LOCUS       NM_019303               1816 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily f,
            polypeptide 4 (Cyp2f4), mRNA.
ACCESSION   NM_019303 XM_006228585
VERSION     NM_019303.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1816)
  AUTHORS   Genter,M.B., Marlowe,J., Kevin Kerzee,J., Dragin,N., Puga,A.,
            Dalton,T.P. and Nebert,D.W.
  TITLE     Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated
            CYPs
  JOURNAL   Biochem Biophys Res Commun 348 (1), 120-123 (2006)
   PUBMED   16876762
REFERENCE   2  (bases 1 to 1816)
  AUTHORS   Forkert,P.G., Baldwin,R.M., Millen,B., Lash,L.H., Putt,D.A.,
            Shultz,M.A. and Collins,K.S.
  TITLE     Pulmonary bioactivation of trichloroethylene to chloral hydrate:
            relative contributions of CYP2E1, CYP2F, and CYP2B1
  JOURNAL   Drug Metab Dispos 33 (10), 1429-1437 (2005)
   PUBMED   15987776
REFERENCE   3  (bases 1 to 1816)
  AUTHORS   Baldwin,R.M., Shultz,M.A. and Buckpitt,A.R.
  TITLE     Bioactivation of the pulmonary toxicants naphthalene and
            1-nitronaphthalene by rat CYP2F4
  JOURNAL   J Pharmacol Exp Ther 312 (2), 857-865 (2005)
   PUBMED   15509722
REFERENCE   4  (bases 1 to 1816)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   5  (bases 1 to 1816)
  AUTHORS   Chen,N., Whitehead,S.E., Caillat,A.W., Gavit,K., Isphording,D.R.,
            Kovacevic,D., McCreary,M.B. and Hoffman,S.M.
  TITLE     Identification and cross-species comparisons of CYP2F subfamily
            genes in mammals
  JOURNAL   Mutat Res 499 (2), 155-161 (2002)
   PUBMED   11827709
REFERENCE   6  (bases 1 to 1816)
  AUTHORS   Lanza,D.L., Code,E., Crespi,C.L., Gonzalez,F.J. and Yost,G.S.
  TITLE     Specific dehydrogenation of 3-methylindole and epoxidation of
            naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid
            cells
  JOURNAL   Drug Metab Dispos 27 (7), 798-803 (1999)
   PUBMED   10383923
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Jun 1, 2021 this sequence version replaced
            XM_006228585.3, NM_019303.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070939.1, SRR23984936.666191.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                JAXUCZ010000001.1  91543768-91543826
            60-250              JAXUCZ010000001.1  91545297-91545487
            251-413             JAXUCZ010000001.1  91545576-91545738
            414-563             JAXUCZ010000001.1  91547931-91548080
            564-724             JAXUCZ010000001.1  91552243-91552403
            725-901             JAXUCZ010000001.1  91552864-91553040
            902-1043            JAXUCZ010000001.1  91553398-91553539
            1044-1231           JAXUCZ010000001.1  91554321-91554508
            1232-1373           JAXUCZ010000001.1  91555960-91556101
            1374-1816           JAXUCZ010000001.1  91557111-91557553
FEATURES             Location/Qualifiers
     source          1..1816
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1816
                     /gene="Cyp2f4"
                     /gene_synonym="Cyp2f1; Cyp2f2; CYP4502F4"
                     /note="cytochrome P450, family 2, subfamily f, polypeptide
                     4"
                     /db_xref="GeneID:54246"
                     /db_xref="RGD:2476"
     exon            1..59
                     /gene="Cyp2f4"
                     /gene_synonym="Cyp2f1; Cyp2f2; CYP4502F4"
                     /inference="alignment:Splign:2.1.0"
     exon            60..250
                     /gene="Cyp2f4"
                     /gene_synonym="Cyp2f1; Cyp2f2; CYP4502F4"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1555
                     /gene="Cyp2f4"
                     /gene_synonym="Cyp2f1; Cyp2f2; CYP4502F4"
                     /note="CYPIIF2; P450-NAH-2; naphthalene hydroxylase;
                     naphthalene dehydrogenase; cytochrome P450-NAH-2;
                     Cytochrome P450, subfamily IIF, polypeptide 1; cytochrome
                     P450, family 2, subfamily f, polypeptide 2; cytochrome
                     P450, subfamily 2F, polypeptide 1"
                     /codon_start=1
                     /product="cytochrome P450 2F2"
                     /protein_id="NP_062176.1"
                     /db_xref="GeneID:54246"
                     /db_xref="RGD:2476"
                     /translation="MDGVSTAILLLLLAVISLSLTFTSWGKGQLPPGPKPLPILGNLL
                     QLRSQDLLTSLTKLSKDYGSVFTVYLGPRRVIVLSGYQTVKEALVDKGEEFSGRGSYP
                     IFFNFTKGNGIAFSDGERWKILRRFSVQILRNFGMGKRSIEERILEEGSFLLDVLRKT
                     EGKPFDPVFILSRSVSNIICSVIFGSRFDYDDERLLTIIHFINDNFQIMSSPWGEMYN
                     IFPSLLDWVPGPHRRVFRNFGGMKDLIARSVREHQDSLDPNSPRDFIDCFLTKMVQEK
                     QDPLSHFNMDTLLMTTHNLLFGGTETVGTTLRHAFLILMKYPKVQARVQEEIDCVVGR
                     SRMPTLEDRASMPYTDAVIHEVQRFADVIPMNLPHRVIRDTPFRGFLIPKGTDVITLL
                     NTVHYDSDQFKTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRLCLGEPLARMELFIYL
                     TSILQNFTLHPLVEPEDIDLTPLSSGLGNLPRPFQLCMRIR"
     exon            251..413
                     /gene="Cyp2f4"
                     /gene_synonym="Cyp2f1; Cyp2f2; CYP4502F4"
                     /inference="alignment:Splign:2.1.0"
     exon            414..563
                     /gene="Cyp2f4"
                     /gene_synonym="Cyp2f1; Cyp2f2; CYP4502F4"
                     /inference="alignment:Splign:2.1.0"
     exon            564..724
                     /gene="Cyp2f4"
                     /gene_synonym="Cyp2f1; Cyp2f2; CYP4502F4"
                     /inference="alignment:Splign:2.1.0"
     exon            725..901
                     /gene="Cyp2f4"
                     /gene_synonym="Cyp2f1; Cyp2f2; CYP4502F4"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1043
                     /gene="Cyp2f4"
                     /gene_synonym="Cyp2f1; Cyp2f2; CYP4502F4"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1231
                     /gene="Cyp2f4"
                     /gene_synonym="Cyp2f1; Cyp2f2; CYP4502F4"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1373
                     /gene="Cyp2f4"
                     /gene_synonym="Cyp2f1; Cyp2f2; CYP4502F4"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1816
                     /gene="Cyp2f4"
                     /gene_synonym="Cyp2f1; Cyp2f2; CYP4502F4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatacaccc ctcagcacac acaagagctc cagaacagta ctacagaata ctgatacagg
       61 cactgcagct gccttcacta tggatggtgt gagcacagcc atcttgcttc tcctcctggc
      121 tgtcatctct ctgtccctga ccttcacctc atggggcaag ggccagctcc ctccaggacc
      181 caagcctctc ccaatcctag gaaacctgct gcagcttcgc tcccaagact tgctgacctc
      241 actcaccaag cttagcaagg actatgggtc agtgttcacg gtgtacctgg ggcccaggcg
      301 tgtgattgtc ctcagcggat atcaaactgt gaaggaggct cttgtggaca aaggggagga
      361 gttcagtggc cgaggctcat accccatctt tttcaacttc accaagggca acggcatcgc
      421 cttctccgat ggagaacgct ggaagatcct ccgaaggttc tctgtccaaa tcctgaggaa
      481 ctttggcatg ggaaaaagaa gcatcgagga gcggatcctg gaagaaggca gcttcctgct
      541 ggacgtgctg cggaaaacgg aaggcaagcc ctttgacccc gtgtttatcc tgagccgctc
      601 ggtctccaac attatttgct ctgtcatctt cggcagtcgt ttcgattatg acgatgaacg
      661 gctgctcacc attatccact ttatcaatga caacttccag attatgagca gcccctgggg
      721 cgagatgtac aacatcttcc cgagtctcct ggactgggtg cctgggccgc acagacgcgt
      781 gttccggaac tttgggggca tgaaagatct catcgcccgc agcgtccgcg agcaccagga
      841 ctccctggac cccaactctc cccgggactt catcgactgc ttcctcacaa aaatggtaca
      901 ggagaagcaa gacccactga gccacttcaa tatggacacc ctactgatga ccacacacaa
      961 cctgctcttt ggtggaacgg agactgtggg caccacttta cgccatgcct tcctcattct
     1021 tatgaagtac cccaaagtgc aagcccgtgt gcaggaagag attgattgtg tggtgggacg
     1081 ttcgcggatg cccacgctgg aggaccgtgc atccatgcct tacacagacg cggtgatcca
     1141 cgaagtgcag cgctttgcag acgtcatccc catgaacctg ccccaccgcg tcattcggga
     1201 cacacctttc aggggcttcc tgatacccaa gggcacagat gtcatcacgc tccttaacac
     1261 cgtgcactat gactccgacc aattcaagac ccctcaggag ttcaatcctg agcattttct
     1321 ggatgccaat caatccttca agaagagccc cgccttcatg ccattttcgg cgggacgccg
     1381 actgtgtctg ggagagccac tggcacgcat ggagctgttc atatacctca cctccattct
     1441 ccagaacttc acgttgcatc cgctggtgga gcctgaggac atcgacctga ccccgctcag
     1501 ctcagggctg ggcaatttgc caaggccttt ccagttgtgt atgcgcattc gctgagtact
     1561 gcaccagggg actgctctgg ccctcttcca ggggtttcac tgttgtgggc ctccattgac
     1621 gtctctctca cgttcccttc cctaaacccg gggcctgcca cgtgtcggta ctttaccctt
     1681 cctatcttaa gcgcatcttc atggaaaaaa tgacgtgaca aaggggaaat acccatctta
     1741 tacgcacaga ccctgttctg cgatgcaccc ttttcctggc tgtttgtatc atttcctagt
     1801 aaatacctta ctagta
//
