LOCUS       NM_017156               2406 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily b,
            polypeptide 12 (Cyp2b12), mRNA.
ACCESSION   NM_017156 XM_346537
VERSION     NM_017156.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2406)
  AUTHORS   Keeney,D.S., Skinner,C., Wei,S., Friedberg,T. and Waterman,M.R.
  TITLE     A keratinocyte-specific epoxygenase, CYP2B12, metabolizes
            arachidonic acid with unusual selectivity, producing a single major
            epoxyeicosatrienoic acid
  JOURNAL   J Biol Chem 273 (15), 9279-9284 (1998)
   PUBMED   9535921
REFERENCE   2  (bases 1 to 2406)
  AUTHORS   Roberts,E.S., Hopkins,N.E., Zaluzec,E.J., Gage,D.A., Alworth,W.L.
            and Hollenberg,P.F.
  TITLE     Identification of active-site peptides from 3H-labeled
            2-ethynylnaphthalene-inactivated P450 2B1 and 2B4 using amino acid
            sequencing and mass spectrometry
  JOURNAL   Biochemistry 33 (12), 3766-3771 (1994)
   PUBMED   8142377
REFERENCE   3  (bases 1 to 2406)
  AUTHORS   Nakayama,K., Suwa,Y., Mizukami,Y., Sogawa,K. and Fujii-Kuriyama,Y.
  TITLE     Cloning and sequencing of a novel rat cytochrome P450 2B-encoding
            gene
  JOURNAL   Gene 136 (1-2), 333-336 (1993)
   PUBMED   8294026
REFERENCE   4  (bases 1 to 2406)
  AUTHORS   Friedberg,T., Grassow,M.A., Bartlomowicz-Oesch,B., Siegert,P.,
            Arand,M., Adesnik,M. and Oesch,F.
  TITLE     Sequence of a novel cytochrome CYP2B cDNA coding for a protein
            which is expressed in a sebaceous gland, but not in the liver
  JOURNAL   Biochem J 287 (Pt 3) (Pt 3), 775-783 (1992)
   PUBMED   1445240
REFERENCE   5  (bases 1 to 2406)
  AUTHORS   Lacroix,D., Desrochers,M., Lambert,M. and Anderson,A.
  TITLE     Alternative splicing of mRNA encoding rat liver cytochrome P450e
            (P450IIB2)
  JOURNAL   Gene 86 (2), 201-207 (1990)
   PUBMED   2323573
REFERENCE   6  (bases 1 to 2406)
  AUTHORS   Pyerin,W. and Taniguchi,H.
  TITLE     Phosphorylation of hepatic phenobarbital-inducible cytochrome P-450
  JOURNAL   EMBO J 8 (10), 3003-3010 (1989)
   PUBMED   2583091
REFERENCE   7  (bases 1 to 2406)
  AUTHORS   Oesch,F., Waxman,D.J., Morrissey,J.J., Honscha,W., Kissel,W. and
            Friedberg,T.
  TITLE     Antibodies targeted against hypervariable and constant regions of
            cytochromes P450IIB1 and P450IIB2
  JOURNAL   Arch Biochem Biophys 270 (1), 23-32 (1989)
   PUBMED   2539047
REFERENCE   8  (bases 1 to 2406)
  AUTHORS   Affolter,M. and Anderson,A.
  TITLE     Segmental homologies in the coding and 3' non-coding sequences of
            rat liver cytochrome P-450e and P-450b cDNAs and cytochrome
            P-450e-like genes
  JOURNAL   Biochem Biophys Res Commun 118 (2), 655-662 (1984)
   PUBMED   6322758
REFERENCE   9  (bases 1 to 2406)
  AUTHORS   Fujii-Kuriyama,Y., Mizukami,Y., Kawajiri,K., Sogawa,K. and
            Muramatsu,M.
  TITLE     Primary structure of a cytochrome P-450: coding nucleotide sequence
            of phenobarbital-inducible cytochrome P-450 cDNA from rat liver
  JOURNAL   Proc Natl Acad Sci U S A 79 (9), 2793-2797 (1982)
   PUBMED   6953431
REFERENCE   10 (bases 1 to 2406)
  AUTHORS   Botelho,L.H., Ryan,D.E. and Levin,W.
  TITLE     Amino acid compositions and partial amino acid sequences of three
            highly purified forms of liver microsomal cytochrome P-450 from
            rats treated with polychlorinated biphenyls, phenobarbital, or
            3-methylcholanthrene
  JOURNAL   J Biol Chem 254 (13), 5635-5640 (1979)
   PUBMED   109438
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 24, 2020 this sequence version replaced NM_017156.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.1468.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               JAXUCZ010000001.1  91135294-91135506
            214-376             JAXUCZ010000001.1  91137184-91137346
            377-526             JAXUCZ010000001.1  91137489-91137638
            527-687             JAXUCZ010000001.1  91137835-91137995
            688-864             JAXUCZ010000001.1  91138741-91138917
            865-1006            JAXUCZ010000001.1  91139649-91139790
            1007-1194           JAXUCZ010000001.1  91141841-91142028
            1195-1336           JAXUCZ010000001.1  91142181-91142322
            1337-2406           JAXUCZ010000001.1  91146025-91147094
FEATURES             Location/Qualifiers
     source          1..2406
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2406
                     /gene="Cyp2b12"
                     /gene_synonym="Cyp2b15"
                     /note="cytochrome P450, family 2, subfamily b, polypeptide
                     12"
                     /db_xref="GeneID:29295"
                     /db_xref="RGD:620088"
     exon            1..213
                     /gene="Cyp2b12"
                     /gene_synonym="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1518
                     /gene="Cyp2b12"
                     /gene_synonym="Cyp2b15"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450, family 2, subfamily b, polypeptide
                     15; cytochrome P-450b type b; CYPIIB12"
                     /codon_start=1
                     /product="cytochrome P450 2B12"
                     /protein_id="NP_058852.2"
                     /db_xref="GeneID:29295"
                     /db_xref="RGD:620088"
                     /translation="MEFGVLLLLTLTVGFLLFLVSQSQPKTHGHLPPGPRPLPFLGNL
                     LQMNRRGFLNSFMQLQEKYGDVFTVHLGPRPVVILCGTDTIREALVDQAEAFSGRGTV
                     AVLHPVVQGYGVIFATGERWKTLRRFSLVTMKEFGMGKRSVDERIKEEAQCLVEELKK
                     YKGAPLNPTFLFQSIAANTICSIVFGERFDYKDHQFLHLLDLVYKTSVLMGSLSSQVF
                     ELYSGFLKYFPGAHKQIFKNLQEMLNYIGHIVEKHRATLDPSAPRDFIDTYLLRMEKE
                     KSNHHTEFNHQNLVISVLSLFFAGTETTSTTLRCTFLIMLKYPHVAEKVQKEIDQVIG
                     SHRLPTPDDRTKMPYTDAVIHEIQRFADLTPIGLPHRVTKDTVFRGYLLPKNTEVYPI
                     LSSALHDPRYFEQPDTFNPEHFLDANGALKKSEAFLPFSTGKRICLGEGIARNELFIF
                     FTAILQNFTLASPVAPEDIDLTPINSGVGKIPSPYQINFLSR"
     exon            214..376
                     /gene="Cyp2b12"
                     /gene_synonym="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
     exon            377..526
                     /gene="Cyp2b12"
                     /gene_synonym="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
     exon            527..687
                     /gene="Cyp2b12"
                     /gene_synonym="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
     exon            688..864
                     /gene="Cyp2b12"
                     /gene_synonym="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1006
                     /gene="Cyp2b12"
                     /gene_synonym="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1194
                     /gene="Cyp2b12"
                     /gene_synonym="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1336
                     /gene="Cyp2b12"
                     /gene_synonym="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..2406
                     /gene="Cyp2b12"
                     /gene_synonym="Cyp2b15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtgttca ctgaagtcaa cagtggttag accaggacca tggaattcgg tgtcttgctc
       61 ctcctcactc tcactgtggg cttcttgcta ttcttagtca gccaaagtca gccaaagacc
      121 catgggcact tgccaccagg acctcgtccc ctgcccttct tggggaacct cttacagatg
      181 aacagaagag gctttctgaa ttctttcatg cagcttcaag aaaaatatgg agatgtgttc
      241 acagtacacc tgggaccaag gcccgtggtc atattgtgtg ggacagacac cataagagag
      301 gctctggtgg accaagctga agctttctct ggtcggggaa cagttgctgt gctccatcca
      361 gttgtacagg gatatggtgt gatctttgcc actggggaac gttggaagac ccttcggcga
      421 ttctctctgg tcaccatgaa agaattcgga atgggaaagc ggagtgtaga tgagaggata
      481 aaggaggagg cccagtgttt ggtggaggag ctgaagaaat acaagggagc ccccctgaac
      541 cccaccttcc tcttccaatc catcgcagca aacaccatct gctccattgt ctttggagag
      601 cgctttgact acaaagacca ccagttcctg catctgctgg atctagtcta taagacatct
      661 gtccttatgg gctccttgtc cagccaggtg tttgagcttt actctggctt cctgaaatac
      721 tttcctggtg cccacaaaca aatcttcaaa aacctacagg aaatgctcaa ctacattggc
      781 catattgtgg agaagcacag ggcaaccttg gaccccagtg ctccacgaga tttcatcgat
      841 acttaccttc tgcgcatgga gaaggagaag tccaaccatc acacagagtt caatcaccag
      901 aaccttgtga tctctgtgct ctctctcttc tttgctggca ccgagaccac cagcaccacg
      961 ctccgttgca ccttcctgat catgctcaag tacccccacg ttgcagagaa agtccaaaag
     1021 gagattgatc aggtgattgg ctcacaccgg ctaccaaccc ctgatgatcg taccaaaatg
     1081 ccatatactg atgcagtcat ccatgagatt cagagatttg cagatctgac cccgattggt
     1141 ctaccacaca gagtcaccaa agacaccgtg ttccgagggt acctgcttcc caagaacact
     1201 gaggtgtacc ccatcctgag ttcagctctc catgacccac ggtactttga acaaccagac
     1261 actttcaatc ctgagcactt cctggatgcc aatggggcac tgaagaagag tgaagctttt
     1321 ctgcccttct ctacaggaaa gcgcatttgt cttggagaag gcattgcccg aaatgaattg
     1381 ttcattttct tcaccgccat cctgcagaac ttcactttgg caagccctgt ggctcctgag
     1441 gacattgacc tcactcccat taacagtggt gtaggcaaaa taccctcacc ataccagata
     1501 aacttcctgt cccgttgaat aggttgagag agaagagtca atggaatgac gtgtccccag
     1561 tgccgtaccc tatgaatgga atagtaaaac ctaatgaagt ggctttcttg ttacatagac
     1621 agagagactt ctggaggcca cagcttgttg tgagacacct ctctcatgct tgttcacagc
     1681 catagtccct acttgttagg aatctagact ccaggatctg tgggaacaga ccagagatgg
     1741 tttctcttga gttggctcca ttctaatccc atgtggtgtg ttggggggtc atgtttgagg
     1801 acccccttcg tagatgagta acagacccta tgatggcatc acagtgctag tgagtagtgg
     1861 ggaacaaaat tatgctgtga gtctagaaga gcaacccctc tcctgcttct gtttcaattc
     1921 agatgaaatt catataacga agctgacaaa atcttttaat tttgtattct ggccagaggc
     1981 tcatgtagtt cacactgacc tcaaaatcct atatacatcc aaagatgtct tgaaatctcg
     2041 atctcctgac cagtgctggc atcacagcca catggacgta tacccagatt ttaaagtgac
     2101 tatatcataa tgtttatatt ttaatctcct ttaatttatt tgcaatatta caacttcact
     2161 atctaattcc aggtattttg tcacacttaa ccaacaccac caaaagcccc aacctattca
     2221 aagatcaatc cctcatcccc tctctccata acctcccctg cactcaacac ccaccgtgcc
     2281 acttttgtct gacttttgtg tcattggact gtcctgaatt gtgtgtctca tagaaaaaca
     2341 acgacatgat ctttaatgct ggctgacttt tatgccacac ccaacttctc aggcccctgt
     2401 actgtg
//
