LOCUS       NM_001134844            1905 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily b,
            polypeptide 1 (Cyp2b1), mRNA.
ACCESSION   NM_001134844
VERSION     NM_001134844.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1905)
  AUTHORS   Kucey,A.S., Velenosi,T.J., Tonial,N.C., Tieu,A., RaoPeters,A.A.E.
            and Urquhart,B.L.
  TITLE     The effect of chronic kidney disease on CYP2B expression and
            activity in male Wistar rats
  JOURNAL   Pharmacol Res Perspect 7 (3), e00475 (2019)
   PUBMED   31049204
  REMARK    GeneRIF: Study demonstrates that CYP2B1 is downregulated in a rat
            model of chronic kidney disease (CKD). CYP2B1 mRNA level was
            significantly decreased in CKD relative to control.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1905)
  AUTHORS   Abdelhadya,D.H., El-Magd,M.A., Elbialy,Z.I. and Saleh,A.A.
  TITLE     Bromuconazole-induced hepatotoxicity is accompanied by upregulation
            of PXR/CYP3A1 and downregulation of CAR/CYP2B1 gene expression
  JOURNAL   Toxicol Mech Methods 27 (7), 544-550 (2017)
   PUBMED   28532222
  REMARK    GeneRIF: Data suggest that liver oxidative damage induced by
            industrial fungicide bromuconazole is due, in part, to
            up-regulation of PXR/CYP3A1 expression and down-regulation of
            CAR/CYP2B1 expression. (PXR = pregnane X receptor; CYP3A1 =
            cytochrome P-450 3A1; CAR = constitutive androstane receptor;
            CYP2B1 = cytochrome P-450 2B1)
REFERENCE   3  (bases 1 to 1905)
  AUTHORS   Ma,J., Wang,J., Cheng,J., Xiao,W., Fan,K., Gu,J., Yu,B., Yin,G.,
            Wu,J., Ren,J., Hou,J., Jiang,Y., Tan,Y. and Jin,W.
  TITLE     Impacts of Blast-Induced Traumatic Brain Injury on Expressions of
            Hepatic Cytochrome P450 1A2, 2B1, 2D1, and 3A2 in Rats
  JOURNAL   Cell Mol Neurobiol 37 (1), 111-120 (2017)
   PUBMED   26913515
  REMARK    GeneRIF: Blast-induced traumatic brain injury was found to have a
            significant impact on CYP2B1 expression in liver.
REFERENCE   4  (bases 1 to 1905)
  AUTHORS   Ibrahim,Z.S., Ahmed,M.M., El-Shazly,S.A., Ishizuka,M. and Fujita,S.
  TITLE     Clofibric acid induces hepatic CYP 2B1/2 via constitutive
            androstane receptor not via peroxisome proliferator activated
            receptor alpha in rat
  JOURNAL   Biosci Biotechnol Biochem 78 (9), 1550-1559 (2014)
   PUBMED   25052003
  REMARK    GeneRIF: The induction of CYP2B by PB or CFA was comparable to
            nuclear CAR levels. CAR nuclear translocation was induced by CFA in
            both rat strains
            Erratum:[Biosci Biotechnol Biochem. 2015;79(6):x. doi:
            10.1080/09168451.2014.945725.. PMID: 25055939]
REFERENCE   5  (bases 1 to 1905)
  AUTHORS   Kobayashi,M., Hoshinaga,Y., Miura,N., Tokuda,Y., Shigeoka,S.,
            Murai,A. and Horio,F.
  TITLE     Ascorbic acid deficiency decreases hepatic cytochrome P-450,
            especially CYP2B1/2B2, and simultaneously induces heme oxygenase-1
            gene expression in scurvy-prone ODS rats
  JOURNAL   Biosci Biotechnol Biochem 78 (6), 1060-1066 (2014)
   PUBMED   25036135
  REMARK    GeneRIF: stimulation of hepatic heme oxygenase-1 expression by
            ascorbic acid deficiency caused the decrease in CYP content in
            liver
REFERENCE   6  (bases 1 to 1905)
  AUTHORS   Pyerin,W. and Taniguchi,H.
  TITLE     Phosphorylation of hepatic phenobarbital-inducible cytochrome P-450
  JOURNAL   EMBO J 8 (10), 3003-3010 (1989)
   PUBMED   2583091
REFERENCE   7  (bases 1 to 1905)
  AUTHORS   Oesch,F., Waxman,D.J., Morrissey,J.J., Honscha,W., Kissel,W. and
            Friedberg,T.
  TITLE     Antibodies targeted against hypervariable and constant regions of
            cytochromes P450IIB1 and P450IIB2
  JOURNAL   Arch Biochem Biophys 270 (1), 23-32 (1989)
   PUBMED   2539047
REFERENCE   8  (bases 1 to 1905)
  AUTHORS   Suwa,Y., Mizukami,Y., Sogawa,K. and Fujii-Kuriyama,Y.
  TITLE     Gene structure of a major form of phenobarbital-inducible
            cytochrome P-450 in rat liver
  JOURNAL   J Biol Chem 260 (13), 7980-7984 (1985)
   PUBMED   2989270
REFERENCE   9  (bases 1 to 1905)
  AUTHORS   Ravishankar,H. and Padmanaban,G.
  TITLE     Regulation of cytochrome P-450 gene expression. Studies with a
            cloned probe
  JOURNAL   J Biol Chem 260 (3), 1588-1592 (1985)
   PUBMED   3838174
REFERENCE   10 (bases 1 to 1905)
  AUTHORS   Botelho,L.H., Ryan,D.E. and Levin,W.
  TITLE     Amino acid compositions and partial amino acid sequences of three
            highly purified forms of liver microsomal cytochrome P-450 from
            rats treated with polychlorinated biphenyls, phenobarbital, or
            3-methylcholanthrene
  JOURNAL   J Biol Chem 254 (13), 5635-5640 (1979)
   PUBMED   109438
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166502.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166502.1, M37134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1905
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1905
                     /gene="Cyp2b1"
                     /gene_synonym="Cyp2b-1; Cypbe"
                     /note="cytochrome P450, family 2, subfamily b, polypeptide
                     1"
                     /db_xref="GeneID:24300"
                     /db_xref="RGD:2466"
     exon            1..188
                     /gene="Cyp2b1"
                     /gene_synonym="Cyp2b-1; Cypbe"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1493
                     /gene="Cyp2b1"
                     /gene_synonym="Cyp2b-1; Cypbe"
                     /EC_number="1.14.14.1"
                     /note="Cytochrome P450 2B1; P450b; P450-B; CYPIIB1;
                     P450-LM2; P450-PB1 and P450-PB2; cytochrome P450b;
                     cytochrome P450-B; cytochrome P450-LM2; cytochrome
                     P450-PB1; cytochrome P450-PB2; Cytochrome P450, subfamily
                     IIB (phenobarbital-inducible) (b, e)"
                     /codon_start=1
                     /product="cytochrome P450 2B1 precursor"
                     /protein_id="NP_001128316.1"
                     /db_xref="GeneID:24300"
                     /db_xref="RGD:2466"
                     /translation="MEPSILLLLALLVGFLLLLVRGHPKSRGNFPPGPRPLPLLGNLL
                     QLDRGGLLNSFMQLREKYGDVFTVHLGPRPVVMLCGTDTIKEALVGQAEDFSGRGTIA
                     VIEPIFKEYGVIFANGERWKALRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKS
                     QGAPLDPTFLFQCITANIICSIVFGERFDYTDRQFLRLLELFYRTFSLLSSFSSQVFE
                     FFSGFLKYFPGAHRQISKNLQEILDYIGHIVEKHRATLDPSAPRDFIDTYLLRMEKEK
                     SNHHTVFHHENLMISLLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGS
                     HRLPTLDDRSKMPYTDAVIHEIQRFSDLVPIGVPHRVTKDTMFRGYLLPKNTEVYPIL
                     SSALHDPQYFDHPDSFNPEHFLDANGALKKSEAFMPFSTGKRICLGEGIARNELFLFF
                     TTILQNFSVSSHLAPKDIDLTPKESGIGKIPPTYQICFSAR"
     exon            189..351
                     /gene="Cyp2b1"
                     /gene_synonym="Cyp2b-1; Cypbe"
                     /inference="alignment:Splign:2.1.0"
     exon            352..501
                     /gene="Cyp2b1"
                     /gene_synonym="Cyp2b-1; Cypbe"
                     /inference="alignment:Splign:2.1.0"
     exon            502..662
                     /gene="Cyp2b1"
                     /gene_synonym="Cyp2b-1; Cypbe"
                     /inference="alignment:Splign:2.1.0"
     exon            663..839
                     /gene="Cyp2b1"
                     /gene_synonym="Cyp2b-1; Cypbe"
                     /inference="alignment:Splign:2.1.0"
     exon            840..981
                     /gene="Cyp2b1"
                     /gene_synonym="Cyp2b-1; Cypbe"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1169
                     /gene="Cyp2b1"
                     /gene_synonym="Cyp2b-1; Cypbe"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1311
                     /gene="Cyp2b1"
                     /gene_synonym="Cyp2b-1; Cypbe"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1879
                     /gene="Cyp2b1"
                     /gene_synonym="Cyp2b-1; Cypbe"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggttacac caggaccatg gagcccagta tcttgctcct ccttgctctc ctcgtgggct
       61 tcttgttact cttagtcagg ggacacccaa agtcccgtgg caacttccca ccaggacctc
      121 gtccccttcc cctcttgggg aacctcctgc agttggacag agggggcctc ctcaattcct
      181 tcatgcagct tcgagaaaaa tatggagatg tgttcacagt acacctggga ccaaggcctg
      241 tggtcatgct atgtgggaca gacaccataa aggaggctct ggtgggccaa gctgaggatt
      301 tctctggtcg gggaacaatc gctgtgattg agccaatctt caaggaatat ggtgtgatct
      361 ttgccaatgg ggaacgctgg aaggcccttc ggcgattctc tctggctacc atgagagact
      421 ttgggatggg aaagaggagt gtggaagaac ggattcagga ggaagcccaa tgtttggtgg
      481 aggaactgcg gaaatcccag ggagccccac tggatcccac cttcctcttc cagtgcatca
      541 cagccaacat catctgctcc attgtgtttg gagagcgctt tgactacaca gaccgccagt
      601 tcctgcgcct gttggagctg ttctaccgga ccttttccct cctaagttca ttctccagcc
      661 aggtgtttga gttcttctct gggttcctga aatactttcc tggtgcccac agacaaatct
      721 ccaaaaacct ccaggaaatc ctcgattaca ttggccatat tgtggagaag cacagggcca
      781 ccttagaccc aagcgctcca cgagacttca tcgacactta ccttctgcgc atggagaagg
      841 agaagtcgaa ccaccacaca gtgttccatc atgagaacct catgatctcc ctgctctctc
      901 tcttctttgc tggcactgag accagcagca ccacactccg ctatggtttc ctgctgatgc
      961 tcaagtaccc ccatgtcgca gagaaagtcc aaaaggagat tgatcaggtg atcggctcac
     1021 accggctacc aacccttgat gaccgcagta aaatgccata cactgatgca gttatccatg
     1081 agattcagag gttttcagat cttgtcccta ttggagtacc acacagagtc accaaagaca
     1141 ccatgttccg agggtacctg cttcccaaga acactgaagt gtaccccatc ctgagttcag
     1201 ctctccatga cccacagtac tttgaccacc cagacagctt caatcctgaa cacttcctgg
     1261 atgccaatgg ggcactgaaa aagagtgaag ctttcatgcc cttctccaca ggaaagcgca
     1321 tttgtcttgg cgaaggcatt gcccgaaatg aattgttcct cttcttcacc accatcctcc
     1381 agaacttctc tgtgtcaagc catttggctc ccaaggacat tgacctcacg cccaaggaga
     1441 gtggcattgg aaaaatacct ccaacgtacc agatctgctt ctcagctcgg tgatccggct
     1501 gaggcagcca tgtgccccag ttctgttggg aatggcctca tgtttctgcc tctgggggac
     1561 ctgctgaaaa ccaggctcaa ggccactgct cacatcttcc tattgcagtt ctccaaagtc
     1621 ccaaggcttt ttcttattcc tgtgaatggc actgaagaag tcaatcggct gtcttatttt
     1681 gacatgtgaa cagagatttc atgagtccac atctcatgct gagtcacttc cctcttcctc
     1741 ctaacagccc atgtccccag ttatcagccc tccatggtct gtgatctgtg ctaatggact
     1801 ctgtatatgg tctcagtgct atgtctacag acttacatag tatgtatggt tcaggtaaac
     1861 agaatcacag agtgtgtgaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
