LOCUS       NM_053763               2426 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 27, subfamily b,
            polypeptide 1 (Cyp27b1), mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_053763
VERSION     NM_053763.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2426)
  AUTHORS   Obaid,A.A., Almasmoum,H., Almaimani,R.A., El-Boshy,M., Aslam,A.,
            Idris,S., Ghaith,M.M., El-Readi,M.Z., Ahmad,J., Farrash,W.F.,
            Mujalli,A., Eid,S.Y., Elzubier,M.E. and Refaat,B.
  TITLE     Vitamin D and calcium co-therapy mitigates pre-established cadmium
            nephropathy by regulating renal calcium homeostatic molecules and
            improving anti-oxidative and anti-inflammatory activities in rat
  JOURNAL   J Trace Elem Med Biol 79, 127221 (2023)
   PUBMED   37244046
REFERENCE   2  (bases 1 to 2426)
  AUTHORS   Varshney,S., Adela,R., Kachhawa,G., Dada,R., Kulshreshtha,V.,
            Kumari,R., Agarwal,R. and Khadgawat,R.
  TITLE     Disrupted placental vitamin D metabolism and calcium signaling in
            gestational diabetes and pre-eclampsia patients
  JOURNAL   Endocrine 80 (1), 191-200 (2023)
   PUBMED   36477942
REFERENCE   3  (bases 1 to 2426)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 2426)
  AUTHORS   Campolina-Silva,G.H., Barata,M.C., Werneck-Gomes,H., Maria,B.T.,
            Mahecha,G.A.B., Belleannee,C. and Oliveira,C.A.
  TITLE     Altered expression of the vitamin D metabolizing enzymes CYP27B1
            and CYP24A1 under the context of prostate aging and pathologies
  JOURNAL   J Steroid Biochem Mol Biol 209, 105832 (2021)
   PUBMED   33596463
  REMARK    GeneRIF: Altered expression of the vitamin D metabolizing enzymes
            CYP27B1 and CYP24A1 under the context of prostate aging and
            pathologies.
REFERENCE   5  (bases 1 to 2426)
  AUTHORS   Nishikawa,M., Yasuda,K., Takamatsu,M., Abe,K., Okamoto,K.,
            Horibe,K., Mano,H., Nakagawa,K., Tsugawa,N., Hirota,Y., Horie,T.,
            Hinoi,E., Okano,T., Ikushiro,S. and Sakaki,T.
  TITLE     Generation of novel genetically modified rats to reveal the
            molecular mechanisms of vitamin D actions
  JOURNAL   Sci Rep 10 (1), 5677 (2020)
   PUBMED   32231239
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2426)
  AUTHORS   Mizokuchi,M., Kubota,M., Tomino,Y. and Koide,H.
  TITLE     Possible mechanism of impaired calcium and vitamin D metabolism in
            nephrotic rats
  JOURNAL   Kidney Int 42 (2), 335-340 (1992)
   PUBMED   1328752
REFERENCE   7  (bases 1 to 2426)
  AUTHORS   Carpenter,T.O., Pendrak,M.L. and Anast,C.S.
  TITLE     Metabolism of 25-hydroxyvitamin D in copper-laden rat: a model of
            Wilson's disease
  JOURNAL   Am J Physiol 254 (2 Pt 1), E150-E154 (1988)
   PUBMED   3348368
REFERENCE   8  (bases 1 to 2426)
  AUTHORS   Ishida,M., Bulos,B., Takamoto,S. and Sacktor,B.
  TITLE     Hydroxylation of 25-hydroxyvitamin D3 by renal mitochondria from
            rats of different ages
  JOURNAL   Endocrinology 121 (2), 443-448 (1987)
   PUBMED   3496213
REFERENCE   9  (bases 1 to 2426)
  AUTHORS   Ikeda,K., Matsumoto,T., Morita,K., Kawanobe,Y., Ezawa,I. and
            Ogata,E.
  TITLE     Role of insulin in the stimulation of renal 25-hydroxyvitamin D3-1
            alpha-hydroxylase by phosphorus deprivation in rats
  JOURNAL   Metabolism 36 (6), 555-557 (1987)
   PUBMED   3295473
REFERENCE   10 (bases 1 to 2426)
  AUTHORS   Warner,M. and Tenenhouse,A.
  TITLE     Regulation of renal vitamin D hydroxylase activity in vitamin D
            deficient rats
  JOURNAL   Can J Physiol Pharmacol 63 (8), 978-982 (1985)
   PUBMED   3000565
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB001992.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB001992.1, AF000139.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2426
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2426
                     /gene="Cyp27b1"
                     /gene_synonym="Cyp40"
                     /note="cytochrome P450, family 27, subfamily b,
                     polypeptide 1"
                     /db_xref="GeneID:114700"
                     /db_xref="RGD:69192"
     exon            1..197
                     /gene="Cyp27b1"
                     /gene_synonym="Cyp40"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1529
                     /gene="Cyp27b1"
                     /gene_synonym="Cyp40"
                     /EC_number="1.14.15.18"
                     /note="P450C1 alpha; P450VD1-alpha; VD3 1A hydroxylase;
                     cytochrome p450 27B1; calcidiol 1-monooxygenase; 25-OHD-1
                     alpha-hydroxylase; 25-hydroxyvitamin D(3)
                     1-alpha-hydroxylase; cytochrome P450 subfamily XXVIIB
                     polypeptide 1; cytochrome P450C1 alpha; cytochrome
                     P450VD1-alpha; 25-hydroxyvitamin D-1 alpha hydroxylase,
                     mitochondrial-like; cytochrome P450, subfamily 27b,
                     polypeptide 1; cytochrome P450 subfamily XXVIIB
                     (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1;
                     cytochrome P450, 40 (25-hydroxyvitamin D3 1
                     alpha-hydroxylase)"
                     /codon_start=1
                     /product="25-hydroxyvitamin D-1 alpha hydroxylase,
                     mitochondrial"
                     /protein_id="NP_446215.1"
                     /db_xref="GeneID:114700"
                     /db_xref="RGD:69192"
                     /translation="MTQAVKLASRVFHRVQLPSQLGSDSVLRSLSDIPGPSTPSFLAE
                     LFCKGGLSRLHELQVHGAARYGPIWSGSFGTLRTVYVADPALVEQLLRQESHCPERCS
                     FSSWSEHRRRHQRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDSVVSDLVR
                     RLRRQRGRGSGLPDLVLDVAGEFYKFGLEGIGAVLLGSRLGCLEAEVPPDTETFIEAV
                     GSVFVSTLLTMAMPSWLHRLIPGPWARLCRDWDQMFAFAQKHVEQREGEAAVRNQGKP
                     EEDLPTGHHLTHFLFREKVSVQSIVGNVTELLLAGVDTVSNTLSWALYELSRHPEVQS
                     ALHSEITGAVNPGSYAHLQATALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDICVGN
                     YVIPQDTLVSLCHYATSRDPAQFREPNSFNPARWLGEGPAPHPFASLPFGFGKRSCIG
                     RRLAELELQMALAQILTHFEVLPEPGALPVKPMTRTVLVPERSIHLQFVDR"
     exon            198..388
                     /gene="Cyp27b1"
                     /gene_synonym="Cyp40"
                     /inference="alignment:Splign:2.1.0"
     exon            389..591
                     /gene="Cyp27b1"
                     /gene_synonym="Cyp40"
                     /inference="alignment:Splign:2.1.0"
     exon            592..792
                     /gene="Cyp27b1"
                     /gene_synonym="Cyp40"
                     /inference="alignment:Splign:2.1.0"
     exon            793..965
                     /gene="Cyp27b1"
                     /gene_synonym="Cyp40"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1138
                     /gene="Cyp27b1"
                     /gene_synonym="Cyp40"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1217
                     /gene="Cyp27b1"
                     /gene_synonym="Cyp40"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1415
                     /gene="Cyp27b1"
                     /gene_synonym="Cyp40"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..2426
                     /gene="Cyp27b1"
                     /gene_synonym="Cyp40"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2426
                     /gene="Cyp27b1"
                     /gene_synonym="Cyp40"
                     /note="43 A nucleotides"
ORIGIN      
        1 gagcagactc ctcaaacaca aacatgaccc aggcagtcaa gctcgcctcc agagtcttcc
       61 atcgagtcca actgccttct cagctgggca gtgactcggt tctccggagt ttatctgata
      121 tccctgggcc ctctacacct agcttcctgg ctgaactctt ctgcaaaggg gggctgtcca
      181 ggctacatga actgcaggtg catggcgctg cgcggtacgg gccaatatgg tccggcagct
      241 tcgggacact tcgcacagtt tatgtggccg accctgcact tgtagagcag ctcctgcgac
      301 aagaaagtca ttgtccagag cgctgtagtt tctcatcttg gtcagagcac cgtcgccgcc
      361 accagcgggc ttgcgggttg ctaacggcgg atggtgaaga atggcagagg ctccgaagtc
      421 tcctggcccc gctactcctc cgacctcaag cagccgccgg ctatgctgga actctggaca
      481 gcgtggtcag tgacctcgtg cgacgactaa ggcgccagcg gggacgtggc tctgggctac
      541 cggacctagt tctggacgtg gcgggagagt tttacaaatt tggcctagaa ggcataggcg
      601 cggtgctgct gggatcgcgc ctgggctgcc tggaggctga agttcctccc gacacagaaa
      661 ccttcattga ggccgtgggc tcggtgtttg tgtctacact cttgaccatg gcaatgccca
      721 gttggctgca ccgccttata cccggaccct gggcccgcct ctgcagagac tgggatcaga
      781 tgtttgcctt tgcccagaag cacgtggagc agcgcgaagg cgaagctgcc gtgaggaacc
      841 agggaaagcc tgaggaggat ttgccaacgg ggcatcactt aacccacttc ctttttcggg
      901 aaaaggtgtc tgtccagtcc atagtgggaa atgtgacaga gctactactg gctggagtgg
      961 acacggtatc caatacgctc tcctgggcac tctatgagct ctcccggcac ccggaagtcc
     1021 agtctgcact ccactctgag atcacaggcg ctgtgaaccc tggctcctat gcccacctcc
     1081 aagccactgc tctgtcccag ctacccctgc taaaggctgt gatcaaagaa gtgttgagat
     1141 tgtaccctgt ggtacctggg aactcccgtg tcccagacag agacatctgt gtaggaaact
     1201 atgttattcc ccaagataca ctggtttccc tctgtcacta tgccacttca agggaccccg
     1261 cccagtttcg ggaacccaac tcttttaatc cagctcgatg gcttggagag ggtccagccc
     1321 cccacccatt tgcatctctt ccttttggct ttggcaaacg aagttgcata gggagacgct
     1381 tggcagagct cgagctacaa atggcgttgg cccagatctt gacccatttt gaggtgctgc
     1441 ctgagccagg tgctcttcca gtcaaaccca tgacccggac tgtcctggta cctgagagga
     1501 gcatccatct ccagtttgta gacagatagt cctgtggaag gcagctgtca tcatctctct
     1561 ccagactgga tttttcttac tatgcacaag aggcacactc tccctcgagg cctgtctgtc
     1621 tgagcaaact tcaggaagca ggcccgggcc tatctgtgct tgacctgact cagcaggtac
     1681 cacagaacca ggatcctttc tcctgctcag tacctctcct gatcattcct caagatccaa
     1741 agccttcaga ttttaacaca tccttaaagg gccaactcgg gggttaacta acagccccag
     1801 gcagcctggg cagggatccc ccactgatcc ttccatgctt acagtgttca ctgacagctg
     1861 tctaagcatc cattgcagca caaactaagt gactgtgcac ctggtctgca cctggtctgc
     1921 acctggttgc gtctctgcct gaccatgtga gctctttgag aagagtgatg actactgggc
     1981 ttttagctct tttccttttt gggacacagt cttgctattg tactccatgc tgtccttgaa
     2041 cccacaagcc ctcacctcac cttcccaagt gttgggttac ggacattagc tatggcttcc
     2101 agctttatta gtctttctat ctcctgccat ggtctatccc cggctatttg atactatata
     2161 ttctcagatt gaatctggac catgtggtag aagggatgac cactcaccag gctctaccca
     2221 ccactttatc ttaatctttt ctctaggaaa gtgaatctct ccttgcctta cagcatttta
     2281 aagctcccct tggctgttct gctctttagc cactctaaag tggatccact ctacttctca
     2341 ccacccatct ttctgcaccc cagcctgtct ttttatattt aaaaaattgt atttattatg
     2401 ttttcaaata aaatgtttac tccttg
//
