LOCUS       NM_012693               2259 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 2, subfamily a,
            polypeptide 2 (Cyp2a2), mRNA.
ACCESSION   NM_012693
VERSION     NM_012693.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2259)
  AUTHORS   Wiwi,C.A. and Waxman,D.J.
  TITLE     Role of hepatocyte nuclear factors in transcriptional regulation of
            male-specific CYP2A2
  JOURNAL   J Biol Chem 280 (5), 3259-3268 (2005)
   PUBMED   15539409
  REMARK    GeneRIF: sex-dependent hepatocyte nuclear factors contribute to the
            sexually dimorphic expression of CYP2A2
REFERENCE   2  (bases 1 to 2259)
  AUTHORS   Hanioka,N., Jinno,H., Tanaka-Kagawa,T., Nishimura,T. and Ando,M.
  TITLE     Interaction of bisphenol A with rat hepatic cytochrome P450 enzymes
  JOURNAL   Chemosphere 41 (7), 973-978 (2000)
   PUBMED   10879814
REFERENCE   3  (bases 1 to 2259)
  AUTHORS   Hanioka,N., Gonzalez,F.J., Lindberg,N.A., Liu,G. and Korzekwa,K.R.
  TITLE     Chimeric cDNA expression and site directed mutagenesis studies of
            cytochrome P450s CYP2A1 and CYP2A2
  JOURNAL   J Steroid Biochem Mol Biol 43 (8), 1037-1043 (1992)
   PUBMED   22217848
  REMARK    GeneRIF: Data suggest that structures of active sites of CYP2A1 and
            CYP2A2 have certain amount of flexibility and that non-specific
            binding (i.e., hydrophobic binding) is involved in differences in
            substrate specificity between these two enzymes.
REFERENCE   4  (bases 1 to 2259)
  AUTHORS   Matsunaga,T., Nomoto,M., Kozak,C.A. and Gonzalez,F.J.
  TITLE     Structure and in vitro transcription of the rat CYP2A1 and CYP2A2
            genes and regional localization of the CYP2A gene subfamily on
            mouse chromosome 7
  JOURNAL   Biochemistry 29 (5), 1329-1341 (1990)
   PUBMED   2322568
REFERENCE   5  (bases 1 to 2259)
  AUTHORS   Arlotto,M.P., Greenway,D.J. and Parkinson,A.
  TITLE     Purification of two isozymes of rat liver microsomal cytochrome
            P450 with testosterone 7 alpha-hydroxylase activity
  JOURNAL   Arch Biochem Biophys 270 (2), 441-457 (1989)
   PUBMED   2650624
REFERENCE   6  (bases 1 to 2259)
  AUTHORS   Matsunaga,T., Nagata,K., Holsztynska,E.J., Lapenson,D.P., Smith,A.,
            Kato,R., Gelboin,H.V., Waxman,D.J. and Gonzalez,F.J.
  TITLE     Gene conversion and differential regulation in the rat P-450 IIA
            gene subfamily. Purification, catalytic activity, cDNA and deduced
            amino acid sequence, and regulation of an adult male-specific
            hepatic testosterone 15 alpha-hydroxylase
  JOURNAL   J Biol Chem 263 (34), 17995-18002 (1988)
   PUBMED   3192524
REFERENCE   7  (bases 1 to 2259)
  AUTHORS   Matsumoto,T., Emi,Y., Kawabata,S. and Omura,T.
  TITLE     Purification and characterization of three male-specific and one
            female-specific forms of cytochrome P-450 from rat liver microsomes
  JOURNAL   J Biochem 100 (5), 1359-1371 (1986)
   PUBMED   2434473
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J04187.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04187.1, BC089818.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2259
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2259
                     /gene="Cyp2a2"
                     /gene_synonym="CYP2A21; RATCYP2A21"
                     /note="cytochrome P450, family 2, subfamily a, polypeptide
                     2"
                     /db_xref="GeneID:24895"
                     /db_xref="RGD:2464"
     exon            1..186
                     /gene="Cyp2a2"
                     /gene_synonym="CYP2A21; RATCYP2A21"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1488
                     /gene="Cyp2a2"
                     /gene_synonym="CYP2A21; RATCYP2A21"
                     /EC_number="1.14.14.1"
                     /note="CYPIIA2; P450-UT-4; testosterone
                     15-alpha-hydroxylase; cytochrome P450-UT-4; cytochrome
                     P450, subfamily 2A, polypeptide 2; Cytochrome P450 IIA2;
                     cytochrome P450, subfamily 2A, polypeptide 1; hepatic
                     steroid hydroxylase IIA2 (CYP2A2)"
                     /codon_start=1
                     /product="cytochrome P450 2A2"
                     /protein_id="NP_036825.1"
                     /db_xref="GeneID:24895"
                     /db_xref="RGD:2464"
                     /translation="MLDTGLLLVVILASLSVMFLVSLWQQKIRERLPPGPTPLPFIGN
                     YLQLNMKDVYSSITQLSERYGPVFTIHLGPRRIVVLYGYDAVKEALVDQAEEFSGRGE
                     LPTFNILFKGYGFSLSNVEQAKRIRRFTIATLRDFGVGKRDVQECILEEAGYLIKTLQ
                     GTCGAPIDPSIYLSKTVSNVINSIVFGNRFDYEDKEFLSLLEMIDEMNIFAASATGQL
                     YDMFHSVMKYLPGPQQQIIKVTQKLEDFMIEKVRQNHSTLDPNSPRNFIDSFLIRMQE
                     EKYVNSEFHMNNLVMSSLGLLFAGTGSVSSTLYHGFLLLMKHPDVEAKVHEEIERVIG
                     RNRQPQYEDHMKMPYTQAVINEIQRFSNLAPLGIPRRIIKNTTFRGFFLPKGTDVFPI
                     IGSLMTEPKFFPNHKDFNPQHFLDDKGQLKKNAAFLPFSIGKRFCLGDSLAKMELFLL
                     LTTILQNFRFKFPMNLEDINEYPSPIGFTRIIPNYTMSFMPI"
     exon            187..349
                     /gene="Cyp2a2"
                     /gene_synonym="CYP2A21; RATCYP2A21"
                     /inference="alignment:Splign:2.1.0"
     exon            350..499
                     /gene="Cyp2a2"
                     /gene_synonym="CYP2A21; RATCYP2A21"
                     /inference="alignment:Splign:2.1.0"
     exon            500..660
                     /gene="Cyp2a2"
                     /gene_synonym="CYP2A21; RATCYP2A21"
                     /inference="alignment:Splign:2.1.0"
     exon            661..837
                     /gene="Cyp2a2"
                     /gene_synonym="CYP2A21; RATCYP2A21"
                     /inference="alignment:Splign:2.1.0"
     exon            838..976
                     /gene="Cyp2a2"
                     /gene_synonym="CYP2A21; RATCYP2A21"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1164
                     /gene="Cyp2a2"
                     /gene_synonym="CYP2A21; RATCYP2A21"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1306
                     /gene="Cyp2a2"
                     /gene_synonym="CYP2A21; RATCYP2A21"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..2259
                     /gene="Cyp2a2"
                     /gene_synonym="CYP2A21; RATCYP2A21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggctacta tgctggacac aggactgctc ctggtggtca tactggcctc cctaagtgtc
       61 atgttcttgg tgtccctctg gcagcagaaa atcagggaga gattgcctcc aggacccact
      121 cctttgcctt tcattggaaa ttatctgcag ctgaatatga aagacgtata cagttccatc
      181 acacagctca gtgagcgcta tggtcctgtg ttcaccattc accttgggcc tcgacggatt
      241 gttgtgcttt atggatacga tgcagtcaaa gaggctttgg tggaccaagc tgaggagttc
      301 agtggacgtg gcgaactgcc tacctttaat atactcttca aaggctatgg tttttcattg
      361 agcaatgtgg aacaggccaa gcgtatcagg cgcttcacca tagccacatt gagagatttt
      421 ggtgtgggca agcgtgatgt acaggagtgt atcctggagg aggcaggcta tttgatcaag
      481 acgttgcagg gcacttgtgg agcccccatt gacccttcca tctacctgag caaaacagtc
      541 tccaatgtca ttaactccat tgtcttcggg aaccgcttcg actatgagga caaagagttc
      601 ttgtcactgt tggagatgat cgatgaaatg aatatatttg cagcctcagc cacagggcag
      661 ctctatgaca tgttccattc agtgatgaag tacctgcctg gaccacagca acagatcatc
      721 aaggttactc agaaactgga agacttcatg atagagaaag tgaggcagaa ccatagtacc
      781 ctggacccca attccccaag gaacttcatt gactcctttc tcatccgcat gcaagaggag
      841 aaatatgtta attcagaatt ccacatgaac aacctagtga tgtcatcatt aggcctcctc
      901 tttgctggga ctgggtcagt cagctccacg ctataccatg gtttcctgct actcatgaag
      961 catccagatg tggaagccaa ggtccatgag gaaattgagc gagtgatcgg caggaaccga
     1021 cagcctcagt atgaggacca catgaagatg ccctacaccc aggctgtgat caatgagatc
     1081 caaagatttt ctaacttggc tcccttgggc attcctcgaa ggattatcaa gaacacaacc
     1141 ttccgtggct tcttcctccc caagggcacc gatgtattcc ctataatagg ttctctgatg
     1201 acagaaccaa agttcttccc taaccacaaa gacttcaacc cccagcactt cctggatgac
     1261 aagggacagt tgaagaagaa tgctgcattt ctcccttttt ccattggaaa gcgattctgc
     1321 ttgggagata gcctggctaa aatggagctc ttcctgctgc tcaccaccat cttgcagaac
     1381 ttccgtttta agttcccaat gaatctagaa gacatcaacg agtaccccag tcccataggg
     1441 tttaccagga tcataccaaa ttacaccatg agcttcatgc ccatctgatt ctgagttgaa
     1501 tcaaggtggg gcaagaggga gggagagcct gaagtggggc cagggtgcag gtggagagaa
     1561 cagagaagat gaagatgagg gttaagaagg gaccacaccc atggaagaaa cacaaaagac
     1621 ttctcagttt ggtaaaattg taacagtcct aataaaaaga aagaaacacc cagtaggcag
     1681 cagtaacaac aactgagact catggggcaa aggtggctca cctctgcaga agctgtcctg
     1741 cccttctctc actcagtcct ctacacaaga gcagcatgtc cccaagccca acgtacaggt
     1801 tcaaaagata gaacttaaaa aatttgaacc taaactgagg tggaaaagac acagttagct
     1861 aggattgaca cattggactc tatcaccagc attcaggagg gagggaacat ggctccctag
     1921 gaggcctgcc agaattacaa agtgaaactc atctcaaaaa aggaacaaca gaaaataaaa
     1981 tttcaaattg atttctctta gaccataaga gtccagatct gtatccaaag ctatttggtt
     2041 atattttttg ttattgttgt tttgtttaca cattgtgttt ttctttcggt ttgtaagtct
     2101 gtttgggata tttaatttac atttactgat tagtgtgggt ggtagggcat accatggctc
     2161 aaatgtggaa accaaagaaa agcttttgga agtgtcatct cccttacaat acgtgtgtcc
     2221 aagaactcaa attcagacaa taaagcttga tagcaagca
//
