LOCUS       NM_173304               1590 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily d,
            polypeptide 5 (Cyp2d5), mRNA.
ACCESSION   NM_173304
VERSION     NM_173304.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1590)
  AUTHORS   Matsunaga,E., Umeno,M. and Gonzalez,F.J.
  TITLE     The rat P450 IID subfamily: complete sequences of four closely
            linked genes and evidence that gene conversions maintained sequence
            homogeneity at the heme-binding region of the cytochrome P450
            active site
  JOURNAL   J Mol Evol 30 (2), 155-169 (1990)
   PUBMED   2107330
REFERENCE   2  (bases 1 to 1590)
  AUTHORS   Matsunaga,E., Zanger,U.M., Hardwick,J.P., Gelboin,H.V., Meyer,U.A.
            and Gonzalez,F.J.
  TITLE     The CYP2D gene subfamily: analysis of the molecular basis of the
            debrisoquine 4-hydroxylase deficiency in DA rats
  JOURNAL   Biochemistry 28 (18), 7349-7355 (1989)
   PUBMED   2819073
REFERENCE   3  (bases 1 to 1590)
  AUTHORS   Ishida,N., Inuzuka,C., Tawaragi,Y., Sugita,O., Nakazato,H.,
            Noguchi,T., Sassa,S. and Kappas,A.
  TITLE     Cytochrome P450CMF cDNA: nucleotide sequence of P450CMF1b
  JOURNAL   Nucleic Acids Res 17 (15), 6407 (1989)
   PUBMED   2771656
REFERENCE   4  (bases 1 to 1590)
  AUTHORS   Ishida,N., Tawaragi,Y., Inuzuka,C., Sugita,O., Kubota,I.,
            Nakazato,H., Noguchi,T. and Sassa,S.
  TITLE     Four species of cDNAs for cytochrome P450 isozymes immunorelated to
            P450C-M/F encode for members of P450IID subfamily, increasing the
            number of members within the subfamily
  JOURNAL   Biochem Biophys Res Commun 156 (2), 681-688 (1988)
   PUBMED   3190674
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J02869.1.
            
            On Jul 3, 2003 this sequence version replaced NM_173304.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J02869.1, BC088097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1590
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1590
                     /gene="Cyp2d5"
                     /gene_synonym="Cyp2d10"
                     /note="cytochrome P450, family 2, subfamily d, polypeptide
                     5"
                     /db_xref="GeneID:286963"
                     /db_xref="RGD:628630"
     exon            1..205
                     /gene="Cyp2d5"
                     /gene_synonym="Cyp2d10"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1531
                     /gene="Cyp2d5"
                     /gene_synonym="Cyp2d10"
                     /EC_number="1.14.14.1"
                     /note="debrisoquine 4-hydroxylase; CYPIID10; P450-DB5;
                     P450-CMF1B; cytochrome P450-DB5; cytochrome P450-CMF1B;
                     cytochrome P450, family 2, subfamily d, polypeptide 10;
                     cytochrome P450CMF1b"
                     /codon_start=1
                     /product="cytochrome P450 2D10"
                     /protein_id="NP_775426.1"
                     /db_xref="GeneID:286963"
                     /db_xref="RGD:628630"
                     /translation="MELLNGTGLWPMAIFTVIFILLVDLMHRHQRWTSRYPPGPVPWP
                     VLGNLLQVDPSNMPYSMYKLQHRYGDVFSLQMGWKPMVIVNRLKAVQEVLVTHGEDTA
                     DRPPVPIFKCLGVKPRSQGVVFASYGPEWREQRRFSVSTLRTFGMGKKSLEEWVTKEA
                     GHLCDAFTAQNGRSINPKAMLNKALCNVIASLIFARRFEYEDPYLIRMLTLVEESLIE
                     VSGFIPEVLNTFPALLRIPGLADKVFQGQKTFMAFLDNLLAENRTTWDPAQPPRNLTD
                     AFLAEVEKAKGNPESSFNDENLRMVVVDLFTAGMVTTATTLTWALLLMILYPDVQRRV
                     QQEIDEVIGQVRCPEMTDQAHMPYTNAVIHEVQRFGDIAPLNLPRITSCDIEVQDFVI
                     PKGTTLIINLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEP
                     LARMELFLFFTCLLQHFSFSVPAGQPRPSTLGNFAISVAPLPYQLCAAVREQGH"
     exon            206..377
                     /gene="Cyp2d5"
                     /gene_synonym="Cyp2d10"
                     /inference="alignment:Splign:2.1.0"
     exon            378..530
                     /gene="Cyp2d5"
                     /gene_synonym="Cyp2d10"
                     /inference="alignment:Splign:2.1.0"
     exon            531..691
                     /gene="Cyp2d5"
                     /gene_synonym="Cyp2d10"
                     /inference="alignment:Splign:2.1.0"
     exon            692..868
                     /gene="Cyp2d5"
                     /gene_synonym="Cyp2d10"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1010
                     /gene="Cyp2d5"
                     /gene_synonym="Cyp2d10"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1198
                     /gene="Cyp2d5"
                     /gene_synonym="Cyp2d10"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1340
                     /gene="Cyp2d5"
                     /gene_synonym="Cyp2d10"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1590
                     /gene="Cyp2d5"
                     /gene_synonym="Cyp2d10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcagcagg gcagtcatgg agctgctgaa tgggactggc ctgtggccca tggccatatt
       61 cacagtcatc ttcatattac tggtggacct gatgcaccgg caccagcgct ggacttctcg
      121 ctaccctcca ggccctgtgc cgtggcctgt gctgggcaac ctgctgcagg tggaccccag
      181 taacatgcca tacagcatgt acaagcttca acaccgctat ggtgacgtgt tcagcctgca
      241 gatgggttgg aagcccatgg tcattgtcaa cagactgaaa gcggtgcagg aagtgctggt
      301 gactcatgga gaggacactg ctgaccgccc tccagtgccc atctttaagt gcctgggtgt
      361 gaagcccaga tcccaaggtg tggtctttgc atcttacggg cctgagtggc gagagcagag
      421 gcgattctct gtgtccaccc tgcgcacctt cggcatgggc aagaaatccc tggaggagtg
      481 ggtgaccaag gaggccggcc acctctgtga tgccttcact gcccagaatg ggcggtccat
      541 caatcccaag gccatgctga acaaagcctt gtgtaatgtg atcgcatccc tcatttttgc
      601 ccgtcgcttt gaatatgaag acccttacct catcaggatg ctgacactag tggaagaaag
      661 tttgatagaa gtctctggtt tcattcctga ggttcttaac acgttcccag cactgctgcg
      721 catcccaggg ctggctgaca aggtcttcca aggtcagaag accttcatgg ccttcctgga
      781 taacctgctg gctgagaaca ggaccacctg ggaccctgcc cagccacccc gaaatctgac
      841 tgatgccttc ctggctgagg tggagaaggc caaggggaat cctgagagca gctttaatga
      901 tgagaaccta cgcatggtgg tagttgacct gttcactgca gggatggtga ccaccgccac
      961 cacactgacc tgggccctac tgctcatgat tctatacccg gatgtgcagc gcagagtcca
     1021 acaagagatt gatgaggtca tagggcaggt gcggtgtcca gagatgacag accaggccca
     1081 catgccctac accaatgctg tcatccatga ggtacagcgc tttggggaca ttgctccatt
     1141 gaatttgcca cgcatcacga gttgtgacat tgaagtgcag gacttcgtca tccccaaggg
     1201 gacgaccctc atcatcaacc tgtcgtccgt gctgaaggat gagactgtct gggagaagcc
     1261 cctccgcttc caccctgaac acttcctgga tgcccagggc aactttgtga agcatgaggc
     1321 cttcatgcca ttctcagcag gccgcagagc atgccttggg gagcccctgg cccgcatgga
     1381 gctcttcctc ttcttcacct gcctcctgca gcacttcagc ttctccgtgc cggccggaca
     1441 gccccggccc agcacccttg gcaactttgc tatttcagtt gcccccttgc cctaccagct
     1501 ctgtgctgcg gtacgggagc aaggacacta attccagtcc agctctacag ggcaagctga
     1561 gccacgttta ataaaccagt cttgaggctg
//
