LOCUS       NM_012541               1882 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus cytochrome P450, family 1, subfamily a,
            polypeptide 2 (Cyp1a2), mRNA.
ACCESSION   NM_012541
VERSION     NM_012541.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1882)
  AUTHORS   Wang,S., Gan,J., Li,J., Wang,Y., Zhang,J., Song,L., Yang,Z., Guo,M.
            and Jiang,X.
  TITLE     Shengmai Yin formula exerts cardioprotective effects on rats with
            chronic heart failure via regulating Linoleic Acid metabolism
  JOURNAL   Prostaglandins Other Lipid Mediat 158, 106608 (2022)
   PUBMED   34958945
REFERENCE   2  (bases 1 to 1882)
  AUTHORS   Xun,T., Lin,Z., Wang,X., Zhan,X., Feng,H., Gan,D. and Yang,X.
  TITLE     Advanced oxidation protein products downregulate CYP1A2 and CYP3A4
            expression and activity via the NF-kappaB-mediated signaling
            pathway in vitro and in vivo
  JOURNAL   Lab Invest 101 (9), 1197-1209 (2021)
   PUBMED   34031539
  REMARK    GeneRIF: Advanced oxidation protein products downregulate CYP1A2
            and CYP3A4 expression and activity via the NF-kappaB-mediated
            signaling pathway in vitro and in vivo.
REFERENCE   3  (bases 1 to 1882)
  AUTHORS   Zhu,Q., Huang,C., Meng,X. and Li,J.
  TITLE     CYP1A2 contributes to alcohol-induced abnormal lipid metabolism
            through the PTEN/AKT/SREBP-1c pathway
  JOURNAL   Biochem Biophys Res Commun 513 (2), 509-514 (2019)
   PUBMED   30979496
REFERENCE   4  (bases 1 to 1882)
  AUTHORS   Wei,J.H., Luo,Q.Q., Tang,Y.J., Chen,J.X., Huang,C.L., Lu,D.G. and
            Tang,Q.L.
  TITLE     Upregulation of microRNA-320 decreases the risk of developing
            steroid-induced avascular necrosis of femoral head by inhibiting
            CYP1A2 both in vivo and in vitro
  JOURNAL   Gene 660, 136-144 (2018)
   PUBMED   29551500
  REMARK    GeneRIF: findings provide evidences that miR-320 might inhibit the
            development of Steroid-induced avascular necrosis of femoral head
            by targeting CYP1A2.
            Erratum:[Gene. 2022 Apr 30;820:146359. doi:
            10.1016/j.gene.2022.146359.. PMID: 35260258]
REFERENCE   5  (bases 1 to 1882)
  AUTHORS   Xu,M., Tang,H., Rong,Q., Zhang,Y., Li,Y., Zhao,L., Ye,G., Shi,F.
            and Lv,C.
  TITLE     The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in
            Rats
  JOURNAL   Biomed Res Int 2017, 6525474 (2017)
   PUBMED   28555194
  REMARK    GeneRIF: acute Formaldehyde (FA) poisoning suppressed the
            activities of CYP2C11, CYP2E1, and CYP3A2 and induced the activity
            of CYP1A2 in rats. And the change of CYP450 activity caused by
            acute FA poisoning may be associated with FA potential carcinogenic
            effects on the airways.
REFERENCE   6  (bases 1 to 1882)
  AUTHORS   Yun,C.H., Hammons,G.J., Jones,G., Martin,M.V., Hopkins,N.E.,
            Alworth,W.L. and Guengerich,F.P.
  TITLE     Modification of cytochrome P450 1A2 enzymes by the mechanism-based
            inactivator 2-ethynylnaphthalene and the photoaffinity label
            4-azidobiphenyl
  JOURNAL   Biochemistry 31 (43), 10556-10563 (1992)
   PUBMED   1420171
REFERENCE   7  (bases 1 to 1882)
  AUTHORS   Doehmer,J., Wolfel,C., Dogra,S., Doehmer,C., Seidel,A., Platt,K.L.,
            Oesch,F. and Glatt,H.R.
  TITLE     Applications of stable V79-derived cell lines expressing rat
            cytochromes P4501A1, 1A2, and 2B1
  JOURNAL   Xenobiotica 22 (9-10), 1093-1099 (1992)
   PUBMED   1441600
REFERENCE   8  (bases 1 to 1882)
  AUTHORS   Wolfel,C., Platt,K.L., Dogra,S., Glatt,H., Wachter,F. and
            Doehmer,J.
  TITLE     Stable expression of rat cytochrome P450IA2 cDNA and hydroxylation
            of 17 beta-estradiol and 2-aminofluorene in V79 Chinese hamster
            cells
  JOURNAL   Mol Carcinog 4 (6), 489-498 (1991)
   PUBMED   1793487
REFERENCE   9  (bases 1 to 1882)
  AUTHORS   Butler,M.A., Iwasaki,M., Guengerich,F.P. and Kadlubar,F.F.
  TITLE     Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase,
            is primarily responsible for the hepatic 3-demethylation of
            caffeine and N-oxidation of carcinogenic arylamines
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 7696-7700 (1989)
   PUBMED   2813353
REFERENCE   10 (bases 1 to 1882)
  AUTHORS   Sogawa,K., Gotoh,O., Kawajiri,K., Harada,T. and Fujii-Kuriyama,Y.
  TITLE     Complete nucleotide sequence of a methylcholanthrene-inducible
            cytochrome P-450 (P-450d) gene in the rat
  JOURNAL   J Biol Chem 260 (8), 5026-5032 (1985)
   PUBMED   2985574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC127476.1.
            
            On Oct 12, 2007 this sequence version replaced NM_012541.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127476.1, FQ210213.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1882              BC127476.1         1-1882
FEATURES             Location/Qualifiers
     source          1..1882
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1882
                     /gene="Cyp1a2"
                     /gene_synonym="CYPD45; P-450d; RATCYPD45"
                     /note="cytochrome P450, family 1, subfamily a, polypeptide
                     2"
                     /db_xref="GeneID:24297"
                     /db_xref="RGD:2459"
     exon            1..41
                     /gene="Cyp1a2"
                     /gene_synonym="CYPD45; P-450d; RATCYPD45"
                     /inference="alignment:Splign:2.1.0"
     exon            42..877
                     /gene="Cyp1a2"
                     /gene_synonym="CYPD45; P-450d; RATCYPD45"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1591
                     /gene="Cyp1a2"
                     /gene_synonym="CYPD45; P-450d; RATCYPD45"
                     /EC_number="1.14.14.1"
                     /EC_number="4.2.1.152"
                     /note="cytochrome P450, subfamily I (aromatic
                     compound-inducible), member A2 (Q42, form d); P-448;
                     CYPIA2; P450-D; cytochrome P-448; cytochrome P-450d;
                     cytochrome P450-D; cytochrome P450, 1a2; Cytochrome P450
                     subfamily I (aromatic compound-inducible) member A2 (Q42
                     form d); cholesterol 25-hydroxylase; hydroperoxy
                     icosatetraenoate dehydratase"
                     /codon_start=1
                     /product="cytochrome P450 1A2"
                     /protein_id="NP_036673.3"
                     /db_xref="GeneID:24297"
                     /db_xref="RGD:2459"
                     /translation="MAFSQYISLAPELLLATAIFCLVFWVLRGTRTQVPKGLKSPPGP
                     WGLPFIGHMLTLGKNPHLSLTKLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVKQGD
                     DFKGRPDLYSFTLITNGKSMTFNPDSGPVWAARRRLAQDALKSFSIASDPTSVSSCYL
                     EEHVSKEANHLISKFQKLMAEVGHFEPVNQVVESVANVIGAMCFGKNFPRKSEEMLNL
                     VKSSKDFVENVTSGNAVDFFPVLRYLPNPALKRFKNFNDNFVLFLQKTVQEHYQDFNK
                     NSIQDITGALFKHSENYKDNGGLIPQEKIVNIVNDIFGAGFETVTTAIFWSILLLVTE
                     PKVQRKIHEELDTVIGRDRQPRLSDRPQLPYLEAFILEIYRYTSFVPFTIPHSTTRDT
                     SLNGFHIPKECCIFINQWQVNHDEKQWKDPFVFRPERFLTNDNTAIDKTLSEKVMLFG
                     LGKRRCIGEIPAKWEVFLFLAILLHQLEFTVPPGVKVDLTPSYGLTMKPRTCEHVQAW
                     PRFSK"
     exon            878..995
                     /gene="Cyp1a2"
                     /gene_synonym="CYPD45; P-450d; RATCYPD45"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1085
                     /gene="Cyp1a2"
                     /gene_synonym="CYPD45; P-450d; RATCYPD45"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1209
                     /gene="Cyp1a2"
                     /gene_synonym="CYPD45; P-450d; RATCYPD45"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1296
                     /gene="Cyp1a2"
                     /gene_synonym="CYPD45; P-450d; RATCYPD45"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1859
                     /gene="Cyp1a2"
                     /gene_synonym="CYPD45; P-450d; RATCYPD45"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactcctaca actctgccag tctccagccc ctgcccttca gtcgtacaga tggcgttctc
       61 ccagtatatc tccttagccc cagagctgct actggccact gccatcttct gtttagtgtt
      121 ctgggtgttg agaggcacaa ggacccaggt tcccaaaggt ctgaagagtc ctcccggacc
      181 ctggggcttg cccttcattg ggcacatgct gaccctgggg aagaacccac acctatctct
      241 gacaaagctg agtcagcagt atggggacgt gctgcagatc cgcattggct ccacacccgt
      301 ggtggtgctg agcggcctga acaccatcaa gcaggcccta gtgaagcagg gggatgactt
      361 caaaggccgg ccagacctct acagcttcac acttatcact aatggcaaga gcatgacttt
      421 caacccagac tctggaccgg tctgggctgc ccgccggcgc ctggcccagg atgccctgaa
      481 gagtttctcc atagcctcag accccacatc agtatcctct tgctacttgg aggagcacgt
      541 gagcaaagag gctaaccatc taatcagcaa gttccagaag ctgatggcag aggttggcca
      601 cttcgaacca gtcaaccagg tggtggaatc ggtggctaat gtcatcggag ccatgtgttt
      661 tgggaagaac ttccccagga agagcgagga gatgctcaac ctcgtgaaga gcagcaagga
      721 ctttgtggag aatgtcacct cagggaatgc tgtggacttc tttccggtcc tgcgctacct
      781 gcccaaccca gccctcaaga ggtttaagaa cttcaatgat aactttgtgc tgtttctgca
      841 gaaaacagtc caggaacact atcaagactt caacaagaac agtatccagg acatcacagg
      901 cgccctgttc aagcacagtg agaactacaa agacaacggt ggtctcatcc ctcaggagaa
      961 gattgtcaac attgtcaatg acatctttgg agctggattt gaaacagtca caacagccat
     1021 cttctggagc attttgctac ttgtgacaga gcccaaggtg cagaggaaga ttcatgagga
     1081 gctggacacg gtgattggca gagatcggca gccacggctt tctgacagac cccagctgcc
     1141 atatctggag gccttcatcc tggagatcta ccgatacaca tcctttgtcc ccttcaccat
     1201 cccccacagc acaacgaggg acacctcact gaatggcttc cacattccca aggagtgctg
     1261 catcttcata aaccagtggc aggtcaacca tgatgagaag cagtggaaag acccctttgt
     1321 gttccgccca gagcggtttc ttaccaatga caacacggcc atcgacaaga ccctgagtga
     1381 gaaggtgatg ctcttcggct tgggaaagcg ccggtgcatt ggggagatcc cggccaagtg
     1441 ggaagtcttc ctcttcttag ccatcctcct gcatcagctg gagttcactg tgccaccggg
     1501 cgtgaaggtg gacctgacac ccagctatgg gctgaccatg aagcccagaa cctgtgaaca
     1561 cgtccaggcc tggccacgct tctccaagtg aagatggccg agacatcggc cgccaccctt
     1621 gttccttttc ctttcttttt aaataacagc tttttcaaga tacaattcct ccaccattta
     1681 attcagctcc aatcaatttt caatattgtc tacactgttc cctgcaaacc catacccatt
     1741 aagatttatg actattcctc ctaccctgtt tcgcttgctg tgccacgtgc taatctagtt
     1801 tttgactcaa tagatttgcc aactctggct gtttcatata aatccagtga gttatggtca
     1861 aaaaaaaaaa aaaaaaaaaa aa
//
