LOCUS       NM_012940               2321 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 1, subfamily b,
            polypeptide 1 (Cyp1b1), mRNA.
ACCESSION   NM_012940 XM_346759
VERSION     NM_012940.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2321)
  AUTHORS   Zuo,C., Fan,P., Yang,Y. and Hu,C.
  TITLE     MiR-488-3p facilitates wound healing through CYP1B1-mediated
            Wnt/beta-catenin signaling pathway by targeting MeCP2
  JOURNAL   J Diabetes Investig 15 (2), 145-158 (2024)
   PUBMED   37961023
  REMARK    GeneRIF: MiR-488-3p facilitates wound healing through
            CYP1B1-mediated Wnt/beta-catenin signaling pathway by targeting
            MeCP2.
REFERENCE   2  (bases 1 to 2321)
  AUTHORS   Lidin,E., Skold,M.K., Angeria,M., Davidsson,J. and Risling,M.
  TITLE     Hippocampal Expression of Cytochrome P450 1B1 in Penetrating
            Traumatic Brain Injury
  JOURNAL   Int J Mol Sci 23 (2), 722 (2022)
   PUBMED   35054909
  REMARK    GeneRIF: Hippocampal Expression of Cytochrome P450 1B1 in
            Penetrating Traumatic Brain Injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2321)
  AUTHORS   Kulas,J., Tucovic,D., Zeljkovic,M., Popovic,D., Popov
            Aleksandrov,A., Kataranovski,M. and Mirkov,I.
  TITLE     Aryl Hydrocarbon Receptor is Involved in the Proinflammatory
            Cytokine Response to Cadmium
  JOURNAL   Biomed Environ Sci 34 (3), 192-202 (2021)
   PUBMED   33766215
  REMARK    GeneRIF: Aryl Hydrocarbon Receptor is Involved in the
            Proinflammatory Cytokine Response to Cadmium.
REFERENCE   4  (bases 1 to 2321)
  AUTHORS   Han,Y., Dong,B., Chen,M. and Yao,C.
  TITLE     LncRNA H19 suppresses pyroptosis of cardiomyocytes to attenuate
            myocardial infarction in a PBX3/CYP1B1-dependent manner
  JOURNAL   Mol Cell Biochem 476 (3), 1387-1400 (2021)
   PUBMED   33389498
  REMARK    GeneRIF: LncRNA H19 suppresses pyroptosis of cardiomyocytes to
            attenuate myocardial infarction in a PBX3/CYP1B1-dependent manner.
REFERENCE   5  (bases 1 to 2321)
  AUTHORS   Alghamdi,A., Aldossary,W., Albahkali,S., Alotaibi,B. and
            Alrfaei,B.M.
  TITLE     The loss of microglia activities facilitates glaucoma progression
            in association with CYP1B1 gene mutation (p.Gly61Glu)
  JOURNAL   PLoS One 15 (11), e0241902 (2020)
   PUBMED   33170892
  REMARK    GeneRIF: The loss of microglia activities facilitates glaucoma
            progression in association with CYP1B1 gene mutation (p.Gly61Glu).
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2321)
  AUTHORS   Stoilov,I., Akarsu,A.N. and Sarfarazi,M.
  TITLE     Identification of three different truncating mutations in
            cytochrome P4501B1 (CYP1B1) as the principal cause of primary
            congenital glaucoma (Buphthalmos) in families linked to the GLC3A
            locus on chromosome 2p21
  JOURNAL   Hum Mol Genet 6 (4), 641-647 (1997)
   PUBMED   9097971
REFERENCE   7  (bases 1 to 2321)
  AUTHORS   Christou,M., Savas,U., Schroeder,S., Shen,X., Thompson,T.,
            Gould,M.N. and Jefcoate,C.R.
  TITLE     Cytochromes CYP1A1 and CYP1B1 in the rat mammary gland:
            cell-specific expression and regulation by polycyclic aromatic
            hydrocarbons and hormones
  JOURNAL   Mol Cell Endocrinol 115 (1), 41-50 (1995)
   PUBMED   8674863
REFERENCE   8  (bases 1 to 2321)
  AUTHORS   Walker,N.J., Gastel,J.A., Costa,L.T., Clark,G.C., Lucier,G.W. and
            Sutter,T.R.
  TITLE     Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent
            expression in livers and kidneys of TCDD-treated animals
  JOURNAL   Carcinogenesis 16 (6), 1319-1327 (1995)
   PUBMED   7788849
REFERENCE   9  (bases 1 to 2321)
  AUTHORS   Bhattacharyya,K.K., Brake,P.B., Eltom,S.E., Otto,S.A. and
            Jefcoate,C.R.
  TITLE     Identification of a rat adrenal cytochrome P450 active in
            polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a
            unique tissue-specific pattern of hormonal and aryl hydrocarbon
            receptor-linked regulation
  JOURNAL   J Biol Chem 270 (19), 11595-11602 (1995)
   PUBMED   7744798
REFERENCE   10 (bases 1 to 2321)
  AUTHORS   Pottenger,L.H., Christou,M. and Jefcoate,C.R.
  TITLE     Purification and immunological characterization of a novel
            cytochrome P450 from C3H/10T1/2 cells
  JOURNAL   Arch Biochem Biophys 286 (2), 488-497 (1991)
   PUBMED   1910294
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U09540.1.
            
            On Apr 12, 2007 this sequence version replaced NM_012940.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U09540.1, SRR8487227.95902.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2321              U09540.1           1-2321
FEATURES             Location/Qualifiers
     source          1..2321
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..2321
                     /gene="Cyp1b1"
                     /note="cytochrome P450, family 1, subfamily b, polypeptide
                     1"
                     /db_xref="GeneID:25426"
                     /db_xref="RGD:2460"
     exon            1..370
                     /gene="Cyp1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..1414
                     /gene="Cyp1b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..2003
                     /gene="Cyp1b1"
                     /EC_number="1.14.14.1"
                     /EC_number="4.2.1.152"
                     /note="CYPIB1; P450RAP; cytochrome P450RAP; cytochrome
                     P450, subfamily 1B, polypeptide 1; hydroperoxy
                     icosatetraenoate dehydratase"
                     /codon_start=1
                     /product="cytochrome P450 1B1"
                     /protein_id="NP_037072.1"
                     /db_xref="GeneID:25426"
                     /db_xref="RGD:2460"
                     /translation="MATSLSADSPQQLSSLSTQQTILLLLVSVLAIVHLGQWLLRQWR
                     RKPWSSPPGPFPWPLIGNAASVGRASHLYFARLARRYGDVFQIRLGSCPVVVLNGESA
                     IHQALVQQGGVFADRPPFASFRVVSGGRSLAFGHYSERWKERRRAAYGTMRAFSTRHP
                     RSRGLLEGHALGEARELVAVLVRRCAGGACLDPTQPIIVAVANVMSAVCFGCRYNHDD
                     AEFLELLSHNEEFGRTVGAGSLVDVMPWLQLFPNPVRTIFREFEQINRNFSNFVLDKF
                     LRHRESLVPGAAPRDMMDAFILSAEKKATGDPGDSPSGLDLEDVPATITDIFGASQDT
                     LSTALLWLLILFTRYPDVQARVQAELDQVVGRDRLPCMSDQPNLPYVMAFLYESMRFT
                     SFLPVTLPHATTANTFVLGYYIPKNTVVFVNQWSVNHDPAKWSNPEDFDPARFLDKDG
                     FINKALASSVMIFSVGKRRCIGEELSKTLLFLFISILAHQCNFKANQNEPSNMSFSYG
                     LSIKPKSFKIHVSLRESMKLLDSAVEKLQAEEACQ"
     exon            1415..2321
                     /gene="Cyp1b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgcagaca cctctgcgac gccagcttga aagccgccgg cgggctggga tttagctcca
       61 ctttatcaac tcccaacccc tcacccatct caaccgcaac tccaactctg tgagaaagtc
      121 ctgactttgc ggagccccag gtgcactgga gctcagcaaa cttgagacac ttcccccctg
      181 tcctccatcc taatctaagt ttaggttctg actgagccaa gagtgggtgc taaagcagcg
      241 ggcctcaggt gtctaggact ccgggtcctt ggggactctc aggttgaagt cttgcagagt
      301 ctgggcagag gctccagagc ttctcccaga ccccactgct ctacaccgct ggaaccgcgc
      361 ttcatcgcag catggccacc agccttagtg cagacagtcc acagcagctg agctcgctgt
      421 ctacccaaca gaccattctt ctgctactcg tttcggtcct ggccatcgtg cacttaggcc
      481 agtggctgct gcgccagtgg cgacggaaac cgtggtcctc gcccccgggt ccctttcctt
      541 ggccattgat cggaaacgcg gcgtctgttg gccgggcatc gcacttgtac ttcgctcgcc
      601 ttgcgaggcg ctatggcgac gtttttcaga tccgtctggg cagctgtccc gtggtggtgc
      661 tgaatggcga gagtgccatc catcaggctc tggtgcagca gggcggcgtc tttgcggacc
      721 ggcctccctt cgcctctttc cgtgtggtgt ctggtggccg cagcctggcg ttcggccact
      781 actcagagcg ctggaaggag cggcgacgtg cagcctatgg cacgatgcgt gccttctcca
      841 cccgccaccc gcgcagccgc ggtctcctcg agggccacgc gctgggagag gctcgagagt
      901 tggtggcagt gttggtgcgg cgctgcgccg gtggcgcctg cctcgatccg acgcagccga
      961 tcatagtggc ggtggctaat gtcatgagcg ctgtatgctt cggctgtcgg tacaaccacg
     1021 acgatgccga gttcctggag ctgctcagcc acaacgagga gttcgggcgc accgtgggcg
     1081 cgggcagcct ggtggacgtg atgccctggc tgcagctttt tcccaacccg gtgcgcacca
     1141 tcttccgcga gttcgagcag atcaaccgca acttcagcaa cttcgtcctg gacaagttcc
     1201 tgaggcaccg agaaagcctc gtgcccgggg ctgctcctcg agacatgatg gacgccttca
     1261 tcctctccgc cgaaaagaag gcgactgggg accctggtga cagtccctcc gggctggatt
     1321 tggaggatgt gcctgccact attacagaca tctttggagc cagccaggac accctttcca
     1381 ccgcgctgct gtggctgctc atcctcttta ccagataccc ggatgtgcag gcccgcgtgc
     1441 aggccgagtt ggaccaggtt gtggggaggg accgcctgcc ctgcatgagt gaccaaccca
     1501 acttaccata cgtcatggct tttctttatg aatccatgcg attcaccagc tttttgcctg
     1561 tcacccttcc acatgccacc actgccaaca cctttgtttt aggctactac atccccaaaa
     1621 acacggtagt ttttgttaac cagtggtctg tgaatcatga cccagcaaag tggtctaacc
     1681 cagaggactt tgatccggcc cgcttcctgg acaaggacgg cttcattaac aaggcactag
     1741 ccagcagcgt gatgatattt tcagtgggca aacgacggtg catcggcgag gagttgtcta
     1801 agacgcttct gtttctcttc atctccatcc tcgctcatca gtgcaatttc aaggctaacc
     1861 aaaacgagcc ctcaaacatg agtttcagtt acggcctgag cattaagccc aagtcgttta
     1921 aaatccatgt gtctctcaga gagtccatga agctccttga tagtgctgtc gagaagctgc
     1981 aagctgagga agcttgccag tgagagaggg agaggccgga ggtaactgaa atgttcaaag
     2041 aaaaccatct cattaactgg agaggaaaac acagatttta ttttctccag cttcattttg
     2101 gcctcagttc tcaagaatga gcggaaacca agtggcctga aggtgaggcg ggcttaccaa
     2161 ttcatggctc ctcaccggcc agcagctgga gatcctgaag tattttgaaa ttgaagagta
     2221 atagggtcca aggaatttgc atactgttcc cccctcaccc ccattaaaca catgcacaca
     2281 aatcagcatg tgtgtacagc tatccaacaa aatatttcag t
//
