LOCUS       NM_017158               1730 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily c,
            polypeptide 7 (Cyp2c7), mRNA.
ACCESSION   NM_017158 XM_577864
VERSION     NM_017158.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1730)
  AUTHORS   Sun,D., Jiang,H., Wu,H., Yang,Y., Kaley,G. and Huang,A.
  TITLE     A novel vascular EET synthase: role of CYP2C7
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 301 (6), R1723-R1730 (2011)
   PUBMED   21940400
  REMARK    GeneRIF: CYP2C7 is an endothelial epoxyeicosatrienoic acid (EET)
            synthase in the female rat vasculature, by which, in nitric oxide
            deficiency, shear stress stimulates the release of EETs to initiate
            vasodilation.
REFERENCE   2  (bases 1 to 1730)
  AUTHORS   Agrawal,A.K. and Shapiro,B.H.
  TITLE     Neonatal phenobarbital imprints overexpression of cytochromes P450
            with associated increase in tumorigenesis and reduced life span
  JOURNAL   FASEB J 19 (3), 470-472 (2005)
   PUBMED   15634872
REFERENCE   3  (bases 1 to 1730)
  AUTHORS   Fan,L.Q., Brown-Borg,H., Brown,S., Westin,S., Mode,A. and
            Corton,J.C.
  TITLE     PPARalpha activators down-regulate CYP2C7, a retinoic acid and
            testosterone hydroxylase
  JOURNAL   Toxicology 203 (1-3), 41-48 (2004)
   PUBMED   15363580
REFERENCE   4  (bases 1 to 1730)
  AUTHORS   Wu,C.C., MacCoss,M.J., Mardones,G., Finnigan,C., Mogelsvang,S.,
            Yates,J.R. 3rd and Howell,K.E.
  TITLE     Organellar proteomics reveals Golgi arginine dimethylation
  JOURNAL   Mol Biol Cell 15 (6), 2907-2919 (2004)
   PUBMED   15047867
REFERENCE   5  (bases 1 to 1730)
  AUTHORS   Oinonen,T., Ronis,M., Wigell,T., Tohmo,K., Badger,T. and
            Lindros,K.O.
  TITLE     Growth hormone-regulated periportal expression of CYP2C7 in rat
            liver
  JOURNAL   Biochem Pharmacol 59 (5), 583-589 (2000)
   PUBMED   10660124
REFERENCE   6  (bases 1 to 1730)
  AUTHORS   Henderson,C.J., Russell,A.L., Allan,J.A. and Wolf,C.R.
  TITLE     Sexual differentiation and regulation of cytochrome P-450 CYP2C7
  JOURNAL   Biochim Biophys Acta 1118 (2), 99-106 (1992)
   PUBMED   1370375
REFERENCE   7  (bases 1 to 1730)
  AUTHORS   Westin,S., Strom,A., Gustafsson,J.A. and Zaphiropoulos,P.G.
  TITLE     Growth hormone regulation of the cytochrome P-450IIC subfamily in
            the rat: inductive, repressive, and transcriptional effects on
            P-450f (IIC7) and P-450PB1 (IIC6) gene expression
  JOURNAL   Mol Pharmacol 38 (2), 192-197 (1990)
   PUBMED   2385231
REFERENCE   8  (bases 1 to 1730)
  AUTHORS   Kimura,H., Yoshioka,H., Sogawa,K., Sakai,Y. and Fujii-Kuriyama,Y.
  TITLE     Complementary DNA cloning of cytochrome P-450s related to
            P-450(M-1) from the complementary DNA library of female rat livers.
            Predicted primary structures for P-450f, PB-1, and PB-1-related
            protein with a bizarre replacement block and their mode of
            transcriptional expression
  JOURNAL   J Biol Chem 263 (2), 701-707 (1988)
   PUBMED   3335521
REFERENCE   9  (bases 1 to 1730)
  AUTHORS   Favreau,L.V., Malchoff,D.M., Mole,J.E. and Schenkman,J.B.
  TITLE     Responses to insulin by two forms of rat hepatic microsomal
            cytochrome P-450 that undergo major (RLM6) and minor (RLM5b)
            elevations in diabetes
  JOURNAL   J Biol Chem 262 (29), 14319-14326 (1987)
   PUBMED   3308889
REFERENCE   10 (bases 1 to 1730)
  AUTHORS   Gonzalez,F.J., Kimura,S., Song,B.J., Pastewka,J., Gelboin,H.V. and
            Hardwick,J.P.
  TITLE     Sequence of two related P-450 mRNAs transcriptionally increased
            during rat development. An R.dre.1 sequence occupies the complete
            3' untranslated region of a liver mRNA
  JOURNAL   J Biol Chem 261 (23), 10667-10672 (1986)
   PUBMED   3015936
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M18335.1.
            
            On Aug 30, 2012 this sequence version replaced NM_017158.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: M18335.1, BC127503.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5756307, SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1730              M18335.1           2-1731
FEATURES             Location/Qualifiers
     source          1..1730
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..1730
                     /gene="Cyp2c7"
                     /gene_synonym="Cyp2c39"
                     /note="cytochrome P450, family 2, subfamily c, polypeptide
                     7"
                     /db_xref="GeneID:29298"
                     /db_xref="RGD:620379"
     exon            1..189
                     /gene="Cyp2c7"
                     /gene_synonym="Cyp2c39"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1494
                     /gene="Cyp2c7"
                     /gene_synonym="Cyp2c39"
                     /EC_number="1.14.14.1"
                     /note="PTF1; P450F; CYPIIC7; cytochrome P450F; cytochrome
                     P450, 2c39; cytochrome P450 2C7-like"
                     /codon_start=1
                     /product="cytochrome P450 2C7"
                     /protein_id="NP_058854.1"
                     /db_xref="GeneID:29298"
                     /db_xref="RGD:620379"
                     /translation="MDLVTFLVLTLSSLILLSLWRQSSRRRKLPPGPTPLPIIGNFLQ
                     IDVKNISQSLTKFSKTYGPVFTLYLGSQPTVILHGYEAIKEALIDNGEKFSGRGSYPM
                     NENVTKGFGIVFSNGNRWKEMRRFTIMNFRNLGIGKRNIEDRVQEEAQCLVEELRKTK
                     GSPCDPSLILNCAPCNVICSITFQNHFDYKDKEMLTFMEKVNENLKIMSSPWMQVCNS
                     FPSLIDYFPGTHHKIAKNINYMKSYLLKKIEEHQESLDVTNPRDFVDYYLIKQKQANN
                     IEQSEYSHENLTCSIMDLIGAGTETMSTTLRYALLLLMKYPHVTAKVQEEIDRVIGRH
                     RSPCMQDRKHMPYTDAMIHEVQRFINFVPTNLPHAVTCDIKFRNYLIPKGTKVLTSLT
                     SVLHDSKEFPNPEMFDPGHFLDENGNFKKSDYFLPFSAGKRACVGEGLARMQLFLFLT
                     TILQNFNLKSLVHPKDIDTMPVLNGFASLPPTYQLCFIPS"
     exon            190..352
                     /gene="Cyp2c7"
                     /gene_synonym="Cyp2c39"
                     /inference="alignment:Splign:2.1.0"
     exon            353..502
                     /gene="Cyp2c7"
                     /gene_synonym="Cyp2c39"
                     /inference="alignment:Splign:2.1.0"
     exon            503..663
                     /gene="Cyp2c7"
                     /gene_synonym="Cyp2c39"
                     /inference="alignment:Splign:2.1.0"
     exon            664..840
                     /gene="Cyp2c7"
                     /gene_synonym="Cyp2c39"
                     /inference="alignment:Splign:2.1.0"
     exon            841..982
                     /gene="Cyp2c7"
                     /gene_synonym="Cyp2c39"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1170
                     /gene="Cyp2c7"
                     /gene_synonym="Cyp2c39"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1312
                     /gene="Cyp2c7"
                     /gene_synonym="Cyp2c39"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1730
                     /gene="Cyp2c7"
                     /gene_synonym="Cyp2c39"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcatcagtaa ggagggtctc catggatctg gtcactttcc tggtacttac tctctcctct
       61 ctcattctcc tctcactctg gagacagagc tctaggagaa ggaagctccc tcctggcccc
      121 actcctctcc caataattgg taatttcctc cagatagatg tgaagaacat cagccaatcc
      181 ttaaccaagt tttcaaaaac ctatggccct gtgttcactc tgtatttggg ctcacagccc
      241 actgtcatat tgcatggata tgaagcaata aaggaagctc tgattgataa cggggagaag
      301 ttttctggta gaggaagcta tccaatgaat gaaaatgtta ctaaaggttt tggcattgtt
      361 tttagcaatg gaaacagatg gaaagagatg agacgattca caatcatgaa ctttcggaat
      421 ttgggaattg gaaaaaggaa cattgaggac cgtgttcaag aggaagcaca gtgcctagtg
      481 gaagaactga ggaaaacaaa aggctcaccc tgtgacccct ccttgatcct gaactgtgct
      541 ccatgcaatg tcatctgctc cattactttc cagaatcatt ttgattataa agataaggaa
      601 atgcttacgt tcatggaaaa agtgaatgag aatctcaaga ttatgagctc cccatggatg
      661 caggtctgca atagttttcc ttcactcatt gactattttc ctggaactca tcacaaaata
      721 gcaaaaaata ttaattatat gaaaagctat ttgttgaaga aaatagaaga acaccaggaa
      781 tcattggatg ttacaaaccc tcgtgatttt gttgattatt acctgattaa acaaaaacag
      841 gcaaacaaca tcgaacaatc agaatattca catgaaaatc tgacatgcag tatcatggat
      901 ctcattggtg cagggacaga gacaatgagc acaacattga gatatgctct cctgcttctg
      961 atgaagtacc cacatgtcac agctaaagtc caggaagaga ttgaccgtgt gattggcaga
     1021 catcgcagcc cctgcatgca ggatagaaaa cacatgccct acactgatgc catgattcat
     1081 gaggtacaga gattcattaa ctttgtcccg accaacctgc cccatgcagt gacctgtgac
     1141 attaaattca ggaactacct catcccgaag ggaacaaaag tgttaacatc actgacatca
     1201 gtgctgcatg acagcaagga gttccccaac ccagagatgt ttgaccctgg ccactttcta
     1261 gatgagaatg gaaactttaa gaaaagtgac tactttttgc ctttctcagc aggaaaacga
     1321 gcttgtgttg gagagggcct ggcccgcatg cagttgtttc tattcttgac aaccatttta
     1381 cagaacttta acctgaaatc tctggttcac ccaaaggaca ttgatacgat gccagttctg
     1441 aatggttttg cctctctgcc acccacttac cagctctgct tcattccttc ctgaatagat
     1501 caggcatttt ggcttctact gtgttgcctt ctgcaatccc cttcaggttt ttatccagtc
     1561 ccttccctct atcatccatc ctgactcttg tcttaagatc cagaaagcac atgcagtttc
     1621 tggagttata gcacaaatcc acttgtatta tctctttcat ataacaattt atgatccctt
     1681 gtgtcattgt gtatccattc ctgagttaaa ataaagcttc actataaaat
//
