LOCUS       NM_138512               1712 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily c,
            polypeptide 22 (Cyp2c22), mRNA.
ACCESSION   NM_138512
VERSION     NM_138512.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1712)
  AUTHORS   Lee,C.M., Lee,B.S., Arnold,S.L., Isoherranen,N. and Morgan,E.T.
  TITLE     Nitric oxide and interleukin-1beta stimulate the
            proteasome-independent degradation of the retinoic acid hydroxylase
            CYP2C22 in primary rat hepatocytes
  JOURNAL   J Pharmacol Exp Ther 348 (1), 141-152 (2014)
   PUBMED   24144795
  REMARK    GeneRIF: CYP2C22 protein is rapidly downregulated in primary rat
            hepatocytes by interleukin(IL)-1beta or nitric oxide-donating
            compounds.
REFERENCE   2  (bases 1 to 1712)
  AUTHORS   Qian,L., Zolfaghari,R. and Ross,A.C.
  TITLE     Liver-specific cytochrome P450 CYP2C22 is a direct target of
            retinoic acid and a retinoic acid-metabolizing enzyme in rat liver
  JOURNAL   J Lipid Res 51 (7), 1781-1792 (2010)
   PUBMED   20147703
  REMARK    GeneRIF: Data demonstrate that CYP2C22 is a high-abundance,
            retinoid-inducible, hepatic P450 with the potential to metabolize
            at-RA, providing additional insight into the role of the CYP2C gene
            family in retinoid homeostasis.
REFERENCE   3  (bases 1 to 1712)
  AUTHORS   Emi,Y., Chijiiwa,C. and Omura,T.
  TITLE     A different cytochrome P450 form is induced in primary cultures of
            rat hepatocytes
  JOURNAL   Proc Natl Acad Sci U S A 87 (24), 9746-9750 (1990)
   PUBMED   2263625
REFERENCE   4  (bases 1 to 1712)
  AUTHORS   Nagata,K., Sasamura,H., Miyata,M., Shimada,M., Yamazoe,Y. and
            Kato,R.
  TITLE     cDNA and deduced amino acid sequences of a male dominant P-450Md
            mRNA in rats
  JOURNAL   Nucleic Acids Res 18 (16), 4934 (1990)
   PUBMED   2395662
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 2, 2020 this sequence version replaced NM_138512.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M58041.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                JAXUCZ010000001.1  248980757-248980767 c
            12-182              JAXUCZ010000001.1  248970991-248971161 c
            183-345             JAXUCZ010000001.1  248968228-248968390 c
            346-495             JAXUCZ010000001.1  248966148-248966297 c
            496-656             JAXUCZ010000001.1  248956443-248956603 c
            657-830             JAXUCZ010000001.1  248953944-248954117 c
            831-972             JAXUCZ010000001.1  248952941-248953082 c
            973-1160            JAXUCZ010000001.1  248947579-248947766 c
            1161-1302           JAXUCZ010000001.1  248944328-248944469 c
            1303-1712           JAXUCZ010000001.1  248941143-248941552 c
FEATURES             Location/Qualifiers
     source          1..1712
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1712
                     /gene="Cyp2c22"
                     /gene_synonym="Cyp2c70; CYPIIC70; P-450Md"
                     /note="cytochrome P450, family 2, subfamily c, polypeptide
                     22"
                     /db_xref="GeneID:171518"
                     /db_xref="RGD:620368"
     exon            1..11
                     /gene="Cyp2c22"
                     /gene_synonym="Cyp2c70; CYPIIC70; P-450Md"
                     /inference="alignment:Splign:2.1.0"
     exon            12..182
                     /gene="Cyp2c22"
                     /gene_synonym="Cyp2c70; CYPIIC70; P-450Md"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1484
                     /gene="Cyp2c22"
                     /gene_synonym="Cyp2c70; CYPIIC70; P-450Md"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450 2C70; cytochrome P-450Md;
                     cytochrome P450 P49; cytochrome P450, family 2, subfamily
                     c, polypeptide 70; cytochrome P450 2c22"
                     /codon_start=1
                     /product="cytochrome P450 2C70 precursor"
                     /protein_id="NP_612521.2"
                     /db_xref="GeneID:171518"
                     /db_xref="RGD:620368"
                     /translation="MALFIFLGIWLSCLVFLFLWNQHHVRRKLPPGPTPLPIFGNILQ
                     VGVKNISKSMCMLAKEYGPVFTMYLGMKPTVVLYGYEVLKEALIDRGEEFSDKMHSSM
                     LSKVSQGLGIVFSNGEIWKQTRRFSLMVLRSMGMGKRTIENRIQEEVVYLLEALRKTN
                     GSPCDPSFLLACVPCNVISSVIFQHRFDYSDEKFQKFIENFHTKIEILASPWAQLCSA
                     YPVLYYLPGIHNKFLKDVTEQKKFILMEINRHRASLNLSNPQDFIDYFLIKMEKEKHN
                     EKSEFTMDNLIVTIGDLFGAGTETTSSTIKYGLLLLLKYPEVTAKIQEEITRVIGRHR
                     RPCMQDRNHMPYTDAVLHEIQRYIDFVPIPLPRKTTQDVEFRGYHIPKGTSVMACLTS
                     ALHDDKEFPNPEKFDPGHFLDEKGNFKKSDYFMAFSAGRRACIGEGLARMEMFLILTS
                     ILQHFTLKPLVNPEDIDTTPVQPGLLSVPPPFELCFIPV"
     exon            183..345
                     /gene="Cyp2c22"
                     /gene_synonym="Cyp2c70; CYPIIC70; P-450Md"
                     /inference="alignment:Splign:2.1.0"
     exon            346..495
                     /gene="Cyp2c22"
                     /gene_synonym="Cyp2c70; CYPIIC70; P-450Md"
                     /inference="alignment:Splign:2.1.0"
     exon            496..656
                     /gene="Cyp2c22"
                     /gene_synonym="Cyp2c70; CYPIIC70; P-450Md"
                     /inference="alignment:Splign:2.1.0"
     exon            657..830
                     /gene="Cyp2c22"
                     /gene_synonym="Cyp2c70; CYPIIC70; P-450Md"
                     /inference="alignment:Splign:2.1.0"
     exon            831..972
                     /gene="Cyp2c22"
                     /gene_synonym="Cyp2c70; CYPIIC70; P-450Md"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1160
                     /gene="Cyp2c22"
                     /gene_synonym="Cyp2c70; CYPIIC70; P-450Md"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1302
                     /gene="Cyp2c22"
                     /gene_synonym="Cyp2c70; CYPIIC70; P-450Md"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1712
                     /gene="Cyp2c22"
                     /gene_synonym="Cyp2c70; CYPIIC70; P-450Md"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacaagaca gccaatggct ctcttcattt ttctggggat ttggctttct tgtttggttt
       61 ttctttttct atggaatcag caccatgtca gaaggaagct cccacctggt cccactcctc
      121 taccaatttt tggcaatatt ttgcaagtgg gtgttaaaaa tatcagcaaa tctatgtgca
      181 tgctagcaaa agagtacggg cctgtgttca ccatgtatct gggcatgaag cccactgtgg
      241 tgctgtatgg atatgaagta ttgaaagaag ctctgattga ccggggagaa gagttttctg
      301 ataaaatgca ttcgtcaatg ctcagtaaag tcagccaagg gttaggcatt gtcttcagca
      361 atggagaaat atggaaacaa acacggcgtt tctccctcat ggtcttaagg tctatgggga
      421 tgggaaagag aactattgaa aaccgaattc aggaggaagt tgtttatctg ctggaagcac
      481 tgagaaaaac caatgggtcc ccctgtgacc ccagcttcct tctggcctgt gttccctgca
      541 atgtgatctc cagtgtcatt ttccagcacc gttttgacta cagtgatgag aaattccaaa
      601 aattcataga gaatttccat acaaaaattg aaattttagc atctccttgg gcccagttgt
      661 gcagtgccta tcctgttcta tactatctcc cgggaatcca taacaaattc ttaaaagatg
      721 tgactgaaca gaaaaagttc atcttgatgg aaataaacag gcatcgagca tctctgaacc
      781 tcagtaaccc tcaggacttt attgactatt tcctgattaa aatggaaaag gaaaaacaca
      841 atgaaaagtc tgaatttacc atggacaacc tgatagtcac cataggtgat ctttttggag
      901 caggaacaga gacaacgagt tccaccataa aatatgggct tttgctcttg ctgaagtacc
      961 cagaggtcac agctaaaatt caggaagaaa ttactcgcgt gattggtaga caccggagac
     1021 cctgcatgca ggacaggaac cacatgccct atacggatgc tgtgctgcat gagatccaga
     1081 gatacattga ttttgttccc attcccttgc ctcgtaagac aacgcaggat gtggagttca
     1141 gaggatacca cattcccaag ggcacaagcg taatggcatg tctgacttct gccctgcacg
     1201 atgacaaaga atttcccaac ccagagaagt tcgaccctgg ccactttctc gatgaaaaag
     1261 gcaacttcaa gaagagtgac tacttcatgg ctttctcagc aggaagaaga gcctgtattg
     1321 gagaaggttt agcccgcatg gagatgttct taatcctgac cagcatttta cagcatttta
     1381 ctttaaaacc tcttgtcaat ccagaggaca tcgacacaac cccagttcaa cctggtttat
     1441 tgtctgtgcc cccacccttt gagctctgtt tcattccagt ctgaagcggc atagtctttc
     1501 acacagatga ctgagaccct gcttctactt gtgagcaaac aggtcctcct gtcctgtgta
     1561 cctgtaactg gcagtccttc ctgaatggca gggatgctac ctctgaactg tcctacattt
     1621 ttttcaattc tttgtgaacc agttccaatt tttcatatgt gaaaaaactt cactgtttta
     1681 gcactaataa agtttttttg tagtgtatgt ca
//
