LOCUS       NM_031543               1626 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily e,
            polypeptide 1 (Cyp2e1), mRNA.
ACCESSION   NM_031543
VERSION     NM_031543.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1626)
  AUTHORS   Tang,X., Miao,Y., Cao,L., Liu,Y., Zhu,X., Zhang,J., Wang,D., Li,X.,
            Zhang,L., Huo,J. and Chen,J.
  TITLE     Adverse outcome pathway exploration of furan-induced liver fibrosis
            in rats: Genotoxicity pathway or oxidative stress pathway through
            CYP2E1 activation?
  JOURNAL   Chemosphere 341, 139998 (2023)
   PUBMED   37657698
  REMARK    GeneRIF: Adverse outcome pathway exploration of furan-induced liver
            fibrosis in rats: Genotoxicity pathway or oxidative stress pathway
            through CYP2E1 activation?
REFERENCE   2  (bases 1 to 1626)
  AUTHORS   Ishteyaque,S., Yadav,K.S., Verma,S., Washimkar,K.R. and Mugale,M.N.
  TITLE     CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis
            and promotes progression of hepatocellular carcinoma
  JOURNAL   Arch Biochem Biophys 745, 109701 (2023)
   PUBMED   37499993
  REMARK    GeneRIF: CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit
            apoptosis and promotes progression of hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 1626)
  AUTHORS   Wang,J., Yang,H., Wang,C. and Kan,C.
  TITLE     Cyp2e1 knockdown attenuates high glucose-induced apoptosis and
            oxidative stress of cardiomyocytes by activating PI3K/Akt signaling
  JOURNAL   Acta Diabetol 60 (9), 1219-1229 (2023)
   PUBMED   37195324
  REMARK    GeneRIF: Cyp2e1 knockdown attenuates high glucose-induced apoptosis
            and oxidative stress of cardiomyocytes by activating PI3K/Akt
            signaling.
REFERENCE   4  (bases 1 to 1626)
  AUTHORS   Zhang,Y., Zhang,L., Xu,P., Qin,X., Wang,P., Cheng,Y., Yao,B. and
            Wang,X.
  TITLE     Cytochrome P450 2E1 gene knockout or inhibition prevents obesity
            induced by high-fat diet via regulating energy expenditure
  JOURNAL   Biochem Pharmacol 202, 115160 (2022)
   PUBMED   35780828
  REMARK    GeneRIF: Cytochrome P450 2E1 gene knockout or inhibition prevents
            obesity induced by high-fat diet via regulating energy expenditure.
REFERENCE   5  (bases 1 to 1626)
  AUTHORS   Shi,J.H., Yang,D.J., Jin,Q., Cheng,N., Shi,Y.B., Bai,Y., Yu,D.S.,
            Guo,W.Z., Ge,G.B. and Zhang,S.J.
  TITLE     Cytochrome P450 2E1 predicts liver functional recovery from
            donation after circulatory death using air-ventilated normothermic
            machine perfusion
  JOURNAL   Sci Rep 12 (1), 7446 (2022)
   PUBMED   35523980
  REMARK    GeneRIF: Cytochrome P450 2E1 predicts liver functional recovery
            from donation after circulatory death using air-ventilated
            normothermic machine perfusion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1626)
  AUTHORS   Richardson,T.H., Schenkman,J.B., Turcan,R., Goldfarb,P.S. and
            Gibson,G.G.
  TITLE     Molecular cloning of a cDNA for rat diabetes-inducible cytochrome
            P450RLM6: hormonal regulation and similarity to the cytochrome
            P4502E1 gene
  JOURNAL   Xenobiotica 22 (6), 621-631 (1992)
   PUBMED   1441586
REFERENCE   7  (bases 1 to 1626)
  AUTHORS   Imaoka,S., Terano,Y. and Funae,Y.
  TITLE     Changes in the amount of cytochrome P450s in rat hepatic microsomes
            with starvation
  JOURNAL   Arch Biochem Biophys 278 (1), 168-178 (1990)
   PUBMED   2321956
REFERENCE   8  (bases 1 to 1626)
  AUTHORS   Umeno,M., Song,B.J., Kozak,C., Gelboin,H.V. and Gonzalez,F.J.
  TITLE     The rat P450IIE1 gene: complete intron and exon sequence,
            chromosome mapping, and correlation of developmental expression
            with specific 5' cytosine demethylation
  JOURNAL   J Biol Chem 263 (10), 4956-4962 (1988)
   PUBMED   2832413
REFERENCE   9  (bases 1 to 1626)
  AUTHORS   Favreau,L.V., Malchoff,D.M., Mole,J.E. and Schenkman,J.B.
  TITLE     Responses to insulin by two forms of rat hepatic microsomal
            cytochrome P-450 that undergo major (RLM6) and minor (RLM5b)
            elevations in diabetes
  JOURNAL   J Biol Chem 262 (29), 14319-14326 (1987)
   PUBMED   3308889
REFERENCE   10 (bases 1 to 1626)
  AUTHORS   Song,B.J., Gelboin,H.V., Park,S.S., Yang,C.S. and Gonzalez,F.J.
  TITLE     Complementary DNA and protein sequences of ethanol-inducible rat
            and human cytochrome P-450s. Transcriptional and
            post-transcriptional regulation of the rat enzyme
  JOURNAL   J Biol Chem 261 (35), 16689-16697 (1986)
   PUBMED   3782137
  REMARK    Erratum:[J Biol Chem 1987 Jun 25;262(18):8940]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031543.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J02627.1, BC081774.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               JAXUCZ010000001.1  205269967-205270157
            192-351             JAXUCZ010000001.1  205270922-205271081
            352-501             JAXUCZ010000001.1  205274533-205274682
            502-662             JAXUCZ010000001.1  205274988-205275148
            663-839             JAXUCZ010000001.1  205275475-205275651
            840-981             JAXUCZ010000001.1  205276440-205276581
            982-1169            JAXUCZ010000001.1  205278457-205278644
            1170-1311           JAXUCZ010000001.1  205279142-205279283
            1312-1626           JAXUCZ010000001.1  205280051-205280365
FEATURES             Location/Qualifiers
     source          1..1626
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1626
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e"
                     /note="cytochrome P450, family 2, subfamily e, polypeptide
                     1"
                     /db_xref="GeneID:25086"
                     /db_xref="RGD:2475"
     exon            1..191
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1496
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e"
                     /EC_number="1.14.14.1"
                     /EC_number="1.14.13.n7"
                     /note="P450-J; CYPIIE1; P450RLM6; 4-nitrophenol
                     2-hydroxylase; cytochrome P450-J; cytochrome P450RLM6;
                     cytochrome P450 subfamily 2e1 (ethanol-inducible);
                     cytochrome P450, subfamily 2E, polypeptide 1"
                     /codon_start=1
                     /product="cytochrome P450 2E1"
                     /protein_id="NP_113731.2"
                     /db_xref="GeneID:25086"
                     /db_xref="RGD:2475"
                     /translation="MAVLGITIALLVWVATLLVISIWKQIYNSWNLPPGPFPLPILGN
                     IFQLDLKDIPKSFTKLAKRFGPVFTLHLGSRRIVVLHGYKAVKEVLLNHKNEFSGRGD
                     IPVFQEYKNKGIIFNNGPTWKDVRRFSLSILRDWGMGKQGNEARIQREAQFLVEELKK
                     TKGQPFDPTFLIGCAPCNVIADILFNKRFDYNDKKCLRLMSLFNENFYLLSTPWIQLY
                     NNFADYLRYLPGSHRKIMKNVSEIKQYTLEKAKEHLQSLDINCARDVTDCLLIEMEKE
                     KHSQEPMYTMENVSVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIG
                     PSRVPAVRDRLDMPYMDAVVHEIQRFINLVPSNLPHEATRDTVFQGYVIPKGTVVIPT
                     LDSLLYDSHEFPDPEKFKPEHFLNENGKFKYSDYFKAFSAGKRVCVGEGLARMELFLL
                     LSAILQHFNLKSLVDPKDIDLSPVTVGFGSIPPQFKLCVIPRS"
     exon            192..351
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e"
                     /inference="alignment:Splign:2.1.0"
     exon            352..501
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e"
                     /inference="alignment:Splign:2.1.0"
     exon            502..662
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e"
                     /inference="alignment:Splign:2.1.0"
     exon            663..839
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e"
                     /inference="alignment:Splign:2.1.0"
     exon            840..981
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1169
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1311
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1626
                     /gene="Cyp2e1"
                     /gene_synonym="Cyp2e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccagtgg caccatggcg gttcttggca tcaccattgc cttgctggtg tgggtggcca
       61 ccctcctcgt catatccatc tggaagcaga tctataacag ttggaacctg cccccaggac
      121 ctttccctct tcccatcctt gggaacattt ttcagctgga tttgaaggat atccccaagt
      181 ctttcaccaa gttggcaaag cgcttcgggc cagtgttcac actgcacctt ggctcaaggc
      241 gcatcgtggt cctgcatggc tacaaggctg tcaaggaggt gctactgaac cacaagaatg
      301 agttttctgg acggggggac attcctgtgt tccaggagta caagaacaag gggattattt
      361 tcaataatgg gcccacatgg aaggatgtgc ggaggttttc cctaagcatt ctccgagact
      421 ggggaatggg gaaacagggt aatgaggccc gcatccaaag ggaggcgcaa ttcctggtgg
      481 aggagctcaa aaagaccaaa ggccagcctt ttgaccccac atttctgatt ggctgcgcac
      541 cctgcaatgt cattgcggat atcctcttca acaaacgttt cgactacaat gacaagaagt
      601 gtctgaggct catgagtttg ttcaatgaaa acttctacct gctgagcacc ccctggatcc
      661 agctttacaa taactttgcg gattatctac gatacctacc tggaagccat agaaaaatca
      721 tgaaaaatgt gtctgaaata aaacagtaca cacttgaaaa agccaaggaa caccttcagt
      781 cactggacat caactgcgcc cgggatgtga ctgactgtct cctcatagag atggagaagg
      841 aaaaacacag ccaagaaccc atgtacacaa tggaaaatgt ttctgtgact ttggccgacc
      901 tgttctttgc aggaactgag accaccagca caactctgag atatgggctc ctgatcctca
      961 tgaaataccc agaaattgaa gagaaacttc atgaagaaat tgacagggtt attgggccaa
     1021 gccgcgtccc tgctgtcaga gacagactgg atatgcccta catggatgct gtggtgcatg
     1081 agatccagag attcatcaat cttgtccctt ccaacctacc ccatgaagca accagagata
     1141 ctgtgttcca aggatatgtc atccccaagg gtacagttgt gattccaact ctggactccc
     1201 tcttatatga cagccatgag tttccagatc cagagaagtt taaacctgag catttcctga
     1261 atgaaaatgg gaagttcaag tacagtgact atttcaaggc attttctgca ggaaagcgtg
     1321 tgtgtgttgg agaaggcctg gcccgcatgg aattgtttct gctcctgtct gctattctgc
     1381 agcattttaa cctgaagtct ctggttgacc ctaaggatat cgacctcagt cctgtcacag
     1441 ttggctttgg cagtatccca ccccaattta aactctgtgt cattccccgt tcatgagacc
     1501 tgaaaacttc ctgatatccc ttccattgtt atcccttaaa ctatgactgt ttttaaaaaa
     1561 cccaagcata tagagttcct atcataaaat gaaaccgaaa aaataaataa aaccttgatg
     1621 aattgt
//
