LOCUS       NM_001013904            1618 bp    mRNA    linear   ROD 15-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily C,
            polypeptide 6 (Cyp2c6), mRNA.
ACCESSION   NM_001013904 XM_215255
VERSION     NM_001013904.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1618)
  AUTHORS   Neyshaburinezhad,N., Rouini,M.R., Entezari,H., Lavasani,H. and
            Hosseinzadeh Ardakani,Y.
  TITLE     Evaluation of changes in cytochrome P450 2C19 activity in type 2
            diabetic rats before and after treatment, by using isolated
            perfused liver model
  JOURNAL   Iran J Basic Med Sci 23 (5), 629-635 (2020)
   PUBMED   32742601
REFERENCE   2  (bases 1 to 1618)
  AUTHORS   Espinoza,N., Galdames,J., Navea,D., Farfan,M.J. and Salas,C.
  TITLE     Frequency of the CYP2C19*17 polymorphism in a Chilean population
            and its effect on voriconazole plasma concentration in
            immunocompromised children
  JOURNAL   Sci Rep 9 (1), 8863 (2019)
   PUBMED   31222084
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1618)
  AUTHORS   Xavier,A.S., Kumar,S.V., Sundaram,R., Francis,J. and Shewade,D.G.
  TITLE     Effect of antituberculosis treatment on CYP2C19 enzyme activity in
            genetically polymorphic South Indian Tamilian population
  JOURNAL   Fundam Clin Pharmacol 30 (6), 607-615 (2016)
   PUBMED   27393733
REFERENCE   4  (bases 1 to 1618)
  AUTHORS   Nabinger,D.D., Mazzoleni,L.E., Sander,G.B., Mazzoleni,F.,
            Osorio,M.C., Klein,M.G., Rech,T.F., Basso da Silva,L., de
            Moraes,G.S., Cristovam,R.A., Nardelli,E.F., Francesconi,C.F. and
            Simon,D.
  TITLE     Influence of CYP2C19 on Helicobacter pylori eradication in
            Brazilian patients with functional dyspepsia
  JOURNAL   Genet Mol Res 15 (3) (2016)
   PUBMED   27706745
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1618)
  AUTHORS   Zhou,B., He,S., Wang,X.I., Zhen,X., Su,X. and Tan,W.
  TITLE     Metabolism of arachidonic acid by the cytochrome P450 enzyme in
            patients with chronic Keshan disease and dilated cardiomyopathy
  JOURNAL   Biomed Rep 4 (2), 251-255 (2016)
   PUBMED   26893848
REFERENCE   6  (bases 1 to 1618)
  AUTHORS   Kimura,H., Sogawa,K., Sakai,Y. and Fujii-Kuriyama,Y.
  TITLE     Alternative splicing mechanism in a cytochrome P-450 (P-450PB-1)
            gene generates the two mRNAs coding for proteins of different
            functions
  JOURNAL   J Biol Chem 264 (4), 2338-2342 (1989)
   PUBMED   2914909
REFERENCE   7  (bases 1 to 1618)
  AUTHORS   Umeno,M., Morris,S., Matsunaga,E., Gelboin,H.V. and Gonzalez,F.J.
  TITLE     Sequence of the 5' end of the developmentally regulated rat P450
            PB1 (P450IIC6) gene
  JOURNAL   Nucleic Acids Res 16 (13), 6249 (1988)
   PUBMED   3399405
REFERENCE   8  (bases 1 to 1618)
  AUTHORS   Kimura,H., Yoshioka,H., Sogawa,K., Sakai,Y. and Fujii-Kuriyama,Y.
  TITLE     Complementary DNA cloning of cytochrome P-450s related to
            P-450(M-1) from the complementary DNA library of female rat livers.
            Predicted primary structures for P-450f, PB-1, and PB-1-related
            protein with a bizarre replacement block and their mode of
            transcriptional expression
  JOURNAL   J Biol Chem 263 (2), 701-707 (1988)
   PUBMED   3335521
REFERENCE   9  (bases 1 to 1618)
  AUTHORS   Friedberg,T., Waxman,D.J., Atchison,M., Kumar,A., Haaparanta,T.,
            Raphael,C. and Adesnik,M.
  TITLE     Isolation and characterization of cDNA clones for cytochromes P-450
            immunochemically related to rat hepatic P-450 form PB-1
  JOURNAL   Biochemistry 25 (24), 7975-7983 (1986)
   PUBMED   3801454
REFERENCE   10 (bases 1 to 1618)
  AUTHORS   Gonzalez,F.J., Kimura,S., Song,B.J., Pastewka,J., Gelboin,H.V. and
            Hardwick,J.P.
  TITLE     Sequence of two related P-450 mRNAs transcriptionally increased
            during rat development. An R.dre.1 sequence occupies the complete
            3' untranslated region of a liver mRNA
  JOURNAL   J Biol Chem 261 (23), 10667-10672 (1986)
   PUBMED   3015936
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001013904.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M13711.1, K03501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               JAXUCZ010000001.1  247879087-247879264
            179-341             JAXUCZ010000001.1  247888292-247888454
            342-491             JAXUCZ010000001.1  247888629-247888778
            492-652             JAXUCZ010000001.1  247889618-247889778
            653-829             JAXUCZ010000001.1  247890849-247891025
            830-971             JAXUCZ010000001.1  247910347-247910488
            972-1159            JAXUCZ010000001.1  247913385-247913572
            1160-1301           JAXUCZ010000001.1  247915175-247915316
            1302-1618           JAXUCZ010000001.1  247916473-247916789
FEATURES             Location/Qualifiers
     source          1..1618
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..1618
                     /gene="Cyp2c6"
                     /gene_synonym="Cyp2c6v1; CYPIIC6; PB1; PTF2"
                     /note="cytochrome P450, family 2, subfamily C, polypeptide
                     6"
                     /db_xref="GeneID:293989"
                     /db_xref="RGD:619934"
     exon            1..178
                     /gene="Cyp2c6"
                     /gene_synonym="Cyp2c6v1; CYPIIC6; PB1; PTF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1483
                     /gene="Cyp2c6"
                     /gene_synonym="Cyp2c6v1; CYPIIC6; PB1; PTF2"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450, subfamily IIC6; cytochrome P450
                     PB1"
                     /codon_start=1
                     /product="cytochrome P450 2C6"
                     /protein_id="NP_001013926.2"
                     /db_xref="GeneID:293989"
                     /db_xref="RGD:619934"
                     /translation="MDLVMLLVLTLTCLILLSIWRQSSGRGKLPPGPIPLPIIGNIFQ
                     LNVKNITQSLTSFSKVYGPVFTLYFGTKPTVILHGYEAVKEALIDHGEEFAERGSFPV
                     AEKINKDLGIVFSHGNRWKEIRRFTLTTLRNLGMGKRNIEDRVQEEARCLVEELRKTN
                     GSPCDPTFILGCAPCNVICSIIFQNRFDYKDQDFLNLMEKLNENMKILSSPWTQFCSF
                     FPVLIDYCPGSHTTLAKNVYHIRNYLLKKIKEHQESLDVTNPRDFIDYYLIKWKQENH
                     NPHSEFTLENLSITVTDLFGAGTETTSTTLRYALLLLLKCPEVTAKVQEEIDRVVGKH
                     RSPCMQDRSRMPYTDAMIHEVQRFIDLIPTNLPHAVTCDIKFRNYLIPKGTTIITSLS
                     SVLHDSKEFPDPEIFDPGHFLDGNGKFKKSDYFMPFSAGKRMCAGEGLARMELFLFLT
                     TILQNFKLKSVLHPKDIDTTPVFNGFASLPPFYELCFIPL"
     exon            179..341
                     /gene="Cyp2c6"
                     /gene_synonym="Cyp2c6v1; CYPIIC6; PB1; PTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            342..491
                     /gene="Cyp2c6"
                     /gene_synonym="Cyp2c6v1; CYPIIC6; PB1; PTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            492..652
                     /gene="Cyp2c6"
                     /gene_synonym="Cyp2c6v1; CYPIIC6; PB1; PTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            653..829
                     /gene="Cyp2c6"
                     /gene_synonym="Cyp2c6v1; CYPIIC6; PB1; PTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            830..971
                     /gene="Cyp2c6"
                     /gene_synonym="Cyp2c6v1; CYPIIC6; PB1; PTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1159
                     /gene="Cyp2c6"
                     /gene_synonym="Cyp2c6v1; CYPIIC6; PB1; PTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1301
                     /gene="Cyp2c6"
                     /gene_synonym="Cyp2c6v1; CYPIIC6; PB1; PTF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1618
                     /gene="Cyp2c6"
                     /gene_synonym="Cyp2c6v1; CYPIIC6; PB1; PTF2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaaactca atggatctgg tcatgttgct ggtgctcact ctcacctgtc ttattctcct
       61 gtcaatctgg agacagagtt ctgggagagg aaagctcccc ccaggcccta ttcctctccc
      121 aattattggc aatatctttc agctaaatgt gaagaacatc acccaatcct taaccagttt
      181 ctcaaaagtg tatggtcctg tatttactct ttactttggc acgaagccca ctgtgatatt
      241 gcatggatat gaagcagtaa aagaagcctt gattgatcat ggggaggagt ttgctgaaag
      301 aggaagcttc ccagtagctg aaaaaattaa taaagacctt ggaattgttt ttagccatgg
      361 aaatagatgg aaagaaataa gacgctttac cctcacgact ctgcggaatt tgggcatggg
      421 gaaaaggaac attgaggatc gtgttcaaga ggaagcacgg tgccttgtgg aggaactgag
      481 gaaaaccaat ggctcaccct gtgaccccac gtttatcctg ggctgtgctc cttgcaatgt
      541 catctgctcc attattttcc agaatcgttt tgattataaa gatcaggatt ttcttaactt
      601 gatggaaaaa ctcaatgaga acatgaagat tttgagcagt ccctggacac agttttgcag
      661 ttttttccct gttttaattg attattgtcc gggaagtcat acgacattag ctaaaaatgt
      721 gtatcatatt agaaactacc ttctgaagaa aataaaagag catcaagaat cactggatgt
      781 tacaaatccc cgggacttta ttgattatta cctaattaag tggaagcagg aaaatcacaa
      841 tccacattcg gaatttacac ttgaaaactt atcaatcact gtgactgatt tgtttggtgc
      901 tgggacagag acaacaagca caacactgag atatgctctg ttgctcctgc tgaagtgtcc
      961 agaggtcaca gctaaagtcc aggaagagat tgatcgtgtg gttggcaaac atcgcagccc
     1021 ttgcatgcag gacaggagcc gcatgcccta cacagatgcc atgattcatg aggtccagag
     1081 gttcattgac ctcattccta ccaacctgcc acatgcggtg acctgtgaca ttaagttcag
     1141 gaactaccta atacccaagg gaacaacaat aataacatca ctctcatcag tgctgcatga
     1201 cagcaaggaa ttccccgacc cagagatatt tgaccctggc cactttttag atgggaatgg
     1261 aaagtttaag aaaagtgact atttcatgcc tttctcagca ggaaaacgga tgtgtgcagg
     1321 agagggccta gcccgcatgg agttattttt attcctgacc acgattttac aaaactttaa
     1381 gctgaaatct gtacttcacc caaaggatat cgatacaact ccagttttca atggatttgc
     1441 ctctctgcca ccattttatg agctgtgctt cattcctctc taaagagatc aaattggctg
     1501 gggatttagc tcagtggtag agcgcttacc taggaagcgc aaggccctgg gttcggtccc
     1561 cagctccgaa aaaaagaacc aaaaaaaaat aaataaataa ataaataaag agatcaaa
//
