LOCUS       NM_173093               1628 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily d,
            polypeptide 3 (Cyp2d3), mRNA.
ACCESSION   NM_173093
VERSION     NM_173093.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1628)
  AUTHORS   Gilbert,E.A., Edwards,R.J., Boobis,A.R., Rose,S. and Jenner,P.
  TITLE     Differential expression of cytochrome P450 enzymes in cultured and
            intact foetal rat ventral mesencephalon
  JOURNAL   J Neural Transm (Vienna) 110 (10), 1091-1101 (2003)
   PUBMED   14523622
REFERENCE   2  (bases 1 to 1628)
  AUTHORS   Chow,T., Imaoka,S., Hiroi,T. and Funae,Y.
  TITLE     Developmental changes in the catalytic activity and expression of
            CYP2D isoforms in the rat liver
  JOURNAL   Drug Metab Dispos 27 (2), 188-192 (1999)
   PUBMED   9929501
REFERENCE   3  (bases 1 to 1628)
  AUTHORS   Wan,J., Imaoka,S., Chow,T., Hiroi,T., Yabusaki,Y. and Funae,Y.
  TITLE     Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae
            and their catalytic specificity
  JOURNAL   Arch Biochem Biophys 348 (2), 383-390 (1997)
   PUBMED   9434752
REFERENCE   4  (bases 1 to 1628)
  AUTHORS   Matsunaga,E., Umeno,M. and Gonzalez,F.J.
  TITLE     The rat P450 IID subfamily: complete sequences of four closely
            linked genes and evidence that gene conversions maintained sequence
            homogeneity at the heme-binding region of the cytochrome P450
            active site
  JOURNAL   J Mol Evol 30 (2), 155-169 (1990)
   PUBMED   2107330
REFERENCE   5  (bases 1 to 1628)
  AUTHORS   Matsunaga,E., Zanger,U.M., Hardwick,J.P., Gelboin,H.V., Meyer,U.A.
            and Gonzalez,F.J.
  TITLE     The CYP2D gene subfamily: analysis of the molecular basis of the
            debrisoquine 4-hydroxylase deficiency in DA rats
  JOURNAL   Biochemistry 28 (18), 7349-7355 (1989)
   PUBMED   2819073
REFERENCE   6  (bases 1 to 1628)
  AUTHORS   Zanger,U.M., Hauri,H.P., Loeper,J., Homberg,J.C. and Meyer,U.A.
  TITLE     Antibodies against human cytochrome P-450db1 in autoimmune
            hepatitis type II
  JOURNAL   Proc Natl Acad Sci U S A 85 (21), 8256-8260 (1988)
   PUBMED   3186722
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB008424.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB008424.1, FQ211667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1628
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1628
                     /gene="Cyp2d3"
                     /gene_synonym="Cyp2d13; Cyp2d6"
                     /note="cytochrome P450, family 2, subfamily d, polypeptide
                     3"
                     /db_xref="GeneID:24303"
                     /db_xref="RGD:2472"
     exon            1..244
                     /gene="Cyp2d3"
                     /gene_synonym="Cyp2d13; Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1558
                     /gene="Cyp2d3"
                     /gene_synonym="Cyp2d13; Cyp2d6"
                     /EC_number="1.14.14.1"
                     /note="CYPIID3; P450-DB3; debrisoquine 4-hydroxylase;
                     cytochrome P450-DB3; cytochrome P450, family 2, subfamily
                     d, polypeptide 13; Cytochrome P450, subfamily IID3;
                     cytochrome P450, family 2, subfamily d, polypeptide 6"
                     /codon_start=1
                     /product="cytochrome P450 2D3"
                     /protein_id="NP_775116.1"
                     /db_xref="GeneID:24303"
                     /db_xref="RGD:2472"
                     /translation="MELLAGTGLWPMAIFTVIFILLVDLMHRRQRWTSRYPPGPVPWP
                     VLGNLLQVDLCNMPYSMYKLQNRYGDVFSLQMGWKPVVVINGLKAVQELLVTCGEDTA
                     DRPEMPIFQHIGYGHKAKGVVLAPYGPEWREQRRFSVSTLRNFGVGKKSLEQWVTDEA
                     SHLCDALTAEAGRPLDPYTLLNKAVCNVIASLIYARRFDYGDPDFIKVLKILKESMGE
                     QTGLFPEVLNMFPVLLRIPGLADKVFPGQKTFLTMVDNLVTEHKKTWDPDQPPRDLTD
                     AFLAEIEKAKGNPESSFNDANLRLVVNDLFGAGMVTTSITLTWALLLMILHPDVQCRV
                     QQEIDEVIGQVRHPEMADQAHMPFTNAVIHEVQRFADIVPMNLPHKTSRDIEVQGFLI
                     PKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEP
                     LARMELFLFFTCLLQRFSFSVPTGQPRPSDYGVFAFLLSPSPYQLCAFKR"
     exon            245..416
                     /gene="Cyp2d3"
                     /gene_synonym="Cyp2d13; Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            417..569
                     /gene="Cyp2d3"
                     /gene_synonym="Cyp2d13; Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            570..730
                     /gene="Cyp2d3"
                     /gene_synonym="Cyp2d13; Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            731..907
                     /gene="Cyp2d3"
                     /gene_synonym="Cyp2d13; Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1049
                     /gene="Cyp2d3"
                     /gene_synonym="Cyp2d13; Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1237
                     /gene="Cyp2d3"
                     /gene_synonym="Cyp2d13; Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1379
                     /gene="Cyp2d3"
                     /gene_synonym="Cyp2d13; Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1628
                     /gene="Cyp2d3"
                     /gene_synonym="Cyp2d13; Cyp2d6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtattgag tgttggccag tggtctttgg tagcctgggc agcagcgggg cagacatgga
       61 gctgctggct gggactggcc tgtggcccat ggccatattc acagtcatct tcatattact
      121 ggtggacctg atgcaccggc gccagcgctg gacttctcgc taccctccag gccctgtgcc
      181 gtggcctgtg ctgggcaacc tgctgcaggt ggacctctgt aacatgccat acagcatgta
      241 caagcttcaa aaccgctatg gtgacgtgtt cagcctacag atgggttgga agccagtggt
      301 ggtgatcaat ggactgaagg cagtgcagga actgctggtg acctgtggag aggacactgc
      361 tgaccgccct gaaatgccca tctttcaaca tataggctat gggcacaaag ctaaaggtgt
      421 ggtgcttgca ccttacgggc ctgagtggcg agagcagagg cgattctctg tgtccaccct
      481 gcgcaacttc ggtgtgggca agaaatccct ggagcagtgg gtgacagacg aggccagcca
      541 cctctgtgat gccctcaccg ctgaggcagg gcggcccctc gatccttaca ccctcctgaa
      601 caaggctgtg tgcaatgtaa ttgcatctct catttatgcc cgccgcttcg actatggaga
      661 ccctgatttc atcaaggtgc taaaaatatt gaaagaaagc atgggagagc aaactggctt
      721 gtttcctgag gttttgaaca tgttcccagt tctcctgcgc atcccagggt tagctgacaa
      781 agtcttccct gggcaaaaga catttctcac catggtggat aacctggtga ctgagcacaa
      841 gaagacttgg gaccctgacc agccacctcg agacctgact gatgcctttc tggctgagat
      901 agagaaggcc aaggggaacc ctgagagtag tttcaatgat gcaaatctac gtctggtggt
      961 caatgacctg tttggtgctg ggatggtgac tacttctatc actctaacct gggccctgct
     1021 gctcatgatc ctgcatccgg atgtgcagtg ccgagtacaa caggaaatcg atgaggtcat
     1081 agggcaggtg cggcatccag agatggcaga ccaggcccac atgccgttca ccaatgctgt
     1141 catccatgag gtgcagcgct ttgcagacat tgtcccaatg aatttgccac acaagacttc
     1201 tcgtgacatt gaagtgcagg gcttccttat ccctaagggg acaaccctca tccccaacct
     1261 gtcctcagtg ctgaaggatg agactgtctg ggagaagccc ctccgattcc accctgaaca
     1321 cttcctggat gcccagggca actttgtgaa gcatgaggcc ttcatgccat tctcagcagg
     1381 ccgcagagca tgcctggggg agcccctggc ccgcatggag ctcttcctct tcttcacctg
     1441 cctcctgcaa cgcttcagct tctccgtgcc cactggacag ccccggccca gcgactatgg
     1501 tgtctttgcc tttctcctta gcccttcccc ctaccagctc tgtgcattca aacgttagaa
     1561 ggaaagaaat tctagtccag cctctacctt agtgtcatac acagattaaa acagttctgt
     1621 ggctgcca
//
