LOCUS       NM_173294               1759 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily b,
            polypeptide 3 (Cyp2b3), mRNA.
ACCESSION   NM_173294
VERSION     NM_173294.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1759)
  AUTHORS   Chang,H.W., Ho,W.C., Huang,C.L. and Wang,R.Y.
  TITLE     Precision therapeutic opioid dosing implications from genetic
            biomarkers and craving score
  JOURNAL   Medicine (Baltimore) 99 (22), e20429 (2020)
   PUBMED   32481444
REFERENCE   2  (bases 1 to 1759)
  AUTHORS   von Braun,A., Castelnuovo,B., Ledergerber,B., Cusato,J.,
            Buzibye,A., Kambugu,A., Fehr,J., Calcagno,A., Lamorde,M. and
            Sekaggya-Wiltshire,C.
  TITLE     High efavirenz serum concentrations in TB/HIV-coinfected Ugandan
            adults with a CYP2B6 516 TT genotype on anti-TB treatment
  JOURNAL   J Antimicrob Chemother 74 (1), 135-138 (2019)
   PUBMED   30239753
REFERENCE   3  (bases 1 to 1759)
  AUTHORS   Wang,Y., Xiang,X., Wu,S.Q., Chen,G., Zhang,M.M., Wang,M.G.,
            Wang,F.J., Sandford,A.J. and He,J.Q.
  TITLE     Association of CYP2B6 gene polymorphisms and anti-tuberculosis
            drug-induced hepatotoxicity in a Chinese population
  JOURNAL   Infect Genet Evol 51, 198-202 (2017)
   PUBMED   28389387
REFERENCE   4  (bases 1 to 1759)
  AUTHORS   Mactier,H., McLaughlin,P., Gillis,C. and Osselton,M.D.
  TITLE     Variations in Infant CYP2B6 Genotype Associated with the Need for
            Pharmacological Treatment for Neonatal Abstinence Syndrome in
            Infants of Methadone-Maintained Opioid-Dependent Mothers
  JOURNAL   Am J Perinatol 34 (9), 918-921 (2017)
   PUBMED   28320034
REFERENCE   5  (bases 1 to 1759)
  AUTHORS   Ahmad,T., Sabet,S., Primerano,D.A., Richards-Waugh,L.L. and
            Rankin,G.O.
  TITLE     Tell-Tale SNPs: The Role of CYP2B6 in Methadone Fatalities
  JOURNAL   J Anal Toxicol 41 (4), 325-333 (2017)
   PUBMED   28184434
REFERENCE   6  (bases 1 to 1759)
  AUTHORS   Desrochers,M., Christou,M., Jefcoate,C., Belzil,A. and Anderson,A.
  TITLE     New proteins in the rat CYP2B subfamily: presence in liver
            microsomes of the constitutive CYP2B3 protein and the
            phenobarbital-inducible protein product of alternatively spliced
            CYP2B2 mRNA
  JOURNAL   Biochem Pharmacol 52 (8), 1311-1319 (1996)
   PUBMED   8937440
REFERENCE   7  (bases 1 to 1759)
  AUTHORS   Jean,A., Reiss,A., Desrochers,M., Dubois,S., Trottier,E.,
            Trottier,Y., Wirtanen,L., Adesnik,M., Waxman,D.J. and Anderson,A.
  TITLE     Rat liver cytochrome P450 2B3: structure of the CYP2B3 gene and
            immunological identification of a constitutive P450 2B3-like
            protein in rat liver
  JOURNAL   DNA Cell Biol 13 (8), 781-792 (1994)
   PUBMED   8068203
REFERENCE   8  (bases 1 to 1759)
  AUTHORS   Labbe,D., Jean,A. and Anderson,A.
  TITLE     A constitutive member of the rat cytochrome P450IIB subfamily:
            full-length coding sequence of the P450IIB3 cDNA
  JOURNAL   DNA 7 (4), 253-260 (1988)
   PUBMED   3396451
REFERENCE   9  (bases 1 to 1759)
  AUTHORS   Affolter,M., Labbe,D., Jean,A., Raymond,M., Noel,D., Labelle,Y.,
            Parent-Vaugeois,C., Lambert,M., Bojanowski,R. and Anderson,A.
  TITLE     cDNA clones for liver cytochrome P-450s from individual
            aroclor-treated rats: constitutive expression of a new P-450 gene
            related to phenobarbital-inducible forms
  JOURNAL   DNA 5 (3), 209-218 (1986)
   PUBMED   3013548
REFERENCE   10 (bases 1 to 1759)
  AUTHORS   Atchison,M. and Adesnik,M.
  TITLE     A cytochrome P-450 multigene family. Characterization of a gene
            activated by phenobarbital administration
  JOURNAL   J Biol Chem 258 (18), 11285-11295 (1983)
   PUBMED   6885818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 2, 2020 this sequence version replaced NM_173294.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088103.1, M20406.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               JAXUCZ010000001.1  90780492-90780687
            197-359             JAXUCZ010000001.1  90813047-90813209
            360-509             JAXUCZ010000001.1  90813351-90813500
            510-670             JAXUCZ010000001.1  90814793-90814953
            671-847             JAXUCZ010000001.1  90827941-90828117
            848-989             JAXUCZ010000001.1  90828568-90828709
            990-1177            JAXUCZ010000001.1  90834063-90834250
            1178-1319           JAXUCZ010000001.1  90834418-90834559
            1320-1759           JAXUCZ010000001.1  90859413-90859852
FEATURES             Location/Qualifiers
     source          1..1759
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1759
                     /gene="Cyp2b3"
                     /gene_synonym="Cyp2b6; CYPIIB3"
                     /note="cytochrome P450, family 2, subfamily b, polypeptide
                     3"
                     /db_xref="GeneID:286953"
                     /db_xref="RGD:628627"
     exon            1..196
                     /gene="Cyp2b3"
                     /gene_synonym="Cyp2b6; CYPIIB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1501
                     /gene="Cyp2b3"
                     /gene_synonym="Cyp2b6; CYPIIB3"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450 2B3; cytochrome P450, subfamily IIB
                     (phenobarbital-inducible), polypeptide 6; cytochrome
                     P450IIB3; cytochrome P450 2B3-like"
                     /codon_start=1
                     /product="cytochrome P450 2B3 precursor"
                     /protein_id="NP_775416.1"
                     /db_xref="GeneID:286953"
                     /db_xref="RGD:628627"
                     /translation="MDTSVLLLLAVLLSFLLFLVRGHAKVHGHLPPGPRPLPLLGNLL
                     QMDRGGFRKSFIQLQEKHGDVFTVYFGPRPVVMLCGTQTIREALVDHAEAFSGRGIIA
                     VLQPIMQEYGVSFVNEERWKILRRLFVATMRDFGIGKQSVEDQIKEEAKCLVEELKNH
                     QGVSLDPTFLFQCVTGNIICSIVFGERFDYRDRQFLRLLDLLYRTFSLISSFSSQMFE
                     VYSDFLKYFPGVHREIYKNLKEVLDYIDHSVENHRATLDPNAPRDFIDTFLLHMEKEK
                     LNHYTEFHHWNLMISVLFLFLAGTESTSNTLCYGFLLMLKYPHVAEKVQKEIDQVIGS
                     QRVPTLDDRSKMPYTEAVIHEIQRFSDVSPMGLPCRITKDTLFRGYLLPKNTEVYFIL
                     SSALHDPQYFEQPDTFNPEHFLDANGALKKCEAFMPFSIGKRMCLGEGIARSELFLFF
                     TTILQNYSVSSPVDPNTIDMTPKESGLAKVAPVYKICFVAR"
     exon            197..359
                     /gene="Cyp2b3"
                     /gene_synonym="Cyp2b6; CYPIIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            360..509
                     /gene="Cyp2b3"
                     /gene_synonym="Cyp2b6; CYPIIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            510..670
                     /gene="Cyp2b3"
                     /gene_synonym="Cyp2b6; CYPIIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            671..847
                     /gene="Cyp2b3"
                     /gene_synonym="Cyp2b6; CYPIIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            848..989
                     /gene="Cyp2b3"
                     /gene_synonym="Cyp2b6; CYPIIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1177
                     /gene="Cyp2b3"
                     /gene_synonym="Cyp2b6; CYPIIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1319
                     /gene="Cyp2b3"
                     /gene_synonym="Cyp2b6; CYPIIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1759
                     /gene="Cyp2b3"
                     /gene_synonym="Cyp2b6; CYPIIB3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcagagtct gattagacca ggatcatgga tactagtgtc cttctcctcc ttgctgtcct
       61 cctcagcttc ttgctattcc tggtcagagg ccatgcaaaa gttcatggtc atcttccacc
      121 aggaccccgt cccttacccc tcttgggaaa cctcttgcag atggacagag gaggctttcg
      181 taagtctttc attcagcttc aagaaaaaca cggagatgtg ttcacagtat actttggacc
      241 taggcctgtg gtcatgctgt gtgggacaca gaccataagg gaggctctgg tggaccatgc
      301 tgaggctttc tctggccggg gaataattgc tgtgcttcag ccaattatgc aggaatacgg
      361 tgtgtccttt gttaatgaag aaaggtggaa gatccttcgg cgattatttg tagccaccat
      421 gagagacttt gggataggaa agcagagtgt ggaggatcag ataaaggagg aggccaaatg
      481 tttagtggag gaactgaaga atcatcaggg agtctccctg gacccaacgt tcctcttcca
      541 gtgcgtcaca ggcaacataa tctgctccat tgtctttgga gagcgctttg actacagaga
      601 ccgccagttc ctgcgcttgc tcgacctgtt gtataggacc ttttccctca taagctcatt
      661 ctccagccag atgtttgagg tctactctga cttcctgaag tactttcctg gtgtccacag
      721 agaaatctac aaaaacctga aggaagtcct cgactacatt gatcatagtg tggagaacca
      781 cagggccact ttggacccca atgctccccg agactttatc gatactttcc ttctgcacat
      841 ggagaaggag aagttgaacc actacacgga gttccatcat tggaacctaa tgatatctgt
      901 gctctttctt ttccttgctg gcactgagtc tacaagcaac actctctgct atggattcct
      961 gctcatgctc aagtaccctc atgttgcaga gaaagtccaa aaggagattg atcaggtgat
     1021 cggctcacag cgggtcccaa cccttgatga ccgctccaaa atgccataca ctgaggcagt
     1081 catccatgag attcagagat tttctgatgt ttctccaatg ggtttgccat gcagaatcac
     1141 caaagacaca ttgttccgag ggtacctgct ccccaagaac actgaggtgt acttcatcct
     1201 gagttcagct ctccatgacc cacagtactt tgaacaacca gacaccttca atcctgagca
     1261 cttcctggat gccaatgggg cactgaagaa atgtgaagct ttcatgccct tctccatagg
     1321 aaagcgtatg tgtcttggag aaggcattgc ccgaagtgaa ttgttccttt tcttcactac
     1381 catcctccag aactactcag tgtccagccc tgtggatcct aacaccattg atatgactcc
     1441 caaggagagt ggattagcca aagtagcccc agtgtacaag atttgctttg tagcccgctg
     1501 attgtgctga ggcagtcagc cgactcactt ctgttcaaaa tggccccatt tttctgattc
     1561 tgggagacct gctggagacc aggcccaagg ttgctgagtc attcctcact tcttcccaac
     1621 agcctcagtc cccatttatc aggtctccat gctctgtgat ctatgctatt ggactatgta
     1681 taaggtctga attctatgtc tacaggtttg cctagtatgt atggttcatg taaacaggat
     1741 catatagtgt atgaacttt
//
