LOCUS       NM_201635               3212 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 24, subfamily a,
            polypeptide 1 (Cyp24a1), mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_201635 XM_006235672
VERSION     NM_201635.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3212)
  AUTHORS   Obaid,A.A., Almasmoum,H., Almaimani,R.A., El-Boshy,M., Aslam,A.,
            Idris,S., Ghaith,M.M., El-Readi,M.Z., Ahmad,J., Farrash,W.F.,
            Mujalli,A., Eid,S.Y., Elzubier,M.E. and Refaat,B.
  TITLE     Vitamin D and calcium co-therapy mitigates pre-established cadmium
            nephropathy by regulating renal calcium homeostatic molecules and
            improving anti-oxidative and anti-inflammatory activities in rat
  JOURNAL   J Trace Elem Med Biol 79, 127221 (2023)
   PUBMED   37244046
REFERENCE   2  (bases 1 to 3212)
  AUTHORS   Varshney,S., Adela,R., Kachhawa,G., Dada,R., Kulshreshtha,V.,
            Kumari,R., Agarwal,R. and Khadgawat,R.
  TITLE     Disrupted placental vitamin D metabolism and calcium signaling in
            gestational diabetes and pre-eclampsia patients
  JOURNAL   Endocrine 80 (1), 191-200 (2023)
   PUBMED   36477942
REFERENCE   3  (bases 1 to 3212)
  AUTHORS   Campolina-Silva,G.H., Barata,M.C., Werneck-Gomes,H., Maria,B.T.,
            Mahecha,G.A.B., Belleannee,C. and Oliveira,C.A.
  TITLE     Altered expression of the vitamin D metabolizing enzymes CYP27B1
            and CYP24A1 under the context of prostate aging and pathologies
  JOURNAL   J Steroid Biochem Mol Biol 209, 105832 (2021)
   PUBMED   33596463
  REMARK    GeneRIF: Altered expression of the vitamin D metabolizing enzymes
            CYP27B1 and CYP24A1 under the context of prostate aging and
            pathologies.
REFERENCE   4  (bases 1 to 3212)
  AUTHORS   Serrano,D., Pozzi,C., Guglietta,S., Fosso,B., Suppa,M.,
            Gnagnarella,P., Corso,F., Bellerba,F., Macis,D., Aristarco,V.,
            Manghi,P., Segata,N., Trovato,C., Zampino,M.G., Marzano,M.,
            Bonanni,B., Rescigno,M. and Gandini,S.
  TITLE     Microbiome as Mediator of Diet on Colorectal Cancer Risk: The Role
            of Vitamin D, Markers of Inflammation and Adipokines
  JOURNAL   Nutrients 13 (2), 363 (2021)
   PUBMED   33504116
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3212)
  AUTHORS   Sadeghi,H. and Heiat,M.
  TITLE     A novel circular RNA hsa_circ_0060927 may serve as a potential
            diagnostic biomarker for human colorectal cancer
  JOURNAL   Mol Biol Rep 47 (9), 6649-6655 (2020)
   PUBMED   32803502
REFERENCE   6  (bases 1 to 3212)
  AUTHORS   Hahn,C.N., Kerry,D.M., Omdahl,J.L. and May,B.K.
  TITLE     Identification of a vitamin D responsive element in the promoter of
            the rat cytochrome P450(24) gene
  JOURNAL   Nucleic Acids Res 22 (12), 2410-2416 (1994)
   PUBMED   8036172
REFERENCE   7  (bases 1 to 3212)
  AUTHORS   Ohyama,Y., Ozono,K., Uchida,M., Shinki,T., Kato,S., Suda,T.,
            Yamamoto,O., Noshiro,M. and Kato,Y.
  TITLE     Identification of a vitamin D-responsive element in the 5'-flanking
            region of the rat 25-hydroxyvitamin D3 24-hydroxylase gene
  JOURNAL   J Biol Chem 269 (14), 10545-10550 (1994)
   PUBMED   8144641
REFERENCE   8  (bases 1 to 3212)
  AUTHORS   Chen,K.S., Prahl,J.M. and DeLuca,H.F.
  TITLE     Isolation and expression of human 1,25-dihydroxyvitamin D3
            24-hydroxylase cDNA
  JOURNAL   Proc Natl Acad Sci U S A 90 (10), 4543-4547 (1993)
   PUBMED   8506296
REFERENCE   9  (bases 1 to 3212)
  AUTHORS   Ohyama,Y., Noshiro,M., Eggertsen,G., Gotoh,O., Kato,Y., Bjorkhem,I.
            and Okuda,K.
  TITLE     Structural characterization of the gene encoding rat
            25-hydroxyvitamin D3 24-hydroxylase
  JOURNAL   Biochemistry 32 (1), 76-82 (1993)
   PUBMED   8418863
REFERENCE   10 (bases 1 to 3212)
  AUTHORS   Ohyama,Y., Noshiro,M. and Okuda,K.
  TITLE     Cloning and expression of cDNA encoding 25-hydroxyvitamin D3
            24-hydroxylase
  JOURNAL   FEBS Lett 278 (2), 195-198 (1991)
   PUBMED   1991512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC100059.1.
            
            On or before Apr 13, 2016 this sequence version replaced
            XM_006235672.2, NM_201635.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100059.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3212              BC100059.1         1-3212
FEATURES             Location/Qualifiers
     source          1..3212
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3212
                     /gene="Cyp24a1"
                     /gene_synonym="24-OHase; 24R-Ohase; Cyp24; P450-CC24;
                     VITD12"
                     /note="cytochrome P450, family 24, subfamily a,
                     polypeptide 1"
                     /db_xref="GeneID:25279"
                     /db_xref="RGD:2462"
     exon            1..603
                     /gene="Cyp24a1"
                     /gene_synonym="24-OHase; 24R-Ohase; Cyp24; P450-CC24;
                     VITD12"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..1890
                     /gene="Cyp24a1"
                     /gene_synonym="24-OHase; 24R-Ohase; Cyp24; P450-CC24;
                     VITD12"
                     /EC_number="1.14.15.16"
                     /note="1,25-dihydroxyvitamin D(3) 24-hydroxylase,
                     mitochondrial; cytochrome P450 24A1; vitamin D(3)
                     24-hydroxylase; cytochrome P450-CC24; Cytochrom P450
                     (25-hydroxyvitamin D24-hydroxylase); cytochrome P450,
                     subfamily 24; 25-hydroxyvitamin D3 24-hydroxylase;
                     25-hydroxyvitaminD324-hydroxylase"
                     /codon_start=1
                     /product="1,25-dihydroxyvitamin D(3) 24-hydroxylase,
                     mitochondrial precursor"
                     /protein_id="NP_963966.1"
                     /db_xref="GeneID:25279"
                     /db_xref="RGD:2462"
                     /translation="MSCPIDKRRTLIAFLRRLRDLGQPPRSVTSKASASRAPKEVPLC
                     PLMTDGETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLG
                     SFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRS
                     AFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLV
                     LYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWD
                     TIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANS
                     LMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVP
                     FTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPF
                     AHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELP
                     IAFRPR"
     exon            604..794
                     /gene="Cyp24a1"
                     /gene_synonym="24-OHase; 24R-Ohase; Cyp24; P450-CC24;
                     VITD12"
                     /inference="alignment:Splign:2.1.0"
     exon            795..888
                     /gene="Cyp24a1"
                     /gene_synonym="24-OHase; 24R-Ohase; Cyp24; P450-CC24;
                     VITD12"
                     /inference="alignment:Splign:2.1.0"
     exon            889..985
                     /gene="Cyp24a1"
                     /gene_synonym="24-OHase; 24R-Ohase; Cyp24; P450-CC24;
                     VITD12"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1077
                     /gene="Cyp24a1"
                     /gene_synonym="24-OHase; 24R-Ohase; Cyp24; P450-CC24;
                     VITD12"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1189
                     /gene="Cyp24a1"
                     /gene_synonym="24-OHase; 24R-Ohase; Cyp24; P450-CC24;
                     VITD12"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1335
                     /gene="Cyp24a1"
                     /gene_synonym="24-OHase; 24R-Ohase; Cyp24; P450-CC24;
                     VITD12"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1502
                     /gene="Cyp24a1"
                     /gene_synonym="24-OHase; 24R-Ohase; Cyp24; P450-CC24;
                     VITD12"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1581
                     /gene="Cyp24a1"
                     /gene_synonym="24-OHase; 24R-Ohase; Cyp24; P450-CC24;
                     VITD12"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1779
                     /gene="Cyp24a1"
                     /gene_synonym="24-OHase; 24R-Ohase; Cyp24; P450-CC24;
                     VITD12"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1899
                     /gene="Cyp24a1"
                     /gene_synonym="24-OHase; 24R-Ohase; Cyp24; P450-CC24;
                     VITD12"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..3212
                     /gene="Cyp24a1"
                     /gene_synonym="24-OHase; 24R-Ohase; Cyp24; P450-CC24;
                     VITD12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacgaggtac atcaaacctg gcggcatccc ttcgaccctc cttgattccc ccgtggcttt
       61 aggccttaga agtctaattt gcagactctc cccatagctg ccaaccccgg cctctcttcc
      121 ccagcccctg tggccagctc agggcagaaa ccagcgccct aagcaccttg cagcatcccg
      181 ggcatctgct tcttcgaagt ccctcctgtt gtaccccatt tcgccacacc cgggggttct
      241 gattgccttt cttccccaaa ccgccaaaac ttcagaaccc agcaactctt cctaaacacc
      301 ttacccgttc cagcccctgc tgagtcccac gggtcgcctg ctactatgag ctgccccatt
      361 gacaaacggc gcaccctgat cgcttttctg cgccgactgc gcgacctggg acagccccca
      421 aggtcggtga catccaaggc gagcgcttcc cgcgctccaa aagaggtgcc cctctgcccg
      481 ctgatgacag acggtgagac tcgaaacgtc acctccttgc ctgggcccac caactggcca
      541 ctgctaggga gtctactgga gattttttgg aaaggtggcc tgaagaaaca gcacgacacg
      601 ctggcagagt accacaagaa gtatggccag attttccgga tgaagctggg ctccttcgac
      661 tccgtgcatc tgggctcgcc gagcctgctg gaagctctgt accgcacaga gagcgcgcat
      721 ccccagcgac tggagatcaa accttggaaa gcctatcgcg accacaggaa cgaagcctac
      781 gggttgatga tcctggaagg acaggagtgg caaagggtcc gcagcgcctt ccagaagaaa
      841 ctcatgaagc ccgtggagat catgaagctg gacaagaaaa tcaatgaggt cttggctgac
      901 tttctagagc gcatggatga gctgtgcgat gagcgaggcc gcatcccaga cctgtacagt
      961 gagctgaaca agtggtcctt tgaaagcatc tgccttgtgt tatatgagaa gagatttggg
     1021 ctccttcaaa aggagacaga agaagaagcg ctgaccttca ttacggccat caaaacgatg
     1081 atgagcacgt ttgggaagat gatggtgacc cccgtggagt tgcacaagcg cctcaacacc
     1141 aaagtgtggc aggcacatac gctggcttgg gacaccattt tcaaatcagt caaaccctgc
     1201 atcgacaacc gcctacagag atattcccag cagcccgggg cagatttcct ctgtgatatt
     1261 tatcagcaag atcacctttc caagaaggaa ctgtacgccg ctgtcacgga gctgcagctc
     1321 gctgcagtgg agacgaccgc gaacagcttg atgtggattc tctacaatct atcccggaat
     1381 cctcaagcgc aacggagact ccttcaggaa gttcagagcg tgctgcctga caatcagacg
     1441 ccacgggcgg aagacctgag gaatatgccc tatttaaagg cctgtctgaa agaatccatg
     1501 aggcttaccc caagtgtgcc atttacaact cggacccttg acaaaccaac ggttctgggt
     1561 gaatacgctc tacccaaagg aacagtgtta accctcaata cccaagtgct gggttctagt
     1621 gaagacaatt ttgaagattc tcataagttc agacccgaac gctggcttca aaaggagaaa
     1681 aagatcaacc ccttcgctca tctcccattc ggcatcggga agagaatgtg catcgggcgc
     1741 cggctggctg agttacagct ccacctggct ctctgctgga taatccaaaa atacgacatt
     1801 gtggccacag acaatgaacc tgtggagatg ctgcaccttg gcatcctggt acccagccgg
     1861 gagctgccaa ttgcgttccg tccacggtag gatgctgagg tttattttca ccccaatcaa
     1921 gaccagcaat cttccccttt ctgcaagaaa gctgcttatg gcttcagtat tcctaagacg
     1981 gcgaacttca aggaccagag catgggacaa cctgcgaaac acggcgcaca cagccttctg
     2041 cagaatgatt ctgacaatga tgtttactaa gcccattact cagggaagca catggggggc
     2101 ggaaatgcca ggcaccgccc actacacttt accacgtgtt tacattagcc aatcagagcc
     2161 cctaagagcc tgcgatcgct ccatctttgt gacgtcaacg gaggctgctg gtcagccact
     2221 ttagtaaagg ttattaagtg tttctgatgc aaaacccaaa gcggcagcgt taattcccgt
     2281 ttacatttca tgaagaaaga cctactatgc tttaattgtc tcagtgggac tgacaaaacg
     2341 tttattatac tcggtttcgt tcaatatttg aggaaacgcc tgctgtaaac cgagctaaac
     2401 attaggctct cgtaaagcta tttttcctgc ttacaagggg aaacattgtt ggaaattaga
     2461 gagtgtctat tttaagaagt tctacagtga agccagctcc ttgcttatga atgcctcgtt
     2521 ggtgcggtca gtggactcta atctcttatt tcattggtac ctttctctgt ggtttcaggg
     2581 tgtggagata gacgaatcaa aagtttctaa gttgtgcgtg tgtcggcgca tgcatgggaa
     2641 tggctgtggg cctgagggta ctttgcttca gtcatgtttt tatataaaga catgaggtac
     2701 ccaatttagt atggaacttg tcctgaaatg taatcatagg gctttctgtg ccttaacttc
     2761 atctattcaa atcgaggact gtaatgtatg cgctctaccc atgctgcctg taatgtacag
     2821 tgggacttga accccttgga aaagcacaat ttcgtaagcg caaaacagtt atgcactact
     2881 gacaaaattt taaaatgttt acatataacg tgcatttttt tcaaccagta ctgtttttct
     2941 atagaggttt actgattatt tctatatatt tgataaagat ttccctttta ggttatggtt
     3001 ttagaatagt ctgaaatata tgtacatttg aatgaatatg tgtgtgtgga tgacaggtat
     3061 atacttcgcc tttcttataa aattatattt agagttataa atccagaaac taaagatgta
     3121 gttttgtggt aaagagtttt ggcctggtct atgttggctc ctgggttcaa tcctcagcac
     3181 tactaaacaa taaaaaataa aataaagaat ta
//
