LOCUS       NM_138515               1778 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily d,
            polypeptide 4 (Cyp2d4), mRNA.
ACCESSION   NM_138515
VERSION     NM_138515.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1778)
  AUTHORS   Kuban,W., Haduch,A., Bromek,E., Basinska-Ziobron,A., Gawlinska,K.,
            Gawlinski,D., Filip,M. and Daniel,W.A.
  TITLE     The Effect of Maternal High-Fat or High-Carbohydrate Diet during
            Pregnancy and Lactation on Cytochrome P450 2D (CYP2D) in the Liver
            and Brain of Rat Offspring
  JOURNAL   Int J Mol Sci 25 (14), 7904 (2024)
   PUBMED   39063146
  REMARK    GeneRIF: The Effect of Maternal High-Fat or High-Carbohydrate Diet
            during Pregnancy and Lactation on Cytochrome P450 2D (CYP2D) in the
            Liver and Brain of Rat Offspring.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1778)
  AUTHORS   Han,L., Jia,Y., Zhao,Y., Sun,C., Zhao,M., Peng,Y. and Zheng,J.
  TITLE     Metabolic activation of zolmitriptan mediated by CYP2D6
  JOURNAL   Xenobiotica 51 (11), 1292-1302 (2021)
   PUBMED   34096834
  REMARK    GeneRIF: Metabolic activation of zolmitriptan mediated by CYP2D6.
REFERENCE   3  (bases 1 to 1778)
  AUTHORS   Zastrozhin,M., Skryabin,V., Smirnov,V., Zastrozhina,A.,
            Grishina,E., Ryzhikova,K., Bure,I., Golovinskii,P., Koporov,S.,
            Bryun,E. and Sychev,D.
  TITLE     Effect of Genetic Polymorphism of the CYP2D6 Gene on the Efficacy
            and Safety of Fluvoxamine in Major Depressive Disorder
  JOURNAL   Am J Ther 29 (1), e26-e33 (2021)
   PUBMED   34117140
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1778)
  AUTHORS   Zhang,J., Zhu,X., Li,Y., Zhu,L., Li,S., Zheng,G., Ren,Q., Xiao,Y.
            and Feng,F.
  TITLE     Correlation of CpG Island Methylation of the Cytochrome P450
            2E1/2D6 Genes with Liver Injury Induced by Anti-Tuberculosis Drugs:
            A Nested Case-Control Study
  JOURNAL   Int J Environ Res Public Health 13 (8), 776 (2016)
   PUBMED   27490558
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1778)
  AUTHORS   Anderson,G.D., Peterson,T.C., Vonder Haar,C., Farin,F.M.,
            Bammler,T.K., MacDonald,J.W., Kantor,E.D. and Hoane,M.R.
  TITLE     Effect of Traumatic Brain Injury, Erythropoietin, and Anakinra on
            Hepatic Metabolizing Enzymes and Transporters in an Experimental
            Rat Model
  JOURNAL   AAPS J 17 (5), 1255-1267 (2015)
   PUBMED   26068867
REFERENCE   6  (bases 1 to 1778)
  AUTHORS   Kawashima,H. and Strobel,H.W.
  TITLE     cDNA cloning of a novel rat brain cytochrome P450 belonging to the
            CYP2D subfamily
  JOURNAL   Biochem Biophys Res Commun 209 (2), 535-540 (1995)
   PUBMED   7733922
REFERENCE   7  (bases 1 to 1778)
  AUTHORS   Dawson,E., Powell,J.F., Nothen,M.M., Crocq,M.A., Lanczik,M.,
            Korner,J., Rietschel,M., van Os,J., Wright,P. and Gill,M.
  TITLE     An association study of debrisoquine hydroxylase (CYP2D6)
            polymorphisms in schizophrenia
  JOURNAL   Psychiatr Genet 4 (4), 215-218 (1994)
   PUBMED   7712118
REFERENCE   8  (bases 1 to 1778)
  AUTHORS   Gaedigk,A., Blum,M., Gaedigk,R., Eichelbaum,M. and Meyer,U.A.
  TITLE     Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of
            impaired drug metabolism in poor metabolizers of the
            debrisoquine/sparteine polymorphism
  JOURNAL   Am J Hum Genet 48 (5), 943-950 (1991)
   PUBMED   1673290
REFERENCE   9  (bases 1 to 1778)
  AUTHORS   Matsunaga,E., Umeno,M. and Gonzalez,F.J.
  TITLE     The rat P450 IID subfamily: complete sequences of four closely
            linked genes and evidence that gene conversions maintained sequence
            homogeneity at the heme-binding region of the cytochrome P450
            active site
  JOURNAL   J Mol Evol 30 (2), 155-169 (1990)
   PUBMED   2107330
REFERENCE   10 (bases 1 to 1778)
  AUTHORS   Ishida,N., Tawaragi,Y., Inuzuka,C., Sugita,O., Kubota,I.,
            Nakazato,H., Noguchi,T. and Sassa,S.
  TITLE     Four species of cDNAs for cytochrome P450 isozymes immunorelated to
            P450C-M/F encode for members of P450IID subfamily, increasing the
            number of members within the subfamily
  JOURNAL   Biochem Biophys Res Commun 156 (2), 681-688 (1988)
   PUBMED   3190674
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U48219.1.
            
            On Jun 3, 2007 this sequence version replaced NM_138515.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U48219.1, BC093609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1778
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1778
                     /gene="Cyp2d4"
                     /gene_synonym="Cyp2d18; Cyp2d22; Cyp2d4v1; Cyp2d4v2;
                     Cyp2d6"
                     /note="cytochrome P450, family 2, subfamily d, polypeptide
                     4"
                     /db_xref="GeneID:171522"
                     /db_xref="RGD:620640"
     exon            1..128
                     /gene="Cyp2d4"
                     /gene_synonym="Cyp2d18; Cyp2d22; Cyp2d4v1; Cyp2d4v2;
                     Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            129..377
                     /gene="Cyp2d4"
                     /gene_synonym="Cyp2d18; Cyp2d22; Cyp2d4v1; Cyp2d4v2;
                     Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1691
                     /gene="Cyp2d4"
                     /gene_synonym="Cyp2d18; Cyp2d22; Cyp2d4v1; Cyp2d4v2;
                     Cyp2d6"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450, subfamily 2D, polypeptide 6;
                     Cytochrome P450, subfamily IID4; CYPIID4; CYPIID18;
                     P450-DB4; P450-CMF3; P450 2D-29/2D-35; debrisoquine
                     4-hydroxylase; cytochrome P450-DB4; cytochrome P450-CMF3;
                     cytochrome P450 2D-29; cytochrome P450 2D-35; cytochrome
                     P450, subfamily IID, polypeptide 6; cytochrome P450,
                     family 2, subfamily d, polypeptide 22; cytochrome P450
                     2d18"
                     /codon_start=1
                     /product="cytochrome P450 2D4"
                     /protein_id="NP_612524.1"
                     /db_xref="GeneID:171522"
                     /db_xref="RGD:620640"
                     /translation="MRMPTGSELWPIAIFTIIFLLLVDLMHRRQRWTSRYPPGPVPWP
                     VLGNLLQIDFQNMPAGFQKLRCRFGDLFSLQLAFESVVVLNGLPALREALVKYSEDTA
                     DRPPLHFNDQSGFGPRSQGVVLARYGPAWRQQRRFSVSTFRHFGLGKKSLEQWVTEEA
                     RCLCAAFADHSGFPFSPNTLLDKAVCNVIASLLFACRFEYNDPRFIRLLDLLKDTLEE
                     ESGFLPMLLNVFPMLLHIPGLLGKVFSGKKAFVAMLDELLTEHKVTWDPAQPPRDLTD
                     AFLAEVEKAKGNPESSFNDENLRVVVADLFMAGMVTTSTTLTWALLFMILRPDVQCRV
                     QQEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADILPLGVPHKTSRDIEVQGFLI
                     PKGTTLIINLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEP
                     LARMELFLFFTCLLQRFSFSVPAGQPRPSNYGVFGALTTPRPYQLCASPR"
     exon            378..549
                     /gene="Cyp2d4"
                     /gene_synonym="Cyp2d18; Cyp2d22; Cyp2d4v1; Cyp2d4v2;
                     Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            550..702
                     /gene="Cyp2d4"
                     /gene_synonym="Cyp2d18; Cyp2d22; Cyp2d4v1; Cyp2d4v2;
                     Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            703..863
                     /gene="Cyp2d4"
                     /gene_synonym="Cyp2d18; Cyp2d22; Cyp2d4v1; Cyp2d4v2;
                     Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1040
                     /gene="Cyp2d4"
                     /gene_synonym="Cyp2d18; Cyp2d22; Cyp2d4v1; Cyp2d4v2;
                     Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1182
                     /gene="Cyp2d4"
                     /gene_synonym="Cyp2d18; Cyp2d22; Cyp2d4v1; Cyp2d4v2;
                     Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1370
                     /gene="Cyp2d4"
                     /gene_synonym="Cyp2d18; Cyp2d22; Cyp2d4v1; Cyp2d4v2;
                     Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1512
                     /gene="Cyp2d4"
                     /gene_synonym="Cyp2d18; Cyp2d22; Cyp2d4v1; Cyp2d4v2;
                     Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1761
                     /gene="Cyp2d4"
                     /gene_synonym="Cyp2d18; Cyp2d22; Cyp2d4v1; Cyp2d4v2;
                     Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgctcctca cagctccccc tccacctctg agtggatcct cctctgagtt tctcttcttc
       61 ctcagagctc ctcctcctcc cggtcctgca aggctccaga cttctcgact tggtttcaga
      121 aagcaccggt ggctgtagtc gggattgaga ggtgtttcca aagaaaccca aagagcagca
      181 gggcagccat gaggatgccg acggggtctg aactgtggcc catagccata ttcacgatca
      241 tcttcctgct tctggtggac ctgatgcaca ggcgccagcg ctggacttct cgctaccctc
      301 cgggccctgt gccctggcct gtgctgggca acctgctgca gatagacttc cagaatatgc
      361 cagcgggctt tcaaaagctg agatgtcgct ttggggacct gttcagctta cagctggcct
      421 ttgagtcggt ggttgtactg aatgggctgc cagccctgcg agaggcactg gtgaaataca
      481 gcgaggacac cgctgaccgg ccaccgctgc atttcaatga ccagtcgggc tttggaccac
      541 gctctcaagg tgtggtcctc gcgaggtatg gacctgcctg gcgtcagcag cggcgcttct
      601 ctgtgtccac cttccgtcac tttggcctgg gcaagaagtc actggagcag tgggtgacag
      661 aggaggccag atgcctctgt gctgccttcg ctgaccatag tggattccct ttcagcccta
      721 acactctact ggacaaagca gtgtgtaacg tgatcgcgtc cctcctcttt gcctgccgct
      781 ttgaatacaa tgacccacgc ttcatcaggc tcctggactt gctgaaggac actcttgagg
      841 aggaatctgg attcctgccc atgctcctga atgtgttccc gatgctccta cacatcccag
      901 ggcttcttgg caaggtattc tctggaaaga aggccttcgt tgccatgctg gacgagctgc
      961 taactgaaca caaggtgacc tgggaccctg cgcagccacc ccgagatctg actgatgcct
     1021 tcctggctga ggtggagaag gccaagggga atcctgagag cagcttcaat gatgagaacc
     1081 tgcgtgtggt ggtggctgac ctgttcatgg cggggatggt gaccacctcc accacactga
     1141 cctgggccct gctgttcatg atcctgcgtc cagatgtgca gtgccgagta caacaggaaa
     1201 tcgatgaggt catagggcag gtgcggcgtc cagagatggc agaccaggca cgaatgccgt
     1261 tcaccaatgc tgtcatccat gaggtgcagc gctttgcaga cattctccct cttggtgtgc
     1321 ctcacaagac ttctcgtgac attgaagtgc agggcttcct tatccctaag gggacgaccc
     1381 tcatcatcaa cctgtcctca gtgctgaagg atgagactgt ctgggagaag cccctccgct
     1441 tccaccctga acacttcctg gatgcccagg gcaactttgt gaagcatgag gccttcatgc
     1501 cattctcagc aggccgcaga gcatgcctgg gggagcccct ggcccgcatg gagctcttcc
     1561 tcttcttcac ctgcctcctg cagcgcttca gcttctccgt gcccgctggg cagccccggc
     1621 ccagcaacta tggcgtcttt ggtgctctga ccaccccgcg cccctaccag ctctgtgctt
     1681 caccccgcta aggggaggca cagcatctca ctcactgtgc ttgctggggt cctagtgtgc
     1741 aataaatggt tttactctga aaaaaaaaaa aaaaaaaa
//
