LOCUS       NM_019184               1856 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, subfamily 2, polypeptide 11
            (Cyp2c11), mRNA.
ACCESSION   NM_019184
VERSION     NM_019184.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1856)
  AUTHORS   Navarro-Mabarak,C., Loaiza-Zuluaga,M., Hernandez-Ojeda,S.L.,
            Camacho-Carranza,R. and Espinosa-Aguirre,J.J.
  TITLE     Neuroinflammation is able to downregulate cytochrome P450
            epoxygenases 2J3 and 2C11 in the rat brain
  JOURNAL   Brain Res Bull 163, 57-64 (2020)
   PUBMED   32707261
  REMARK    GeneRIF: Neuroinflammation is able to downregulate cytochrome P450
            epoxygenases 2J3 and 2C11 in the rat brain.
REFERENCE   2  (bases 1 to 1856)
  AUTHORS   Navarro-Mabarak,C., Mitre-Aguilar,I.B., Camacho-Carranza,R.,
            Arias,C., Zentella-Dehesa,A. and Espinosa-Aguirre,J.J.
  TITLE     Role of NF-kappaB in cytochrome P450 epoxygenases down-regulation
            during an inflammatory process in astrocytes
  JOURNAL   Neurochem Int 129, 104499 (2019)
   PUBMED   31271766
  REMARK    GeneRIF: Inflammation in astrocytes could down-regulate CYP2C11
            mRNA, protein and activity.Inhibition of NF-kappaB partially
            prevented the down-regulation of CYP2C11 mRNA and protein.NF-kappaB
            is able to bind to at least two response elements in the promoter
            of Cyp2c11.
REFERENCE   3  (bases 1 to 1856)
  AUTHORS   Wei,Y., Yang,L., Zhang,X., Sui,D., Wang,C., Wang,K., Shan,M.,
            Guo,D. and Wang,H.
  TITLE     Generation and Characterization of a CYP2C11-Null Rat Model by
            Using the CRISPR/Cas9 Method
  JOURNAL   Drug Metab Dispos 46 (5), 525-531 (2018)
   PUBMED   29444903
  REMARK    GeneRIF: A CYP2C11-null rat model was successfully generated and is
            a valuable tool to study the in vivo function of CYP2C11.
REFERENCE   4  (bases 1 to 1856)
  AUTHORS   Raish,M., Ahmad,A., Alkharfy,K.M., Jan,B.L., Mohsin,K., Ahad,A.,
            Al-Jenoobi,F.I. and Al-Mohizea,A.M.
  TITLE     Effects of Paeonia emodi on hepatic cytochrome P450 (CYP3A2 and
            CYP2C11) expression and pharmacokinetics of carbamazepine in rats
  JOURNAL   Biomed Pharmacother 90, 694-698 (2017)
   PUBMED   28419964
  REMARK    GeneRIF: The PE extract also showed a significant potential to
            reduce CYP3A and CYP2C protein expression by approximately 50%.
REFERENCE   5  (bases 1 to 1856)
  AUTHORS   Xu,M., Tang,H., Rong,Q., Zhang,Y., Li,Y., Zhao,L., Ye,G., Shi,F.
            and Lv,C.
  TITLE     The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in
            Rats
  JOURNAL   Biomed Res Int 2017, 6525474 (2017)
   PUBMED   28555194
  REMARK    GeneRIF: acute Formaldehyde (FA) poisoning suppressed the
            activities of CYP2C11, CYP2E1, and CYP3A2 and induced the activity
            of CYP1A2 in rats. And the change of CYP450 activity caused by
            acute FA poisoning may be associated with FA potential carcinogenic
            effects on the airways.
REFERENCE   6  (bases 1 to 1856)
  AUTHORS   Strom,A., Mode,A., Zaphiropoulos,P., Nilsson,A.G., Morgan,E. and
            Gustafsson,J.A.
  TITLE     Cloning and pretranslational hormonal regulation of testosterone 16
            alpha-hydroxylase (P-45016 alpha) in male rat liver
  JOURNAL   Acta Endocrinol (Copenh) 118 (2), 314-320 (1988)
   PUBMED   2455430
REFERENCE   7  (bases 1 to 1856)
  AUTHORS   Zaphiropoulos,P.G., Mode,A., Strom,A., Husman,B., Andersson,G. and
            Gustafsson,J.A.
  TITLE     Sequence and regulation of two growth-hormone-controlled,
            sex-specific isozymes of cytochrome P-450 in rat liver,
            P-450(15)beta and P-450(16)alpha
  JOURNAL   Acta Med Scand Suppl 723, 161-167 (1988)
   PUBMED   3164963
REFERENCE   8  (bases 1 to 1856)
  AUTHORS   Morishima,N., Yoshioka,H., Higashi,Y., Sogawa,K. and
            Fujii-Kuriyama,Y.
  TITLE     Gene structure of cytochrome P-450(M-1) specifically expressed in
            male rat liver
  JOURNAL   Biochemistry 26 (25), 8279-8285 (1987)
   PUBMED   2894840
REFERENCE   9  (bases 1 to 1856)
  AUTHORS   Yoshioka,H., Morohashi,K., Sogawa,K., Miyata,T., Kawajiri,K.,
            Hirose,T., Inayama,S., Fujii-Kuriyama,Y. and Omura,T.
  TITLE     Structural analysis and specific expression of microsomal
            cytochrome P-450(M-1) mRNA in male rat livers
  JOURNAL   J Biol Chem 262 (4), 1706-1711 (1987)
   PUBMED   3805049
  REMARK    Erratum:[J Biol Chem 1987 Jun 15;262(17):8438]
REFERENCE   10 (bases 1 to 1856)
  AUTHORS   Matsumoto,T., Emi,Y., Kawabata,S. and Omura,T.
  TITLE     Purification and characterization of three male-specific and one
            female-specific forms of cytochrome P-450 from rat liver microsomes
  JOURNAL   J Biochem 100 (5), 1359-1371 (1986)
   PUBMED   2434473
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J02657.1.
            
            On Jan 25, 2008 this sequence version replaced NM_019184.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J02657.1, U33173.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..1856
                     /gene="Cyp2c11"
                     /gene_synonym="Cyp2c; Cyp2c11l; CYP2CII"
                     /note="cytochrome P450, subfamily 2, polypeptide 11"
                     /db_xref="GeneID:29277"
                     /db_xref="RGD:2469"
     exon            1..188
                     /gene="Cyp2c11"
                     /gene_synonym="Cyp2c; Cyp2c11l; CYP2CII"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1523
                     /gene="Cyp2c11"
                     /gene_synonym="Cyp2c; Cyp2c11l; CYP2CII"
                     /EC_number="1.14.14.1"
                     /note="UT-2; P450H; CYPIIC11; P450-UT-A; P-450(M-1);
                     cytochrome P450H; cytochrome P450-UT-2; cytochrome
                     P450-UT-A; cytochrome P-450(M-1); cytochrome P450, 2c29;
                     cytochrome P450, subfamily IIC (mephenytoin
                     4-hydroxylase), polypeptide 11; cytochrome P450 2C11-like"
                     /codon_start=1
                     /product="cytochrome P450 2C11"
                     /protein_id="NP_062057.2"
                     /db_xref="GeneID:29277"
                     /db_xref="RGD:2469"
                     /translation="MDPVLVLVLTLSSLLLLSLWRQSFGRGKLPPGPTPLPIIGNTLQ
                     IYMKDIGQSIKKFSKVYGPIFTLYLGMKPFVVLHGYEAVKEALVDLGEEFSGRGSFPV
                     SERVNKGLGVIFSNGMQWKEIRRFSIMTLRTFGMGKRTIEDRIQEEAQCLVEELRKSK
                     GAPFDPTFILGCAPCNVICSIIFQNRFDYKDPTFLNLMHRFNENFRLFSSPWLQVCNT
                     FPAIIDYFPGSHNQVLKNFFYIKNYVLEKVKEHQESLDKDNPRDFIDCFLNKMEQEKH
                     NPQSEFTLESLVATVTDMFGAGTETTSTTLRYGLLLLLKHVDVTAKVQEEIERVIGRN
                     RSPCMKDRSQMPYTDAVVHEIQRYIDLVPTNLPHLVTRDIKFRNYFIPKGTNVIVSLS
                     SILHDDKEFPNPEKFDPGHFLDERGNFKKSDYFMPFSAGKRICAGEALARTELFLFFT
                     TILQNFNLKSLVDVKDIDTTPAISGFGHLPPFYEACFIPVQRADSLSSHL"
     exon            189..351
                     /gene="Cyp2c11"
                     /gene_synonym="Cyp2c; Cyp2c11l; CYP2CII"
                     /inference="alignment:Splign:2.1.0"
     exon            352..501
                     /gene="Cyp2c11"
                     /gene_synonym="Cyp2c; Cyp2c11l; CYP2CII"
                     /inference="alignment:Splign:2.1.0"
     exon            502..662
                     /gene="Cyp2c11"
                     /gene_synonym="Cyp2c; Cyp2c11l; CYP2CII"
                     /inference="alignment:Splign:2.1.0"
     exon            663..839
                     /gene="Cyp2c11"
                     /gene_synonym="Cyp2c; Cyp2c11l; CYP2CII"
                     /inference="alignment:Splign:2.1.0"
     exon            840..981
                     /gene="Cyp2c11"
                     /gene_synonym="Cyp2c; Cyp2c11l; CYP2CII"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1169
                     /gene="Cyp2c11"
                     /gene_synonym="Cyp2c; Cyp2c11l; CYP2CII"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1311
                     /gene="Cyp2c11"
                     /gene_synonym="Cyp2c; Cyp2c11l; CYP2CII"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1856
                     /gene="Cyp2c11"
                     /gene_synonym="Cyp2c; Cyp2c11l; CYP2CII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctccctga gaaggctgcc atggatccag tcctagtcct ggtgctcact ctctcctctc
       61 tgcttctcct ctcactctgg agacagagct ttgggagagg gaagctccct cctggtccaa
      121 cacctctccc aatcattgga aacacccttc agatatatat gaaggacatc ggccaatcaa
      181 taaaaaagtt ttcaaaagtc tacggcccta tatttactct gtatttgggc atgaagccct
      241 ttgtggtgtt gcatgggtat gaagctgtga aggaagctct tgttgatcta ggagaggaat
      301 tttctggaag aggcagtttt ccagtatctg aaagagttaa caagggcctt ggagtcattt
      361 ttagcaatgg gatgcaatgg aaggagatcc ggcgtttctc catcatgacc ctgaggactt
      421 ttgggatggg caagaggacc attgaggacc gtattcaaga ggaggctcag tgccttgtgg
      481 aggaactgag gaagagcaaa ggtgcccctt ttgatcccac ctttatcctg ggctgtgctc
      541 cctgcaatgt gatatgctcc attattttcc agaatcgctt tgattataaa gatccgactt
      601 ttcttaactt gatgcacaga tttaatgaaa acttcaggct tttcagctcc ccatggctac
      661 aggtctgcaa tactttccct gccattattg attacttccc tggaagtcat aaccaagtac
      721 ttaagaattt cttctatata aaaaactatg ttttggagaa agtaaaagaa caccaagagt
      781 ccttggacaa ggacaatcct cgggacttca ttgattgttt cttgaacaaa atggaacagg
      841 aaaagcacaa tccgcagtct gagtttaccc ttgaaagctt ggtggctact gtaactgaca
      901 tgtttggagc tggcacagaa acaacaagta ccactctgag gtatggactc ctgctgctgc
      961 tgaaacacgt ggatgtcaca gctaaagtcc aggaagagat agaacgtgta attggcagaa
     1021 accggagccc ctgcatgaaa gacaggagcc agatgcccta cacggatgct gtagtgcatg
     1081 agatccagag atatattgac cttgtcccca caaacctgcc tcatttagtg acacgtgata
     1141 taaaattcag aaactacttc attcccaagg gtaccaatgt gatagtatcg ctgtcatcca
     1201 tactgcatga tgacaaagaa tttcctaatc cagagaagtt tgaccctggt cactttctag
     1261 atgagagagg taactttaag aagagtgact actttatgcc attctcagca ggaaagagga
     1321 tatgtgcagg agaagccctg gctcgcacgg agctgttttt gttcttcacc accattttac
     1381 agaattttaa cctgaagtct ctggttgatg taaaagacat tgacacaaca ccagctatca
     1441 gtggatttgg ccatttgccc cctttttacg aggcttgttt tattcctgtg caaagggcag
     1501 actctctaag ctctcatctg taatgtctct tctgagggtc ctgtctactt cattcttggt
     1561 actatagtag ctttaactca catatcccca tttccttcgg atccagtgaa catcaaacct
     1621 cattgagttg agttccctga gtcaatatat agttctattc ctgttcccta tatcttgtga
     1681 cgttccctat atcttgtgac attcccatgc agtacttaca tagttagtgc taatacttgt
     1741 atgacttcat tactgttaat actgttttca ctatataaaa gcaaaatatt ttagaatatg
     1801 agaattcaga gtcatctgtt cccttcatgt gctaaataaa tactaatttt tggacc
//
