LOCUS       NM_031572               1713 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily c,
            polypeptide 12 (Cyp2c12), mRNA.
ACCESSION   NM_031572 NM_012709 XM_003749107
VERSION     NM_031572.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1713)
  AUTHORS   Endo,M., Takahashi,Y., Sasaki,Y., Saito,T. and Kamataki,T.
  TITLE     Novel gender-related regulation of CYP2C12 gene expression in rats
  JOURNAL   Mol Endocrinol 19 (5), 1181-1190 (2005)
   PUBMED   15661834
  REMARK    GeneRIF: gender-related expression results from the inaccessibility
            of STAT5 to the GH-responsive element in male
REFERENCE   2  (bases 1 to 1713)
  AUTHORS   Zaphiropoulos,P.G., Mode,A., Strom,A., Moller,C., Fernandez,C. and
            Gustafsson,J.A.
  TITLE     cDNA cloning, sequence, and regulation of a major female-specific
            and growth hormone-inducible rat liver cytochrome P-450 active in
            15 beta-hydroxylation of steroid sulfates
  JOURNAL   Proc Natl Acad Sci U S A 85 (12), 4214-4217 (1988)
   PUBMED   2837761
REFERENCE   3  (bases 1 to 1713)
  AUTHORS   Zaphiropoulos,P.G., Mode,A., Strom,A., Husman,B., Andersson,G. and
            Gustafsson,J.A.
  TITLE     Sequence and regulation of two growth-hormone-controlled,
            sex-specific isozymes of cytochrome P-450 in rat liver,
            P-450(15)beta and P-450(16)alpha
  JOURNAL   Acta Med Scand Suppl 723, 161-167 (1988)
   PUBMED   3164963
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031572.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03786.1, BC089790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               JAXUCZ010000001.1  248676867-248677034 c
            169-331             JAXUCZ010000001.1  248675576-248675738 c
            332-481             JAXUCZ010000001.1  248675299-248675448 c
            482-642             JAXUCZ010000001.1  248665814-248665974 c
            643-819             JAXUCZ010000001.1  248664532-248664708 c
            820-961             JAXUCZ010000001.1  248641994-248642135 c
            962-1149            JAXUCZ010000001.1  248635468-248635655 c
            1150-1291           JAXUCZ010000001.1  248626838-248626979 c
            1292-1713           JAXUCZ010000001.1  248619887-248620308 c
FEATURES             Location/Qualifiers
     source          1..1713
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..1713
                     /gene="Cyp2c12"
                     /gene_synonym="Cyp2c40; P450pb1; RATP4515B2; RATP4515B8"
                     /note="cytochrome P450, family 2, subfamily c, polypeptide
                     12"
                     /db_xref="GeneID:25011"
                     /db_xref="RGD:2470"
     CDS             1..1473
                     /gene="Cyp2c12"
                     /gene_synonym="Cyp2c40; P450pb1; RATP4515B2; RATP4515B8"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450, 2c40; UT-1; P450I; 15-beta;
                     CYPIIC12; P450-UT-I; cytochrome P450I; cytochrome
                     P450-UT-1; cytochrome P450-UT-I; cytochrome P450 15-beta;
                     cytochrome P450, family 2, subfamily c, polypeptide 40;
                     Cytochrom P450 15-beta"
                     /codon_start=1
                     /product="cytochrome P450 2C12, female-specific"
                     /protein_id="NP_113760.2"
                     /db_xref="GeneID:25011"
                     /db_xref="RGD:2470"
                     /translation="MDPFVVLVLSLSFLLLLYLWRPSPGRGKLPPGPTPLPIFGNFLQ
                     IDMKDIRQSISNFSKTYGPVFTLYFGSQPTVVLHGYEAVKEALIDYGEEFSGRGRMPV
                     FEKATKGLGISFSRGNVWRATRHFTVNTLRSLGMGKRTIEIKVQEEAEWLVMELKKTK
                     GSPCDPKFIIGCAPCNVICSIIFQNRFDYKDKDFLSLIENVNEYIKIVSTPAFQVFNA
                     FPILLDYCPGNHKTHSKHFAAIKSYLLKKIKEHEESLDVSNPRDFIDYFLIQRCQENG
                     NQQMNYTQEHLAILVTNLFIGGTETSSLTLRFALLLLMKYPHITDKVQEEIGQVIGRH
                     RSPCMLDRIHMPYTNAMIHEVQRYIDLAPNGLLHEVTCDTKFRDYFIPKGTAVLTSLT
                     SVLHDSKEFPNPEMFDPGHFLDENGNFKKSDYFMPFSAGKRKCVGEGLASMELFLFLT
                     TILQNFKLKSLSDPKDIDINSIRSEFSSIPPTFQLCFIPV"
     exon            1..168
                     /gene="Cyp2c12"
                     /gene_synonym="Cyp2c40; P450pb1; RATP4515B2; RATP4515B8"
                     /inference="alignment:Splign:2.1.0"
     exon            169..331
                     /gene="Cyp2c12"
                     /gene_synonym="Cyp2c40; P450pb1; RATP4515B2; RATP4515B8"
                     /inference="alignment:Splign:2.1.0"
     exon            332..481
                     /gene="Cyp2c12"
                     /gene_synonym="Cyp2c40; P450pb1; RATP4515B2; RATP4515B8"
                     /inference="alignment:Splign:2.1.0"
     exon            482..642
                     /gene="Cyp2c12"
                     /gene_synonym="Cyp2c40; P450pb1; RATP4515B2; RATP4515B8"
                     /inference="alignment:Splign:2.1.0"
     exon            643..819
                     /gene="Cyp2c12"
                     /gene_synonym="Cyp2c40; P450pb1; RATP4515B2; RATP4515B8"
                     /inference="alignment:Splign:2.1.0"
     exon            820..961
                     /gene="Cyp2c12"
                     /gene_synonym="Cyp2c40; P450pb1; RATP4515B2; RATP4515B8"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1149
                     /gene="Cyp2c12"
                     /gene_synonym="Cyp2c40; P450pb1; RATP4515B2; RATP4515B8"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1291
                     /gene="Cyp2c12"
                     /gene_synonym="Cyp2c40; P450pb1; RATP4515B2; RATP4515B8"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1713
                     /gene="Cyp2c12"
                     /gene_synonym="Cyp2c40; P450pb1; RATP4515B2; RATP4515B8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggatccat ttgtggtctt ggtgctcagt ctgtcctttc tgcttctcct gtatctatgg
       61 agaccaagcc ctgggagagg gaagcttcct cctggcccta ctcctctccc aatttttgga
      121 aattttcttc agatagatat gaaggacatc cgtcaatcaa tatccaattt ttctaaaacc
      181 tatggccctg tgttcacttt gtatttcggc tcacagccta ctgtggtatt gcatggctat
      241 gaggcagtga aagaagccct cattgattat ggggaagagt tctctggaag gggaagaatg
      301 ccagtttttg aaaaggctac taaaggactg ggcattagtt ttagccgtgg aaatgtatgg
      361 agagccacaa gacatttcac agtcaatacc ctgaggagtt tgggcatggg gaaacggacc
      421 attgagatca aagtgcaaga ggaagcagag tggctagtga tggaactgaa gaaaaccaaa
      481 ggctcaccct gtgatcccaa attcatcata ggatgtgctc cctgcaatgt catctgctcc
      541 attatcttcc agaatcgttt cgattataaa gataaggatt ttcttagctt gatagaaaac
      601 gtgaatgagt acattaaaat tgtgagcact cctgcatttc aggttttcaa cgcattccct
      661 attcttctgg attattgtcc aggaaatcat aagacacatt caaaacattt tgctgctatt
      721 aagagttacc ttttgaagaa aataaaagaa catgaagaat cgttggatgt ttcaaatcct
      781 cgggacttca ttgattactt cctaattcaa agatgtcagg aaaatggcaa tcagcagatg
      841 aactatacac aagaacatct ggcaatcctg gtgactaatt tgtttattgg tggaacagag
      901 acatcaagct taacgctgag atttgcactt ttgctcttga tgaagtaccc acacatcaca
      961 gataaagtcc aggaagagat tggccaagtg attgggagac accgcagccc ctgtatgttg
     1021 gacaggatcc acatgcccta cacaaatgcc atgattcatg aggttcagag atatattgac
     1081 cttgccccaa atggtttgtt gcatgaagtg acctgtgaca ctaaattcag agactacttc
     1141 atacccaagg gaacagcagt actaacatca cttacatcag tgctgcatga cagtaaggaa
     1201 ttccccaacc cagagatgtt tgacccaggt cactttctag atgagaatgg aaactttaag
     1261 aaaagtgact acttcatgcc tttctcagca ggaaaacgga aatgtgtggg agagggcctt
     1321 gccagtatgg agctgttttt gttcctgacc accattttac agaatttcaa actgaaatct
     1381 ctgtctgatc caaaggacat cgatataaac tcaatacgtt ctgagttttc atcaattcct
     1441 ccaactttcc agctgtgctt cattcctgtc taatgaagac ctaaaagcag aaatgaagat
     1501 gaggaaacat tctattgtga tgtcttctga catcacccac agaaatttct atttacaact
     1561 gtcctagaaa taccactatg tactttcttc ttcccacagc ttatgtcttc taattgccca
     1621 aagataacaa ttctacatta tacagtttct gaagttaatg taaaagattc tgagaaaaaa
     1681 aagtcaattc aaataaaaaa agttctaatg tga
//
