LOCUS       NM_001135668            1488 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily b,
            polypeptide 15 (Cyp2b15), mRNA.
ACCESSION   NM_001135668 XM_001062874 XM_001070774 XM_001070818 XM_001070869
VERSION     NM_001135668.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1488)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   2  (bases 1 to 1488)
  AUTHORS   Roberts,E.S., Hopkins,N.E., Zaluzec,E.J., Gage,D.A., Alworth,W.L.
            and Hollenberg,P.F.
  TITLE     Identification of active-site peptides from 3H-labeled
            2-ethynylnaphthalene-inactivated P450 2B1 and 2B4 using amino acid
            sequencing and mass spectrometry
  JOURNAL   Biochemistry 33 (12), 3766-3771 (1994)
   PUBMED   8142377
REFERENCE   3  (bases 1 to 1488)
  AUTHORS   Nakayama,K., Suwa,Y., Mizukami,Y., Sogawa,K. and Fujii-Kuriyama,Y.
  TITLE     Cloning and sequencing of a novel rat cytochrome P450 2B-encoding
            gene
  JOURNAL   Gene 136 (1-2), 333-336 (1993)
   PUBMED   8294026
REFERENCE   4  (bases 1 to 1488)
  AUTHORS   Friedberg,T., Grassow,M.A., Bartlomowicz-Oesch,B., Siegert,P.,
            Arand,M., Adesnik,M. and Oesch,F.
  TITLE     Sequence of a novel cytochrome CYP2B cDNA coding for a protein
            which is expressed in a sebaceous gland, but not in the liver
  JOURNAL   Biochem J 287 (Pt 3) (Pt 3), 775-783 (1992)
   PUBMED   1445240
REFERENCE   5  (bases 1 to 1488)
  AUTHORS   Lacroix,D., Desrochers,M., Lambert,M. and Anderson,A.
  TITLE     Alternative splicing of mRNA encoding rat liver cytochrome P450e
            (P450IIB2)
  JOURNAL   Gene 86 (2), 201-207 (1990)
   PUBMED   2323573
REFERENCE   6  (bases 1 to 1488)
  AUTHORS   Pyerin,W. and Taniguchi,H.
  TITLE     Phosphorylation of hepatic phenobarbital-inducible cytochrome P-450
  JOURNAL   EMBO J 8 (10), 3003-3010 (1989)
   PUBMED   2583091
REFERENCE   7  (bases 1 to 1488)
  AUTHORS   Oesch,F., Waxman,D.J., Morrissey,J.J., Honscha,W., Kissel,W. and
            Friedberg,T.
  TITLE     Antibodies targeted against hypervariable and constant regions of
            cytochromes P450IIB1 and P450IIB2
  JOURNAL   Arch Biochem Biophys 270 (1), 23-32 (1989)
   PUBMED   2539047
REFERENCE   8  (bases 1 to 1488)
  AUTHORS   Affolter,M. and Anderson,A.
  TITLE     Segmental homologies in the coding and 3' non-coding sequences of
            rat liver cytochrome P-450e and P-450b cDNAs and cytochrome
            P-450e-like genes
  JOURNAL   Biochem Biophys Res Commun 118 (2), 655-662 (1984)
   PUBMED   6322758
REFERENCE   9  (bases 1 to 1488)
  AUTHORS   Fujii-Kuriyama,Y., Mizukami,Y., Kawajiri,K., Sogawa,K. and
            Muramatsu,M.
  TITLE     Primary structure of a cytochrome P-450: coding nucleotide sequence
            of phenobarbital-inducible cytochrome P-450 cDNA from rat liver
  JOURNAL   Proc Natl Acad Sci U S A 79 (9), 2793-2797 (1982)
   PUBMED   6953431
REFERENCE   10 (bases 1 to 1488)
  AUTHORS   Botelho,L.H., Ryan,D.E. and Levin,W.
  TITLE     Amino acid compositions and partial amino acid sequences of three
            highly purified forms of liver microsomal cytochrome P-450 from
            rats treated with polychlorinated biphenyls, phenobarbital, or
            3-methylcholanthrene
  JOURNAL   J Biol Chem 254 (13), 5635-5640 (1979)
   PUBMED   109438
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D17349.2.
            
            On or before Oct 5, 2008 this sequence version replaced
            XM_001070818.1, XM_001070869.1, XM_001070774.1, XM_001062874.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1488
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1488
                     /gene="Cyp2b15"
                     /note="cytochrome P450, family 2, subfamily b, polypeptide
                     15"
                     /db_xref="GeneID:685222"
                     /db_xref="RGD:1596474"
     CDS             1..1488
                     /gene="Cyp2b15"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P-450b type b; CYPIIB15"
                     /codon_start=1
                     /product="cytochrome P450 2B15"
                     /protein_id="NP_001129140.1"
                     /db_xref="GeneID:685222"
                     /db_xref="RGD:1596474"
                     /translation="MELGVLLLLTFTVGFLLLLASQNRPKTHGHLPPGPRPLPFLGNL
                     LQMNRRGLLRSFMQLQEKYGDVFTVHLGPRPVVILCGTDTIREALVDQAEAFSGRGTV
                     AVLHPVVQGYGVIFANGERWKILRRFSLVTMRNFGMGKRSVEERIKEEAQCLVEELKK
                     YKGALLNPTSIFQSIAANIICSIVFGERFDYKDHQFLRLLDLIYQTFSLMGSLSSQVF
                     ELFSGFLKYFPGVHKQISKNLQEILNYIDHSVEKHRATLDPNTPRDFINTYLLRMEKE
                     KSNHHTEFHHQNLVISVLSLFFTGTETTSTTLRYSFLIMLKYPHVAEKVQKEIDQVIG
                     SHRLPTLDDRTKMPYTDAVIHEIQRFADLIPIGLPHRVTNDTMFLGYLLPKNTEVYPI
                     LSSALHDPRYFDHPDTFNPEHFLDVNGTLKKSEAFLPFSTGKRICLGEGIAQNELFIF
                     FTAILQNFSLASPVAPEDIDLSPINSGISKIPSPYQIHFLSRCVG"
     exon            1..174
                     /gene="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
     exon            175..337
                     /gene="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
     exon            338..487
                     /gene="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
     exon            488..648
                     /gene="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
     exon            649..825
                     /gene="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
     exon            826..967
                     /gene="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1155
                     /gene="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1297
                     /gene="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1488
                     /gene="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaactcg gtgtcttgct cctcctcact ttcactgtgg gcttcttgct attattagcc
       61 agccaaaatc ggccaaagac ccatggccac ttaccaccag gacctcgtcc cctgcccttc
      121 ttggggaacc tcttacagat gaacagaaga ggccttctgc gttctttcat gcagcttcaa
      181 gaaaaatatg gagatgtgtt cacagtacac ctgggaccaa ggcccgtggt catattgtgt
      241 gggacagaca ccataagaga ggctctggtg gaccaagctg aagcgttctc tggtcgggga
      301 acagttgctg tgctccatcc agttgtacag ggatatggtg tgatctttgc caatggggaa
      361 cgttggaaga tccttcggcg attctctctg gtcaccatga gaaacttcgg gatgggaaag
      421 cgcagtgtag aggagaggat aaaggaagag gcccagtgtt tggtggagga actgaagaaa
      481 tacaagggag ccctcctgaa ccccacctcc atcttccagt ccatcgcagc aaacatcata
      541 tgctccattg tctttggaga gcgctttgac tacaaagacc accagttcct gcgtctgctg
      601 gatctgatct atcagacatt ttcccttatg ggctccttgt ccagccaggt gtttgagctt
      661 ttctctggct tcctgaaata cttccctggt gtccacaaac aaatctccaa aaacctacaa
      721 gaaatcctca actacattga ccacagtgtg gagaagcaca gggccacctt ggaccccaac
      781 actccacgag acttcatcaa tacctacctt ctgcgcatgg aaaaggagaa gtccaaccat
      841 cacacagagt tccatcacca gaaccttgtg atctctgtgc tctctctctt ctttactggc
      901 accgagacga ccagcaccac actccgttac agcttcctga tcatgctcaa gtacccccac
      961 gtcgcagaga aagtccaaaa ggagattgat caggtgatcg gctcacaccg gctaccaacc
     1021 cttgatgatc gtaccaaaat gccatacact gatgcagtca tccatgagat tcagagattt
     1081 gcagatctga tcccgattgg tctaccacac agagtcacca atgacaccat gttcctaggg
     1141 tacctgctcc ccaagaacac tgaggtttac cccatcctga gttcagctct ccatgaccca
     1201 cggtactttg accacccaga caccttcaat cctgagcact tcctggatgt caatgggaca
     1261 ctgaagaaga gtgaagcttt tctgcccttc tccacaggaa agcgcatttg tcttggagaa
     1321 ggcattgccc aaaatgaatt gttcattttc ttcaccgcca tcctccagaa cttctctttg
     1381 gcaagccctg tggctcctga ggacattgac ctcagtccca ttaacagtgg tataagcaaa
     1441 ataccctcac cataccagat tcacttcctg tcccgctgtg tgggttga
//
