LOCUS       NM_012542               1696 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily a,
            polypeptide 3 (Cyp2a3), mRNA.
ACCESSION   NM_012542
VERSION     NM_012542.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1696)
  AUTHORS   Baur,J.A., Pearson,K.J., Price,N.L., Jamieson,H.A., Lerin,C.,
            Kalra,A., Prabhu,V.V., Allard,J.S., Lopez-Lluch,G., Lewis,K.,
            Pistell,P.J., Poosala,S., Becker,K.G., Boss,O., Gwinn,D., Wang,M.,
            Ramaswamy,S., Fishbein,K.W., Spencer,R.G., Lakatta,E.G., Le
            Couteur,D., Shaw,R.J., Navas,P., Puigserver,P., Ingram,D.K., de
            Cabo,R. and Sinclair,D.A.
  TITLE     Resveratrol improves health and survival of mice on a high-calorie
            diet
  JOURNAL   Nature 444 (7117), 337-342 (2006)
   PUBMED   17086191
REFERENCE   2  (bases 1 to 1696)
  AUTHORS   Abu-Bakar,A., Moore,M.R. and Lang,M.A.
  TITLE     Evidence for induced microsomal bilirubin degradation by cytochrome
            P450 2A5
  JOURNAL   Biochem Pharmacol 70 (10), 1527-1535 (2005)
   PUBMED   16183037
REFERENCE   3  (bases 1 to 1696)
  AUTHORS   Ling,G., Hauer,C.R., Gronostajski,R.M., Pentecost,B.T. and Ding,X.
  TITLE     Transcriptional regulation of rat CYP2A3 by nuclear factor 1:
            identification of a novel NFI-A isoform, and evidence for
            tissue-selective interaction of NFI with the CYP2A3 promoter in
            vivo
  JOURNAL   J Biol Chem 279 (27), 27888-27895 (2004)
   PUBMED   15123731
  REMARK    GeneRIF: CYP2a3 trans activation requires NFIA transcription
            factors
REFERENCE   4  (bases 1 to 1696)
  AUTHORS   Gopalakrishnan,R., Gupta,A., Carlton,P.S., Morse,M.A. and
            Stoner,G.D.
  TITLE     Functional role of cytochrome p-450 2a3 in
            N-nitrosomethylbenzylamine metabolism in rat esophagus
  JOURNAL   J Toxicol Environ Health A 65 (15), 1077-1091 (2002)
   PUBMED   12167220
  REMARK    GeneRIF: CYP2A3 levels in the rat esophagus can be a determinant of
            its ability to metabolize carcinogen N-nitrosomethylbenzylamine in
            vivo
REFERENCE   5  (bases 1 to 1696)
  AUTHORS   Ueno,T. and Gonzalez,F.J.
  TITLE     Complete sequence of the rat CYP2A3 gene specifically transcribed
            in lung
  JOURNAL   Nucleic Acids Res 18 (15), 4623-4624 (1990)
   PUBMED   2388852
REFERENCE   6  (bases 1 to 1696)
  AUTHORS   Kimura,S., Kozak,C.A. and Gonzalez,F.J.
  TITLE     Identification of a novel P450 expressed in rat lung: cDNA cloning
            and sequence, chromosome mapping, and induction by
            3-methylcholanthrene
  JOURNAL   Biochemistry 28 (9), 3798-3803 (1989)
   PUBMED   2751996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1, J02852.1 and AA819453.1.
            
            On Oct 12, 2007 this sequence version replaced NM_012542.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J02852.1, SRR22582424.2064876.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMN13663612
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                JAXUCZ010000001.1  91299584-91299604
            22-321              J02852.1           1-300
            322-343             JAXUCZ010000001.1  91300171-91300192
            344-493             JAXUCZ010000001.1  91300874-91301023
            494-981             J02852.1           473-960
            982-1161            JAXUCZ010000001.1  91305200-91305379
            1162-1679           J02852.1           1141-1658
            1680-1696           AA819453.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1696
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1696
                     /gene="Cyp2a3"
                     /gene_synonym="Cyp2a3a; RATCYP2A3A"
                     /note="cytochrome P450, family 2, subfamily a, polypeptide
                     3"
                     /db_xref="GeneID:24299"
                     /db_xref="RGD:2465"
     CDS             1..1485
                     /gene="Cyp2a3"
                     /gene_synonym="Cyp2a3a; RATCYP2A3A"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450, subfamily IIA
                     (phenobarbital-inducble)/ (cytochrome P450 IIA3); CYPIIA3;
                     coumarin 7-hydroxylase; cytochrome P450, family 2,
                     subfamily A, polypeptide 3a"
                     /codon_start=1
                     /product="cytochrome P450 2A3"
                     /protein_id="NP_036674.1"
                     /db_xref="GeneID:24299"
                     /db_xref="RGD:2465"
                     /translation="MLASGLLLVASVAFLSVLVLMSVWKQRKLSGKLPPGPTPLPFIG
                     NYLQLNTEKMYSSLMKISQRYGPVFTIHLGPRRVVVLCGQEAVKEALVDQAEEFSGRG
                     EQATFDWLFKGYGVAFSSGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIESF
                     RKTNGALIDPTFYLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQ
                     LYEMFSSVMKHLPGPQQQAFKELQGLEDFITKKVEQNQRTLDPNSPRDFIDSFLIRML
                     EEKKNPNTEFYMKNLVLTTLNLFFAGTETVSTTLRYGFLLLMKHPDIEAKVHEEIDRV
                     IGRNRQAKYEDRMKMPYTEAVIHEIQRFADMIPMGLARRVTKDTKFREFLLPKGTEVF
                     PMLGSVLKDPKFFSNPNDFNPKHFLDDKGQFKKSDAFVPFSIGKRYCFGEGLARMELF
                     LFLTNIMQNFCFKSPQAPQDIDVSPRLVGFATIPPNYTMSFLSR"
     exon            1..180
                     /gene="Cyp2a3"
                     /gene_synonym="Cyp2a3a; RATCYP2A3A"
                     /inference="alignment:Splign:2.1.0"
     exon            181..343
                     /gene="Cyp2a3"
                     /gene_synonym="Cyp2a3a; RATCYP2A3A"
                     /inference="alignment:Splign:2.1.0"
     exon            344..493
                     /gene="Cyp2a3"
                     /gene_synonym="Cyp2a3a; RATCYP2A3A"
                     /inference="alignment:Splign:2.1.0"
     exon            494..654
                     /gene="Cyp2a3"
                     /gene_synonym="Cyp2a3a; RATCYP2A3A"
                     /inference="alignment:Splign:2.1.0"
     exon            655..831
                     /gene="Cyp2a3"
                     /gene_synonym="Cyp2a3a; RATCYP2A3A"
                     /inference="alignment:Splign:2.1.0"
     exon            832..973
                     /gene="Cyp2a3"
                     /gene_synonym="Cyp2a3a; RATCYP2A3A"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1161
                     /gene="Cyp2a3"
                     /gene_synonym="Cyp2a3a; RATCYP2A3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1303
                     /gene="Cyp2a3"
                     /gene_synonym="Cyp2a3a; RATCYP2A3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1680
                     /gene="Cyp2a3"
                     /gene_synonym="Cyp2a3a; RATCYP2A3A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctggcct caggactcct tctggtggcc tcagtggcct tcctcagtgt cctggtcttg
       61 atgtctgtct ggaagcagag gaagctctca gggaagctgc ctcctggacc caccccattg
      121 cccttcatcg ggaactacct ccagctgaac acagagaaaa tgtacagctc tctcatgaag
      181 atcagccaac gttacggtcc tgtattcacc atccacctgg gacctcgccg agttgtggtg
      241 ctgtgcggac aggaggcagt caaggaggct ctggtggacc aagctgagga attcagtggt
      301 cggggagagc aggccacctt cgactggctt ttcaaaggct atggggtagc cttcagcagc
      361 ggggagcgag ccaaacagct aaggcgcttc tccatcgcca cgctgcggga cttcggcgtg
      421 ggcaagcgtg gcatcgagga gcgtatccaa gaggaggcgg gctttctcat cgagtcattt
      481 cgaaagacga acggtgccct cattgacccc accttctatc tgagccggac agtctccaat
      541 gtcattagct caatagtctt cggggaccgc ttcgactatg aggacaaaga gttcctgtca
      601 ctgcttcgaa tgatgctggg aagcttccag ttcacagcta cctccacggg gcagctctat
      661 gagatgttct cttctgtgat gaaacacctg ccaggccccc agcaacaggc ctttaaggag
      721 ctgcaggggc tggaggactt cataaccaag aaggtggaac agaatcagcg cacgctggat
      781 cccaattccc caagggactt catcgactct ttcctcatcc gaatgctgga ggaaaagaag
      841 aaccccaata ctgagttcta catgaagaac ttggtgctga ctaccctaaa tctcttcttt
      901 gccggcacag agaccgtcag caccaccctg cgttacggct ttctgttgct catgaagcac
      961 ccggatattg aggctaaggt ccacgaggag attgaccggg tgattggcag gaaccggcag
     1021 gccaagtatg aggaccgaat gaagatgccc tacacggagg ctgtgatcca cgagatccag
     1081 agatttgcag acatgatccc catgggcctg gctcgcaggg tcaccaagga caccaagttt
     1141 cgagagttcc tcctccccaa gggtactgaa gtatttccta tgctgggctc tgtactgaaa
     1201 gaccctaagt tcttctccaa ccccaacgac ttcaacccaa agcacttcct agatgacaag
     1261 ggacagttta agaagagtga tgcctttgtg cccttttcca ttggaaaacg gtattgtttc
     1321 ggggaaggac tggcaaggat ggaactcttt ctcttcctca caaacatcat gcagaacttc
     1381 tgcttcaaat ccccacaggc accccaggac atcgatgtgt ctcctagact tgtgggcttt
     1441 gccacaatcc caccaaacta cactatgagt ttcttgtccc gttgagccag cattgcgtga
     1501 gagtaaaggg aagaatgggg gttgaaactt agaaagggtc ggatgtactg aagaaacaga
     1561 ggaaaaagag tagacctgct gaagatatat atttcaaagg tagagccaga gaagggggaa
     1621 atatctacta tgctgtgaat aggaataata aaataataaa agtagatatt atttatggca
     1681 aaaaaaaaaa aaaaaa
//
