LOCUS       NM_031839               1954 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily c,
            polypeptide 23 (Cyp2c23), mRNA.
ACCESSION   NM_031839 XM_346585
VERSION     NM_031839.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1954)
  AUTHORS   Munoz,M., Lopez-Oliva,M.E., Pinilla,E., Martinez,M.P., Sanchez,A.,
            Rodriguez,C., Garcia-Sacristan,A., Hernandez,M., Rivera,L. and
            Prieto,D.
  TITLE     CYP epoxygenase-derived H2O2 is involved in the endothelium-derived
            hyperpolarization (EDH) and relaxation of intrarenal arteries
  JOURNAL   Free Radic Biol Med 106, 168-183 (2017)
   PUBMED   28212823
  REMARK    GeneRIF: CYP2C11 and CYP2C23 epoxygenases were highly expressed in
            interlobar renal arteries and renal cortex, respectively, and were
            co-localized with eNOS in renal endothelial cells. These results
            demonstrate that H2O2 is involved in the EDH-type relaxant
            responses of renal arteries and that CYP 2C epoxygenases are
            physiologically relevant endothelial sources of vasodilator H2O2 in
            the kidney.
REFERENCE   2  (bases 1 to 1954)
  AUTHORS   Sarkar,P., Narayanan,J. and Harder,D.R.
  TITLE     Differential effect of amyloid beta on the cytochrome P450
            epoxygenase activity in rat brain
  JOURNAL   Neuroscience 194, 241-249 (2011)
   PUBMED   21843605
  REMARK    GeneRIF: Epoxygenase activity of cultured astrocytes and neurons
            shows reduction in total epoxyeicosatrienoic acids and DiHETE
            production (to 80% and approximately 70% of vehicle respectively)
            in presence of amyloid beta.
REFERENCE   3  (bases 1 to 1954)
  AUTHORS   Wang,R.X., Chai,Q., Lu,T. and Lee,H.C.
  TITLE     Activation of vascular BK channels by docosahexaenoic acid is
            dependent on cytochrome P450 epoxygenase activity
  JOURNAL   Cardiovasc Res 90 (2), 344-352 (2011)
   PUBMED   21187320
  REMARK    GeneRIF: docosahexaenoic acid-mediated vasodilatation is mediated
            through CYP epoxygenase metabolites by activation of vascular BK
            channels
REFERENCE   4  (bases 1 to 1954)
  AUTHORS   Sun,P., Lin,D.H., Yue,P., Jiang,H., Gotlinger,K.H.,
            Schwartzman,M.L., Falck,J.R., Goli,M. and Wang,W.H.
  TITLE     High potassium intake enhances the inhibitory effect of 11,12-EET
            on ENaC
  JOURNAL   J Am Soc Nephrol 21 (10), 1667-1677 (2010)
   PUBMED   20595684
  REMARK    GeneRIF: High dietary potassium enhances the inhibitory effect of
            arachidonic acid and 11,12-epoxyeicosatrienoic acid on ENaC by
            increasing cytochrome P450 epoxygenase activity and decreasing
            soluble epoxide hydrolase activity, respectively.
REFERENCE   5  (bases 1 to 1954)
  AUTHORS   Singh,H. and Schwartzman,M.L.
  TITLE     Renal vascular cytochrome P450-derived eicosanoids in
            androgen-induced hypertension
  JOURNAL   Pharmacol Rep 60 (1), 29-37 (2008)
   PUBMED   18276983
  REMARK    GeneRIF: Increased vascular tone brought about by downregulation of
            CYP2C23 and decreased levels of vasodilatory EETs may constitute
            important factors in androgen-induced hypertension.
REFERENCE   6  (bases 1 to 1954)
  AUTHORS   Muller,D.N., Theuer,J., Shagdarsuren,E., Kaergel,E., Honeck,H.,
            Park,J.K., Markovic,M., Barbosa-Sicard,E., Dechend,R., Wellner,M.,
            Kirsch,T., Fiebeler,A., Rothe,M., Haller,H., Luft,F.C. and
            Schunck,W.H.
  TITLE     A peroxisome proliferator-activated receptor-alpha activator
            induces renal CYP2C23 activity and protects from angiotensin
            II-induced renal injury
  JOURNAL   Am J Pathol 164 (2), 521-532 (2004)
   PUBMED   14742258
REFERENCE   7  (bases 1 to 1954)
  AUTHORS   Holla,V.R., Makita,K., Zaphiropoulos,P.G. and Capdevila,J.H.
  TITLE     The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is
            upregulated during dietary salt loading
  JOURNAL   J Clin Invest 104 (6), 751-760 (1999)
   PUBMED   10491410
REFERENCE   8  (bases 1 to 1954)
  AUTHORS   Imaoka,S., Wedlund,P.J., Ogawa,H., Kimura,S., Gonzalez,F.J. and
            Kim,H.Y.
  TITLE     Identification of CYP2C23 expressed in rat kidney as an arachidonic
            acid epoxygenase
  JOURNAL   J Pharmacol Exp Ther 267 (2), 1012-1016 (1993)
   PUBMED   8246128
REFERENCE   9  (bases 1 to 1954)
  AUTHORS   Karara,A., Makita,K., Jacobson,H.R., Falck,J.R., Guengerich,F.P.,
            DuBois,R.N. and Capdevila,J.H.
  TITLE     Molecular cloning, expression, and enzymatic characterization of
            the rat kidney cytochrome P-450 arachidonic acid epoxygenase
  JOURNAL   J Biol Chem 268 (18), 13565-13570 (1993)
   PUBMED   8514789
REFERENCE   10 (bases 1 to 1954)
  AUTHORS   Cook,E.A., Groenewegen,W.A., Gloger,I.S., Piggott,J.R.,
            Suckling,K.E. and Wolf,C.R.
  TITLE     cDNA and deduced amino acid sequence of a novel cytochrome P-450
            from female rat liver mRNA with high homology to P-450 IIC family
  JOURNAL   Nucleic Acids Res 18 (23), 7156 (1990)
   PUBMED   2263487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC078707.1.
            
            On Apr 5, 2007 this sequence version replaced NM_031839.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078707.1, U04733.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1954              BC078707.1         1-1954
FEATURES             Location/Qualifiers
     source          1..1954
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1954
                     /gene="Cyp2c23"
                     /note="cytochrome P450, family 2, subfamily c, polypeptide
                     23"
                     /db_xref="GeneID:83790"
                     /db_xref="RGD:620370"
     exon            1..204
                     /gene="Cyp2c23"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1509
                     /gene="Cyp2c23"
                     /EC_number="1.14.14.1"
                     /note="CYPIIC23; arachidonic acid epoxygenase"
                     /codon_start=1
                     /product="cytochrome P450 2C23"
                     /protein_id="NP_114027.2"
                     /db_xref="GeneID:83790"
                     /db_xref="RGD:620370"
                     /translation="MELLGFTTLALVVSVTCLSLLSVWTKLRTRGRLPPGPTPLPIIG
                     NLLQLNLKDIPASLSKLAKEYGPVYTLYFGTSPTVVLHGYDVVKEALLQQGDEFLGRG
                     PLPIIEDTHKGYGLIFSNGERWKVMRRFSLMTLRNFGMGKRSLEERVQEEARCLVEEL
                     QKTKAQPFDPTFILACAPCNVICSILFNDRFQYNNKTFLNLMDLLNKNFQQVNSVWCQ
                     MYNLWPTIIKYLPGKHIEFAKRIDDVKNFILEKVKEHQKSLDPANPRDYIDCFLSKIE
                     EEKDNLKSEFHLENLAVCGSNLFTAGTETTSTTLRFGLLLLMKYPEVQAKVHEELDRV
                     IGRHQPPSMKDKMKLPYTDAVLHEIQRYITLLPSSLPHAVVQDTKFRDYVIPKGTTVL
                     PMLSSVMLDQKEFANPEKFDPGHFLDKNGCFKKTDYFVPFSLGKRACVGESLARMELF
                     LFFTTLLQKFSLKTLVEPKDLDIKPITTGIINLPPPYKLCLVPR"
     exon            205..367
                     /gene="Cyp2c23"
                     /inference="alignment:Splign:2.1.0"
     exon            368..517
                     /gene="Cyp2c23"
                     /inference="alignment:Splign:2.1.0"
     exon            518..678
                     /gene="Cyp2c23"
                     /inference="alignment:Splign:2.1.0"
     exon            679..855
                     /gene="Cyp2c23"
                     /inference="alignment:Splign:2.1.0"
     exon            856..997
                     /gene="Cyp2c23"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1185
                     /gene="Cyp2c23"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1327
                     /gene="Cyp2c23"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1930
                     /gene="Cyp2c23"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccatgaac atcccagggc taaaatggag ctgctgggat tcactacgct tgctctcgtg
       61 gtttcggtga cttgcctcag cctcctttca gtgtggacaa aactgcgcac tagggggagg
      121 ctgcccccgg gccccacccc ccttcccatt attgggaatc tactgcaact gaacctcaag
      181 gacatccctg catcgctttc caagctggcc aaagagtacg ggcctgttta cacgctgtac
      241 tttggaacct ctcctactgt ggtcctacat ggctatgatg tggtgaagga ggcgcttctc
      301 cagcaagggg atgagttcct cgggagagga cctctgccca tcatcgaaga tacccataag
      361 ggatatggac tcattttcag taatggagag aggtggaaag tcatgcgacg cttctccctc
      421 atgactctga ggaacttcgg aatggggaag agaagcctag aggagagggt gcaggaggaa
      481 gcccggtgcc ttgtggagga attacaaaaa acaaaagctc agccctttga ccccaccttc
      541 atcctggcct gtgctccctg caacgtgatc tgctccattc ttttcaacga tcgattccag
      601 tacaacaaca agacgttcct caaccttatg gatcttttaa ataaaaattt tcaacaagtg
      661 aactccgtgt ggtgccagat gtacaacctt tggccaacga tcataaagta tctccctgga
      721 aagcatatag aatttgcaaa aagaattgat gatgttaaaa acttcattct tgaaaaagtg
      781 aaggaacacc agaagtccct ggatcctgcc aaccctcggg actacattga ctgttttctc
      841 agcaagattg aggaggagaa ggacaacctg aagtctgagt tccatctgga gaacttggct
      901 gtctgtgggt ctaacttgtt tacggcaggc accgagacaa ccagcaccac cctgagattc
      961 gggctcctgc tccttatgaa gtatccagag gtgcaagcca aagttcatga ggaacttgac
     1021 cgtgtgattg gacgccacca accccccagc atgaaggaca agatgaagct gccttatacc
     1081 gatgctgtat tgcatgagat tcaaagatac atcactctcc ttccttccag tctgccccat
     1141 gctgtggtcc aggacacaaa attcagagac tatgtcatcc ccaagggtac tactgtactc
     1201 ccgatgctgt cttccgtcat gctggatcaa aaggagtttg ccaacccaga gaagtttgat
     1261 ccaggacact ttctggataa aaatggctgc ttcaagaaga cagactactt tgttcccttc
     1321 tcccttggaa agcgggcctg tgttggtgag agtttggccc ggatggagct cttcctgttc
     1381 ttcaccaccc ttctgcaaaa gttttccctg aagactctgg tggagcccaa ggaccttgac
     1441 atcaagccta ttactaccgg gattatcaat ttgccgccac cttacaagct gtgccttgtt
     1501 cctagataag ggtttatcct tctaatcatt caaatcaaag taattgtttc ctttttctat
     1561 aaatattctt tttatgctaa gcactgccta ggccagaaac atcatgcatg aaaaccacat
     1621 ggacatttat ttcgatttaa aaatctaggt cttaaaagct tccaggacac aggcagtgtg
     1681 tctgtgtccc tcaactgctc tagaaaccag gccccaagca caactgacac cagatatgca
     1741 agaccctcat cagacgccac ctacaagtag cactgtgtgc tcttctgtag ctttggaaat
     1801 agaattgttt tctgtcattg tttcaataga gaaattaatg taatggccta cgttcatttt
     1861 cctgttcaca cttaaaaaca tttacatgat ttgtgccaca ttcacaaaat aaattctcac
     1921 cctgacaata aaaaaaaaaa aaaaaaaaaa aaaa
//
