LOCUS       NM_153313               1623 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily d,
            polypeptide 1 (Cyp2d1), mRNA.
ACCESSION   NM_153313
VERSION     NM_153313.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1623)
  AUTHORS   Kuban,W., Haduch,A., Bromek,E., Basinska-Ziobron,A., Gawlinska,K.,
            Gawlinski,D., Filip,M. and Daniel,W.A.
  TITLE     The Effect of Maternal High-Fat or High-Carbohydrate Diet during
            Pregnancy and Lactation on Cytochrome P450 2D (CYP2D) in the Liver
            and Brain of Rat Offspring
  JOURNAL   Int J Mol Sci 25 (14), 7904 (2024)
   PUBMED   39063146
  REMARK    GeneRIF: The Effect of Maternal High-Fat or High-Carbohydrate Diet
            during Pregnancy and Lactation on Cytochrome P450 2D (CYP2D) in the
            Liver and Brain of Rat Offspring.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1623)
  AUTHORS   Danek,P.J. and Daniel,W.A.
  TITLE     Long-Term Treatment with Atypical Antipsychotic Iloperidone
            Modulates Cytochrome P450 2D (CYP2D) Expression and Activity in the
            Liver and Brain via Different Mechanisms
  JOURNAL   Cells 10 (12), 3472 (2021)
   PUBMED   34943983
  REMARK    GeneRIF: Long-Term Treatment with Atypical Antipsychotic
            Iloperidone Modulates Cytochrome P450 2D (CYP2D) Expression and
            Activity in the Liver and Brain via Different Mechanisms.
            Erratum:[Cells. 2024 Dec 23;13(24):2133. doi:
            10.3390/cells13242133.. PMID: 39768231]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1623)
  AUTHORS   Haduch,A., Puklo,R., Alenina,N., Nikiforuk,A., Popik,P., Bader,M.
            and Daniel,W.A.
  TITLE     The effect of ageing and cerebral serotonin deficit on the activity
            of cytochrome P450 2D (CYP2D) in the brain and liver of male rats
  JOURNAL   Neurochem Int 141, 104884 (2020)
   PUBMED   33091481
  REMARK    GeneRIF: The effect of ageing and cerebral serotonin deficit on the
            activity of cytochrome P450 2D (CYP2D) in the brain and liver of
            male rats.
REFERENCE   4  (bases 1 to 1623)
  AUTHORS   Salmin,S.F., Giroux,M.C., Vachon,P. and Beaudry,F.
  TITLE     In vitro metabolism of specific CYP2D and CYP3A opioid substrates
            using rat liver S9 fractions and mass spectrometry reveal a severe
            metabolic impairment with increasing age
  JOURNAL   Biomed Chromatogr 31 (2) (2017)
   PUBMED   27390106
  REMARK    GeneRIF: This study suggests that there is an impairment of CYP2D
            and CYP3A metabolism in aging rats.
REFERENCE   5  (bases 1 to 1623)
  AUTHORS   Ma,J., Wang,J., Cheng,J., Xiao,W., Fan,K., Gu,J., Yu,B., Yin,G.,
            Wu,J., Ren,J., Hou,J., Jiang,Y., Tan,Y. and Jin,W.
  TITLE     Impacts of Blast-Induced Traumatic Brain Injury on Expressions of
            Hepatic Cytochrome P450 1A2, 2B1, 2D1, and 3A2 in Rats
  JOURNAL   Cell Mol Neurobiol 37 (1), 111-120 (2017)
   PUBMED   26913515
  REMARK    GeneRIF: CYP2D1 expression in liver is significantly impacted by
            blast-induced traumatic brain injury.
REFERENCE   6  (bases 1 to 1623)
  AUTHORS   Gilbert,E.A., Edwards,R.J., Boobis,A.R., Rose,S. and Jenner,P.
  TITLE     Differential expression of cytochrome P450 enzymes in cultured and
            intact foetal rat ventral mesencephalon
  JOURNAL   J Neural Transm (Vienna) 110 (10), 1091-1101 (2003)
   PUBMED   14523622
  REMARK    GeneRIF: There were marked differences in the degree of expression
            of the isoforms of P450, for example CYP2D1 was only weakly
            expressed in foetal ventral mesencephalon (VM) sections but
            expression was strong in VM cultures.
REFERENCE   7  (bases 1 to 1623)
  AUTHORS   Wan,J., Imaoka,S., Chow,T., Hiroi,T., Yabusaki,Y. and Funae,Y.
  TITLE     Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae
            and their catalytic specificity
  JOURNAL   Arch Biochem Biophys 348 (2), 383-390 (1997)
   PUBMED   9434752
REFERENCE   8  (bases 1 to 1623)
  AUTHORS   Matsunaga,E., Zanger,U.M., Hardwick,J.P., Gelboin,H.V., Meyer,U.A.
            and Gonzalez,F.J.
  TITLE     The CYP2D gene subfamily: analysis of the molecular basis of the
            debrisoquine 4-hydroxylase deficiency in DA rats
  JOURNAL   Biochemistry 28 (18), 7349-7355 (1989)
   PUBMED   2819073
REFERENCE   9  (bases 1 to 1623)
  AUTHORS   Ishida,N., Tawaragi,Y., Inuzuka,C., Sugita,O., Kubota,I.,
            Nakazato,H., Noguchi,T. and Sassa,S.
  TITLE     Four species of cDNAs for cytochrome P450 isozymes immunorelated to
            P450C-M/F encode for members of P450IID subfamily, increasing the
            number of members within the subfamily
  JOURNAL   Biochem Biophys Res Commun 156 (2), 681-688 (1988)
   PUBMED   3190674
REFERENCE   10 (bases 1 to 1623)
  AUTHORS   Gonzalez,F.J., Matsunaga,T., Nagata,K., Meyer,U.A., Nebert,D.W.,
            Pastewka,J., Kozak,C.A., Gillette,J., Gelboin,H.V. and
            Hardwick,J.P.
  TITLE     Debrisoquine 4-hydroxylase: characterization of a new P450 gene
            subfamily, regulation, chromosomal mapping, and molecular analysis
            of the DA rat polymorphism
  JOURNAL   DNA 6 (2), 149-161 (1987)
   PUBMED   3582092
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_153313.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB008422.1, M16654.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               JAXUCZ010000007.1  115793191-115793430 c
            241-412             JAXUCZ010000007.1  115792058-115792229 c
            413-565             JAXUCZ010000007.1  115791661-115791813 c
            566-726             JAXUCZ010000007.1  115791410-115791570 c
            727-903             JAXUCZ010000007.1  115790608-115790784 c
            904-1045            JAXUCZ010000007.1  115790283-115790424 c
            1046-1233           JAXUCZ010000007.1  115789895-115790082 c
            1234-1375           JAXUCZ010000007.1  115789371-115789512 c
            1376-1623           JAXUCZ010000007.1  115789026-115789273 c
FEATURES             Location/Qualifiers
     source          1..1623
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1623
                     /gene="Cyp2d1"
                     /gene_synonym="Cyp2d9"
                     /note="cytochrome P450, family 2, subfamily d, polypeptide
                     1"
                     /db_xref="GeneID:266684"
                     /db_xref="RGD:708427"
     exon            1..240
                     /gene="Cyp2d1"
                     /gene_synonym="Cyp2d9"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1566
                     /gene="Cyp2d1"
                     /gene_synonym="Cyp2d9"
                     /EC_number="1.14.14.1"
                     /note="debrisoquine 4-hydroxylase; CYPIID1; P450-DB1;
                     P450-UT-7; P450-CMF1A; cytochrome P450-DB1; cytochrome
                     P450-UT-7; cytochrome P450-CMF1A; cytochrome P450, family
                     2, subfamily d, polypeptide 9"
                     /codon_start=1
                     /product="cytochrome P450 2D1"
                     /protein_id="NP_695225.1"
                     /db_xref="GeneID:266684"
                     /db_xref="RGD:708427"
                     /translation="MELLNGTGLWSMAIFTVIFILLVDLMHRRHRWTSRYPPGPVPWP
                     VLGNLLQVDLSNMPYSLYKLQHRYGDVFSLQKGWKPMVIVNRLKAVQEVLVTHGEDTA
                     DRPPVPIFKCLGVKPRSQGVILASYGPEWREQRRFSVSTLRTFGMGKKSLEEWVTKEA
                     GHLCDAFTAQAGQSINPKAMLNKALCNVIASLIFARRFEYEDPYLIRMVKLVEESLTE
                     VSGFIPEVLNTFPALLRIPGLADKVFQGQKTFMALLDNLLAENRTTWDPAQPPRNLTD
                     AFLAEVEKAKGNPESSFNDENLRMVVVDLFTAGMVTTATTLTWALLLMILYPDVQRRV
                     QQEIDEVIGQVRCPEMTDQAHMPYTNAVIHEVQRFGDIAPLNLPRITSCDIEVQDFVI
                     PKGTTLIINLSSVLKDETVWEKPHRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEP
                     LARMELFLFFTCLLQRFSFSVPVGQPRPSTHGFFAFPVAPLPYQLCAVVREQGL"
     exon            241..412
                     /gene="Cyp2d1"
                     /gene_synonym="Cyp2d9"
                     /inference="alignment:Splign:2.1.0"
     exon            413..565
                     /gene="Cyp2d1"
                     /gene_synonym="Cyp2d9"
                     /inference="alignment:Splign:2.1.0"
     exon            566..726
                     /gene="Cyp2d1"
                     /gene_synonym="Cyp2d9"
                     /inference="alignment:Splign:2.1.0"
     exon            727..903
                     /gene="Cyp2d1"
                     /gene_synonym="Cyp2d9"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1045
                     /gene="Cyp2d1"
                     /gene_synonym="Cyp2d9"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1233
                     /gene="Cyp2d1"
                     /gene_synonym="Cyp2d9"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1375
                     /gene="Cyp2d1"
                     /gene_synonym="Cyp2d9"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1623
                     /gene="Cyp2d1"
                     /gene_synonym="Cyp2d9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttaagtgtt ggtcatttgt ctttgggagc ctgggcagca gcaaggcagc catggagctg
       61 ctgaatggga ctggcctgtg gtccatggcc atattcacag tcatcttcat attactggtg
      121 gacctgatgc accggcgcca tcgctggact tctcgctacc ctccaggccc tgtgccgtgg
      181 cctgtgctgg gcaacctgct gcaggtggac ctcagtaaca tgccatacag cctctacaag
      241 cttcaacacc gctatggtga cgtgttcagc ctgcagaagg gttggaagcc catggtcatt
      301 gtcaacagac tgaaagcggt gcaggaagtg ctggtgactc atggagagga cactgctgac
      361 cgccctccag tgcccatctt taagtgcctg ggtgtgaagc ccagatccca aggtgtgatc
      421 cttgcatctt acgggcctga gtggcgagag cagaggcgat tctctgtgtc caccctgcgc
      481 accttcggca tgggcaagaa atccctggag gagtgggtga ccaaggaggc cggccacctc
      541 tgtgatgcct tcactgccca ggctgggcag tccatcaatc ccaaggccat gctgaacaaa
      601 gccttgtgta atgtgatcgc atccctcatt tttgcccgtc gctttgaata tgaagaccct
      661 tacctcatca ggatggtgaa actagtggaa gagagtttga cagaagtctc tggtttcatt
      721 cctgaggttc ttaacacgtt cccagcactg ctgcgcatcc cagggctggc tgacaaggtc
      781 ttccaaggtc agaagacctt catggcctta ctggataacc tgctggctga gaacaggacc
      841 acctgggacc ctgcccagcc accccgaaat ctgactgatg ccttcctggc tgaggtggag
      901 aaggccaagg ggaatcctga gagcagcttt aatgatgaga acctacgcat ggtggtagtt
      961 gacctgttca ctgcagggat ggtgaccacc gccaccacac tgacctgggc cctactgctc
     1021 atgattctat acccggatgt gcagcgcaga gtccaacaag agattgatga ggtcataggg
     1081 caggtgcggt gtccagagat gacagaccag gcccacatgc cctacaccaa tgctgtcatc
     1141 catgaggtac agcgctttgg ggacattgct ccattgaatt tgccacgcat cacgagttgt
     1201 gacattgaag tgcaggactt cgtcatcccc aaggggacga ccctcatcat caacctgtcg
     1261 tccgtgctga aggatgagac cgtctgggag aagccccacc gcttccatcc agaacacttc
     1321 ctggatgccc agggcaactt tgtgaagcat gaggccttca tgccattctc agcaggccgc
     1381 agagcatgcc ttggggagcc cctggcccgc atggagctct tcctcttctt cacctgcctc
     1441 ctgcagcgct tcagcttctc cgtgcccgtc ggacagcccc ggcccagcac ccatggcttc
     1501 tttgcttttc cagttgcccc cttgccctac cagctctgtg ctgtggtacg ggagcaagga
     1561 ctctaattcc agtccagctc tacagggcaa gctgagccac gtttaataaa ccagtctttt
     1621 ggc
//
