LOCUS       NM_012540               2616 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 1, subfamily a,
            polypeptide 1 (Cyp1a1), mRNA.
ACCESSION   NM_012540
VERSION     NM_012540.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2616)
  AUTHORS   Chen,J.C. and He,M.Q.
  TITLE     Inhibition of CYP1A1 expression enhances diabetic wound healing by
            modulating inflammation and oxidative stress in a rat model
  JOURNAL   Tissue Cell 90, 102483 (2024)
   PUBMED   39059132
  REMARK    GeneRIF: Inhibition of CYP1A1 expression enhances diabetic wound
            healing by modulating inflammation and oxidative stress in a rat
            model.
REFERENCE   2  (bases 1 to 2616)
  AUTHORS   Xu,Y., Wang,Y., Xiao,H. and Li,Y.
  TITLE     Hypoxia caused by unilateral nasal obstruction decreases mandibular
            density in rats through inhibition of Cyp1a1 expression
  JOURNAL   J Oral Pathol Med 52 (8), 786-794 (2023)
   PUBMED   37489271
  REMARK    GeneRIF: Hypoxia caused by unilateral nasal obstruction decreases
            mandibular density in rats through inhibition of Cyp1a1 expression.
REFERENCE   3  (bases 1 to 2616)
  AUTHORS   Yoda,T., Tochitani,T., Usui,T., Kouchi,M., Inada,H., Hosaka,T.,
            Kanno,Y., Miyawaki,I. and Yoshinari,K.
  TITLE     Involvement of the CYP1A1 inhibition-mediated activation of aryl
            hydrocarbon receptor in drug-induced hepatotoxicity
  JOURNAL   J Toxicol Sci 47 (9), 359-373 (2022)
   PUBMED   36047110
  REMARK    GeneRIF: Involvement of the CYP1A1 inhibition-mediated activation
            of aryl hydrocarbon receptor in drug-induced hepatotoxicity.
REFERENCE   4  (bases 1 to 2616)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 2616)
  AUTHORS   Masaki,T., Okazawa,M., Asano,R., Inagaki,T., Ishibashi,T.,
            Yamagishi,A., Umeki-Mizushima,S., Nishimura,M., Manabe,Y.,
            Ishibashi-Ueda,H., Shirai,M., Tsuchimochi,H., Pearson,J.T.,
            Kumanogoh,A., Sakata,Y., Ogo,T., Kishimoto,T. and Nakaoka,Y.
  TITLE     Aryl hydrocarbon receptor is essential for the pathogenesis of
            pulmonary arterial hypertension
  JOURNAL   Proc Natl Acad Sci U S A 118 (11) (2021)
   PUBMED   33836606
REFERENCE   6  (bases 1 to 2616)
  AUTHORS   Wolfel,C., Platt,K.L., Dogra,S., Glatt,H., Wachter,F. and
            Doehmer,J.
  TITLE     Stable expression of rat cytochrome P450IA2 cDNA and hydroxylation
            of 17 beta-estradiol and 2-aminofluorene in V79 Chinese hamster
            cells
  JOURNAL   Mol Carcinog 4 (6), 489-498 (1991)
   PUBMED   1793487
REFERENCE   7  (bases 1 to 2616)
  AUTHORS   Kikuchi,H., Sagami,I., Fujii,H., Ohmachi,T. and Watanabe,M.
  TITLE     Complementary DNA sequence of 3-methylcholanthrene-inducible P-450
            from the rat lung
  JOURNAL   Tohoku J Exp Med 160 (4), 323-332 (1990)
   PUBMED   2382261
REFERENCE   8  (bases 1 to 2616)
  AUTHORS   Amelizad,Z., Narbonne,J.F., Wolf,C.R., Robertson,L.W. and Oesch,F.
  TITLE     Effect of nutritional imbalances on cytochrome P-450 isozymes in
            rat liver
  JOURNAL   Biochem Pharmacol 37 (17), 3245-3249 (1988)
   PUBMED   3041969
REFERENCE   9  (bases 1 to 2616)
  AUTHORS   Cheng,K.C., Park,S.S., Krutzsch,H.C., Grantham,P.H., Gelboin,H.V.
            and Friedman,F.K.
  TITLE     Amino-terminal sequence and structure of monoclonal antibody
            immunopurified cytochromes P-450
  JOURNAL   Biochemistry 25 (9), 2397-2402 (1986)
   PUBMED   3718958
REFERENCE   10 (bases 1 to 2616)
  AUTHORS   Fagan,J.B., Pastewka,J.V., Chalberg,S.C., Gozukara,E.,
            Guengerich,F.P. and Gelboin,H.V.
  TITLE     Noncoordinate regulation of the mRNAs encoding cytochromes
            P-450BNF/MC-B and P-450ISF/BNF-G
  JOURNAL   Arch Biochem Biophys 244 (1), 261-272 (1986)
   PUBMED   3753838
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012540.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X00469.1, SRR26643295.31882.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345330, SAMN12840107
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                JAXUCZ010000008.1  66991982-66992039
            59-909              JAXUCZ010000008.1  66994520-66995370
            910-1036            JAXUCZ010000008.1  66995835-66995961
            1037-1126           JAXUCZ010000008.1  66996046-66996135
            1127-1250           JAXUCZ010000008.1  66996229-66996352
            1251-1337           JAXUCZ010000008.1  66996501-66996587
            1338-2616           JAXUCZ010000008.1  66996734-66998012
FEATURES             Location/Qualifiers
     source          1..2616
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2616
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; Cyp45c; Cypc45c;
                     P-450MC; P1-450; P450-C; P450DX"
                     /note="cytochrome P450, family 1, subfamily a, polypeptide
                     1"
                     /db_xref="GeneID:24296"
                     /db_xref="RGD:2458"
     exon            1..58
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; Cyp45c; Cypc45c;
                     P-450MC; P1-450; P450-C; P450DX"
                     /inference="alignment:Splign:2.1.0"
     exon            59..909
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; Cyp45c; Cypc45c;
                     P-450MC; P1-450; P450-C; P450DX"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1647
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; Cyp45c; Cypc45c;
                     P-450MC; P1-450; P450-C; P450DX"
                     /EC_number="1.14.14.1"
                     /EC_number="4.2.1.152"
                     /note="cytochrome P450, subfamily I (aromatic
                     compound-inducible), member A1 (C6, form c) (C6, form c);
                     CYPIA1; P450MT2; cytochrome P450-C; cytochrome P450MT2;
                     cytochrome P450, 1a1; P450form6; xenobiotic monooxygenase;
                     aryl hydrocarbon hydroxylase; flavoprotein-linked
                     monooxygenase; dioxin-inducible; cytochrome P1-450;
                     microsomal monooxygenase; cytochrome P450 subfamily I
                     (aromatic compound-inducible) member A1 (C6 form c) (C6
                     form c); cytochrome P450-P1; cytochrome P450 form 6;
                     hydroperoxy icosatetraenoate dehydratase"
                     /codon_start=1
                     /product="cytochrome P450 1A1"
                     /protein_id="NP_036672.3"
                     /db_xref="GeneID:24296"
                     /db_xref="RGD:2458"
                     /translation="MPSVYGFPAFTSATELLLAVTTFCLGFWVVRVTRTWVPKGLKSP
                     PGPWGLPFIGHVLTLGKNPHLSLTKLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVK
                     QGDDFKGRPDLYSFTLIANGQSMTFNPDSGPLWAARRRLAQNALKSFSIASDPTLASS
                     CYLEEHVSKEAEYLISKFQKLMAEVGHFDPFKYLVVSVANVICAICFGRRYDHDDQEL
                     LSIVNLSNEFGEVTGSGYPADFIPILRYLPNSSLDAFKDLNKKFYSFMKKLIKEHYRT
                     FEKGHIRDITDSLIEHCQDRRLDENANVQLSDDKVITIVFDLFGAGFDTITTAISWSL
                     MYLVTNPRIQRKIQEELDTVIGRDRQPRLSDRPQLPYLEAFILETFRHSSFVPFTIPH
                     STIRDTSLNGFYIPKGHCVFVNQWQVNHDQELWGDPNEFRPERFLTSSGTLDKHLSEK
                     VILFGLGKRKCIGETIGRLEVFLFLAILLQQMEFNVSPGEKVDMTPAYGLTLKHARCE
                     HFQVQMRSSGPQHLQA"
     exon            910..1036
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; Cyp45c; Cypc45c;
                     P-450MC; P1-450; P450-C; P450DX"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1126
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; Cyp45c; Cypc45c;
                     P-450MC; P1-450; P450-C; P450DX"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1250
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; Cyp45c; Cypc45c;
                     P-450MC; P1-450; P450-C; P450DX"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1337
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; Cyp45c; Cypc45c;
                     P-450MC; P1-450; P450-C; P450DX"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..2616
                     /gene="Cyp1a1"
                     /gene_synonym="AHH; AHRR; CP11; CYP1; Cyp45c; Cypc45c;
                     P-450MC; P1-450; P450-C; P450DX"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catcctccct ggggtcctag agaacactct tcagttcagt ccttcctcac agccaaagca
       61 gccacctaga tcatgccttc tgtgtatgga ttcccagcct tcacatcagc cacagagctg
      121 ctcctggccg tcaccacatt ctgccttgga ttctgggtgg ttagagtcac aagaacctgg
      181 gttcccaaag gtctgaagag tccacccgga ccctggggct tgcccttcat agggcacgtg
      241 ctgaccctgg ggaagaaccc acacctgtca ctgacaaaac tgagtcagca gtatggggac
      301 gtgctgcaga tccgtattgg ctccacaccc gtggtggtgc tgagcggcct gaacaccatc
      361 aagcaggccc tggtgaaaca gggggatgac ttcaaaggcc ggccagacct ctacagcttc
      421 acacttatcg ctaatggcca gagcatgact ttcaacccag actctggacc gctgtgggct
      481 gcccgccggc gcctggccca gaatgcgctg aagagtttct ccatagcctc agacccaaca
      541 ctggcatcct cttgctactt ggaagagcac gtgagcaaag aggctgaata cttaatcagc
      601 aagttccaga agctgatggc agaggttggc cacttcgacc ctttcaagta tttggtggtg
      661 tcagtggcca atgtcatctg tgccatatgc tttggcagac gttatgacca cgatgaccaa
      721 gagctgctca gcatagtcaa tctaagcaat gagtttgggg aggttactgg ttctggatac
      781 ccagctgact tcattcctat cctccgttac ctccctaact cttccctgga tgccttcaag
      841 gacttgaata agaagttcta cagtttcatg aagaagctaa tcaaagagca ctacaggaca
      901 tttgagaagg gccacatccg ggacatcaca gacagcctca ttgagcattg tcaggacagg
      961 aggctggacg agaatgccaa tgtccagctc tcagatgata aggtcattac gattgttttt
     1021 gacctctttg gagctgggtt tgacacaatc acaactgcta tctcttggag cctcatgtac
     1081 ctggtaacca accctaggat acagagaaag atccaggagg agttagacac agtgattggc
     1141 agggatcggc agccccggct ttctgacaga cctcagctgc cctatctgga ggccttcatc
     1201 ctggagacct tccgacattc atcctttgtc ccattcacca tcccccacag caccataaga
     1261 gatacaagtc tgaatggctt ctatatcccc aagggacact gtgtctttgt gaaccagtgg
     1321 caggttaacc atgaccagga actatggggt gatccaaacg agttccggcc tgaaaggttt
     1381 cttacctcca gtggcactct ggacaaacac ctgagtgaga aggtcattct ctttggtttg
     1441 ggcaagcgaa agtgcattgg ggagaccatt ggccgactgg aggtctttct cttcctggcc
     1501 atcttgctgc agcaaatgga atttaatgtg tcaccaggcg agaaggtgga tatgactcct
     1561 gcctatgggc tgactttaaa acatgcccgc tgtgagcact tccaagtgca gatgcggtct
     1621 tctggtcctc agcatctcca ggcttagact gtcctggatg ctcaccagac caggtggctg
     1681 ttcctaggat tcaacttcag tcagaaacac agaccctggg gcattgtgcc tgcctcctac
     1741 tttggacttg tttctctata tgctgaacac agacactggg cacagcagag acccacagga
     1801 acctcagatc cttctcaagt tcagcatcaa ctaggagacc taaaagggtt atgagatacc
     1861 tgggcctcag aaaacccctg aagagctctc taggtcctcc agtggctggc tggtttgaaa
     1921 aatacttaca acaggtcatg ccaggatctg gctggttact ttgacaaccg ggagtagccc
     1981 agaatggagg gagaagagaa ctcaaaatac tggcacggag gtgctcttgc catctgctga
     2041 ggctcaactg tcttccaaca tgggtttatg acactacatg tgggggtgta gcaccttcat
     2101 ttaccctaca tagaaataaa caaggtctcc ttgtccttgc aaagcccatg ttcctgttta
     2161 ggaagggctg agagttgtgt gtagaaagac ctaagaacat agggacagac tttctgggca
     2221 gtaagaccag gtttagagta aaggaatgcc ttttgagaca gtattgtgta gtccaggctg
     2281 cctctgaact tgctaccaag ggtggccttg aactccttaa ttcttttttc tgcttttacc
     2341 accctaccaa gtgctagggt acagtcatga accgctacac cagctcttgg tctcttgtct
     2401 ttactgtata aaacgtttct ttctttcttt tttttttaaa gaaaatgttt gtgcataaga
     2461 gttttttatt gtggcctgta ttttgcttat gcatttgtat tagtcgtact tcaatagatt
     2521 tagataattc gcttagtgta atagagaaaa atctaactca agtatccaga aatatatagg
     2581 aaaaacgtac ctgagctaaa taaaaatatt acctgg
//
