LOCUS       NM_175766               3665 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily j,
            polypeptide 3 (Cyp2j3), mRNA.
ACCESSION   NM_175766
VERSION     NM_175766.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3665)
  AUTHORS   Navarro-Mabarak,C., Loaiza-Zuluaga,M., Hernandez-Ojeda,S.L.,
            Camacho-Carranza,R. and Espinosa-Aguirre,J.J.
  TITLE     Neuroinflammation is able to downregulate cytochrome P450
            epoxygenases 2J3 and 2C11 in the rat brain
  JOURNAL   Brain Res Bull 163, 57-64 (2020)
   PUBMED   32707261
  REMARK    GeneRIF: Neuroinflammation is able to downregulate cytochrome P450
            epoxygenases 2J3 and 2C11 in the rat brain.
REFERENCE   2  (bases 1 to 3665)
  AUTHORS   Navarro-Mabarak,C., Mitre-Aguilar,I.B., Camacho-Carranza,R.,
            Arias,C., Zentella-Dehesa,A. and Espinosa-Aguirre,J.J.
  TITLE     Role of NF-kappaB in cytochrome P450 epoxygenases down-regulation
            during an inflammatory process in astrocytes
  JOURNAL   Neurochem Int 129, 104499 (2019)
   PUBMED   31271766
  REMARK    GeneRIF: Inflammation in astrocytes could down-regulate CYP2J3
            mRNA, protein and activity. Inhibition of NF-kappaB prevented the
            down-regulation of CYP2J3 mRNA and protein .NF-kappaB is able to
            bind to at least two response elements in the promoter of Cyp2j3.
REFERENCE   3  (bases 1 to 3665)
  AUTHORS   Liu,M., Zhu,Q., Wu,J., Yu,X., Hu,M., Xie,X., Yang,Z., Yang,J.,
            Feng,Y.Q. and Yue,J.
  TITLE     Glutamate affects the production of epoxyeicosanoids within the
            brain: The up-regulation of brain CYP2J through the MAPK-CREB
            signaling pathway
  JOURNAL   Toxicology 381, 31-38 (2017)
   PUBMED   28237619
  REMARK    GeneRIF: Increases in CYP2J3 mRNA levels were observed in the
            frontal cortex, hippocampus, cerebellum, and brain stem from rats
            that received the subcutaneous injection with a subneurotoxic dose
            of monosodium l-glutamate.
REFERENCE   4  (bases 1 to 3665)
  AUTHORS   Xu,X., Tu,L., Feng,W., Ma,B., Li,R., Zheng,C., Li,G. and Wang,D.W.
  TITLE     CYP2J3 gene delivery up-regulated adiponectin expression via
            reduced endoplasmic reticulum stress in adipocytes
  JOURNAL   Endocrinology 154 (5), 1743-1753 (2013)
   PUBMED   23515292
  REMARK    GeneRIF: Beneficial roles of the CYP epoxygenase 2J3 and its
            metabolites epoxyeicosatrienoic acids on adiponectin expression and
            secretion.
REFERENCE   5  (bases 1 to 3665)
  AUTHORS   Ishihara,Y., Hamaguchi,A., Sekine,M., Hirakawa,A. and Shimamoto,N.
  TITLE     Accumulation of cytochrome P450 induced by proteasome inhibition
            during cardiac ischemia
  JOURNAL   Arch Biochem Biophys 527 (1), 16-22 (2012)
   PUBMED   22885143
  REMARK    GeneRIF: The protein levels of CYP 2c6, 2e1 and 2j3 increased in
            the ischemic region of the rat hearts, while the mRNA levels of
            CYPs were unchanged.
REFERENCE   6  (bases 1 to 3665)
  AUTHORS   Xu,X., Tu,L., Wang,L., Fang,X. and Wang,D.W.
  TITLE     CYP2J3 gene delivery reduces insulin resistance via upregulation of
            eNOS in fructose-treated rats
  JOURNAL   Cardiovasc Diabetol 10, 114 (2011)
   PUBMED   22189162
  REMARK    GeneRIF: CYP2J3-derived epoxyeicosatrienoic acids may alleviate
            insulin resistance at least in part through upregulated eNOS
            expression.
            Erratum:[Cardiovasc Diabetol. 2014;13:17]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3665)
  AUTHORS   Yu,G.G., Zeng,X.J., Wang,H.X., Lu,L.Q., Zheng,S.P., Ma,L.Q.,
            Chang,J., Wang,J., Zhang,D.M., Du,F.H. and Zhang,L.K.
  TITLE     Cytochrome P450 2J3/epoxyeicosatrienoic acids mediate the
            cardioprotection induced by ischaemic post-conditioning, but not
            preconditioning, in the rat
  JOURNAL   Clin Exp Pharmacol Physiol 38 (1), 63-70 (2011)
   PUBMED   21105892
  REMARK    GeneRIF: endogenous activation of CYP2J3/EET may be an essential
            trigger leading to the protective effects of ischemic
            Post-conditioning, but not ischemic preconditioning, in the rat
            heart.
REFERENCE   8  (bases 1 to 3665)
  AUTHORS   Xu,X., Zhao,C.X., Wang,L., Tu,L., Fang,X., Zheng,C., Edin,M.L.,
            Zeldin,D.C. and Wang,D.W.
  TITLE     Increased CYP2J3 expression reduces insulin resistance in
            fructose-treated rats and db/db mice
  JOURNAL   Diabetes 59 (4), 997-1005 (2010)
   PUBMED   20068141
  REMARK    GeneRIF: Overexpression of CYP2J3 protects against diabetes and
            insulin resistance in peripheral tissues through activation of
            insulin receptor and AMP kinase pathways
REFERENCE   9  (bases 1 to 3665)
  AUTHORS   Yamasaki,T., Izumi,S., Ide,H. and Ohyama,Y.
  TITLE     Identification of a novel rat microsomal vitamin D3 25-hydroxylase
  JOURNAL   J Biol Chem 279 (22), 22848-22856 (2004)
   PUBMED   15026419
  REMARK    GeneRIF: CYP2J3 is the principal P450 responsible for vitamin D3
            25-hydroxylation in rat liver
REFERENCE   10 (bases 1 to 3665)
  AUTHORS   Wu,S., Chen,W., Murphy,E., Gabel,S., Tomer,K.B., Foley,J.,
            Steenbergen,C., Falck,J.R., Moomaw,C.R. and Zeldin,D.C.
  TITLE     Molecular cloning, expression, and functional significance of a
            cytochrome P450 highly expressed in rat heart myocytes
  JOURNAL   J Biol Chem 272 (19), 12551-12559 (1997)
   PUBMED   9139707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 15, 2021 this sequence version replaced NM_175766.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U39943.1, BC089766.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760494 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               JAXUCZ010000005.1  116360281-116360499 c
            220-382             JAXUCZ010000005.1  116356077-116356239 c
            383-532             JAXUCZ010000005.1  116354311-116354460 c
            533-693             JAXUCZ010000005.1  116353735-116353895 c
            694-870             JAXUCZ010000005.1  116348877-116349053 c
            871-1012            JAXUCZ010000005.1  116346697-116346838 c
            1013-1200           JAXUCZ010000005.1  116343186-116343373 c
            1201-1339           JAXUCZ010000005.1  116341475-116341613 c
            1340-3665           JAXUCZ010000005.1  116335755-116338080 c
FEATURES             Location/Qualifiers
     source          1..3665
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..3665
                     /gene="Cyp2j3"
                     /gene_synonym="Cyp2j9"
                     /note="cytochrome P450, family 2, subfamily j, polypeptide
                     3"
                     /db_xref="GeneID:313375"
                     /db_xref="RGD:631442"
     exon            1..219
                     /gene="Cyp2j3"
                     /gene_synonym="Cyp2j9"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1518
                     /gene="Cyp2j3"
                     /gene_synonym="Cyp2j9"
                     /EC_number="1.14.14.1"
                     /note="CYPIIJ3; cytochrome P450, family 2, subfamily j,
                     polypeptide 9; cytochrome P450 monooxygenase; cytochrome
                     P450, 2j9"
                     /codon_start=1
                     /product="cytochrome P450 2J3"
                     /protein_id="NP_786942.1"
                     /db_xref="GeneID:313375"
                     /db_xref="RGD:631442"
                     /translation="MLVTAGSLLGAIWTVLHLRILLLAAVTFLFLADFLKHRRPKNYP
                     PGPWRLPLVGCLFHLDPKQPHLSLQQFVKKYGNVLSLDFANIPSVVVTGMPLIKEIFT
                     QMEHNFLNRPVTLLRKHLFNKNGLIFSSGQTWKEQRRFALMTLRNFGLGKKSLEQRIQ
                     EEAYHLVEAIKDEGGLPFDPHFNINKAVSNIICSVTFGERFEYHDSQFQEMLRLLDEA
                     MCLESSMMCQLYNIFPRILQYLPGSHQTLFSNWRKLKLFISDIIKNHRRDWDPDEPRD
                     FIDAFLKEMAKYPDKTTTSFNEENLICSTLDLFFAGTETTSTTLRWALLCMALYPEVQ
                     EKMQAEIDRVIGQGRQPNLADRDSMPYTNAVIHEVQRIGNIIPFNVPREVAVDTYLAG
                     FNLPKGTMILTNLTALHRDPKEWATPDTFNPEHFLENGQFKKRESFLPFSMGKRACLG
                     EQLARSELFIFITSLIQKFTFKPPVNEKLSLQFRMSVTISPVSHRLCAIPRL"
     exon            220..382
                     /gene="Cyp2j3"
                     /gene_synonym="Cyp2j9"
                     /inference="alignment:Splign:2.1.0"
     exon            383..532
                     /gene="Cyp2j3"
                     /gene_synonym="Cyp2j9"
                     /inference="alignment:Splign:2.1.0"
     exon            533..693
                     /gene="Cyp2j3"
                     /gene_synonym="Cyp2j9"
                     /inference="alignment:Splign:2.1.0"
     exon            694..870
                     /gene="Cyp2j3"
                     /gene_synonym="Cyp2j9"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1012
                     /gene="Cyp2j3"
                     /gene_synonym="Cyp2j9"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1200
                     /gene="Cyp2j3"
                     /gene_synonym="Cyp2j9"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1339
                     /gene="Cyp2j3"
                     /gene_synonym="Cyp2j9"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..3665
                     /gene="Cyp2j3"
                     /gene_synonym="Cyp2j9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atatcagcca tgcttgtcac agcgggttcc ctactagggg ccatttggac cgtgctccat
       61 ctccggattt tgctgctggc tgctgtcacc tttctgttcc tggctgattt cctcaaacac
      121 cggcgcccca agaactaccc gccagggcct tggcgcctgc ccttagtggg ttgcttgttc
      181 catttggatc ctaaacagcc acacctatcc cttcagcagt ttgtgaagaa atatgggaat
      241 gttttaagcc tggattttgc taacattcct tcagtggttg taactggcat gcccttaatc
      301 aaagaaatct ttactcaaat ggagcacaat tttttgaatc gccctgtcac tcttctccga
      361 aaacatctct ttaacaaaaa tggattgatc ttctccagtg gccagacatg gaaggagcaa
      421 aggaggtttg ccctgatgac tctgaggaac tttggactag gaaagaagag cttagagcag
      481 cgaatacaag aggaagccta ccaccttgtg gaggccataa aagatgaggg aggactgcct
      541 tttgaccctc acttcaatat caacaaagca gtctctaata tcatttgctc tgtcaccttt
      601 ggggagcgct ttgagtacca tgacagtcag tttcaggaga tgctgaggct actggatgag
      661 gccatgtgtt tggagtcatc aatgatgtgc cagctctaca atatctttcc aaggatactt
      721 cagtatcttc ctggatcaca ccaaacactt ttcagcaact ggagaaaact gaagttgttt
      781 atttctgata ttattaagaa tcaccggaga gactgggatc cagatgagcc aagggacttc
      841 attgatgctt tcctcaagga aatggcaaag tacccagaca agactactac aagtttcaat
      901 gaagaaaacc tcatctgcag tactttggat cttttctttg ctggtacaga gacaacatcc
      961 actacactgc gctgggctct gctctgcatg gccctgtacc cagaagtcca agaaaaaatg
     1021 caggctgaga ttgacagagt gattggccaa ggaagacagc caaacctggc agaccgagac
     1081 tccatgccct acaccaacgc cgtcattcac gaggtgcaga gaataggcaa catcatcccc
     1141 tttaatgttc ccagggaagt ggcagttgac acctatttgg ctggatttaa cttgccaaag
     1201 ggtactatga ttctaaccaa cttaactgca ctgcacaggg accctaaaga gtgggccacc
     1261 ccggacacct tcaacccaga gcactttttg gagaatggac agtttaagaa gagagaatcc
     1321 tttctgcctt tctcaatggg aaagcgagca tgtcttggag aacaactggc caggtccgag
     1381 ctgttcattt ttatcacttc tcttatccaa aaatttacct tcaagccccc ggtcaacgag
     1441 aagcttagtc tgcaattcag aatgtccgtc accatttccc cagtcagtca ccgcctttgc
     1501 gcaattccta ggctgtgatg tcgaagagga aagtatgaag aaatggcatc tgcatggagg
     1561 acactggtgt ctgctcacat tgaggggata gaattaaaga tgactgaggg agtgtgtgca
     1621 atgagactaa ggaaattgaa tcaagttatg ggttcattaa gtagaaagcc acttgtgagc
     1681 tcaatggtac agcttcacga ctgacatctt gcagagaaaa atgattcttc cagaaaagaa
     1741 aatgattacg ggatcatgga gaatggatta agtgactatg taaatcataa aaacgatcat
     1801 aaaatttata cctttacttt gcctcctatt tttctccttt cattgatgtg catttgcttc
     1861 tggactgcag acatagttca gctatattgc taaaaggagt aaataagagt tactctgatt
     1921 ctgcggtgaa ggcagtatag atgtccacct aaaggctctc ctatttgtca gatctatagc
     1981 tgccttgcct tgctctgcct ctaagtggtc catttgaaag tcagtctggc aggatgactc
     2041 ccaacaggca ggctaagcaa gtgctataga agcagtttct atgaattact tatagcagta
     2101 ggatcttgac cttggaccca ggatatggta aggagtaacc acagaaaaac aaattctgga
     2161 agcattctga ttcaggaaag atttcctata cccatttaac ttttttttac ctagaatcct
     2221 ccactagaag tttgtccaga aacattcttt cataggactt ggctatgttg gatatgaatg
     2281 tcacttgcct ctaagattac atcattccag ttactagcct gaacatactt ggccctggca
     2341 caacattttt caatggggag tattaaatga aagaaatttt tttctgggtg tgatcagtaa
     2401 gggcaaataa caatgataaa gtaagctact gacaagaaaa tttgacctcc ttactattaa
     2461 aacaacaaag ttgcctaatg aaggacatca ccccaaaatt ttttggttcc caagaagcta
     2521 ggcctcagag atttaaatgg gttagagaca aaatcaccaa tactggtgac tttgtgattc
     2581 agtgaaaagc tgattcgagc aaaaccttga gaaacagcac cataaaccat gatagcaagc
     2641 aagcacttgt gtggggtagc ctgaggttcc attccaaggt cagggtatct acagaaaatg
     2701 ggtaatgcta actcctacac cacacgtttg atactacaca gtaaatgtgt ctctgtatgt
     2761 gtcagtgtta gagtaataaa aggggccaag aggccaggac atttaagaag tttcgaaaag
     2821 gactgactgg gaagccaaag ctggggatct gataggaagg tcagagcccc tgtactaata
     2881 ccatagcaaa ccaaacagag agtggaaagc ctgagaagca atggtagtgt gagtgggaac
     2941 aatatgaatc aaggcttgtg agtgaagttt cagaacggag tccagctgca gagaaaacag
     3001 ggcactacta caactagaca aagaagtggg ttagatggat ggatggccga ttcagacagg
     3061 caaacaagta gatggactga tagcattcaa atagaccagg aataccctgg ctgatggtct
     3121 ttgacacaca ttcttggtga ggaccatagt gactgcagag cttggtctcc acctttttat
     3181 gggatccagg tagggagttg ataggcctct tttcttggtt tggtgtgtcc aatagttttc
     3241 ttttgcctgt aagctcagac attcaaaact gtttcttgca cagggccaga tgctgctgca
     3301 ttggatagcc aggctccctg caaactgggt ccttcccttt attaacaaaa gtgctcagaa
     3361 gccccagttg tgacccctgg agcacacagc ctcttcaggt tacatagcat ggcaggaaag
     3421 caagtacagc ctctgattgc ctagacgcaa ggcagcttga atagaaactc cacagctttt
     3481 cttcacctgt cagtcatttg tagcttctag cataagctat atattaactt agagacctct
     3541 gctcaatagc aacttacaag aacaagacac ttccttattc tcataggcta ctgttgctgt
     3601 caagatctaa accttggagc ctgtctgtgt tattcacagt gttattaaaa gagacttacc
     3661 taaaa
//
