gatgctggag
     1561 aagcaaagag aaaaaggaag atgtggtgta tgccctgaag catctgggct tgctcaagtg
     1621 agaggagaag gtgttacgga atgaatgtga ttcgagcaat attgaagaaa tttgacttag
     1681 aaaattgaag caaactccta gaatgatggc ctcttgattt ggtggtgggc acatcactta
     1741 tgagctcagt ggcgtgcctt tgcatctaaa agttaggagg acaatggtga ttcttcctat
     1801 aaacaaggtg gattagtgaa tttaaaatga attaaacatc aaaattaaaa ctataattat
     1861 tattttaaaa gtaaactttc taagttcatc atgaatcgta tcttgattgg tgtatcatca
     1921 gtttgcctcc ttccaccttt catacacttg tatctggaac attgatgtgt tggcctacag
     1981 cagtgcaaga agagaataag aatcagaact gagctgtgat tgcatccaca gaaatgggct
     2041 attgagactc ccagatgaca gatctgtcac tagcttcagt agatctacat ccaaattgat
     2101 ctggaaacca gcagagcagg gatctttccc aactcagagg catgcaaaac aaatgatata
     2161 aaatcaatta cctagttttt aattttaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2221 aaa
//
