LOCUS       NM_130408               1754 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus cytochrome P450, family 26, subfamily a,
            polypeptide 1 (Cyp26a1), mRNA.
ACCESSION   NM_130408
VERSION     NM_130408.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1754)
  AUTHORS   Foti RS, Isoherranen N, Zelter A, Dickmann LJ, Buttrick BR, Diaz P
            and Douguet D.
  TITLE     Identification of Tazarotenic Acid as the First Xenobiotic
            Substrate of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1
  JOURNAL   J Pharmacol Exp Ther 357 (2), 281-292 (2016)
   PUBMED   26937021
REFERENCE   2  (bases 1 to 1754)
  AUTHORS   Trasino SE, Benoit YD and Gudas LJ.
  TITLE     Vitamin A deficiency causes hyperglycemia and loss of pancreatic
            beta-cell mass
  JOURNAL   J Biol Chem 290 (3), 1456-1473 (2015)
   PUBMED   25451926
REFERENCE   3  (bases 1 to 1754)
  AUTHORS   Liu HY, Chao H, Liu ZK, Xia HF, Song Z, Yang Y and Peng JP.
  TITLE     Regulation of cyp26a1 on Th17 cells in mouse peri-implantation
  JOURNAL   J Cell Mol Med 18 (3), 455-467 (2014)
   PUBMED   24325348
  REMARK    GeneRIF: The cyp26a1-regulated Th17 cells are dependent on all
            trans retinoic acid signalling, which is delivered through RARalpha
            in mouse peri-implantation.
REFERENCE   4  (bases 1 to 1754)
  AUTHORS   Zhang Y, Li R, Li Y, Chen W, Zhao S and Chen G.
  TITLE     Vitamin A status affects obesity development and hepatic expression
            of key genes for fuel metabolism in Zucker fatty rats
  JOURNAL   Biochem Cell Biol 90 (4), 548-557 (2012)
   PUBMED   22554462
REFERENCE   5  (bases 1 to 1754)
  AUTHORS   Osanai M and Lee GH.
  TITLE     Enhanced expression of retinoic acid-metabolizing enzyme CYP26A1 in
            sunlight-damaged human skin
  JOURNAL   Med Mol Morphol 44 (4), 200-206 (2011)
   PUBMED   22179182
REFERENCE   6  (bases 1 to 1754)
  AUTHORS   White JA, Ramshaw H, Taimi M, Stangle W, Zhang A, Everingham S,
            Creighton S, Tam SP, Jones G and Petkovich M.
  TITLE     Identification of the human cytochrome P450, P450RAI-2, which is
            predominantly expressed in the adult cerebellum and is responsible
            for all-trans-retinoic acid metabolism
  JOURNAL   Proc Natl Acad Sci U S A 97 (12), 6403-6408 (2000)
   PUBMED   10823918
REFERENCE   7  (bases 1 to 1754)
  AUTHORS   Sonneveld E, van den Brink CE, van der Leede BM, Schulkes RK,
            Petkovich M, van der Burg B and van der Saag PT.
  TITLE     Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific
            for all-trans-RA and can be induced through RA receptors in human
            breast and colon carcinoma cells
  JOURNAL   Cell Growth Differ 9 (8), 629-637 (1998)
   PUBMED   9716180
REFERENCE   8  (bases 1 to 1754)
  AUTHORS   Abu-Abed SS, Beckett BR, Chiba H, Chithalen JV, Jones G, Metzger D,
            Chambon P and Petkovich M.
  TITLE     Mouse P450RAI (CYP26) expression and retinoic acid-inducible
            retinoic acid metabolism in F9 cells are regulated by retinoic acid
            receptor gamma and retinoid X receptor alpha
  JOURNAL   J Biol Chem 273 (4), 2409-2415 (1998)
   PUBMED   9442090
REFERENCE   9  (bases 1 to 1754)
  AUTHORS   White JA, Beckett-Jones B, Guo YD, Dilworth FJ, Bonasoro J, Jones G
            and Petkovich M.
  TITLE     cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI)
            identifies a novel family of cytochromes P450
  JOURNAL   J Biol Chem 272 (30), 18538-18541 (1997)
   PUBMED   9228017
REFERENCE   10 (bases 1 to 1754)
  AUTHORS   Fujii H, Sato T, Kaneko S, Gotoh O, Fujii-Kuriyama Y, Osawa K, Kato
            S and Hamada H.
  TITLE     Metabolic inactivation of retinoic acid by a novel P450
            differentially expressed in developing mouse embryos
  JOURNAL   EMBO J 16 (14), 4163-4173 (1997)
   PUBMED   9250660
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF439720.2.
            
            On Oct 31, 2005 this sequence version replaced NM_130408.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF439720.2, DQ266888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1754
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..1754
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26"
                     /note="cytochrome P450, family 26, subfamily a,
                     polypeptide 1"
                     /db_xref="GeneID:154985"
                     /db_xref="RGD:620161"
     exon            1..232
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1537
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26"
                     /EC_number="1.14.-.-"
                     /note="retinoic acid hydroxylase; cytochrome P450, 26,
                     retinoic acid; retinoic acid hydrolase"
                     /codon_start=1
                     /product="cytochrome P450, family 26, subfamily a,
                     polypeptide 1"
                     /protein_id="NP_569092.2"
                     /db_xref="GeneID:154985"
                     /db_xref="RGD:620161"
                     /translation="MGLPALLASALCTFVLPLLLFLAALKLWDLYCVSSRDRSCALPL
                     PPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILL
                     GEHRLVSVHWPASVRTILGAGCLSNLHDSSHKQRKKVIMQAFNREALQCYVPVIAEEV
                     SGCLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPGPAGGGEDEQQLVEAFEEMT
                     RNLFSLPIDVPFSGLYRGVKARNLIHARIEENIRAKIRRLQAAEPDAGCKDALQLLIE
                     HSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEIKSKG
                     LLCKSHHEDKLDMETLEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGW
                     NVIYSICDTHDVADSFTNKEEFNPDRFTSLHPEDTSRFSFIPFGGGLRSCVGKEFAKI
                     LLKIFTVELARRCDWQLLNGPPTMKTSPPVYPVDNLPARFTHFQGDI"
     exon            233..457
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26"
                     /inference="alignment:Splign:2.1.0"
     exon            458..748
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26"
                     /inference="alignment:Splign:2.1.0"
     exon            749..907
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1042
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1195
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1727
                     /gene="Cyp26a1"
                     /gene_synonym="Cyp26"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagggcggcg gcggcaggtg gcgcgggagg cttgctgcgt gccatggggc tcccggcgct
       61 gctggccagt gctctctgca ccttcgtgct gccgctgctg ctcttcctgg cggcgctcaa
      121 gctctgggac ctgtactgtg tgagcagccg cgatcgcagc tgcgctctcc ccttgccccc
      181 gggtaccatg ggcttcccat tctttgggga aacattgcag atggtgctgc agcggaggaa
      241 gtttctgcag atgaagcgca ggaaatacgg cttcatctac aagacgcatc tgtttgggcg
      301 gcccacggtg cgagtgatgg gcgcggataa tgtgcggcgc atcttgctgg gggagcaccg
      361 gttggtgtca gtgcactggc ctgcttcggt gcgcaccatc ctgggcgccg gctgcctctc
      421 caacctgcat gattcctcgc acaagcagcg aaagaaggtg attatgcagg ccttcaaccg
      481 agaggcgctc cagtgctacg tgccagtgat tgctgaagaa gtgagcggtt gtctggagca
      541 gtggctaagc tgcggcgagc gcggcctcct ggtctacccc gaggtgaagc gcctcatgtt
      601 ccgcatcgcc atgcgcatcc tgctgggctg cgagccgggt ccagcgggcg gcggggaaga
      661 cgagcagcag ctagtggagg ctttcgagga gatgacccgc aatctcttct ctctccccat
      721 tgacgtgccc tttagcgggc tgtaccgggg cgtgaaggcg cggaacctta tccacgcgcg
      781 catcgaggag aacattcggg ccaagatccg ccggcttcag gccgcagagc cggatgcggg
      841 ctgcaaggac gcactgcagc tcttgattga gcactcatgg gagagaggag agaggctgga
      901 tatgcaggca ctaaaacaat cgtccacaga gctcctcttt ggtggccatg aaactacagc
      961 cagtgcagcc acatcactga tcacctacct aggactctac ccacatgtcc tccaaaaagt
     1021 tcgagaagag ataaagagca agggcttact ttgcaagagc catcacgagg acaagttaga
     1081 catggaaact ttggaacagc tcaaatacat tgggtgtgtt attaaggaga cccttcgatt
     1141 gaatcctccg gttccgggag ggtttcgggt ggctctgaag acttttgagc tgaacggtta
     1201 ccagattccc aaggggtgga atgttattta cagtatctgt gacacccatg acgtggcaga
     1261 cagcttcact aacaaggagg agtttaatcc cgaccgattt acatcgcttc atccagagga
     1321 cacctccagg ttcagtttca ttccatttgg aggaggcctt cggagctgcg taggcaaaga
     1381 gtttgcaaaa attcttctta agatatttac cgtggagctg gccagacgtt gtgactggca
     1441 gctgctaaat ggacctccta caatgaagac aagccccccc gtttaccctg tggacaatct
     1501 tcctgcaaga ttcacccact tccagggaga tatctgacag ctatttcagt tcttggactc
     1561 atttgaagtg tacattgttt ttttttttta aatagtgtca tgttgccttt atttaatttc
     1621 taaatgtata gtataatatt tatatgtctt tactacagcc ccatggtctt taaatattaa
     1681 aataatgaat ttgtatgatt tcccaataaa gtaaaatttt aaagtgcaaa aaaaaaaaaa
     1741 aaaaaaaaaa aaaa
//
