LOCUS       NM_181087               4550 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 26, subfamily b,
            polypeptide 1 (Cyp26b1), mRNA.
ACCESSION   NM_181087
VERSION     NM_181087.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4550)
  AUTHORS   Wang,T., Dai,L., Shen,S., Yang,Y., Yang,M., Yang,X., Qiu,Y. and
            Wang,W.
  TITLE     Comprehensive Molecular Analyses of a Macrophage-Related Gene
            Signature With Regard to Prognosis, Immune Features, and Biomarkers
            for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and
            the LASSO Algorithm
  JOURNAL   Front Immunol 13, 843408 (2022)
   PUBMED   35693827
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4550)
  AUTHORS   Foti,R.S., Isoherranen,N., Zelter,A., Dickmann,L.J., Buttrick,B.R.,
            Diaz,P. and Douguet,D.
  TITLE     Identification of Tazarotenic Acid as the First Xenobiotic
            Substrate of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1
  JOURNAL   J Pharmacol Exp Ther 357 (2), 281-292 (2016)
   PUBMED   26937021
REFERENCE   3  (bases 1 to 4550)
  AUTHORS   Chenery,A., Burrows,K., Antignano,F., Underhill,T.M., Petkovich,M.
            and Zaph,C.
  TITLE     The retinoic acid-metabolizing enzyme Cyp26b1 regulates CD4 T cell
            differentiation and function
  JOURNAL   PLoS One 8 (8), e72308 (2013)
   PUBMED   23991089
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4550)
  AUTHORS   Messner,B., Kern,J., Wiedemann,D., Schwaiger,S., Turkcan,A.,
            Ploner,C., Trockenbacher,A., Aumayr,K., Bonaros,N., Laufer,G.,
            Stuppner,H., Untergasser,G. and Bernhard,D.
  TITLE     5-Methoxyleoligin, a lignan from Edelweiss, stimulates
            CYP26B1-dependent angiogenesis in vitro and induces arteriogenesis
            in infarcted rat hearts in vivo
  JOURNAL   PLoS One 8 (3), e58342 (2013)
   PUBMED   23554885
  REMARK    GeneRIF: 5ML induces CYP26B1-dependent angiogenesis in vitro, and
            arteriogenesis in vivo.
REFERENCE   5  (bases 1 to 4550)
  AUTHORS   Jorgensen,A., Nielsen,J.E., Blomberg Jensen,M., Graem,N. and
            Rajpert-De Meyts,E.
  TITLE     Analysis of meiosis regulators in human gonads: a sexually
            dimorphic spatio-temporal expression pattern suggests involvement
            of DMRT1 in meiotic entry
  JOURNAL   Mol Hum Reprod 18 (11), 523-534 (2012)
   PUBMED   22899867
REFERENCE   6  (bases 1 to 4550)
  AUTHORS   Hagglund,M., Berghard,A., Strotmann,J. and Bohm,S.
  TITLE     Retinoic acid receptor-dependent survival of olfactory sensory
            neurons in postnatal and adult mice
  JOURNAL   J Neurosci 26 (12), 3281-3291 (2006)
   PUBMED   16554478
REFERENCE   7  (bases 1 to 4550)
  AUTHORS   Marlier,A. and Gilbert,T.
  TITLE     Expression of retinoic acid-synthesizing and -metabolizing enzymes
            during nephrogenesis in the rat
  JOURNAL   Gene Expr Patterns 5 (2), 179-185 (2004)
   PUBMED   15567713
REFERENCE   8  (bases 1 to 4550)
  AUTHORS   Yashiro,K., Zhao,X., Uehara,M., Yamashita,K., Nishijima,M.,
            Nishino,J., Saijoh,Y., Sakai,Y. and Hamada,H.
  TITLE     Regulation of retinoic acid distribution is required for
            proximodistal patterning and outgrowth of the developing mouse limb
  JOURNAL   Dev Cell 6 (3), 411-422 (2004)
   PUBMED   15030763
REFERENCE   9  (bases 1 to 4550)
  AUTHORS   Chapman,J.S., Weiss,K.L., Curley,R.W. Jr., Highland,M.A. and
            Clagett-Dame,M.
  TITLE     Hydrolysis of 4-HPR to atRA occurs in vivo but is not required for
            retinamide-induced apoptosis
  JOURNAL   Arch Biochem Biophys 419 (2), 234-243 (2003)
   PUBMED   14592467
REFERENCE   10 (bases 1 to 4550)
  AUTHORS   White,J.A., Ramshaw,H., Taimi,M., Stangle,W., Zhang,A.,
            Everingham,S., Creighton,S., Tam,S.P., Jones,G. and Petkovich,M.
  TITLE     Identification of the human cytochrome P450, P450RAI-2, which is
            predominantly expressed in the adult cerebellum and is responsible
            for all-trans-retinoic acid metabolism
  JOURNAL   Proc Natl Acad Sci U S A 97 (12), 6403-6408 (2000)
   PUBMED   10823918
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_181087.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY245532.2, SRR26643287.11465.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               JAXUCZ010000004.1  118615817-118616176 c
            361-585             JAXUCZ010000004.1  118612238-118612462 c
            586-861             JAXUCZ010000004.1  118604918-118605193 c
            862-1017            JAXUCZ010000004.1  118604548-118604703 c
            1018-1302           JAXUCZ010000004.1  118602954-118603238 c
            1303-4550           JAXUCZ010000004.1  118599356-118602603 c
FEATURES             Location/Qualifiers
     source          1..4550
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..4550
                     /gene="Cyp26b1"
                     /note="cytochrome P450, family 26, subfamily b,
                     polypeptide 1"
                     /db_xref="GeneID:312495"
                     /db_xref="RGD:631379"
     exon            1..360
                     /gene="Cyp26b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1695
                     /gene="Cyp26b1"
                     /codon_start=1
                     /product="cytochrome P450 26B1"
                     /protein_id="NP_851601.2"
                     /db_xref="GeneID:312495"
                     /db_xref="RGD:631379"
                     /translation="MLFEGLELVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKS
                     CKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENV
                     RKILLGEHQLVSTEWPRSARVLLGPNTVANSIGDIHRNKRKVFSKIFSHEALESYLPK
                     IQLVIQDTLRAWSSQPEAINVYQEAQRLTFRMAVRVLLGFSIPEEDLGNLFEVYQQFV
                     ENVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYSDALDILIESSKE
                     HGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPAVLEKLREELRAQGLLHG
                     GGCPCEGTLRLDMLSGLRYLDCVIKEVMRLFTPVSGGYRTVLQTFELDGFQIPKGWSV
                     MYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLF
                     LKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAML
                     SATV"
     exon            361..585
                     /gene="Cyp26b1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..861
                     /gene="Cyp26b1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1017
                     /gene="Cyp26b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1302
                     /gene="Cyp26b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..4550
                     /gene="Cyp26b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagtctcc agcccctttc cctcggcccc atctcctggg tttcttcgag gggtgccagg
       61 acccccggcc gcagcttccc ctcccccgtc actctggtcc ggccctcccc tcccccatcc
      121 cggaccgcac agccaatccc ccaagcggcc gccaacatgc tgtttgaggg cttggagttg
      181 gtgtcggcgc tggccaccct cgccgcgtgc ctggtgtccg tgacgctgct tctggcggtg
      241 tcgcagcagc tgtggcagct gcgctgggct gccacccgcg acaagagctg caagctgcct
      301 atccccaagg gctccatggg attcccgctc atcggagaga ctggtcactg gttgctacag
      361 ggttccggct tccagtcgtc gcgccgcgag aagtatggca acgttttcaa gacacactta
      421 ctggggcggc cgttgatccg tgtgaccggt gcggagaacg tgcgcaagat cctactgggc
      481 gaacaccagc tagtgagcac ggagtggccg cggagcgcac gcgtgctgct gggacccaac
      541 acggtggcca actccattgg cgacatccac cgcaacaagc gcaaggtctt ctccaagatc
      601 ttcagccatg aggcactcga gagctacctg cccaagatcc aactggtgat ccaggacaca
      661 cttcgagcct ggagcagcca gcctgaggcc atcaatgtgt atcaggaggc ccagcgactc
      721 accttccgaa tggccgtgcg ggttctgctg ggcttcagca tccccgagga ggacctggga
      781 aacctctttg aggtgtacca gcagtttgtg gagaatgtct tctctctgcc ggtggacctg
      841 cccttcagcg gctaccggag gggcatccaa gctcggcaga tccttcagaa gggcctagag
      901 aaggctatcc gtgagaagct tcagtgtacc cagggcaaag actactcaga cgccctggac
      961 attctcattg agagcagcaa ggagcacggc aaggagatga ccatgcagga gctgaaggat
     1021 gggaccctgg agctgatctt cgcagcctat gccactacgg ccagtgccag cacatccttg
     1081 atcatgcaac tactgaaaca ccctgcagtg ctggaaaagc tacgggagga actgcgggcc
     1141 cagggcctgc tgcatggtgg tggctgcccc tgcgagggca ccctgcgcct ggacatgctc
     1201 agtggcctgc gctacctgga ctgcgtcatc aaggaggtca tgaggctctt cacgcccgtc
     1261 tcaggaggct accgcactgt gctgcagacc ttcgaactgg atggtttcca gatccccaag
     1321 ggctggagtg tcatgtatag catccgtgac actcacgaca cagcgcctgt gttcaaggat
     1381 gtgaatgtgt ttgaccctga ccgcttcagc caggcgcgca gtgaggataa ggatggccgc
     1441 ttccattacc tcccatttgg cggtggtgtg cggacctgcc tgggcaaaca cttggccaag
     1501 ctgttcctga aggtgctggc agtggagctg gctagcacaa gccgcttcga gctggccacc
     1561 cggaccttcc ctcgcatcac tctggtccct gtcttgcacc ccgtggatgg cctcagtgtc
     1621 aagttctttg gtctagactc caatcagaat gagattctgc ctgagacaga ggccatgttg
     1681 agtgctacgg tgtagcctca ctctggtctc agcccagccc agcagcgggg gtgggggaca
     1741 gagatagaaa cctgtggggt agggaggggc tggatgggag gccagcagcc cccctatgtt
     1801 gttctctggc ctcttccccg gcaaaccctc cctaaagaca aaagtgcccc gccccctcct
     1861 gactcccacc ctcttggatc tccactgccc cctagcttag ctcctgggac agagccagga
     1921 caatttgccc atgacagtgt tagtgagctg cagtacatgc ttatgacctc tgaacgcttc
     1981 cttccctaac cccccttgtc tttttgttgg tggtcaggtg cctgtgaagc caggagggag
     2041 gaaagtgggg ggggggcctt ggagcactct ttgacactct cacatccccc ctctgtcact
     2101 gctcaaatgg tgcccagaac agtgttgtgg gaatcctcac ctaagccagc cttgacaggg
     2161 aaggagatga caccggcttt gaggggccca taccagccta cctagttcgg acattggaag
     2221 ttacctatcg ctgctatttg tcctctcttc tgaccttggg gtacagacct tggggtacag
     2281 gagcctacag gcttaatcct cagatcttcc ttggtggccc tgggcaggga caccagcact
     2341 cctcccccat gggaccaact gagccaggtg ttttctggct atagctgggc tcccagctgc
     2401 ccacccttgt ccccctgtcc catatttatt cactgacctt ggctacactg aggtctggag
     2461 catcctcccc aacacccacc caccaccacc aacactgcca ccaccacatg cacacacctg
     2521 ccagcctctg acctagctct ccttttcagg gctaatgtga ggcaagaaga tgtgtgtctg
     2581 gtctaaccca gttctttggt agagggttaa cagccctcct gggctctagg caaaagatgt
     2641 agcttaacct cagagtcaga cacccagcat ctttgccagg tgttcttagc acctgctccc
     2701 aggcggtcaa agcccccggg catgtgggcc taggggctac cacttcctgt tcactcactg
     2761 cctgccccag tgccagccac tcccctggtg aggatgcatg aggatacggg ttcttctgaa
     2821 gggacttctg ttcccttcct taactctctg cccctttgct cttggaagag tcctccaccc
     2881 catacccact cccaacccca tgccacagtc tgctaagccc agctcagaat ttgggataga
     2941 gaagaaagcc gagaggtaag gtggagagag ccctctctct gagctgtgtc aggccctgtg
     3001 gggtctggag aagctgcagg ggaggctata gctggaaagg aatagagaag gagaggagga
     3061 agatgaggac agggcataag tgagttgtca gaagtggttc agttgcagaa gggccagtgg
     3121 ggggtgtgga aggtgactgg gtagaaggtg aggggctcct gccactggca ttttgagggt
     3181 tggccatgcg ggaccttcct gggaaggatt tggggctctg gtgtgtctct aggcaatttt
     3241 gtctgttttc agattcctct gggctttttg tttcccatcc attgcttttg cctgtcactc
     3301 aggcagtggc acattttctc tagaaaacag gaacatagaa cgacagttct tattgacctg
     3361 accctggatg gccattgtca cgagggtcag ccacatctcc cgagccacac agaacatcct
     3421 agaagccgcc tttcccaaat gtttcactgc tctgcatttt ttttctgaca gaacaaactg
     3481 cagcattaga ataccaggga aattattgtg gagttcaaaa ataaccataa acccgcaccc
     3541 ccccccctcc cagctctgaa acagaccaca ccatgtagaa gctcatcaac gtttatgaag
     3601 taggtgcatg ctgccctcac ttcacaaacc agtgctgggg agactcatct tcctgcacac
     3661 taaccctgct tgcccacagc caactgtttc agattgaaga tgtggcatat agctctgtcc
     3721 ctggtaaggg acagagggac tggagggccc cagcaggtgt cgggggcctt ccctttcagg
     3781 gggccagccc aggaggtgtg gtgaaggaaa agctgagggg aatccctgtg agggtgggag
     3841 gaaggaaaga tggtctgcct ggatgggtct caaaggtaac aggcaaaggg acctagccta
     3901 ggcacctgtg ggtgtggcac ccgtctcacc tctgtagctg tgtctgttcc gtgtttgtgt
     3961 gtttcattgt ggtagcatta atgggtgatg tattctcaca ttcctaacta ttgtaacttg
     4021 acattaaaaa aaaaaaacaa aaacaaaccc cacaaaaact tcctgccaca ggcttgcaga
     4081 ttgaagcact ttcaaagtta gacgctggcg tgtgcattct gggcaaccgt tttgaccctg
     4141 cccaggtttc tgttatttta tacacaaaac ttttttttca taaatgttat aattttgtgt
     4201 ccgtctttat aaactattat aagtactatt ttgttataat tcaaaataga tatttagtat
     4261 aaagtttttg ctgttaaata tttgttattt agtaaaatat gaattgttct ttattgtaaa
     4321 catggttcaa aatattaata tgcttttatc acagttgttt taatattgaa aaagcacttg
     4381 tgtgtctcgt cttggtatga gctggtgctt gtgtgtgtgt cttggctgtc gtgtggtttt
     4441 gatgtatata taatattcca cgttgcatat tacaacaacg aatgtcctgc attttgtgaa
     4501 atactcaatg tgctctttta ttggcttcca taataaactg tggggactca
//
