LOCUS       NM_012730               1674 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily d,
            polypeptide 2 (Cyp2d2), mRNA.
ACCESSION   NM_012730
VERSION     NM_012730.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1674)
  AUTHORS   Kuban,W., Haduch,A., Bromek,E., Basinska-Ziobron,A., Gawlinska,K.,
            Gawlinski,D., Filip,M. and Daniel,W.A.
  TITLE     The Effect of Maternal High-Fat or High-Carbohydrate Diet during
            Pregnancy and Lactation on Cytochrome P450 2D (CYP2D) in the Liver
            and Brain of Rat Offspring
  JOURNAL   Int J Mol Sci 25 (14), 7904 (2024)
   PUBMED   39063146
  REMARK    GeneRIF: The Effect of Maternal High-Fat or High-Carbohydrate Diet
            during Pregnancy and Lactation on Cytochrome P450 2D (CYP2D) in the
            Liver and Brain of Rat Offspring.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1674)
  AUTHORS   Iwaki,M., Niwa,T., Nakamura,Y., Kawase,A. and Komura,H.
  TITLE     Relative contribution of rat CYP isoforms responsible for
            stereoselective metabolism of carvedilol
  JOURNAL   J Toxicol Sci 43 (1), 59-63 (2018)
   PUBMED   29415952
  REMARK    GeneRIF: It shows the highest metabolic activities against
            enantiomers of carvedilol.
REFERENCE   3  (bases 1 to 1674)
  AUTHORS   Bogacz,A., Bartkowiak-Wieczorek,J., Mikolajczak,P.L.,
            Rakowska-Mrozikiewicz,B., Grzeskowiak,E., Wolski,H., Czerny,B. and
            Mrozikiewicz,P.M.
  TITLE     The influence of soybean extract on the expression level of
            selected drug transporters, transcription factors and cytochrome
            P450 genes encoding phase I drug-metabolizing enzymes
  JOURNAL   Ginekol Pol 85 (5), 348-353 (2014)
   PUBMED   25011215
REFERENCE   4  (bases 1 to 1674)
  AUTHORS   Liu,R., Qin,M., Hang,P., Liu,Y., Zhang,Z. and Liu,G.
  TITLE     Effects of Panax notoginseng saponins on the activities of CYP1A2,
            CYP2C9, CYP2D6 and CYP3A4 in rats in vivo
  JOURNAL   Phytother Res 26 (8), 1113-1118 (2012)
   PUBMED   22162298
  REMARK    GeneRIF: Panax notoginseng saponins had no significant effects on
            the activities of CYP2C9, CYP2D6, and CYP3A4, but it could induce
            the activity of CYP1A2 in rats in vivo.
REFERENCE   5  (bases 1 to 1674)
  AUTHORS   Grondin,M., Hamel,F., Sarhan,F. and Averill-Bates,D.A.
  TITLE     Metabolic activity of cytochrome p450 isoforms in hepatocytes
            cryopreserved with wheat protein extract
  JOURNAL   Drug Metab Dispos 36 (10), 2121-2129 (2008)
   PUBMED   18617602
REFERENCE   6  (bases 1 to 1674)
  AUTHORS   Wan,J., Imaoka,S., Chow,T., Hiroi,T., Yabusaki,Y. and Funae,Y.
  TITLE     Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae
            and their catalytic specificity
  JOURNAL   Arch Biochem Biophys 348 (2), 383-390 (1997)
   PUBMED   9434752
REFERENCE   7  (bases 1 to 1674)
  AUTHORS   Matsunaga,E., Umeno,M. and Gonzalez,F.J.
  TITLE     The rat P450 IID subfamily: complete sequences of four closely
            linked genes and evidence that gene conversions maintained sequence
            homogeneity at the heme-binding region of the cytochrome P450
            active site
  JOURNAL   J Mol Evol 30 (2), 155-169 (1990)
   PUBMED   2107330
REFERENCE   8  (bases 1 to 1674)
  AUTHORS   Matsunaga,E., Zanger,U.M., Hardwick,J.P., Gelboin,H.V., Meyer,U.A.
            and Gonzalez,F.J.
  TITLE     The CYP2D gene subfamily: analysis of the molecular basis of the
            debrisoquine 4-hydroxylase deficiency in DA rats
  JOURNAL   Biochemistry 28 (18), 7349-7355 (1989)
   PUBMED   2819073
REFERENCE   9  (bases 1 to 1674)
  AUTHORS   Ishida,N., Tawaragi,Y., Inuzuka,C., Sugita,O., Kubota,I.,
            Nakazato,H., Noguchi,T. and Sassa,S.
  TITLE     Four species of cDNAs for cytochrome P450 isozymes immunorelated to
            P450C-M/F encode for members of P450IID subfamily, increasing the
            number of members within the subfamily
  JOURNAL   Biochem Biophys Res Commun 156 (2), 681-688 (1988)
   PUBMED   3190674
REFERENCE   10 (bases 1 to 1674)
  AUTHORS   Gonzalez,F.J., Matsunaga,T., Nagata,K., Meyer,U.A., Nebert,D.W.,
            Pastewka,J., Kozak,C.A., Gillette,J., Gelboin,H.V. and
            Hardwick,J.P.
  TITLE     Debrisoquine 4-hydroxylase: characterization of a new P450 gene
            subfamily, regulation, chromosomal mapping, and molecular analysis
            of the DA rat polymorphism
  JOURNAL   DNA 6 (2), 149-161 (1987)
   PUBMED   3582092
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 20, 2020 this sequence version replaced NM_012730.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M22330.1, AB008423.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               JAXUCZ010000007.1  115818993-115819281 c
            290-461             JAXUCZ010000007.1  115818202-115818373 c
            462-614             JAXUCZ010000007.1  115817815-115817967 c
            615-775             JAXUCZ010000007.1  115817581-115817741 c
            776-952             JAXUCZ010000007.1  115816729-115816905 c
            953-1094            JAXUCZ010000007.1  115816409-115816550 c
            1095-1282           JAXUCZ010000007.1  115816034-115816221 c
            1283-1424           JAXUCZ010000007.1  115815562-115815703 c
            1425-1674           JAXUCZ010000007.1  115815212-115815461 c
FEATURES             Location/Qualifiers
     source          1..1674
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1674
                     /gene="Cyp2d2"
                     /gene_synonym="Cyp2d26; CYPIID26; P450-CMF2; P450-DB2"
                     /note="cytochrome P450, family 2, subfamily d, polypeptide
                     2"
                     /db_xref="GeneID:25053"
                     /db_xref="RGD:2471"
     exon            1..289
                     /gene="Cyp2d2"
                     /gene_synonym="Cyp2d26; CYPIID26; P450-CMF2; P450-DB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1603
                     /gene="Cyp2d2"
                     /gene_synonym="Cyp2d26; CYPIID26; P450-CMF2; P450-DB2"
                     /EC_number="1.14.14.1"
                     /note="debrisoquine 4-hydroxylase; cytochrome P450-DB2;
                     cytochrome P450-CMF2; cytochrome P450, family 2, subfamily
                     d, polypeptide 26; Cytochrome P450, subfamily IID2"
                     /codon_start=1
                     /product="cytochrome P450 2D26"
                     /protein_id="NP_036862.2"
                     /db_xref="GeneID:25053"
                     /db_xref="RGD:2471"
                     /translation="MGLLIGDDLWAVVIFTAIFLLLVDLVHRHKFWTAHYPPGPVPLP
                     GLGNLLQVDFENMPYSLYKLRSRYGDVFSLQIAWKPVVVINGLKAVRELLVTYGEDTA
                     DRPLLPIYNHLGYGNKSKGVVLAPYGPEWREQRRFSVSTLRDFGVGKKSLEQWVTEEA
                     GHLCDTFAKEAEHPFNPSILLSKAVSNVIASLVYARRFEYEDPFFNRMLKTLKESFGE
                     DTGFMAEVLNAIPILLQIPGLPGKVFPKLNSFIALVDKMLIEHKKSWDPAQPPRDMTD
                     AFLAEMQKAKGNPESSFNDENLRLVVIDLFMAGMVTTSTTLSWALLLMILHPDVQRRV
                     HEEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADIVPTNIPHMTSRDIKFQGFLI
                     PKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEP
                     LARMELFLFFTCLLQRFSFSVLAGRPRPSTHGVYALPVTPQPYQLCAVAR"
     exon            290..461
                     /gene="Cyp2d2"
                     /gene_synonym="Cyp2d26; CYPIID26; P450-CMF2; P450-DB2"
                     /inference="alignment:Splign:2.1.0"
     exon            462..614
                     /gene="Cyp2d2"
                     /gene_synonym="Cyp2d26; CYPIID26; P450-CMF2; P450-DB2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..775
                     /gene="Cyp2d2"
                     /gene_synonym="Cyp2d26; CYPIID26; P450-CMF2; P450-DB2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..952
                     /gene="Cyp2d2"
                     /gene_synonym="Cyp2d26; CYPIID26; P450-CMF2; P450-DB2"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1094
                     /gene="Cyp2d2"
                     /gene_synonym="Cyp2d26; CYPIID26; P450-CMF2; P450-DB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1282
                     /gene="Cyp2d2"
                     /gene_synonym="Cyp2d26; CYPIID26; P450-CMF2; P450-DB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1424
                     /gene="Cyp2d2"
                     /gene_synonym="Cyp2d26; CYPIID26; P450-CMF2; P450-DB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1674
                     /gene="Cyp2d2"
                     /gene_synonym="Cyp2d26; CYPIID26; P450-CMF2; P450-DB2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttaagggac caggttccca gtctgttgta agaggatctt tcctgattct aagtgtctgg
       61 acaagtattc cttcaaaagc ctgcaagccg tggggcagcc atggggctgc tgattggaga
      121 tgacctctgg gctgtggtca tattcacagc catcttcttg cttctggtgg acctggtgca
      181 ccggcacaaa ttctggactg cccactaccc tcccggccct gtgccactcc ctgggctggg
      241 aaacctgctg caggtggact ttgagaacat gccatatagc ttatacaagc ttcgaagccg
      301 ctatggtgac gtgttcagcc tacagatagc ctggaagcct gtagttgtga tcaacgggct
      361 gaaggccgtg cgggaactgc tggtgaccta tggagaggac actgctgacc gccccctact
      421 gcccatctat aatcacctgg gctatgggaa caaatcaaaa ggtgtggtcc ttgcacctta
      481 cggacctgag tggcgagagc agagacgatt ctctgtgtcc accctgcgtg acttcggcgt
      541 gggcaagaaa tcgctggagc agtgggtgac agaggaggcc ggccacctct gtgacacctt
      601 cgccaaggag gctgaacatc ccttcaatcc cagcatcctc ctgagtaagg ctgtgagcaa
      661 cgtgattgcc tcccttgttt atgctcgtcg atttgagtat gaggaccctt tcttcaacag
      721 gatgctcaaa acattgaagg agagctttgg agaggacacc ggcttcatgg cagaggtgct
      781 gaacgcaatc ccaattctcc ttcagattcc tgggctgcct ggcaaagtct tccccaagct
      841 caattcattt atagccttag tggataagat gttaattgag cacaagaaaa gctgggatcc
      901 tgcccagccg ccccgagaca tgactgatgc cttcctagca gagatgcaaa aggccaaggg
      961 gaatcctgag agcagcttca atgatgaaaa tctgcgcttg gtggtgattg acctgttcat
     1021 ggcggggatg gtgaccacct caaccacact gtcctgggcc cttctgctca tgatcctgca
     1081 tccagatgtg cagcgccgag tccacgagga gattgatgag gtcatagggc aggtgcgtcg
     1141 tccagagatg gcagaccagg cacgaatgcc gttcaccaat gctgtcatcc atgaggtgca
     1201 gcgctttgca gacatcgtcc cgacaaatat accacatatg acatcccgag acattaaatt
     1261 ccaaggcttc ctcatcccca aggggacaac cctcatcccc aacctgtcct ccgtgctgaa
     1321 ggatgagacc gtctgggaga agcccctccg cttccatcca gaacacttcc tggatgccca
     1381 gggcaacttt gtgaagcatg aggccttcat gccattctca gcaggccgca gagcatgcct
     1441 gggggagccc ctggcccgca tggagctctt cctcttcttc acctgcctcc tgcagcgctt
     1501 cagcttctcg gtgctggccg gccggccccg gcccagcacc catggcgtct acgcattgcc
     1561 agttactcca cagccttacc aactctgtgc agtggctcgc tagcaggggc aggggctcca
     1621 ttcttctccc cggtttggtc tgattgatgt ccaataaaca acttctgtat cttc
//
