LOCUS       NM_017085               2712 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 19, subfamily a,
            polypeptide 1 (Cyp19a1), mRNA.
ACCESSION   NM_017085
VERSION     NM_017085.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2712)
  AUTHORS   Zhao,J., He,C., Fan,X., Wang,L., Zhao,L., Liu,H., Shen,W.,
            Jiang,S., Pei,K., Gao,J., Qi,Y., Liu,Y., Zhao,J., Zhang,R., Lu,C.,
            Tong,J. and Huai,J.
  TITLE     Tripeptidyl peptidase II coordinates the homeostasis of calcium and
            lipids in the central nervous system and its depletion causes
            presenile dementia in female mice through calcium/lipid
            dyshomeostasis-induced autophagic degradation of CYP19A1
  JOURNAL   Theranostics 14 (4), 1390-1429 (2024)
   PUBMED   38389851
  REMARK    GeneRIF: Tripeptidyl peptidase II coordinates the homeostasis of
            calcium and lipids in the central nervous system and its depletion
            causes presenile dementia in female mice through calcium/lipid
            dyshomeostasis-induced autophagic degradation of CYP19A1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2712)
  AUTHORS   Ma,B., Qiao,H., Guo,Y., Wei,J., Yang,Q., Feng,X. and Li,Z.
  TITLE     TGF-beta1 induced activations of Smad2 and miRNAs inhibit SF-1- and
            LRH-1-dependent CYP19 expression in rat Leydig cellsdagger
  JOURNAL   Biol Reprod 108 (5), 778-790 (2023)
   PUBMED   36857632
  REMARK    GeneRIF: TGF-beta1 induced activations of Smad2 and miRNAs inhibit
            SF-1- and LRH-1-dependent CYP19 expression in rat Leydig
            cellsdagger.
REFERENCE   3  (bases 1 to 2712)
  AUTHORS   Brzoskwinia,M., Pardyak,L., Kaminska,A., Tworzydlo,W., Hejmej,A.,
            Marek,S., Bilinski,S.M. and Bilinska,B.
  TITLE     Flutamide treatment reveals a relationship between steroidogenic
            activity of Leydig cells and ultrastructure of their mitochondria
  JOURNAL   Sci Rep 11 (1), 13772 (2021)
   PUBMED   34215832
  REMARK    GeneRIF: Flutamide treatment reveals a relationship between
            steroidogenic activity of Leydig cells and ultrastructure of their
            mitochondria.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2712)
  AUTHORS   Krentzel,A.A., Willett,J.A., Johnson,A.G. and Meitzen,J.
  TITLE     Estrogen receptor alpha, G-protein coupled estrogen receptor 1, and
            aromatase: Developmental, sex, and region-specific differences
            across the rat caudate-putamen, nucleus accumbens core and shell
  JOURNAL   J Comp Neurol 529 (4), 786-801 (2021)
   PUBMED   32632943
  REMARK    GeneRIF: Estrogen receptor alpha, G-protein coupled estrogen
            receptor 1, and aromatase: Developmental, sex, and region-specific
            differences across the rat caudate-putamen, nucleus accumbens core
            and shell.
REFERENCE   5  (bases 1 to 2712)
  AUTHORS   Lite,C., Ahmed,S.S.S.J., Santosh,W. and Seetharaman,B.
  TITLE     Prenatal exposure to bisphenol-A altered miRNA-224 and protein
            expression of aromatase in ovarian granulosa cells concomitant with
            elevated serum estradiol levels in F1 adult offspring
  JOURNAL   J Biochem Mol Toxicol 33 (6), e22317 (2019)
   PUBMED   30817060
  REMARK    GeneRIF: Prenatal exposure to bisphenol-A altered miRNA-224 and
            protein expression of aromatase in ovarian granulosa cells
            concomitant with elevated serum estradiol levels in F1 adult
            offspring.
REFERENCE   6  (bases 1 to 2712)
  AUTHORS   Gray,S.A., Mannan,M.A. and O'Shaughnessy,P.J.
  TITLE     Development of cytochrome P450 aromatase mRNA levels and enzyme
            activity in ovaries of normal and hypogonadal (hpg) mice
  JOURNAL   J Mol Endocrinol 14 (3), 295-301 (1995)
   PUBMED   7669221
REFERENCE   7  (bases 1 to 2712)
  AUTHORS   Rogler,L.E. and Pintar,J.E.
  TITLE     Expression of the P450 side-chain cleavage and adrenodoxin genes
            begins during early stages of adrenal cortex development
  JOURNAL   Mol Endocrinol 7 (3), 453-461 (1993)
   PUBMED   8097866
REFERENCE   8  (bases 1 to 2712)
  AUTHORS   Lephart,E.D., Peterson,K.G., Noble,J.F., George,F.W. and
            McPhaul,M.J.
  TITLE     The structure of cDNA clones encoding the aromatase P-450 isolated
            from a rat Leydig cell tumor line demonstrates differential
            processing of aromatase mRNA in rat ovary and a neoplastic cell
            line
  JOURNAL   Mol Cell Endocrinol 70 (1), 31-40 (1990)
   PUBMED   2340950
REFERENCE   9  (bases 1 to 2712)
  AUTHORS   Hickey,G.J., Krasnow,J.S., Beattie,W.G. and Richards,J.S.
  TITLE     Aromatase cytochrome P450 in rat ovarian granulosa cells before and
            after luteinization: adenosine 3',5'-monophosphate-dependent and
            independent regulation. Cloning and sequencing of rat aromatase
            cDNA and 5' genomic DNA
  JOURNAL   Mol Endocrinol 4 (1), 3-12 (1990)
   PUBMED   2157976
REFERENCE   10 (bases 1 to 2712)
  AUTHORS   Santen,R.J., Worgul,T.J., Lipton,A., Harvey,H., Boucher,A.,
            Samojlik,E. and Wells,S.A.
  TITLE     Aminoglutethimide as treatment of postmenopausal women with
            advanced breast carcinoma
  JOURNAL   Ann Intern Med 96 (1), 94-101 (1982)
   PUBMED   7053713
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jun 3, 2021 this sequence version replaced NM_017085.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.30234.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-419               JAXUCZ010000008.1  63476116-63476534   c
            420-570             JAXUCZ010000008.1  63469609-63469759   c
            571-725             JAXUCZ010000008.1  63463395-63463549   c
            726-902             JAXUCZ010000008.1  63460026-63460202   c
            903-1017            JAXUCZ010000008.1  63457185-63457299   c
            1018-1132           JAXUCZ010000008.1  63456526-63456640   c
            1133-1295           JAXUCZ010000008.1  63455673-63455835   c
            1296-1537           JAXUCZ010000008.1  63451975-63452216   c
            1538-2712           JAXUCZ010000008.1  63449148-63450322   c
FEATURES             Location/Qualifiers
     source          1..2712
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2712
                     /gene="Cyp19a1"
                     /gene_synonym="Aromatase; Cyp19; Cyp19a; p450arom"
                     /note="cytochrome P450, family 19, subfamily a,
                     polypeptide 1"
                     /db_xref="GeneID:25147"
                     /db_xref="RGD:2457"
     exon            1..419
                     /gene="Cyp19a1"
                     /gene_synonym="Aromatase; Cyp19; Cyp19a; p450arom"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1786
                     /gene="Cyp19a1"
                     /gene_synonym="Aromatase; Cyp19; Cyp19a; p450arom"
                     /EC_number="1.14.14.14"
                     /note="cytochrome P450 19A1; cytochrome P450 family 19
                     subfamily a; CYPXIX; P-450AROM; estrogen synthetase;
                     estrogen synthase; cytochrome P-450AROM; Cytochrome P450,
                     19, aromatase; cytochrome P450, subfamily 19; cytochrome
                     P450 19A1-like"
                     /codon_start=1
                     /product="aromatase"
                     /protein_id="NP_058781.2"
                     /db_xref="GeneID:25147"
                     /db_xref="RGD:2457"
                     /translation="MFLEMLNPMHYNVTIMVPETVPVSAMPLLLIMGLLLLIRNCESS
                     SSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSS
                     MVHVMKHSNYISRFGSKRGLQCIGMHENGIIFNNNPSLWRTVRPFFMKALTGPGLIRM
                     VEVCVESIKQHLDRLGDVTDNSGYVDVVTLMRHIMLDTSNTLFLGIPLDESSIVKKIQ
                     GYFNAWQALLIKPNIFFKISWLYRKYERSVKDLKDEIEILVEKKRQKVSSAEKLEDCM
                     DFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYVMLLLIAEYPEVETAILK
                     EIHTVVGDRDIRIGDVQNLKVVENFINESLRYQPVVDLVMRRALEDDVIDGYPVKKGT
                     NIILNIGRMHRLEYFPKPNEFTLENFEKNVPYRYFQPFGFGPRSCAGKYIAMVMMKVV
                     LVTLLKRFHVKTLQKRCIENMPKNNDLSLHLDEDSPIVEIIFSPRNSEKYLKQ"
     exon            420..570
                     /gene="Cyp19a1"
                     /gene_synonym="Aromatase; Cyp19; Cyp19a; p450arom"
                     /inference="alignment:Splign:2.1.0"
     exon            571..725
                     /gene="Cyp19a1"
                     /gene_synonym="Aromatase; Cyp19; Cyp19a; p450arom"
                     /inference="alignment:Splign:2.1.0"
     exon            726..902
                     /gene="Cyp19a1"
                     /gene_synonym="Aromatase; Cyp19; Cyp19a; p450arom"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1017
                     /gene="Cyp19a1"
                     /gene_synonym="Aromatase; Cyp19; Cyp19a; p450arom"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1132
                     /gene="Cyp19a1"
                     /gene_synonym="Aromatase; Cyp19; Cyp19a; p450arom"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1295
                     /gene="Cyp19a1"
                     /gene_synonym="Aromatase; Cyp19; Cyp19a; p450arom"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1537
                     /gene="Cyp19a1"
                     /gene_synonym="Aromatase; Cyp19; Cyp19a; p450arom"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..2712
                     /gene="Cyp19a1"
                     /gene_synonym="Aromatase; Cyp19; Cyp19a; p450arom"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgagtatg cacgtcactc tacccactca agggcaagat gataaggttc tatcagacca
       61 accgctgaac aggacctgag tctcccaagg tcatccttgt tttgacttgt aaccacaaat
      121 ttgtcttgcc ttgtcactat aaaacatctg tccattccag cacccttaca agtgacagga
      181 gccacagcca aactactgct ttgcgtgcta acatcactac tgctttcttc ctatagaact
      241 ttacattttt ccttctgagg caaaatagca caagatgttt ttggaaatgc tgaaccccat
      301 gcactataat gtcaccatca tggtcccgga aactgtgcct gtcagtgcca tgccacttct
      361 gctgatcatg ggcctcctcc tcctgattcg gaattgtgag agctcatctt ccataccagg
      421 tcctggctac tgtctgggaa tcgggcctct catttcccat ggcagattct tgtggatggg
      481 gattggaagt gcctgcaact actacaataa gatgtatgga gagttcatga gagtctggat
      541 cagtggagag gagacactca tcatcagcaa gtcctcgagc atggtccatg tgatgaagca
      601 cagcaactac atctccagat tcggcagcaa gcgtgggctg cagtgcattg gcatgcacga
      661 gaatggcatc atatttaaca acaacccgag cctgtggaga acggtccgcc ctttcttcat
      721 gaaagctctg acgggccctg gtcttattcg aatggtagaa gtctgtgtgg aatccatcaa
      781 gcagcatttg gacaggctgg gtgacgtcac tgacaactcg ggctacgtgg acgtggtgac
      841 cctcatgaga cacatcatgc tggacacttc taacacgctc ttcctgggga tccccctgga
      901 cgaaagttct attgtgaaga aaatccaggg ttattttaat gcctggcaag cactccttat
      961 caaaccaaac atcttcttta agatttcttg gctctacaga aagtatgaga gatccgtcaa
     1021 ggacttgaaa gacgagatcg aaattctggt ggaaaagaaa agacagaaag tttcctcagc
     1081 agagaaactg gaagactgta tggattttgc aactgatttg attttcgctg agagacgtgg
     1141 agacctgaca aaggagaacg tgaatcagtg tatattggaa atgctgattg cggcccctga
     1201 caccatgtcc gtcactctgt acgtcatgtt gcttctcatc gcagagtatc cggaggtgga
     1261 aacagctata ctgaaggaaa tccacactgt tgttggtgac agagacataa ggattggtga
     1321 tgtgcaaaat ttgaaagtgg tggaaaactt cattaacgag agcctgcggt atcagcctgt
     1381 cgtggacttg gtcatgcgca gagccctgga ggatgacgtg attgacggct acccggttaa
     1441 aaagggaact aacatcattc tgaacatcgg aagaatgcac aggctcgagt atttccccaa
     1501 gcccaatgaa tttacccttg aaaactttga gaagaacgtt ccctacaggt attttcagcc
     1561 atttggcttt gggccccgca gctgtgctgg gaagtacatc gccatggtga tgatgaaagt
     1621 tgtcctggtt acacttttga aacgattcca tgtgaagaca ttgcaaaaaa ggtgtattga
     1681 aaatatgccg aaaaataatg acttgtcctt gcatctagat gaggacagcc ccattgtgga
     1741 aataattttc tctccaagga attcagaaaa gtacctcaaa cagtgaacaa gtggggtctg
     1801 tctactctga cacattactc atcgatagtt acctgggaac catcagtttt atcgagtagg
     1861 tggcctcaac ctcaccacgg atgtttgatg gtctgaagca ttttatgatc acagctccta
     1921 tggtttgtca gcaagccgag catccatcca gagagccggg atgcaaaaga aaggagtcca
     1981 tgttggggac cagtaaagag actgaagcct taaaggacca atcctacaaa atatacattg
     2041 ggaaagcagg ccatcagtaa aacccatctg gtctcctgct agagttccaa agttgtcgtc
     2101 agcacatcta aatgactctg gcagaagtac ttaagttatt agaaaggcca ggccatgtgg
     2161 ggtcaggcat aaatgaacaa aggaactttc atttgtgtgt gtgtgtgtgt gtgtgtgtgt
     2221 gtgtgtgtgt gtgtgtgtgt gtgttgaggg taagtgggaa gtaacaatct agactcttcc
     2281 cacaagttaa gcccggttgc ttatgatgga tccccatgta aactgttttg ggggcaaaag
     2341 ttaaacatgg gagtattgtt tcttactctc agttcgtgct cccaggagtg tagcttgact
     2401 gtagtaggtg tagattcagg tagaacatgc ctaagtcgta ttagcctgag taaaatatag
     2461 ctaggactct gtgtgtggtg tggggggaaa atcacatggt gcatttcaaa taaataggtc
     2521 tttttaaaaa gccatttgca ttgttgctta gctcctttag cagtctgagg aaggaaatcc
     2581 ctctgtgact acattgagta cagcaggcca gtgggccccc acttctaaag agtcatctct
     2641 tcctttgacg taccttctca cctttttttg tcatgacccc attctttcaa agaataaaga
     2701 gttgaaccct ca
//
